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European Journal of Medical Research Dec 2022Epiphyseal plate injury, a common problem in pediatric orthopedics, may result in poor bone repair or growth defects. Epiphyseal plate, also known as growth plate is a... (Review)
Review
Epiphyseal plate injury, a common problem in pediatric orthopedics, may result in poor bone repair or growth defects. Epiphyseal plate, also known as growth plate is a layer of hyaline cartilage tissue between the epiphysis and metaphyseal and has the ability to grow longitudinally. Under normal physiological conditions, the epiphyseal plate has a certain axial resistance to stress, but it is fragile in growth phase and can be damaged by excessive stress, leading to detachment or avulsion of the epiphysis, resulting in life-long devastating consequences for patients. There is an obvious inflammatory response in the phase of growth plate injury, the limited physiological inflammatory response locally favors tissue repair and the organism, but uncontrolled chronic inflammation always leads to tissue destruction and disease progression. Interleukin-1β (IL-1β), as representative inflammatory factors, not only affect the inflammatory phase response to bone and soft tissue injury, but have a potentially important role in the later repair phase, though the exact mechanism is not fully understood. At present, epiphyseal plate injuries are mainly treated by corrective and reconstructive surgery, which is highly invasive with limited effectiveness, thus new therapeutic approaches are urgently needed, so a deeper understanding and exploration of the pathological mechanisms of epiphyseal plate injuries at the cellular molecular level is an entry point. In this review, we fully introduced the key role of IL-1 in the progression of epiphyseal plate injury and repair, deeply explored the mechanism of IL-1 on the molecular transcript level and endocrine metabolism of chondrocytes from multiple aspects, and summarized other possible mechanisms to provide theoretical basis for the clinical treatment and in-depth study of epiphyseal plate injury in children.
Topics: Child; Humans; Growth Plate; Chondrocytes; Interleukin-1beta; Epiphyses
PubMed: 36575508
DOI: 10.1186/s40001-022-00893-8 -
Cells Jan 2021The long-term outcomes of osteosarcoma have improved; however, patients with metastases, recurrence or axial disease continue to have a poor prognosis. Computer... (Review)
Review
The long-term outcomes of osteosarcoma have improved; however, patients with metastases, recurrence or axial disease continue to have a poor prognosis. Computer navigation in surgery is becoming ever more commonplace, and the proposed advantages, including precision during surgery, is particularly applicable to the field of orthopaedic oncology and challenging areas such as the axial skeleton. Within this article, we provide an overview of the field of computer navigation and computer-assisted tumour surgery (CATS), in particular its relevance to the surgical management of osteosarcoma.
Topics: Animals; Bone Neoplasms; Bone and Bones; Computers; Humans; Osteosarcoma; Printing, Three-Dimensional; Surgery, Computer-Assisted
PubMed: 33498287
DOI: 10.3390/cells10020195 -
PeerJ 2023The functional biomechanics of the lumbar spine have been better understood by finite element method (FEM) simulations. However, there are still areas where the behavior...
The functional biomechanics of the lumbar spine have been better understood by finite element method (FEM) simulations. However, there are still areas where the behavior of soft tissues can be better modeled or described in a different way. The purpose of this research is to develop and validate a lumbar spine section intended for biomechanical research. A FE model of the 50th percentile adult male (AM) Total Human Model for Safety (THUMS) v6.1 was used to implement the modifications. The main modifications were to apply orthotropic material properties and nonlinear stress-strain behavior for ligaments, hyperelastic material properties for annulus fibrosus and nucleus pulposus, and the specific content of collagenous fibers in the annulus fibrosus ground substance. Additionally, a separation of the nucleus pulposus from surrounding bones and tissues was implemented. The FE model was subjected to different loading modes, in which intervertebral rotations and disc pressures were calculated. Loading modes contained different forces and moments acting on the lumbar section: axial forces (compression and tension), shear forces, pure moments, and combined loading modes of axial forces and pure moments. The obtained ranges of motion from the modified numerical model agreed with experimental data for all loading modes. Moreover, intradiscal pressure validation for the modified model presented a good agreement with the data available from the literature. This study demonstrated the modifications of the THUMS v6.1 model and validated the obtained numerical results with existing literature in the sub-injurious range. By applying the proposed changes, it is possible to better model the behavior of the human lumbar section under various loads and moments.
Topics: Adult; Male; Humans; Intervertebral Disc; Finite Element Analysis; Lumbar Vertebrae; Annulus Fibrosus; Nucleus Pulposus
PubMed: 37583909
DOI: 10.7717/peerj.15805 -
Journal of Biomechanics Jan 2022Femoral condyle motion of the knee is generally reported using a morphological trans-epicondyle axis (TEA) or geometric center axis (GCA) in the investigation of the...
Femoral condyle motion of the knee is generally reported using a morphological trans-epicondyle axis (TEA) or geometric center axis (GCA) in the investigation of the knee kinematics. Axial rotation of the femur is recognized as a characteristic motion of the knee during flexion, but is controversial in the literature. This study investigated the biomechanical factors that could be associated to the axial rotations of the femur using both physiological and morphological measurement methods. Twenty healthy knees were investigated during a weightbearing flexion from 0° to 120° at a 15° increment using an imaging technique. A 3D model was constructed for each knee using MR images. Tibiofemoral cartilage contact points were determined at each flexion position to represent physiological knee motion. The contact distance on each condyle was measured between consecutive contact points. The TEA and GCA were used to measure morphological anteroposterior translations of the femoral condyles. The differences between the medial and lateral condyle motions were used to calculate the physiological and morphological axial rotations of the femur. Both the physiological and morphological methods measured external rotations of the femur at low flexion range (0°-45°) and minimal rotations at higher flexion angles. However, the morphological method measured larger posterior translations of the lateral femoral condyle than the medial condyle (p < 0.05), implying a medial pivoting rotation; in contrast, the physiological method measured larger contact distances on the medial condyle than on the lateral condyle (p < 0.05), implying a lateral pivoting rotation. These data could provide useful references for future investigation of kinematics of the knee before and after surgical repair, such as using total knee arthroplasty.
Topics: Arthroplasty, Replacement, Knee; Biomechanical Phenomena; Epiphyses; Femur; Humans; Knee Joint; Range of Motion, Articular; Rotation
PubMed: 34923296
DOI: 10.1016/j.jbiomech.2021.110906 -
Frontiers in Endocrinology 2022Bone marrow adipose tissue (BMAT) is a dynamic tissue which is associated with osteoporosis, bone metastasis, and primary bone tumors. The aim of this study is to...
Gender- and Age-Associated Differences in Bone Marrow Adipose Tissue and Bone Marrow Fat Unsaturation Throughout the Skeleton, Quantified Using Chemical Shift Encoding-Based Water-Fat MRI.
Bone marrow adipose tissue (BMAT) is a dynamic tissue which is associated with osteoporosis, bone metastasis, and primary bone tumors. The aim of this study is to determine region-specific variations and age- and gender-specific differences in BMAT and BMAT composition in healthy subjects. In this cross-sectional study, we included 40 healthy subjects (26 male: mean age 49 years, range 22-75 years; 14 female: mean age 50 years, range 29-71) and determined the bone marrow signal fat fraction and bone marrow unsaturation in the spine (C3-L5), pelvis, femora, and tibiae using chemical shift encoding-based water-fat imaging (WFI) with multiple gradient echoes (mGRE). Regions of interest covered the individual vertebral bodies, pelvis and proximal epimetaphysis, diaphysis, and distal epimetaphysis of the femur and tibia. The spinal fat fraction increased from cervical to lumbar vertebral bodies (mean fat fraction ( ± SD or (IQR): cervical spine 0.37 ± 0.1; thoracic spine 0.41 ± 0.08. lumbar spine 0.46 ± 0.01; p < 0.001). The femoral fat fraction increased from proximal to distal (proximal 0.78 ± 0.09; diaphysis 0.86 (0.15); distal 0.93 ± 0.02; p < 0.001), while within the tibia the fat fraction decreased from proximal to distal (proximal 0.92 ± 0.01; diaphysis 0.91 (0.02); distal 0.90 ± 0.01; p < 0.001). In female subjects, age was associated with fat fraction in the spine, pelvis, and proximal femur (ρ = 0.88 p < 0.001; ρ = 0.87 p < 0.001; ρ = 0.63 p = 0.02; ρ = 0.74 p = 0.002, respectively), while in male subjects age was only associated with spinal fat fraction (ρ = 0.40 p = 0.04). Fat fraction and unsaturation were negatively associated within the spine (r = -0.40 p = 0.01), while in the extremities fat fraction and unsaturation were positively associated (distal femur: r = 0.42 p = 0.01; proximal tibia: r = 0.47, p = 0.002; distal tibia: r = 0.35 p = 0.03), both independent of age and gender. In conclusion, we confirm the distinct, age- and gender-dependent, distribution of BMAT throughout the human skeleton and we show that, contradicting previous animal studies, bone marrow unsaturation in human subjects is highest within the axial skeleton compared to the appendicular skeleton. Furthermore, we show that BMAT unsaturation was negatively correlated with BMAT within the spine, while in the appendicular skeleton, BMAT and BMAT unsaturation were positively associated.
Topics: Adipose Tissue; Animals; Bone Marrow; Bone and Bones; Cross-Sectional Studies; Female; Humans; Lumbar Vertebrae; Magnetic Resonance Imaging; Male; Water
PubMed: 35574007
DOI: 10.3389/fendo.2022.815835 -
Gait & Posture Jul 2021Based on Euler/Cardan analysis, prior investigations have reported up to 80° of glenohumeral (GH) external rotation during arm elevation, dependent on the plane of...
BACKGROUND
Based on Euler/Cardan analysis, prior investigations have reported up to 80° of glenohumeral (GH) external rotation during arm elevation, dependent on the plane of elevation (PoE). However, the subtraction of Euler/Cardan angles does not compute the rotation around the humerus' longitudinal axis (i.e. axial rotation). Clinicians want to understand the true rotation around the humerus' longitudinal axis and rely on laboratories to inform their understanding of underlying shoulder biomechanics, especially for the GH joint since its motion cannot be visually ascertained. True GH axial rotation has not been previously measured in vivo, and its difference from Euler/Cardan (apparent) axial rotation is unknown.
RESEARCH QUESTION
What is the true GH axial rotation during arm elevation and external rotation, and does it vary from apparent axial rotation and by PoE?
METHODS
Twenty healthy subjects (10 M/10 F, ages 22-66) were recorded using biplane fluoroscopy while performing arm elevation in the coronal, scapular and sagittal planes, and external rotation in 0° and 90° of abduction. Apparent GH axial rotation was computed using the xz'y'' and yx'y'' sequences. True GH axial rotation was computed by integrating the projection of GH angular velocity onto the humerus' longitudinal axis. One-dimensional statistical parametric mapping was utilized to compare apparent versus true axial rotation, axial rotation versus 0°, and detect differences in axial rotation by PoE.
RESULTS
In contrast to apparent axial rotation, true GH axial rotation does not differ by PoE and is not different than 0° during arm elevation at higher elevation angles. The spherical area between the sequence-specific and actual humeral trajectory explains the difference between apparent and true axial rotation.
SIGNIFICANCE
Proper quantification of axial rotation is important because biomechanics literature informs clinical understanding of shoulder biomechanics. Clinicians care about true axial rotation, which should be reported in future studies of shoulder kinematics.
Topics: Adult; Aged; Arm; Biomechanical Phenomena; Humans; Middle Aged; Range of Motion, Articular; Scapula; Shoulder; Shoulder Joint; Young Adult
PubMed: 33989999
DOI: 10.1016/j.gaitpost.2021.05.004 -
Der Orthopade May 2021A cornerstone in the treatment of osteoarthritis in young patients is the evaluation and correction of the leg axis. The combination of a joint injury (meniscus,... (Review)
Review
A cornerstone in the treatment of osteoarthritis in young patients is the evaluation and correction of the leg axis. The combination of a joint injury (meniscus, cartilage, ligament) and an axis deviation inevitably, depending on its extent and the patient's comorbidities such as obesity, leads to progressive osteoarthritis of the knee after a few years. In addition to the precise deformity analysis for osteotomy planning, it is important to know the normal ranges of the corresponding angles and to define a target value for axis correction. Reflecting the repertoire of different osteotomy options around the knee (open vs. closed, tibial vs. femoral, medial vs. lateral), the side effects in relation to patellofemoral maltracking, ligamentary balancing and leg length should then be assessed. Especially with regard to possible (and probable) prosthetic operations at some time in the future of young patients, new bony deformities or ligamentous insufficiencies, which potentially arise from overcorrection, must be avoided.
Topics: Femur; Humans; Knee Joint; Osteoarthritis, Knee; Osteotomy; Radiography; Tibia
PubMed: 33844033
DOI: 10.1007/s00132-021-04103-x -
Journal of Orthopaedic Surgery and... Apr 2022To determine whether there is a correlation between the type of ossification and radiological parameters, modified thoracic JOA scores, and complications in patients...
BACKGROUND
To determine whether there is a correlation between the type of ossification and radiological parameters, modified thoracic JOA scores, and complications in patients with thoracic ossification of ligamentum flavum treated by posterior thoracic surgery.
METHODS
This retrospective cohort study included 48 patients with thoracic myelopathy caused by single-level thoracic ossification of ligamentum flavum who underwent thoracic posterior approach surgery in our Hospital o between December 2013 to December 2018. Patients were divided into unilateral, bilateral, and bridged groups in axial position, and beak and round groups in sagittal position. The differences were analyzed according to the ossification morphology.
RESULTS
In axial myelopathy, there was no significant difference in preop and postop JOA scores and RR among the three groups in axial position (P = 0.884). In sagittal view, there was no significant difference in preoperative JOA score between the two groups (P = 0.710), while the postop JOA score and the recovery rate in the beak group were significantly lower than that of the round group (P = 0.010, P = 0.034). Two-way ANOVA showed that sagittal morphology had a significant effect on postop JOA score (P = 0.028), but axial morphology don't (P = 0.431); there was no interaction between them (P = 0.444). For the recovery rate, sagittal morphology also had a significant effect (P = 0.043), but axial ossification don't (P = 0.998); there was no interaction between them (P = 0.479).
CONCLUSION
Sagittal morphology had a significant adverse effect on postop JOA score and surgical outcome, while axial morphology had no effect on surgical outcome, and there was no interaction between sagittal morphology and axial morphology.
Topics: Decompression, Surgical; Humans; Ligamentum Flavum; Ossification, Heterotopic; Osteogenesis; Retrospective Studies; Spinal Cord Diseases; Thoracic Vertebrae; Treatment Outcome
PubMed: 35413915
DOI: 10.1186/s13018-022-03064-x -
Knee Surgery, Sports Traumatology,... Dec 2023The aim of this study was to assess the biomechanical effects of subtalar ligament injury and reconstruction on stability of the subtalar joint in all three spatial...
PURPOSE
The aim of this study was to assess the biomechanical effects of subtalar ligament injury and reconstruction on stability of the subtalar joint in all three spatial planes.
METHODS
Fifteen fresh frozen cadaveric legs were used, with transfixed tibiotalar joints to isolate motion to the subtalar joint. An arthrometer fixed to the lateral aspect of the calcaneus measured angular displacement in all three spatial planes on the inversion and eversion stress tests. Stress manoeuvres were tested with the intact joint, and then repeated after sequentially sectioning the inferior extensor retinaculum (IER), cervical ligament (CL), interosseous talocalcaneal ligament (ITCL), arthroscopic graft reconstruction of the ITCL, and sectioning of the calcaneo-fibular ligament (CFL).
RESULTS
Sectioning the ITCL significantly increased angular displacement upon inversion and eversion in the coronal and sagittal planes. Reconstruction of the ITCL significantly improved angular stability against eversion in the axial and sagittal planes, and against inversion in the axial and coronal planes, at the zero time point after reconstruction. After sectioning the CFL, resistance to eversion decreased significantly in all three planes.
CONCLUSION
Progressive injury of ligamentous stabilisers, particularly the ITCL, led to increasing angular displacement of the subtalar joint measured with the inversion and eversion stress tests, used in clinical practice. Reconstruction of the ITCL using tendon graft significantly stabilised the subtalar joint in the axial and sagittal planes against eversion and in the axial and coronal planes against inversion, immediately after surgery.
Topics: Humans; Subtalar Joint; Biomechanical Phenomena; Cadaver; Ankle Joint; Ligaments, Articular; Joint Instability; Allografts
PubMed: 37955675
DOI: 10.1007/s00167-023-07622-6 -
Scientific Reports Apr 2021The myodural bridge (MDB) connects the suboccipital musculature to the spinal dura mater (SDM) as it passed through the posterior atlanto-occipital and the atlanto-axial...
The myodural bridge (MDB) connects the suboccipital musculature to the spinal dura mater (SDM) as it passed through the posterior atlanto-occipital and the atlanto-axial interspaces. Although the actual function of the MDB is not understood at this time, it has recently been proposed that head movement may assist in powering the movement of cerebrospinal fluid (CSF) via muscular tension transmitted to the SDM via the MDB. But there is little information about it. The present study utilized dogs as the experimental model to explore the MDB's effects on the CSF pressure (CSFP) during stimulated contractions of the suboccipital muscles as well as during manipulated movements of the atlanto-occiptal and atlanto-axial joints. The morphology of MDB was investigated by gross anatomic dissection and by histological observation utilizing both light microscopy and scanning electron microscopy. Additionally biomechanical tensile strength tests were conducted. Functionally, the CSFP was analyzed during passive head movements and electrical stimulation of the suboccipital muscles, respectively. The MDB was observed passing through both the dorsal atlanto-occipital and the atlanto-axial interspaces of the canine and consisted of collagenous fibers. The tensile strength of the collagenous fibers passing through the dorsal atlanto-occipital and atlanto-axial interspaces were 0.16 ± 0.04 MPa and 0.82 ± 0.57 MPa, respectively. Passive head movement, including lateral flexion, rotation, as well as flexion-extension, all significantly increased CSFP. Furthermore, the CSFP was significantly raised from 12.41 ± 4.58 to 13.45 ± 5.16 mmHg when the obliques capitis inferior (OCI) muscles of the examined specimens were electrically stimulated. This stimulatory effect was completely eliminated by severing the myodural bridge attachments to the OCI muscle. Head movements appeared to be an important factor affecting CSF pressure, with the MDB of the suboccipital muscles playing a key role this process. The present study provides direct evidence to support the hypothesis that the MDB may be a previously unappreciated significant power source (pump) for CSF circulation.
Topics: Animals; Atlanto-Occipital Joint; Biomechanical Phenomena; Cervical Vertebrae; Dogs; Microscopy, Electron, Scanning; Neck Muscles
PubMed: 33850172
DOI: 10.1038/s41598-021-86934-4