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Frontiers in Surgery 2022
PubMed: 35836609
DOI: 10.3389/fsurg.2022.952874 -
National Science Review Feb 2022
PubMed: 35198220
DOI: 10.1093/nsr/nwac014 -
Frontiers in Oncology 2021
PubMed: 34745975
DOI: 10.3389/fonc.2021.750690 -
Diagnostics (Basel, Switzerland) Jul 2022S100 proteins are a family of low-molecular-weight proteins characterized by two calcium-binding sites with a helix-loop-helix ("EF-hand-type") domain. The S100 family... (Review)
Review
S100 proteins are a family of low-molecular-weight proteins characterized by two calcium-binding sites with a helix-loop-helix ("EF-hand-type") domain. The S100 family of proteins is distributed across various organs and can interact with diverse molecules. Among the proteins of the S100 family, S100 calcium-binding protein A2 (S100A2) has been identified in mammary epithelial cells, glands, lungs, kidneys, and prostate gland, exhibiting various physiological and pathological actions in human disorders, such as inflammatory diseases and malignant tumors. In this review, we introduce basic knowledge regarding S100A2 regulatory mechanisms. Although S100A2 is a tumor suppressor, we describe the various influences of S100A2 on cancer and inflammatory diseases.
PubMed: 35885660
DOI: 10.3390/diagnostics12071756 -
Journal of Medical Ultrasonics (2001) Jan 2022
Topics: Clinical Medicine; Humans; Research; Ultrasonics
PubMed: 35037085
DOI: 10.1007/s10396-021-01186-z -
Frontiers in Network Physiology 2023
PubMed: 37900301
DOI: 10.3389/fnetp.2023.1284256 -
Cardiology Plus 2023
PubMed: 37206089
DOI: 10.1097/CP9.0000000000000037 -
Frontiers in Cardiovascular Medicine 2021In recent years, the vital role of genetic factors in human diseases have been widely recognized by scholars with the deepening of life science research, accompanied by... (Review)
Review
In recent years, the vital role of genetic factors in human diseases have been widely recognized by scholars with the deepening of life science research, accompanied by the rapid development of gene-editing technology. In early years, scientists used homologous recombination technology to establish gene knock-out and gene knock-in animal models, and then appeared the second-generation gene-editing technology zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) that relied on nucleic acid binding proteins and endonucleases and the third-generation gene-editing technology that functioned through protein-nucleic acids complexes-CRISPR/Cas9 system. This holds another promise for refractory diseases and genetic diseases. Cardiovascular disease (CVD) has always been the focus of clinical and basic research because of its high incidence and high disability rate, which seriously affects the long-term survival and quality of life of patients. Because some inherited cardiovascular diseases do not respond well to drug and surgical treatment, researchers are trying to use rapidly developing genetic techniques to develop initial attempts. However, significant obstacles to clinical application of gene therapy still exists, such as insufficient understanding of the nature of cardiovascular disease, limitations of genetic technology, or ethical concerns. This review mainly introduces the types and mechanisms of gene-editing techniques, ethical concerns of gene therapy, the application of gene therapy in atherosclerosis and inheritable cardiovascular diseases, in-stent restenosis, and delivering systems.
PubMed: 34805315
DOI: 10.3389/fcvm.2021.760140 -
Biomedicines Mar 2023The periodontal ligament is located between the bone (alveolar bone) and the cementum of the tooth, and it is connected by tough fibers called Sharpey's fibers. To... (Review)
Review
The periodontal ligament is located between the bone (alveolar bone) and the cementum of the tooth, and it is connected by tough fibers called Sharpey's fibers. To maintain healthy teeth, the foundation supporting the teeth must be healthy. Periodontal diseases, also known as tooth loss, cause the alveolar bone to dissolve. The alveolar bone, similar to the bones in other body parts, is repeatedly resorbed by osteoclasts and renewed by osteogenic cells. This means that an old bone is constantly being resorbed and replaced by a new bone. In periodontal diseases, the alveolar bone around the teeth is absorbed, and as the disease progresses, the alveolar bone shrinks gradually. In most cases, the resorbed alveolar bone does not return to its original form even after periodontal disease is cured. Gum covers the tooth surface so that it matches the shape of the resorbed alveolar bone, exposing more of the tooth surface than before, making the teeth look longer, leaving gaps between the teeth, and in some cases causing teeth to sting. Previously, the only treatment for periodontal diseases was to stop the disease from progressing further before the teeth fell out, and restoration to the original condition was almost impossible. However, a treatment method that can help in the regeneration of the supporting tissues of the teeth destroyed by periodontal diseases and the restoration of the teeth to their original healthy state as much as possible is introduced. Recently, with improvements in implant material properties, implant therapy has become an indispensable treatment method in dentistry and an important prosthetic option. Treatment methods and techniques, which are mainly based on experience, have gradually accumulated scientific evidence, and the number of indications for treatment has increased. The development of bone augmentation methods has contributed remarkably to the expansion of indications, and this has been made possible by various advances in materials science. The induced pluripotent stem cell (iPS) cell technology for regenerating periodontal tissues, including alveolar bone, is expected to be applied in the treatment of diseases, such as tooth loss and periodontitis. This review focuses on the alveolar bone and describes clinical practice, techniques, and the latest basic research.
PubMed: 36979821
DOI: 10.3390/biomedicines11030843 -
Blood Cancer Discovery Jul 2020This editorial integrates the views of 's editors-in-chief and scientific editors to explore the current and near-future landscape of the study of hematologic...
This editorial integrates the views of 's editors-in-chief and scientific editors to explore the current and near-future landscape of the study of hematologic malignancies-from the most intriguing new developments in clinical and basic research to the greatest upcoming challenges and how they will be confronted.
Topics: Hematologic Neoplasms; Humans; Research
PubMed: 34661134
DOI: 10.1158/2643-3249.BCD-20-0083