-
JPMA. the Journal of the Pakistan... Oct 2023Diabetes and other cardiometabolic diseases occur across the world, and do not discriminate between populations. This communication reviews the epidemiology and etiology...
Diabetes and other cardiometabolic diseases occur across the world, and do not discriminate between populations. This communication reviews the epidemiology and etiology of diabetes in the transgender population, and highlights clinical issues that must be kept in mind while evaluating and managing the condition. It adds value to existing literature by equipping health care professionals with specific skills designed to enhance diabetes care delivery, and results, in transgender individuals.
Topics: Humans; Transgender Persons; Transsexualism; Diabetes Mellitus; Delivery of Health Care
PubMed: 37876084
DOI: 10.47391/JPMA.23-72 -
Journal of Feline Medicine and Surgery Jul 2022Diabetes mellitus (DM) is one of the most common feline endocrine disorders. It has been shown by several studies that DM in cats frequently coexists with pancreatitis. (Review)
Review
PRACTICAL RELEVANCE
Diabetes mellitus (DM) is one of the most common feline endocrine disorders. It has been shown by several studies that DM in cats frequently coexists with pancreatitis.
CLINICAL CHALLENGES
It has not been definitively established what the exact pathogenetic association between DM and pancreatitis is in the cat. However, the association between these two conditions is most likely bidirectional, with DM predisposing cats to pancreatitis and vice versa. Diagnosis of pancreatitis in cats with DM is crucial because concurrent pancreatitis commonly leads to difficulties in the management of DM. When pancreatitis is associated with diabetic ketoacidosis (DKA), therapeutic management is even more challenging.
AIMS
This review focuses on the concurrent presence of DM or DKA and pancreatitis in cats, mainly focusing on their clinical management.
EVIDENCE BASE
Information provided in this review is based on feline-specific clinical research when available. In addition, comparative and human research, as well as clinical experience, has been used to enrich knowledge in areas where feline-specific research is not yet available.
Topics: Animals; Cat Diseases; Cats; Comorbidity; Diabetes Mellitus; Diabetic Ketoacidosis; Lipase; Pancreatitis
PubMed: 35775305
DOI: 10.1177/1098612X221106355 -
Journal of Diabetes Investigation May 2024Compared with normative birthweight persons, individuals with a lower birthweight had a higher chance of developing type 2 diabetes at a younger age, a lower body mass...
Compared with normative birthweight persons, individuals with a lower birthweight had a higher chance of developing type 2 diabetes at a younger age, a lower body mass index at diagnosis, a lesser family history of diabetes and greater probability of comorbidities.
Topics: Humans; Risk Factors; Birth Weight; Diabetes Mellitus, Type 2; Infant, Newborn; Diabetes Mellitus; Female
PubMed: 38279766
DOI: 10.1111/jdi.14154 -
Journal of the American Society of... Aug 2021
Topics: Diabetes Mellitus; Graft Survival; Kidney Transplantation
PubMed: 34330768
DOI: 10.1681/ASN.2021060777 -
BMJ Open Diabetes Research & Care Nov 2023Patient-reported outcome (PRO) measures are increasingly used in clinical diabetes care to increase patient involvement and improve healthcare services. The objectives... (Review)
Review
BACKGROUND
Patient-reported outcome (PRO) measures are increasingly used in clinical diabetes care to increase patient involvement and improve healthcare services. The objectives were to identify instruments used to measure PROs in outpatient diabetes clinics and to investigate the use of these PRO measures alongside the experiences of patients and healthcare personnel in a clinical setting.
RESEARCH DESIGN AND METHODS
A scoping review was conducted according to the framework of Arksey and O'Malley with scoping searches of Cinahl, EMBASE, Medline and Health and Psychosocial Instruments. Studies reporting on adults with diabetes in a clinical setting where the PRO measure response directly affected patient care were eligible for inclusion.
RESULTS
In total, 35 197 citations were identified, of which 7 reports presenting 4 different PRO measures were included in the review. All four of the included items measured psychosocial aspects of diabetes, and three included elements of the Problem Areas in Diabetes scale. All the patients were satisfied with the use of PRO measures in clinical care, whereas the level of satisfaction among healthcare personnel with PRO measures varied within and among studies.
CONCLUSIONS
The limited number of eligible studies in this review suggests that research on PRO measures for diabetes outpatient care is scarce. Patients welcome the opportunity to express their concerns through the systematic collection of PRO measures, and some healthcare personnel value the broader insight that PRO measures provide into the impact of diabetes on patients' lives. However, the heterogeneity among services and among patients challenges the implementation of PRO measures. Research is needed to explore how PRO measures in clinical outpatient care affect healthcare personnel workflow.
REVIEW REGISTRATION
https://doi.org/10.17605/OSF.IO/46AHC.
Topics: Adult; Humans; Health Personnel; Patient Reported Outcome Measures; Ambulatory Care; Ambulatory Care Facilities; Diabetes Mellitus
PubMed: 37963648
DOI: 10.1136/bmjdrc-2023-003628 -
Current Diabetes Reports Nov 2019This review is based on a recent invited lecture at the American Diabetes Association's 79th annual Scientific Sessions entitled "Major Advances and Discoveries in... (Review)
Review
PURPOSE
This review is based on a recent invited lecture at the American Diabetes Association's 79th annual Scientific Sessions entitled "Major Advances and Discoveries in Diabetes - The Year in Review."
RECENT FINDINGS
Here I provide a written account of my presentation entitled "Major Discoveries in Diabetes over the Past Year." I highlight several recent advances in basic science that are relevant for the diabetes field, with insight into how the key takeaways impact basic science. I also speculate on how these breakthroughs challenge the field to move the basic science "discovery" into the clinic, as well as offering a perspective on unanswered questions in relation to these advances. The review should in no way be taken as an endorsement of the highlighted work or a denunciation of any work not selected. Rather, it is a personal reflection that provides a glimpse into what is on the horizon in this rapidly evolving and exciting field!
Topics: Diabetes Mellitus; Humans
PubMed: 31686269
DOI: 10.1007/s11892-019-1255-x -
Frontiers in Endocrinology 2023
Topics: Humans; Diabetic Nephropathies; Kidney Failure, Chronic; Diabetes Mellitus, Type 2
PubMed: 36742398
DOI: 10.3389/fendo.2023.1142285 -
International Journal of Molecular... May 2024Diabetes mellitus (DM) is known as the first non-communicable global epidemic. It is estimated that 537 million people have DM, but the condition has been properly... (Review)
Review
Diabetes mellitus (DM) is known as the first non-communicable global epidemic. It is estimated that 537 million people have DM, but the condition has been properly diagnosed in less than half of these patients. Despite numerous preventive measures, the number of DM cases is steadily increasing. The state of chronic hyperglycaemia in the body leads to numerous complications, including diabetic cardiomyopathy (DCM). A number of pathophysiological mechanisms are behind the development and progression of cardiomyopathy, including increased oxidative stress, chronic inflammation, increased synthesis of advanced glycation products and overexpression of the biosynthetic pathway of certain compounds, such as hexosamine. There is extensive research on the treatment of DCM, and there are a number of therapies that can stop the development of this complication. Among the compounds used to treat DCM are antiglycaemic drugs, hypoglycaemic drugs and drugs used to treat myocardial failure. An important element in combating DCM that should be kept in mind is a healthy lifestyle-a well-balanced diet and physical activity. There is also a group of compounds-including coenzyme Q10, antioxidants and modulators of signalling pathways and inflammatory processes, among others-that are being researched continuously, and their introduction into routine therapies is likely to result in greater control and more effective treatment of DM in the future. This paper summarises the latest recommendations for lifestyle and pharmacological treatment of cardiomyopathy in patients with DM.
Topics: Humans; Diabetic Cardiomyopathies; Hypoglycemic Agents; Oxidative Stress; Antioxidants; Diabetes Mellitus; Animals
PubMed: 38732253
DOI: 10.3390/ijms25095027 -
International Journal of Molecular... Mar 2021Since 2015, 170 small molecules, 60 antibody-based entities, 12 peptides, and 15 gene- or cell-therapies have been approved by FDA for diverse disease indications.... (Review)
Review
Since 2015, 170 small molecules, 60 antibody-based entities, 12 peptides, and 15 gene- or cell-therapies have been approved by FDA for diverse disease indications. Recent advancement in medicine is facilitated by identification of new targets and mechanisms of actions, advancement in discovery and development platforms, and the emergence of novel technologies. Early disease detection, precision intervention, and personalized treatments have revolutionized patient care in the last decade. In this review, we provide a comprehensive overview of current and emerging therapeutic modalities developed in the recent years. We focus on nine diseases in three major therapeutics areas, diabetes, autoimmune, and neurological disorders. The pathogenesis of each disease at physiological and molecular levels is discussed and recently approved drugs as well as drugs in the clinic are presented.
Topics: Autoimmune Diseases; Diabetes Mellitus; Humans; Nervous System Diseases
PubMed: 33802091
DOI: 10.3390/ijms22062805 -
Frontiers in Endocrinology 2022Diabetes mellitus is a chronic disease caused by the interaction of genetics and the environment that can lead to chronic damage to many organ systems. Genome-wide... (Review)
Review
Diabetes mellitus is a chronic disease caused by the interaction of genetics and the environment that can lead to chronic damage to many organ systems. Genome-wide association studies have identified accumulating single-nucleotide polymorphisms related to type 2 diabetes mellitus and gestational diabetes mellitus. Genetic risk score (GRS) has been utilized to evaluate the incidence risk to improve prediction and optimize treatments. This article reviews the research progress in the use of the GRS in diabetes mellitus in recent years and discusses future prospects.
Topics: Pregnancy; Female; Humans; Diabetes, Gestational; Genome-Wide Association Study; Genetic Predisposition to Disease; Diabetes Mellitus, Type 2; Alleles; Risk Factors
PubMed: 36339414
DOI: 10.3389/fendo.2022.955821