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Anais Brasileiros de Dermatologia 2020Pachydermoperiostosis (PDP) or primary hypertrophic osteoarthropathy (PHO) is a rare hereditary disease characterized by digital clubbing, pachydermia, and periostosis....
Pachydermoperiostosis (PDP) or primary hypertrophic osteoarthropathy (PHO) is a rare hereditary disease characterized by digital clubbing, pachydermia, and periostosis. Its pathogenesis is uncertain and the diagnosis is based on clinical and radiological data. A complete form of the syndrome is reported in a male patient with disease onset in adolescence, with compatible clinical and radiological findings, presenting the three cardinal findings as well as other associated manifestations, such as hyperhidrosis and acne.
Topics: Erythema; Humans; Male; Osteoarthropathy, Primary Hypertrophic; Scalp Dermatoses; Young Adult
PubMed: 31889594
DOI: 10.1016/j.abd.2019.04.009 -
Skin Research and Technology : Official... Jun 2024Rosacea is a chronic inflammatory skin condition associated with erythema, inflammation and skin sensitivity. (Randomized Controlled Trial)
Randomized Controlled Trial
Randomised, split-face study of a dermocosmetic cream containing Sphingobioma xenophaga extract and Neurosensine in subjects with rosacea associated with erythema and sensitive skin.
INTRODUCTION
Rosacea is a chronic inflammatory skin condition associated with erythema, inflammation and skin sensitivity.
OBJECTIVES
To assess the benefit of a dermocosmetic cream (DC cream) containing Sphingobioma xenophaga extract and soothing agent in adult females with rosacea-associated erythema and sensitive skin.
MATERIALS AND METHODS
During phase 1, DC was applied twice daily on the randomized half-face and compared to usual-skincare (USC) for 28 days. During phase 2, DC was applied on the full face twice daily for 56 days. Clinical, instrumental and skin sensitivity assessments were performed at all visits; demodex density (standardized skin surface biopsy (SSSB) method) was performed at baseline and D28, quality of life (QoL) was assessed using the stigmatization questionnaire (SQ), Rosacea Quality of Life index (ROSAQoL) and Dermatology Life Quality Index (DLQI) at baseline and D84.
RESULTS
At D28, a significant benefit of DC over USC was observed for erythema, tightness, burning and stinging (all p ≤ 0.05), erythema measured by chromameter (p < 0.01), corneometry and transepidermal water loss (p < 0.0001 and p < 0.05, respectively), skin sensitivity (p < 0.001) and significant reduction of mean demodex density (p < 0.05) on the DC side. At D84, DC significantly (all p < 0.05) improved clinical signs and symptoms on both sides of the face compared to baseline; SQ, ROSAQoL and DLQI scores improved by 40.4%, 25.0% and 55.7%, respectively compared to baseline. Tolerance was excellent.
CONCLUSION
DC significantly improved erythema, skin sensitivity, demodex count, QoL and feeling of stigmatization of subjects with rosacea and is very well tolerated.
Topics: Humans; Rosacea; Female; Middle Aged; Adult; Erythema; Skin Cream; Quality of Life; Animals; Aged
PubMed: 38899754
DOI: 10.1111/srt.13735 -
Skin Research and Technology : Official... Jan 2022Skin sensitivity (SS) is a commonly occurring response to a range of stimuli, including environmental conditions (e.g., sun exposure), chemical irritants (e.g., soaps... (Review)
Review
BACKGROUND
Skin sensitivity (SS) is a commonly occurring response to a range of stimuli, including environmental conditions (e.g., sun exposure), chemical irritants (e.g., soaps and cosmetics), and mechanical forces (e.g., while shaving). From both industry and academia, many efforts have been taken to quantify the characteristics of SS in a standardised manner, but the study is hindered by the lack of an objective definition.
METHODS
A review of the scientific literature regarding different parameters attributed to the loss of skin integrity and linked with exhibition of SS was conducted. Articles included were screened for mechanical stimulation of the skin, with objective quantification of tissue responses using biophysical or imaging techniques. Additionally, studies where cohorts of SS and non-SS individuals were reported have been critiqued.
RESULTS
The findings identified that the structure and function of the stratum corneum and its effective barrier properties are closely associated with SS. Thus, an array of skin tissue responses has been selected for characterization of SS due to mechanical stimuli, including: transepidermal water loss, hydration, redness, temperature, and sebum index. Additionally, certain imaging tools allow quantification of the superficial skin layers, providing structural characteristics underlying SS.
CONCLUSION
This review proposes a multimodal approach for identification of SS, providing a means to characterise skin tissue responses objectively. Optical coherence tomography (OCT) has been suggested as a suitable tool for dermatological research with clinical applications. Such an approach would enhance the knowledge underlying the multifactorial nature of SS and aid the development of personalised solutions in medical and consumer devices.
Topics: Epidermis; Erythema; Humans; Sebum; Skin; Skin Physiological Phenomena
PubMed: 34708455
DOI: 10.1111/srt.13104 -
Skin Research and Technology : Official... Feb 2024Previous studies have demonstrated the coexistence of erythema nodosum (EN) and inflammatory bowel disease (IBD), while the exact etiology of the co-occurrence of the...
BACKGROUND
Previous studies have demonstrated the coexistence of erythema nodosum (EN) and inflammatory bowel disease (IBD), while the exact etiology of the co-occurrence of the two disorders remains uncertain.
METHODS
A bidirectional two-sample Mendelian randomization (MR) design was employed to determine the causal link between EN and IBD. Genetic variations associated with Crohn's disease (CD) and ulcerative colitis (UC) were derived from accessible genome-wide association studies pertaining to European ancestry. The FinnGen database was used to find the genetic variations containing EN. In the forward model, IBD was identified as the exposure, whereas in the reverse model, EN was identified as the exposure. The causal link between IBD and EN was examined using a range of different analysis techniques, the primary one being the inverse variance weighted (IVW) method, including inverse variance weighted-fixed effects (IVW-FE) and inverse-variance weighted-multiplicative random effects (IVW-MRE). To strengthen the results, assessments of sensitivity, heterogeneity, and pleiotropy were also conducted.
RESULTS
MR results showed that IBD increased the risk of EN (IVW-MRE: OR = 1.242, 95% CI = 1.068-1.443, p = 0.005). Furthermore, there was a strong correlation found between CD and a higher risk of EN (IVW-FE: OR = 1.250, 95% CI = 1.119-1.396, p = 8.036 × 10 ). However, UC did not appear to be linked to EN (IVW-FE: OR = 1.104, 95% CI = 0.868-1.405, p = 0.421). The reverse MR analysis findings did not imply that EN was linked to IBD. Horizontal pleiotropy did not appear to exist, and the robustness of these findings was confirmed.
CONCLUSION
The current investigation found that in European populations, IBD and its subtype CD could raise the incidence of EN.
Topics: Humans; Erythema Nodosum; Genome-Wide Association Study; Mendelian Randomization Analysis; Inflammatory Bowel Diseases; Databases, Factual
PubMed: 38297958
DOI: 10.1111/srt.13600 -
Indian Journal of Dermatology,... 2022
Topics: Erythema; Erythema Chronicum Migrans; Erythema Multiforme; Humans; Lyme Disease
PubMed: 35389014
DOI: 10.25259/IJDVL_53_2021 -
Medicina Clinica Apr 2022
Topics: COVID-19 Vaccines; Coronavirus; Erythema; Eye Diseases; Eyelids; Humans; Vaccination
PubMed: 34426009
DOI: 10.1016/j.medcli.2021.06.026 -
Skin Research and Technology : Official... Mar 2022
Topics: Erythema Nodosum; Humans; Panniculitis
PubMed: 34813122
DOI: 10.1111/srt.13112 -
Internal Medicine (Tokyo, Japan) Jun 2022
Topics: BNT162 Vaccine; Erythema Multiforme; Humans; Vaccination
PubMed: 35431308
DOI: 10.2169/internalmedicine.9544-22 -
Journal of the European Academy of... Jan 2022
Topics: COVID-19; COVID-19 Vaccines; Erythema Multiforme; Humans; SARS-CoV-2
PubMed: 34547118
DOI: 10.1111/jdv.17689 -
Indian Journal of Pediatrics Jan 2022
Topics: COVID-19; Erythema; Humans; Mucocutaneous Lymph Node Syndrome; Perineum; Systemic Inflammatory Response Syndrome
PubMed: 33712925
DOI: 10.1007/s12098-021-03717-5