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Urology Case Reports May 2024Malakoplakia is a granulomatous tissue inflammation with a characteristic histological appearance, mainly affecting the urogenital system and morphologically reflecting...
Malakoplakia is a granulomatous tissue inflammation with a characteristic histological appearance, mainly affecting the urogenital system and morphologically reflecting a macrophage disease. If bladder involvement is the most common, renal involvement is very rare and may be responsible for a differential diagnosis problem with renal cell carcinoma. We present a clinical case of renal malacoplakia mimicking malignant renal cell carcinoma diagnosed after partial nephrectomy in a 58-year-old woman with no history of recurrent urinary infections.
PubMed: 38655150
DOI: 10.1016/j.eucr.2024.102737 -
Hinyokika Kiyo. Acta Urologica Japonica Jan 2023A 70-year-old-man was referred with urination pain and pyuria. Prostate specific antigen was 10.6 ng/ml, and urine culture was Escherichia coli. The abdominal...
A 70-year-old-man was referred with urination pain and pyuria. Prostate specific antigen was 10.6 ng/ml, and urine culture was Escherichia coli. The abdominal ultrasonography showed irregular low echo at the right lobe of prostate. Prostate magnetic resonance imaging (MRI) showed an extracapsular infiltrated prostate tumor in the right lobe. Levofloxacin was administered and prostate biopsy was performed. The pathological examination revealed that the prostate tissue was filled with inflammatory cells and had lost its glandular duct structure. The patient was diagnosed with malacoplakia of the prostate. Four months after prostate biopsy, prostate MRI imaging showed disappearance of the extracapsular infiltration in right peripheral zone.
Topics: Male; Humans; Aged; Prostate; Malacoplakia; Prostatic Neoplasms; Prostate-Specific Antigen; Biopsy; Magnetic Resonance Imaging
PubMed: 36727457
DOI: 10.14989/ActaUrolJap_69_1_19 -
Journal of Cutaneous Pathology Jul 2021
Topics: Aged; Allografts; Anal Canal; Escherichia coli Infections; Humans; Immunocompromised Host; Malacoplakia; Male; Myelodysplastic Syndromes; Skin Ulcer; Stem Cell Transplantation; Transplant Recipients
PubMed: 33470456
DOI: 10.1111/cup.13761 -
Medicina (Kaunas, Lithuania) Jan 2023Colonic malakoplakia is an uncommon granulomatous development of cells resulting from the impaired capacity of the mononuclear cells to eliminate the phagocytosed...
Colonic malakoplakia is an uncommon granulomatous development of cells resulting from the impaired capacity of the mononuclear cells to eliminate the phagocytosed bacteria, and in rare cases it can also affect the gastrointestinal tract. We report the case of a 78-year-old female patient that was admitted to hospital by The Emergency Department with the diagnosis of bowel obstruction, confirmed by the clinical and paraclinical investigations. We decided to surgically manage the case for suspicious symptomatic colonic neoplasm. The histological examination of the surgical specimens revealed colonic malakoplakia, characterized by the presence of the aggregated granular histiocytes and Michaelis-Gutmann bodies. Through this paper, we want to raise awareness for Malakoplakia, which remains an extremely rare disease that may affect multiple organs, and because it does not present specific symptoms or clinical manifestations, the final diagnosis remains the histopathological study. The clinical conduct should be decided after taking into consideration all the aspects of this pathology along with the benefits and risks for the patient.
Topics: Female; Humans; Aged; Malacoplakia; Colonic Neoplasms
PubMed: 36676780
DOI: 10.3390/medicina59010156 -
BMJ Case Reports Jul 2021Malakoplakia is a rare chronic inflammatory condition, which primarily occurs in genitourinary tract, with prostatic malakoplakia being extremely rare. We present two...
Malakoplakia is a rare chronic inflammatory condition, which primarily occurs in genitourinary tract, with prostatic malakoplakia being extremely rare. We present two cases of acute urinary retention, with clinically firm nodular prostate and a raised serum prostate-specific antigen. Transrectal ultrasound-guided prostatic biopsy showed features of malakoplakia. There was a significant reduction of size of prostate on transrectal ultrasonography after 4 weeks of antibiotics. However, one patient had failed trial without catheter and was subjected to transurethral resection of prostate. The biopsy of the prostatic chips also showed features of malakoplakia. Other patient improved symptomatically after antibiotics and was managed conservatively. Both the patients are on regular follow-up and are asymptomatic. Prostatic malakoplakia presenting as urinary retention is very uncommon with around 12 cases in the literature. Recognition of prostatic malakoplakia is important because clinically it can masquerade prostatic malignancy. Treatment with antibiotics is necessary before subjecting the patients for surgery in patients with obstructive symptoms.
Topics: Humans; Malacoplakia; Male; Prostatic Neoplasms; Transurethral Resection of Prostate; Urinary Retention
PubMed: 34321270
DOI: 10.1136/bcr-2021-243927 -
BMC Nephrology Jun 2024Malakoplakia is a rare inflammatory disorder believed to result from a defect in macrophage phagocytic function triggering a granulomatous reaction. It can present with...
Malakoplakia is a rare inflammatory disorder believed to result from a defect in macrophage phagocytic function triggering a granulomatous reaction. It can present with genitourinary, gastrointestinal, or cutaneous manifestations in immunocompromised or, less commonly, immunocompetent hosts. We describe a case of renal malakoplakia in a young, otherwise healthy patient presenting with nephromegaly and sepsis following an E. coli urinary tract infection. We discuss diagnosis and management, including antibiotic selection and the decision to pursue nephrectomy. This case highlights the potential for kidney recovery with prolonged antibiotic therapy in conjunction with adjunct immunomodulatory therapies and source control.
Topics: Humans; Malacoplakia; Urinary Tract Infections; Escherichia coli Infections; Male; Anti-Bacterial Agents; Adult; Female; Escherichia coli
PubMed: 38890600
DOI: 10.1186/s12882-024-03640-9 -
Bladder Malakoplakia Simulating Neoplasm in a Young Girl: Report of a Case and Review of Literature.Urology Journal Dec 2019Malakoplakia is a granulomatous disorder caused by infectious process. It was described by Von Hanseman in 1901 for the first time and then by Michaelis and Gutman in...
Malakoplakia is a granulomatous disorder caused by infectious process. It was described by Von Hanseman in 1901 for the first time and then by Michaelis and Gutman in 1902. Although the most frequent site of involvement is genitourinary tract, various organs have been reported to be affected. The peak age incidence is about 50 years and it is rare in childhood. In this paper we report a case of bladder malakoplakia which to our knowledge is the youngest with isolated bladder malakoplakia that has been reported.
Topics: Biopsy; Cystectomy; Diagnosis, Differential; Female; Humans; Infant; Malacoplakia; Tomography, X-Ray Computed; Ultrasonography; Urinary Bladder; Urinary Bladder Diseases; Urinary Bladder Neoplasms
PubMed: 30596224
DOI: 10.22037/uj.v0i0.4428 -
Journal of Gastrointestinal and Liver... Sep 2019
Topics: Anemia, Iron-Deficiency; Anemia, Macrocytic; Cecal Diseases; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Liver Cirrhosis, Alcoholic; Malacoplakia; Male; Middle Aged; Treatment Outcome
PubMed: 31517320
DOI: 10.15403/jgld-418 -
Indian Journal of Cancer 2021
Topics: Humans; Magnetic Resonance Imaging; Malacoplakia; Male; Middle Aged
PubMed: 34100418
DOI: 10.4103/ijc.IJC_164_20