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Infection Control and Hospital... Jun 2022The purpose of this document is to highlight practical recommendations to assist acute care hospitals to prioritize and implement strategies to prevent...
The purpose of this document is to highlight practical recommendations to assist acute care hospitals to prioritize and implement strategies to prevent ventilator-associated pneumonia (VAP), ventilator-associated events (VAE), and non-ventilator hospital-acquired pneumonia (NV-HAP) in adults, children, and neonates. This document updates the Strategies to Prevent Ventilator-Associated Pneumonia in Acute Care Hospitals published in 2014. This expert guidance document is sponsored by the Society for Healthcare Epidemiology (SHEA), and is the product of a collaborative effort led by SHEA, the Infectious Diseases Society of America, the American Hospital Association, the Association for Professionals in Infection Control and Epidemiology, and The Joint Commission, with major contributions from representatives of a number of organizations and societies with content expertise.
Topics: Adult; Child; Cross Infection; Healthcare-Associated Pneumonia; Hospitals; Humans; Infant, Newborn; Infection Control; Pneumonia; Pneumonia, Ventilator-Associated; Ventilators, Mechanical
PubMed: 35589091
DOI: 10.1017/ice.2022.88 -
Journal of Intensive Care Medicine Nov 2022Since the inception of critical care medicine and artificial ventilation, literature and research on weaning has transformed daily patient care in intensive care units... (Review)
Review
Since the inception of critical care medicine and artificial ventilation, literature and research on weaning has transformed daily patient care in intensive care units (ICU). As our knowledge of mechanical ventilation (MV) improved, so did the need to study patient-ventilator interactions and weaning predictors. Randomized trials have evaluated the use of protocol-based weaning (vs. usual care) to study the duration of MV in ICUs, different techniques to conduct spontaneous breathing trials (SBT), and strategies to eventually extubate a patient whose initial SBT failed. Despite considerable milestones in the management of multiple diseases contributing to reversible respiratory failure, in the application of early rehabilitative interventions to preserve muscle integrity, and in ventilator technology that mitigates against ventilator injury and dyssynchrony, major barriers to successful liberation from MV persist. This review provides a broad encompassing view of weaning classification, causes of weaning failure, and evidence behind weaning predictors and weaning modes.
Topics: Humans; Intensive Care Units; Respiration, Artificial; Respiratory Insufficiency; Ventilator Weaning; Ventilators, Mechanical
PubMed: 35815895
DOI: 10.1177/08850666221095436 -
Intensive Care Medicine Dec 2020Mechanical ventilation may have adverse effects on both the lung and the diaphragm. Injury to the lung is mediated by excessive mechanical stress and strain, whereas the... (Review)
Review
Mechanical ventilation may have adverse effects on both the lung and the diaphragm. Injury to the lung is mediated by excessive mechanical stress and strain, whereas the diaphragm develops atrophy as a consequence of low respiratory effort and injury in case of excessive effort. The lung and diaphragm-protective mechanical ventilation approach aims to protect both organs simultaneously whenever possible. This review summarizes practical strategies for achieving lung and diaphragm-protective targets at the bedside, focusing on inspiratory and expiratory ventilator settings, monitoring of inspiratory effort or respiratory drive, management of dyssynchrony, and sedation considerations. A number of potential future adjunctive strategies including extracorporeal CO removal, partial neuromuscular blockade, and neuromuscular stimulation are also discussed. While clinical trials to confirm the benefit of these approaches are awaited, clinicians should become familiar with assessing and managing patients' respiratory effort, based on existing physiological principles. To protect the lung and the diaphragm, ventilation and sedation might be applied to avoid excessively weak or very strong respiratory efforts and patient-ventilator dysynchrony.
Topics: Diaphragm; Humans; Lung; Respiration; Respiration, Artificial; Ventilators, Mechanical
PubMed: 33140181
DOI: 10.1007/s00134-020-06288-9 -
Respiratory Care Jan 2022Mechanical ventilators display detailed waveforms which contain a wealth of clinically relevant information. Although much has been written about interpretation of...
Mechanical ventilators display detailed waveforms which contain a wealth of clinically relevant information. Although much has been written about interpretation of waveforms and patient-ventilator interactions, variability remains on the nomenclature (multiple and ambiguous terms) and waveform interpretation. There are multiple reasons for this variability (legacy terms, language, multiple definitions). In addition, there is no widely accepted systematic method to read ventilator waveforms. We propose a standardized nomenclature and taxonomy along with a method to interpret mechanical ventilator displayed waveforms.
Topics: Humans; Respiration, Artificial; Ventilators, Mechanical; Patients
PubMed: 34470804
DOI: 10.4187/respcare.09316 -
Respiratory Care Aug 2019Airway management techniques are aimed at reducing complications associated with artificial airways and mechanical ventilation, such as retained secretions. The impact... (Review)
Review
Airway management techniques are aimed at reducing complications associated with artificial airways and mechanical ventilation, such as retained secretions. The impact of airway management techniques on ventilator-associated events (VAEs) varies considerably by modality. Closed-suction techniques are generally recommended but have limited, if any, impact on VAEs. Normal saline instillation during suctioning is not recommended. Devices designed specifically to remove biofilm from the inside of endotracheal tubes appear to be safe, but their role in VAE prevention is uncertain. Subglottic secretion clearance by artificial cough maneuvers is promising, but more research is needed to assess its clinical feasibility. Continuous cuff-pressure management appears to be effective in reducing microaspiration of subglottic secretions.
Topics: Airway Management; Humans; Iatrogenic Disease; Intubation, Intratracheal; Pneumonia, Ventilator-Associated; Respiration, Artificial; Suction; Ventilators, Mechanical
PubMed: 31346073
DOI: 10.4187/respcare.07107 -
Respiratory Care Jun 2020Mechanical ventilation in critically ill patients must effectively unload inspiratory muscles and provide safe ventilation (ie, enhancing gas exchange, protect the lungs... (Review)
Review
Mechanical ventilation in critically ill patients must effectively unload inspiratory muscles and provide safe ventilation (ie, enhancing gas exchange, protect the lungs and the diaphragm). To do that, the ventilator should be in synchrony with patient's respiratory rhythm. The complexity of such interplay leads to several concerning issues that clinicians should be able to recognize. Asynchrony between the patient and the ventilator may induce several deleterious effects that require a proper physiological understanding to recognize and manage them. Different tools have been developed and proposed beyond the careful analysis of the ventilator waveforms to help clinicians in the decision-making process. Moreover, appropriate handling of asynchrony requires clinical skills, physiological knowledge, and suitable medication management. New technologies and devices are changing our daily practice, from automated real-time recognition of asynchronies and their distribution during mechanical ventilation, to smart alarms and artificial intelligence algorithms based on physiological big data and personalized medicine. Our goal as clinicians is to provide care of patients based on the most accurate and current knowledge, and to incorporate new technological methods to facilitate and improve the care of the critically ill.
Topics: Critical Illness; Humans; Pulmonary Ventilation; Respiration, Artificial; Respiratory Mechanics; Ventilators, Mechanical
PubMed: 32457175
DOI: 10.4187/respcare.07404 -
Respiratory Care Jun 2020Ventilator graphic monitoring is common in ICUs. The graphic information provides clinicians with immediate clues regarding patient-ventilator interaction and ventilator... (Review)
Review
Ventilator graphic monitoring is common in ICUs. The graphic information provides clinicians with immediate clues regarding patient-ventilator interaction and ventilator function. These display tools are aimed at reducing complications associated with mechanical ventilation, such as patient-ventilator asynchrony. It is also useful to assess respiratory mechanics in mechanically ventilated patients using both scalar and plot displays on the ventilator. Additional information can be gained by observing secondary ventilator measures including stress index, inflection points, and work of breathing. Ventilator graphics impact mechanical ventilation management through optimizing effectiveness of patient care and enhancing promptness of clinician response. Despite being a valuable asset in providing high-quality patient care, many bedside clinicians do not have a thorough understanding of ventilator graphics. Mastery of ventilator graphics interpretation is key in managing patients who are receiving ventilatory support.
Topics: Humans; Intensive Care Units; Monitoring, Physiologic; Respiration, Artificial; Respiratory Mechanics; Respiratory Physiological Phenomena; Ventilators, Mechanical
PubMed: 32457168
DOI: 10.4187/respcare.07805 -
Respiratory Care Nov 2020Mechanical ventilation is a supportive treatment commonly applied in critically ill patients. Whenever the patient is spontaneously breathing, the pressure applied to... (Review)
Review
Mechanical ventilation is a supportive treatment commonly applied in critically ill patients. Whenever the patient is spontaneously breathing, the pressure applied to the respiratory system depends on the sum of the pressure generated by the respiratory muscles and the pressure generated by the ventilator. Patient-ventilator interaction is of utmost importance in spontaneously breathing patients, and thus the ventilator should be able to adapt to patient's changes in ventilatory demand and respiratory mechanics. Nevertheless, a lack of coordination between patient and ventilator due to a mismatch between neural and ventilator timing throughout the respiratory cycle may make weaning difficult and lead to prolonged mechanical ventilation. Therefore, appropriate monitoring of asynchronies is mandatory to improve the applied strategies and thus improve patient-ventilator interaction. We conducted a literature review regarding patient-ventilator interaction with a focus on the different kinds of inspiratory and expiratory asynchronies, their monitoring, clinical implications, possible prevention, and treatment. We believe that monitoring patient-ventilator interaction is mandatory in spontaneously breathing patients to understand, by using the available technologies, the type of asynchrony and consequently improve the adaptation of the ventilator to the patient's needs. Asynchronies are relatively frequent during mechanical ventilation in critically ill patients, and they are associated with poor outcomes. This review summarizes the different types of asynchronies and their mechanisms, consequences, and potential management. The development and understanding of monitoring tools are necessary to allow a better appraisal of this area, which may lead to better outcomes for patients.
Topics: Humans; Respiration; Respiration, Artificial; Respiratory Mechanics; Respiratory Muscles; Ventilators, Mechanical
PubMed: 32665426
DOI: 10.4187/respcare.07284 -
Respiratory Care Aug 2019In 2013, the United States Centers for Disease Control and Prevention redefined surveillance for quality of care in ventilated patients by shifting from... (Review)
Review
In 2013, the United States Centers for Disease Control and Prevention redefined surveillance for quality of care in ventilated patients by shifting from ventilator-associated pneumonia (VAP) definitions to ventilator-associated event (VAE) definitions. VAE definitions were designed to overcome many of the limitations of VAP definitions, including their complexity, subjectivity, limited correlation with outcomes, and incomplete capture of many important and morbid complications of mechanical ventilation. VAE definitions broadened the focus of surveillance from pneumonia alone to the syndrome of nosocomial complications in ventilated patients, as marked by sustained increases in ventilator settings after a period of stable or decreasing ventilator settings. Qualitative studies suggest that most VAEs are caused by pneumonia, fluid overload, ARDS, and atelectasis. Only about 40% of clinically diagnosed VAPs meet VAE criteria, likely because the VAE requirement for a sustained increase in ventilator settings sets a threshold effect that selects for patients with severe disease. VAEs are associated with a doubling of the risk of death compared to patients without VAEs and compared to patients who meet traditional VAP criteria. Risk factors for VAEs include sedation with benzodiazepines or propofol, volume overload, high tidal-volume ventilation, high inspiratory driving pressures, oral care with chlorhexidine, blood transfusions, stress ulcer prophylaxis, and patient transport. Potential strategies to prevent VAEs include minimizing sedation, paired daily spontaneous awakening and breathing trials, early mobility, conservative fluid management, conservative transfusion thresholds, and low tidal-volume ventilation. A limited number of studies that have tested subsets of these interventions have reported substantial decreases in VAEs; no group, however, has thus far assessed the impact of a fully optimized VAE prevention bundle that includes all of these interventions upon VAE rates and other outcomes.
Topics: Centers for Disease Control and Prevention, U.S.; Humans; Iatrogenic Disease; Respiration, Artificial; Risk Factors; Terminology as Topic; United States; Ventilators, Mechanical
PubMed: 31346070
DOI: 10.4187/respcare.07059 -
Critical Care Clinics Oct 2021This review describes the management of mechanical ventilation in patients with acute respiratory distress syndrome, including in those with coronavirus disease 2019.... (Review)
Review
This review describes the management of mechanical ventilation in patients with acute respiratory distress syndrome, including in those with coronavirus disease 2019. Low tidal volume ventilation with a moderate to high positive end-expiratory pressure remains the foundation of an evidence-based approach. We consider strategies for setting positive end-expiratory pressure levels, the use of recruitment maneuvers, and the potential role of driving pressure. Rescue therapies including prone positioning and extracorporeal membrane oxygenation are also discussed.
Topics: COVID-19; Humans; Respiration, Artificial; Respiratory Distress Syndrome; SARS-CoV-2; Ventilators, Mechanical
PubMed: 34548137
DOI: 10.1016/j.ccc.2021.05.008