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Women's Health (London, England) 2024Across the globe, metabolic syndrome, hyperuric acid, and their related diseases, such as cardiovascular disease, diabetes, and insulin resistance, are increasing in... (Review)
Review
Across the globe, metabolic syndrome, hyperuric acid, and their related diseases, such as cardiovascular disease, diabetes, and insulin resistance, are increasing in incidence due to metabolic imbalances. Due to the pathogenesis, women are more prone to these diseases than men. As estrogen levels decrease after menopause, obesity and metabolic disorders are more likely to occur. Men are also affected by hyperuric acid. To provide ideas for the prevention and treatment of metabolic syndrome and hyperuricemia, this article reviews and analyzes the relationship between estrogen receptors, metabolic syndrome, and hyperuricemia.
Topics: Male; Humans; Female; Metabolic Syndrome; Receptors, Estrogen; Hyperuricemia; Insulin Resistance; Obesity
PubMed: 38420694
DOI: 10.1177/17455057241227362 -
Panminerva Medica Sep 2022
Topics: Humans; Metabolic Syndrome; Surveys and Questionnaires; Urologic Diseases
PubMed: 34931510
DOI: 10.23736/S0031-0808.21.04638-3 -
Osteoarthritis and Cartilage Jan 2020There is no clear evidence from epidemiological and animal studies of a direct link between metabolic syndrome (MetS) and cartilage degeneration in osteoarthritis (OA)...
There is no clear evidence from epidemiological and animal studies of a direct link between metabolic syndrome (MetS) and cartilage degeneration in osteoarthritis (OA) once body mass index (BMI) has been considered. However, recent epidemiological studies indicate a significant role for MetS in predicting increased knee pain after adjustment for BMI. This implies there are mechanisms that underlie both MetS and OA pain. In addition to the common systemic inflammatory and pro-inflammatory components of the two disorders, there are other molecular mechanisms that may link MetS and OA pain. These include regulation of the endocannabinoid system, activation of the transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1) channel and gut dysbiosis. These three mechanisms are interlinked and are the target of therapeutic dietary or pharmacological interventions. Exploring and understanding these mechanisms may help improve outcomes for both pain and metabolic comorbidities affecting individuals with OA.
Topics: Animals; Arthralgia; Humans; Metabolic Syndrome; Osteoarthritis
PubMed: 31408694
DOI: 10.1016/j.joca.2019.06.015 -
Vascular Health and Risk Management 2022According to data from the American Heart Association and the World Health Organization, cardiovascular disease (CVD) is the most frequent cause of premature death.... (Review)
Review
According to data from the American Heart Association and the World Health Organization, cardiovascular disease (CVD) is the most frequent cause of premature death. Several inflammatory and non-inflammatory skin diseases have been associated with metabolic syndrome and cardiovascular risk (CVR). Here, we classified these conditions into traditionally CVR-associated and those that have been linked to a lesser degree. Psoriasis and hidradenitis suppurativa are commonly associated with CVD, sharing common inflammatory pathways and a higher prevalence of traditional cardiovascular risk factors. Many other diseases could be associated indirectly - with no common pathogenic features with the atheromatous disease - but share a higher prevalence of standard cardiovascular risk and chronic inflammatory state. This review aims to highlight the associated cardiovascular risk that exists for some dermatologic diseases and sensitize cardiologists, dermatologists, and first care providers to implement risk factor control promptly.
Topics: Cardiovascular Diseases; Hidradenitis Suppurativa; Humans; Metabolic Syndrome; Psoriasis; Skin
PubMed: 35210782
DOI: 10.2147/VHRM.S343319 -
Journal of Atherosclerosis and... Dec 2022
Topics: Humans; Child; Obesity, Abdominal; Metabolic Syndrome; Obesity; Body Mass Index; Biomarkers; Risk Factors
PubMed: 35676031
DOI: 10.5551/jat.ED207 -
Reviews in the Neurosciences Oct 2023Parkinson's disease (PD) is one of the most widespread neurodegenerative diseases. PD is associated with progressive loss of substantia nigra dopaminergic neurons,... (Review)
Review
Parkinson's disease (PD) is one of the most widespread neurodegenerative diseases. PD is associated with progressive loss of substantia nigra dopaminergic neurons, including various motor symptoms (e.g., bradykinesia, rigidity, and resting tremor), as well as non-motor symptoms (e.g., cognitive impairment, constipation, fatigue, sleep disturbance, and depression). PD involves multiple biological processes, including mitochondrial or lysosomal dysfunction, oxidative stress, insulin resistance, and neuroinflammation. Metabolic syndrome (MetS), a collection of numerous connected cerebral cardiovascular conditions, is a common and growing public health problem associated with many chronic diseases worldwide. MetS components include central/abdominal obesity, systemic hypertension, diabetes, and atherogenic dyslipidemia. MetS and PD share multiple pathophysiological processes, including insulin resistance, oxidative stress, and chronic inflammation. In recent years, MetS has been linked to an increased risk of PD, according to studies; however, the specific mechanism remains unclear. Researchers also found that some related metabolic therapies are potential therapeutic strategies to prevent and improve PD. This article reviews the epidemiological relationship between components of MetS and the risk of PD and discusses the potentially relevant mechanisms and recent progress of MetS as a risk factor for PD. Furthermore, we conclude that MetS-related therapies are beneficial for the prevention and treatment of PD.
Topics: Humans; Parkinson Disease; Metabolic Syndrome; Insulin Resistance; Neurodegenerative Diseases; Mitochondria
PubMed: 36450297
DOI: 10.1515/revneuro-2022-0093 -
Frontiers in Endocrinology 2023The association between () infection and metabolic syndrome (MetS) has been studied previously; however, the results remain controversial, which could be partly due to...
BACKGROUND AND AIM
The association between () infection and metabolic syndrome (MetS) has been studied previously; however, the results remain controversial, which could be partly due to the different criteria used for defining MetS. We adopted five MetS criteria to provide better understanding of the association between infection and MetS.
METHODS
Physical examination data of 100,708 subjects were obtained from January 2014 to December 2018. MetS was defined based on five criteria including: International Diabetes Federation (IDF), The Third Report of the National Cholesterol Education Program Expert Panel, Adult Treatment Panel III (ATP III), Joint Statement of International Multi-Societies (JIS), Chinese Diabetes Society (CDS), and the Guidelines for the Prevention and Treatment of Type 2 Diabetes in China (2017 edition)(CDS DM). Multivariate logistic regression analysis was performed to elucidate the association between infection and MetS and its components.
RESULTS
The prevalence of MetS defined assessed using IDF, ATP III, JIS, CDS and CDS DM criteria was 15.8%, 19.9%, 23.7%, 8.7% and 15.4%, respectively. In males, the prevalence of MetS assessed using the five criteria in -positive group was higher than that in negative-group; however, in females, same results were obtained using the three international criteria. In males, the prevalence of all MetS components was found to be higher in the -positive group than those in the negative group; however, in females, only the prevalence of dyslipidemia and waist circumferences exhibited significant differences. Multivariate logistic regression analysis revealed that infection in males was positively correlated with MetS. Additionally, infection was found to be positively correlated with the waist circumference in the general population, and with hypertension and hyperglycemia in males.
CONCLUSIONS
infection was found to be positively associated with MetS in males in China.
Topics: Male; Adult; Female; Humans; Metabolic Syndrome; Helicobacter pylori; Diabetes Mellitus, Type 2; Helicobacter Infections; Adenosine Triphosphate
PubMed: 37404306
DOI: 10.3389/fendo.2023.1188487 -
Nutrients Sep 2020Metabolic syndrome (MetS), as originally defined by Jean Vague in 1940, was identified as a cluster of chronic, inflammatory pathologies, such as arterial hypertension,...
Metabolic syndrome (MetS), as originally defined by Jean Vague in 1940, was identified as a cluster of chronic, inflammatory pathologies, such as arterial hypertension, abdominal obesity, high glucose levels, high triglyceride levels and low HDL levels in the blood [...].
Topics: Diet; Feeding Behavior; Humans; Metabolic Syndrome
PubMed: 32957427
DOI: 10.3390/nu12092840 -
Nutrients Jun 2023Patients with plaque psoriasis have an increased risk of metabolic syndrome. However, no studies have assessed the nutritional status or screening methods of this... (Review)
Review
Patients with plaque psoriasis have an increased risk of metabolic syndrome. However, no studies have assessed the nutritional status or screening methods of this population. This review aimed to identify and summarise metabolic syndrome screening criteria and the tools/methods used in nutrition assessment in patients with plaque psoriasis. : PubMed, Web of Science, Ovid and Scopus were searched from inception to March 2023, following the Arkensey and O'Malley framework, to identify articles that report nutritional assessment methods/tools and metabolic screening criteria. Twenty-one studies were identified. Overall, these studies used four different screening criteria to define metabolic syndrome. Patients with psoriasis had a high prevalence of metabolic syndrome and had a poor nutritional status compared to controls. However, only anthropometric measures such as weight, height and waist circumference were employed to determine the nutritional status. Only two studies assessed the vitamin D status. Patients with psoriasis have a poor nutritional status, and they are at risk of nutrient deficiencies. However, these health aspects are not routinely assessed and may increase the risk of malnutrition among these patients. Therefore, additional assessments, such as body composition and dietary assessment, are needed to determine the nutritional status to provide a suitable intervention.
Topics: Humans; Nutritional Status; Metabolic Syndrome; Nutrition Assessment; Vitamins; Psoriasis; Malnutrition
PubMed: 37375611
DOI: 10.3390/nu15122707 -
Medicina (Kaunas, Lithuania) Feb 2021The link between psoriasis and sport is a controversial issue. The topic has been poorly investigated, and nowadays there are many unsolved questions, dealing with the... (Review)
Review
The link between psoriasis and sport is a controversial issue. The topic has been poorly investigated, and nowadays there are many unsolved questions, dealing with the role of psoriasis in influencing the sporting habits of patients and, vice versa, the impact of sport activity on course, severity and extent of the disease, with particular regard to the indirect benefits on cardiovascular risk and metabolic syndrome. Moreover, the role of physical activity on patients' quality of life and the potential limitations on physical activity due to joint involvement have not been well elucidated until now. In this narrative review we will try to provide answers to these queries.
Topics: Arthritis, Psoriatic; Humans; Metabolic Syndrome; Psoriasis; Quality of Life; Sports
PubMed: 33578921
DOI: 10.3390/medicina57020161