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Scientific Reports Oct 2022This study aimed to prepare a bioactive acrylic material by adding different types of glasses. Commercially available polymerized acrylic resin was mixed with 10% of...
This study aimed to prepare a bioactive acrylic material by adding different types of glasses. Commercially available polymerized acrylic resin was mixed with 10% of four different types of glasses in the powder form and cured. Flexural strength, sorption, and solubility of the samples were tested according to ISO 20795-1:2013. The total number of samples used in the tests were 60. The materials were placed in artificial saliva of pH 4 and 7, and elution was performed for 0, 1, 28, and 42 days. The collected samples were analyzed using inductively coupled plasma atomic emission spectrometry to detect Ca, P, and Si ions and using ion chromatography to detect F ions. The materials obtained after modification with glasses showed lower compressive strength compared with pure polymethyl methacrylate but met the standard requirements. Two glass types showed higher solubility values compared with the value defined by the ISO standard. Biomin C and S53P4 released Ca, P, and Si ions, respectively, after 42 days in artificial saliva. Acrylic resins modified with 10% Biomin C and S53P4 glasses can be a valuable source of Ca and P ions under acid conditions for 28 and 42 days.
Topics: Acrylic Resins; Materials Testing; Polymethyl Methacrylate; Powders; Saliva, Artificial
PubMed: 36198737
DOI: 10.1038/s41598-022-20840-1 -
Clinical and Applied... 2023Since Charnley introduced acrylic cement to seal metallic hip prostheses in the 1950s, reports of perioperative fatal cardiorespiratory and vascular dysfunctions have... (Review)
Review
Since Charnley introduced acrylic cement to seal metallic hip prostheses in the 1950s, reports of perioperative fatal cardiorespiratory and vascular dysfunctions have been published. Studies on humans and animals have shown neurogenic stimulation and substantial local and systemic activation of coagulation are caused by surgical bone marrow damage and chemical cell destruction by toxic monomeric methyl methacrylate from the implanted cement and other tissue-released substances. Venous blood-borne cell fragments and conjugates of activated cells from the surgical site are sequestered and trapped in the pulmonary microcirculation. A substantial hypercoagulation occurs in the lung circulation. Hypercoagulable blood is passed over to the arterial side and may cause vessel obliteration and organ damage. This process may affect the brain, heart, and kidneys and, through the release of vasoactive substances, introduce hemodynamic imbalances that can lead to fatal outcomes in susceptible populations such as elderly patients with hip fractures. The main underlying pathophysiologic processes leading to these occasionally devastating outcomes are a substantial activation of coagulation and cell destruction caused by the toxic substance released by curing bone cement and several vasoactive substances.
Topics: Animals; Humans; Aged; Bone Cements; Blood Coagulation; Hip Prosthesis; Methylmethacrylate
PubMed: 37792504
DOI: 10.1177/10760296231198036 -
Polymers Jul 2023Poly(methylmethacrylate--methacrylic acid) (PMMA--MAA) polymers were prepared via cobalt-mediated free radical copolymerization and were characterized after synthesis....
Poly(methylmethacrylate--methacrylic acid) (PMMA--MAA) polymers were prepared via cobalt-mediated free radical copolymerization and were characterized after synthesis. The synthesis led to a 98.5% conversion and a final ratio between the two units, MMA/MAA, was equal to 63:37 mol%. PMMA--MAA was then used as a matrix for cellulose-based nanocomposites to tailor filler compatibility, thanks to the presence of carboxylic groups capable of generating strong H-bonds with the cellulose surface. Cellulose nanofibers (CNFs) were dispersed using a solution with a mixture of two solvents to tailor compatibility of both the components. For this purpose, CNFs were successfully re-dispersed in methanol using the solvent exchange method and tetrahydrofuran/methanol mixtures at different ratios were used for the preparation of the films. Fully transparent films of PMMA--MAA + CNF were prepared up to 15 wt% of CNF with a good dispersion in the matrix. This dispersion state leads to the reinforcement of the polymethacrylate matrix, increasing its tensile strength whilst preserving optical transparency.
PubMed: 37571119
DOI: 10.3390/polym15153226 -
PloS One 2023This study evaluated surface properties and adhesion/biofilm formation by Candida albicans on 3D printed denture base resins used in 3D printing. Disc-shaped specimens...
This study evaluated surface properties and adhesion/biofilm formation by Candida albicans on 3D printed denture base resins used in 3D printing. Disc-shaped specimens (15 mm x 3 mm) of two 3D-printed resins (NextDent Denture 3D+, NE, n = 64; and Cosmos Denture, CO, n = 64) and a heat-polymerized resin (Lucitone 550, LU, control, n = 64) were analyzed for surface roughness (Ra μm) and surface free energy (erg cm-2). Microbiologic assays (90-min adhesion and 48-h biofilm formation by C. albicans) were performed five times in triplicate, with the evaluation of the specimens' surface for: (i) colony forming units count (CFU/mL), (ii) cellular metabolism (XTT assay), and (iii) fluorescence and thickness of biofilm layers (confocal laser scanning microscopy). Data were analyzed using parametric and nonparametric tests (α = 0.05). LU presented higher surface roughness Ra (0.329±0.076 μm) than NE (0.295±0.056 μm) (p = 0.024), but both were similar to CO (0.315±0.058 μm) (p = 1.000 and p = 0.129, respectively). LU showed lower surface free energy (47.47±2.01 erg cm-2) than CO (49.61±1.88 erg cm-2) and NE (49.23±2.16 erg cm-2) (p<0.001 for both). The CO and NE resins showed greater cellular metabolism (p<0.001) and CO only, showed greater colonization (p = 0.015) by C. albicans than LU in the 90-min and 48-hour periods. It can be concluded that both 3D-printed denture base resins are more prone to colonization by C. albicans, and that their surface free energy may be more likely associated with that colonization than their surface roughness.
Topics: Candida albicans; Denture Bases; Biofilms; Surface Properties; Printing, Three-Dimensional; Materials Testing; Polymethyl Methacrylate
PubMed: 37792886
DOI: 10.1371/journal.pone.0292430 -
Clinical and Experimental Dental... Dec 2022To compare the marginal and internal fit and fracture resistance of three-unit provisional fixed dental prostheses (FDPs) fabricated by additive, subtractive, and...
OBJECTIVES
To compare the marginal and internal fit and fracture resistance of three-unit provisional fixed dental prostheses (FDPs) fabricated by additive, subtractive, and conventional methods.
MATERIAL AND METHODS
Eighty 3-unit FDPs were fabricated on metal dies of the maxillary right second premolar and second molar by four different techniques (n = 20): The direct method by using autopolymerizing polymethyl methacrylate (PMMA), indirect method by the compression molding technique, subtractive manufacturing by using PMMA blocks, and additive manufacturing by using digital light processing technology. The adaptation of restorations at the marginal, axial, cuspal, and fossa areas was assessed by using the silicone replica technique. After thermocycling and cyclic loading, the fracture resistance was measured by a universal testing machine. Data were analyzed by a two-way analysis of variance (ANOVA), ANOVA, and Tukey test (α = .05).
RESULTS
The mean gap measured in the additive group was lower than that in all other groups at all points (p < .05); however, the difference in the marginal gap with the subtractive group was not significant (p = .995). The mean marginal and axial gaps in the subtractive group were significantly lower than the corresponding values in both conventional groups (p < .05). A significant difference existed between all groups regarding the mean cuspal and fossa gaps (p < .05). The mean fracture resistance of the additive group was significantly higher than that of indirect (p = .018) and direct (p < .001) groups, and the fracture resistance of the subtractive group was significantly higher than that of the direct group (p = .020).
CONCLUSION
The digitally fabricated provisional FDPs showed superior marginal and internal fit and higher fracture resistance than the conventionally fabricated FDPs. Between the digital methods, the additive technique yielded superior internal fit.
Topics: Dental Marginal Adaptation; Dental Prosthesis Design; Computer-Aided Design; Polymethyl Methacrylate; Bicuspid
PubMed: 35871472
DOI: 10.1002/cre2.637 -
Orthopaedic Surgery Dec 2021To investigate the biomechanical and elution properties of meropenem-loaded bone cement.
OBJECTIVE
To investigate the biomechanical and elution properties of meropenem-loaded bone cement.
METHODS
Bone cement (Palacos LV) with 5% (2 g/4 0g), 10% (4 g/40 g), and 15% (6 g/40 g) meropenem; 5% (2 g/40 g) and 10% (4 g/40 g) vancomycin; and blank bone cement were prepared in a total of six groups named A2, A4, A6, B2, B4, and A0 (antibiotic-free). 36 cylinder specimens (6-mm diameter and 12-mm height) of all six groups were molded for a compression test. After the compression test, because of mechanical properties below the ISO standard requirements, groups B2, B4 were not subjected to a bending test. So a total of 24 rectangular strip specimens (10-mm width, 75-mm length, and 3.3-mm thickness) for groups A2, A4, A6 and A0 were molded for the bending test. Between-group differences of compressive strength, bending strength and bending modulus were analyzed. The meropenem standard was prepared as a series of standard solutions to calculate the standard curve. At a constant temperature of 37 °C, separately, meropenem-loaded bone cement cylinder specimens (12 mm in diameter and 17 mm in length) of A2, A4 and A6 were serially immersed in saline solution without stirring. The eluent drug concentration at 24, 48, 72 h and 6, 12, 24 days was measured and the drug concentration-time curve of meropenem was constructed.
RESULTS
With the exception of groups B2 and B4, all cements compressive strength values were well above the minimum requirement of the ISO 5833 standard (70 MPa). The compressive strength and bending strength values of group A4 were higher than those of group A0 (P < 0.05), but no difference was found between the A0, A2 and A6 groups (P > 0.05). There were no intergroup differences of bending modulus between the A0, A2, A4 and A6 groups (P > 0.05). A standard curve of meropenem was obtained and a regression equation was constructed: Y = 15.0265 X + 13.5218, r = 1.00. At 37 °C, the release of meropenem was rapid during the first 48 h for all A2, A4, A6 samples, and subsequent release continued to decrease.
CONCLUSION
When adding up to 15% (6 g/40 g) meropenem to the bone cement, the biomechanical properties were not reduced, and bone cement with 10% (4 g/40 g) meropenem had the best performance. At a constant temperature of 37°C, meropenem can be released from bone cement for up to 24 days.
Topics: Anti-Bacterial Agents; Biomechanical Phenomena; Bone Cements; Compressive Strength; Humans; Materials Testing; Meropenem; Polymethyl Methacrylate; Powders; Vancomycin
PubMed: 34734478
DOI: 10.1111/os.13139 -
European Journal of Medical Research Jun 2023Sepsis occurs as a result of dysregulated host response to infection. However, cytokine adsorption therapy may restore the balance of proinflammatory and... (Randomized Controlled Trial)
Randomized Controlled Trial
Comparison of the cytokine adsorption ability in continuous renal replacement therapy using polyethyleneimine-coated polyacrylonitrile (AN69ST) or polymethylmethacrylate (PMMA) hemofilters: a pilot single-center open-label randomized control trial.
BACKGROUND
Sepsis occurs as a result of dysregulated host response to infection. However, cytokine adsorption therapy may restore the balance of proinflammatory and anti-inflammatory mediator responses in patients with sepsis. This study aimed to determine the cytokine adsorption ability of two different types of continuous renal replacement therapy (CRRT) hemofilters for polyethyleneimine-coated polyacrylonitrile (AN69ST) (surface-treated) and polymethylmethacrylate (PMMA) CRRT.
METHODS
We performed a randomized controlled trial among sepsis patients undergoing CRRT, who were randomly assigned (1:1) to receive either AN69ST or PMMA-CRRT. The primary outcome was cytokine clearance of hemofilter adsorption (CHA). The secondary endpoints were the intensive care unit (ICU) and 28-day mortalities.
RESULTS
We randomly selected 52 patients. Primary outcome data were available for 26 patients each in the AN69ST-CRRT and PMMA-CRRT arms. The CHA of high-mobility group box 1, tumor necrosis factor, interleukin (IL)-8, monokine induced by interferon-γ, and macrophage inflammatory protein were significantly higher in the AN69ST-CRRT group than in the PMMA-CRRT group (P < 0.001, P < 0.01, P < 0.001, P < 0.001 and P < 0.001, respectively). In contrast, the CHA of IL-6 was significantly higher in the PMMA-CRRT group than in the AN69ST-CRRT group (P < 0.001). In addition, the 28-day mortality was not significantly different between the two groups (50% in AN69ST-CRRT vs. 30.8% in PMMA-CRRT, P = 0.26).
CONCLUSION
AN69ST and PMMA membranes have different cytokine CHA in patients with sepsis. Therefore, these two hemofilters may have to be used depending on the target cytokine.
TRIAL REGISTRATION NUMBER
This study was registered in the University Hospital Medical Information Network on November 1, 2017 (Trial No: UMIN000029450, https://center6.umin.ac.jp ).
Topics: Humans; Continuous Renal Replacement Therapy; Cytokines; Polymethyl Methacrylate; Polyethyleneimine; Adsorption
PubMed: 37391846
DOI: 10.1186/s40001-023-01184-6 -
Polimery W Medycynie 2023Occlusal splints can protect teeth during bruxism, preventing tooth wear, as well as during sports activities, shielding them from impacts.
BACKGROUND
Occlusal splints can protect teeth during bruxism, preventing tooth wear, as well as during sports activities, shielding them from impacts.
OBJECTIVES
To verify the influence of thermal cycles and disinfection on the roughness, microhardness and color of polyethylene terephthalate glycol/thermoplastic polyurethane (PETG/TPU) and poly(methyl methacrylate) (PMMA).
MATERIAL AND METHODS
Thirty-six PETG/TPU samples and 36 PMMA samples were prepared (ø10 mm × 3 mm). Six groups were created according to the material and the disinfection method used (n = 12 each): PETG/TPU (glister), PETG/TPU (hypochlorite), PETG/TPU (soap), PMMA (glister), PMMA (hypochlorite), and PMMA (soap). Roughness, Knoop microhardness and color evaluations were performed before the experiments (T1), after thermocycling (T2) and after disinfection (T3). Three-way repeated measures analysis of variance (ANOVA) and Tukey's test were used for statistical evaluations.
RESULTS
For roughness and color, ANOVA showed statistical significance based on the interaction between thermal cycling, material and disinfectant factors. In terms of Knoop microhardness, ANOVA showed statistical significance based on the interaction between thermal cycling and material factors.
CONCLUSIONS
Roughness results were clinically acceptable in all groups at all time points, except the PETG/TPU and PMMA groups disinfected with hypochlorite. Microhardness significantly increased for both materials after thermal cycling, and at all time points, the microhardness of PMMA was significantly higher than that of PETG/TPU. After thermal cycling, the color changes were clinically unacceptable in all groups.
Topics: Polymethyl Methacrylate; Disinfection; Hypochlorous Acid; Materials Testing; Soaps; Surface Properties
PubMed: 36929643
DOI: 10.17219/pim/159350 -
Journal of Oral Science 2022This study compared the bond strengths of four adhesive systems and four different resin composite block materials: Gradia Block (GR), Shofu Block HC (SH), Estelite...
PURPOSE
This study compared the bond strengths of four adhesive systems and four different resin composite block materials: Gradia Block (GR), Shofu Block HC (SH), Estelite Block (ES), and KZR-CAD HR2 (KZ).
METHODS
A primer (PZ-AB) containing a silane (γ-MPTS) with 10-methacryloyloxydecyl dihydrogen phosphate (MDP) was applied to ground surfaces of the resin composite block specimens, and the specimens were then bonded to stainless-steel rods using two methyl methacrylate-tributylborane (MMA-TBB)-based luting agents (SB and MT), designated as the PZ-AB/SB and PZ-AB/MT adhesive systems, respectively. The SB resin contained 4-methacryloyloxyethyl trimellitate anhydride (4-META), whereas the MT resin did not. The SB resin without primer (No primer/SB) and a dual-curing composite-type adhesive system (UPA/RelyX) were used as controls. The 24-h tensile bond strengths were determined and analyzed using the Tukey-Kramer HSD test (α = 0.05, n = 8).
RESULTS
The highest bond strengths were obtained for the GR/PZ-AB/MT, GR/PZ-AB/SB, KZ/PZ-AB/MT, ES/PZ-AB/SB, and KZ/No primer/SB groups, whereas the KZ/UPA/RelyX, ES/UPA/RelyX, SH/UPA/RelyX, and SH/No primer/SB groups exhibited the lowest bond strengths.
CONCLUSION
For each resin composite block material primed with γ-MPTS and MDP, the MMA-TBB-based luting agents, irrespective of the presence of 4-META, provided higher bond strengths than the dual-curing composite-type adhesive system.
Topics: Boron Compounds; Dental Bonding; Dental Cements; Materials Testing; Methacrylates; Methylmethacrylate; Phosphates; Silanes
PubMed: 35370182
DOI: 10.2334/josnusd.21-0513 -
The Journal of Adhesive Dentistry Apr 2021To investigate the impact of pretreatment and conditioning on shear bond strength (SBS), surface free energy (SFE) and surface roughness (SR) between...
PURPOSE
To investigate the impact of pretreatment and conditioning on shear bond strength (SBS), surface free energy (SFE) and surface roughness (SR) between polyetheretherketone (PEEK) and cold-cured polymethylmethacrylate (PMMA).
MATERIALS AND METHODS
PEEK substrates (Dentokeep PEEK Disc, nt-trading) were air abraded with Al2O3 particles of different grain sizes applied with varying pressure at 1) 0.2 MPa - 50 µm Al2O3; 2) 0.4 MPa - 50 µm Al2O3; 3) 0.2 MPa - 110 µm Al2O3; 4) 0.4 MPa - 110 µm Al2O3; or 5) without air abrasion (n = 172/group). Surface properties were quantified using SFE and SR (n = 10/group), and scanning electron microscope imaging (n = 2/group). Substrates were conditioned with a) Visio.link (VL, Bredent); b) Scotchbond Universal (SU, 3M Oral Care); c) Bonding Fluid (BF, Schütz Dental); or d) without conditioning (WC; n = 40/subgroup) and bonded to the polymer (Futura Jet, Schütz Dental). SBS and fracture types were determined before and after 10,000 thermal cycles (n = 20/subgroup). Univariate ANOVA, Kruskal-Wallis test, Mann-Whitney U-test, Kaplan-Meier survival estimates, and Weibull distribution were computed (p < 0.05). Ciba-Geigy tables and the chi-squared test were used to analyze fracture type distributions.
RESULTS
An increase in particle size and pressure resulted in similar or increased SBS, Weibull characteristic strength, and Weibull moduli (p < 0.001 - 0.046). The lowest results were observed for the control group (without air abrasion), while pretreatment with 0.4 MPa - 110 µm Al2O3 presented the highest values (p < 0.001). In comparison with the other conditioning procedures, VL showed high (p < 0.001 - 0.03), and SU and WC low SBS (p < 0.001 - 0.006). Although it did not influence SFE, an increase in particle size and pressure led to an increased SR (p < 0.001).
CONCLUSION
Pretreatment with 0.4 MPa - 110 µm Al2O3 can be recommended to increase bonding properties between PEEK and PMMA. Application of adhesives such as VL can enhance SBS further.
Topics: Air Abrasion, Dental; Benzophenones; Dental Bonding; Dental Stress Analysis; Dentures; Ketones; Materials Testing; Polyethylene Glycols; Polymers; Polymethyl Methacrylate; Resin Cements; Shear Strength; Surface Properties
PubMed: 33825428
DOI: 10.3290/j.jad.b1079579