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Cureus May 2022Oral malignancy is endemic in India due to high addiction to tobacco and betel nuts. In addition, benign oral tumors are also very common in India. Studies comparing...
BACKGROUND
Oral malignancy is endemic in India due to high addiction to tobacco and betel nuts. In addition, benign oral tumors are also very common in India. Studies comparing the demographic profile of benign and malignant oral tumors are scarce in India.
METHODS
In this retrospective study, biopsy records of patients with solid tumors who presented to the Oral and Maxillofacial Surgery department from 2006 to 2018 were analyzed. The age and gender distribution of benign and malignant tumors were compared using Student's t-test and Fisher's exact test, respectively.
RESULTS
Out of the 429 biopsies reported, non-neoplastic lesions, which included hyperplasias/dysplasia (107) and cystic lesions (113), were excluded, while neoplastic lesions (209) were included in our study. Out of these, 77 (37%) were malignant while 132 (63%) were benign tumors. Among the benign tumors, the most common were fibromas of various types (52/132, 39%) and odontogenic tumors (33/132, 25%); and among the malignant tumors squamous cell carcinoma was the most common (64/77, 83%). The mean age of patients with malignant tumors was significantly higher than benign tumors (51±14 versus 32±16 years; p<0.01). Alarmingly, 23% of malignant tumors were seen in patients ≤40 years of age.
CONCLUSION
In central India, 37% of all neoplasms of the oral cavity are malignant 63% are benign. The average age of presentation of malignant oral tumors is 51 years, and almost one-fourth of all oral malignancies occur in patients below 40 years of age. The high frequency of younger patients developing oral cancer calls for urgent measures to spread awareness about oral cancer and its causative factors in India.
PubMed: 35761915
DOI: 10.7759/cureus.25345 -
Journal of Oral and Maxillofacial... 2022Odontogenic myxofibroma is a benign tumour that is rarely encountered in any bone other than jaws. It accounts for only 3-11% of all odontogenic tumours. The...
Odontogenic myxofibroma is a benign tumour that is rarely encountered in any bone other than jaws. It accounts for only 3-11% of all odontogenic tumours. The pathogenesis of these tumours is still controversial and may arise from myxomatous degeneration or fibrous stroma or from the mesenchymal portion of the tooth germ. Clinically, they are slow-growing and can cause gradual expansion of the cortical plates, loosening, displacement of teeth, and rarely root resorption. Biologically, the tumour is locally aggressive with a high recurrence rate, which warrants extensive surgical treatment. Here, we present a case of central odontogenic myxofibroma in a 45-year-old female resulting in the extensive involvement of the mandible within a month.
PubMed: 36588850
DOI: 10.4103/jomfp.jomfp_385_21 -
Tomography (Ann Arbor, Mich.) Feb 2024Since there are many differential diagnoses for cemento-osseous dysplasia (COD), it is very difficult for dentists to avoid misdiagnosis. In particular, if COD is...
BACKGROUND
Since there are many differential diagnoses for cemento-osseous dysplasia (COD), it is very difficult for dentists to avoid misdiagnosis. In particular, if COD is related to an embedded tooth, differential diagnosis is difficult. However, there have been no reports on the characteristics of the imaging findings of COD associated with embedded teeth. The aim of the present study was to investigate the occurrence and imaging characteristics of cemento-osseous dysplasia (COD) associated with embedded teeth, in order to appropriately diagnose COD with embedded teeth.
METHODS
The radiographs with or without histological findings of 225 patients with COD were retrospectively analyzed. A retrospective search through the picture archiving and communication system (PACS) of the Division of Oral and Maxillofacial Radiology of Kyushu Dental University Hospital was performed to identify patients with COD between 2011 and 2022.
RESULTS
Fifteen COD-associated embedded mandibular third molars were identified in 13 patients. All 13 patients were asymptomatic. On imaging, COD associated with embedded mandibular third molars appeared as masses that included calcifications around the apex of the tooth. On panoramic tomography, COD showed inconspicuous internal calcification similar to that of odontogenic cysts or simple bone cysts, especially in patients with COD only around the mandibular third molar region. Those with prominent calcification resembled cemento-ossifying fibroma, calcifying epithelial odontogenic tumor, calcifying odontogenic cyst, adenomatoid odontogenic tumor, and so on, as categories of masses that include calcifications on panoramic tomography and computed tomography.
CONCLUSIONS
The current investigation is the first to report and analyze the imaging characteristics of COD associated with embedded teeth. It is important to consider the differences between COD and other cystic lesions on panoramic tomography, and the differences between COD and masses that include calcifications on CT.
Topics: Humans; Retrospective Studies; Odontogenic Tumors; Cementoma; Radiography; Tomography, X-Ray Computed
PubMed: 38393286
DOI: 10.3390/tomography10020018 -
Clinical Case Reports Jul 2022Central odontogenic fibroma (COF) is an extremely rare benign odontogenic tumor, which is associated with an unerupted tooth in one-third of the cases. Hyperplastic...
Central odontogenic fibroma (COF) is an extremely rare benign odontogenic tumor, which is associated with an unerupted tooth in one-third of the cases. Hyperplastic dental follicle (HDF) is an odontogenic hamartomatous lesion associated with delayed or tooth eruption failure in young patients. Dentigerous cyst (DC) is an epithelial-lined developmental cyst surrounding the crown of an unerupted or impacted tooth. Here, we present a case of 13-year-old boy with pericoronal radiolucency around impacted right maxillary canine tooth, which detected during routine dental examination on panoramic radiograph. The size of radiolucency was varied between 5 and 10 mm and was asymmetrical. Lesion was underwent biopsy with suspicion to a dentigerous cyst. On microscopic examination, the lesion was composed of a cellular fibrous connective tissue with odontogenic epithelium in the form of strands or nests throughout the lesion and calcifications in the form of basophilic cementum-like material and dentinoid. Due to its nonspecific histological features, we encountered a diagnostic dilemma. In this case report, we discuss the clinical and radiologic features of COF, DC, and HDF. We preferred COF for this lesion. By combining surgical and orthodontic treatments, the impacted tooth was directed to its correct position in the maxilla. This case report highlights the importance of clinicopathological correlation in the diagnosis of pericoronal radiolucencies.
PubMed: 35903507
DOI: 10.1002/ccr3.6163 -
Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi... Dec 2023Cemento-ossifying fibroma (COF) is a mesenchymal benign odontogenic tumor, which may lead to impacted or ectopic permanent teeth. Autotransplantation of teeth is a...
Cemento-ossifying fibroma (COF) is a mesenchymal benign odontogenic tumor, which may lead to impacted or ectopic permanent teeth. Autotransplantation of teeth is a surgical process, in which a tooth is transplanted from one position to another in the same individual. This method can effectively restore the patient's mastication and aesthetics and is feasible in replacing missing teeth. This study reports a case of simultaneous COF resection combined with heterotopic canine autotransplantation to repair dentition defect, which effectively promotes the restoration of bone continuity and stability and achieves immediate and long-term aesthetic function requirements.
Topics: Humans; Cementoma; Transplantation, Autologous; Esthetics, Dental; Fibroma, Ossifying; Odontogenic Tumors
PubMed: 38597041
DOI: 10.7518/hxkq.2023.2023103 -
BMC Oral Health Sep 2021Cemento-ossifying fibroma (COF) and cementoblastoma (CB) are rare benign odontogenic tumors with a predilection for the mandible. Cemento-ossifying fibroma is a...
BACKGROUND
Cemento-ossifying fibroma (COF) and cementoblastoma (CB) are rare benign odontogenic tumors with a predilection for the mandible. Cemento-ossifying fibroma is a fibro-osseous lesion that originates in the tooth bearing areas of jaw and shows cementum-like tissue in a fibrotic stroma. Cementoblastoma is classically related to roots of teeth with the presence of calcified cementum-like material. To date, only a single case of concomitant unilateral COF and CB has been reported in the literature.
CASE PRESENTATION
We present an unusual case of a 37-year-old female who presented with two discrete bilateral swellings in the right and left mandible for 10 years. The larger tumor involved the left posterior mandible with extension anteriorly to the left and right anterior mandibles, and the smaller tumor was present in right posterior mandible. Radiology revealed two distinct lesions involving both sides of mandible. Histopathological examination showed characteristic features of cemento-ossifying fibroma in sections of the larger tumor and cementoblastoma in sections of smaller tumor.
CONCLUSION
This case shows the very unique bilateral co-existence of COF and CB, the second case reported in literature to date.
Topics: Adult; Cementoma; Female; Fibroma, Ossifying; Humans; Mandible; Mandibular Neoplasms; Odontogenic Tumors
PubMed: 34493273
DOI: 10.1186/s12903-021-01794-8 -
Journal of Oral and Maxillofacial... Feb 2022Benign mesenchymal odontogenic tumors are lesions derived from the mesenchymal components of the tooth-forming apparatus and are consequently found within the jawbone....
Benign mesenchymal odontogenic tumors are lesions derived from the mesenchymal components of the tooth-forming apparatus and are consequently found within the jawbone. Benign fibro-osseous tumors are part of this category of lesions in which normal bone is substituted, initially by fibrous tissue and within time become infiltrated by osteoid and cementoid elements. They are asymptomatic, slow-growing lesions and remain undiagnosed until swelling of the face becomes prominent and they share similar radiological characteristics. Herein, we report three cases of ossifying fibroma, cemento-osseous fibroma and periapical cemento-osseous dysplasia and analyze all the correlating factors, clinical history, radiological and histological features, intraoperative appearance, and treatment with a 3-year follow-up period. Despite the advances in the identification of these pathologies, clinicians still face difficulties in their classification and the diagnosis due to overlap in both histological and radiographic findings. An accurate final diagnosis is essential for appropriate treatment and an informative prognosis.
PubMed: 35450255
DOI: 10.4103/jomfp.jomfp_94_21 -
Pakistan Journal of Medical Sciences 2019To study the clinocopathological factors and presence of Human Pappiloma Virus in ameloblastoma by immnohistochemistry.
OBJECTIVE
To study the clinocopathological factors and presence of Human Pappiloma Virus in ameloblastoma by immnohistochemistry.
METHODS
It was a cross sectional study on 50 surgical specimens of ameloblastoma, completed in six months. These were selected and processed for initial screening by H&E and then by immunohistochemistry (IHC) for detection of Human Papilloma Virus (HPV). The questionnaire was designed to study the clinicopathological factors associated in these patients. Sections of 4µm were cut, placed on special positive charged glass slides in the Department of Pathology, King Edward Medical University. It was then examined by the histopathologists for grading and scoring of these lesions. Chi Square test was used to assess the differences found in types of ameloblastomas. The p-value was smaller than 0.05 (p < 0.05).
RESULTS
The mean age of the patients (12-80 years old) was 38.6±15.1 years, with male-female ratio 2.84: 1. HPV was positive in 9 (18%), whereas negative in of 41 (82%) patients. Among the positive, reactive HPV with score-1 was 8 and score-2 was 1. According to histological variant, follicular was present in 78%, Plexiform pattern in 8%, Conventional and Desmoplastic variants in one patient each; and Cystic and Acanthomatous were seen in two and three patients respectively. The mandible was involved in 39 patients, maxilla and right maxilla involved in 4 patients each, right retromolar, cheek and angle of mandible was seen in one patient each. About 16% patients had anterior, 66% had posterior and 18% had both anterior and posterior regions involved. Among the HPV positive reactive statistically, no significant difference was found with smoking, Paan and exposure to pesticides, factory or mine (p-value > 0.05). Among HPV positive reactive patients, eight had ameloblastoma whereas, 1 had ameloblastomic fibroma. There was no statistical significance of type, location and region of tumor in HPV positivity.
CONCLUSION
Mandible and posterior region was more commonly involved. Follicular pattern was most common. There was no effect of exposure to pesticides, factory or mine, smoke and human papilloma virus in the etiology of ameloblastoma because only 18% of patients showed the association of HPV16.
PubMed: 31777517
DOI: 10.12669/pjms.35.6.909 -
Asian Journal of Surgery May 2024
Topics: Humans; Fibroma; Mandibular Neoplasms; Odontogenic Tumors
PubMed: 38350778
DOI: 10.1016/j.asjsur.2024.01.177 -
BMJ Case Reports Aug 2020Juvenile ossifying fibromas (JOFs) are a rare group of fibro-osseous lesions, typically of odontogenic origin. Juvenile psammomatoid ossifying fibroma (JPOF) is one...
Juvenile ossifying fibromas (JOFs) are a rare group of fibro-osseous lesions, typically of odontogenic origin. Juvenile psammomatoid ossifying fibroma (JPOF) is one variant, that is, histopathologically distinguished by spherical ossicles resembling psammoma bodies. JPOF tumours are most commonly found in craniofacial skeletal structures and can be locally aggressive. Thus, early management by complete surgical excision is crucial for good outcomes, although recurrence is still possible. Secondary aneurysmal bone cyst (ABC) formation has been reported with JOF lesions, but less commonly with the JPOF variant. We describe an unusual case of JPOF that presented in the calcaneus with secondary ABC formation.
Topics: Adolescent; Bone Cysts, Aneurysmal; Bone Neoplasms; Calcaneus; Diagnosis, Differential; Fibroma, Ossifying; Humans; Magnetic Resonance Imaging; Male; Radiography
PubMed: 32816930
DOI: 10.1136/bcr-2020-234555