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Molecules (Basel, Switzerland) Oct 2020With the increasing debate on sustainability, there is a strong market trend to formulate more sustainable products for topical application. Several studies emphasize...
With the increasing debate on sustainability, there is a strong market trend to formulate more sustainable products for topical application. Several studies emphasize the potential applications of natural, organic, or green chemistry-derived ingredients, but comparative studies between conventional ingredients and sustainable alternatives are lacking. This type of study is considered an excellent baseline and time-saving strategy for future studies. In addition, one of the main challenges of replacing ingredients by sustainable alternatives in topical vehicles is to maintain high-quality products. Thus, the main goal of this research study was to create a well-defined strategy supported by specific experimental data for the development of sustainable topical vehicles with high-quality standards. The study was designed to evaluate the effects of replacing conventional ingredients (e.g., hydrocarbons, silicones, and preservatives) by sustainable ones on the physical, chemical, and microbiological features of topical emulsions. Additionally, in vivo assessment studies were performed to evaluate the safety, biological efficacy, and sensorial aspects of the developed formulations. The results obtained showed that the replacement of ingredients by sustainable alternatives has an effective impact on the physicochemical and structural properties of the emulsions, mainly on their rheological behavior. However, using appropriate strategies for ingredient selection and rheological adjustment, it is possible to overcome some barriers created by the use of natural raw materials, thus developing appealing and high-quality sustainable topical vehicles.
Topics: Administration, Topical; Dimethylpolysiloxanes; Drug Carriers; Drug Compounding; Emulsions; Ethylene Glycols; Excipients; Glass; Humans; Hydrocarbons; Oils; Petrolatum; Polyesters; Polyethylene Terephthalates; Rheology; Silicones; Waxes
PubMed: 33105792
DOI: 10.3390/molecules25214887 -
Skin Pharmacology and Physiology 2023Dry skin is a hallmark of impaired skin barrier function. Moisturizers are a mainstay of treatment to help the skin retain moisture, and there is a high consumer demand...
INTRODUCTION
Dry skin is a hallmark of impaired skin barrier function. Moisturizers are a mainstay of treatment to help the skin retain moisture, and there is a high consumer demand for effective products. However, the development and optimization of new formulations are hampered due to lack of reliable efficacy measures using in vitro models.
METHODS
In this study, a microscopy-based barrier functional assay was developed using an in vitro skin model of chemically induced barrier damage to evaluate the occlusive activity of moisturizers.
RESULTS
The assay was validated by demonstrating the different effects on barrier function between humectant (glycerol) and occlusive (petrolatum). Significant changes in barrier function were observed upon tissue disruption, which was ameliorated by commercial moisturizing products.
CONCLUSION
This newly developed experimental method may be helpful to develop new and improved occlusive moisturizers for the treatment of dry skin conditions.
Topics: Humans; Emollients; Skin; Petrolatum; Skin Diseases; Skin Absorption
PubMed: 36863326
DOI: 10.1159/000529630 -
Saudi Medical Journal Jan 2023To update a possible role of cosmeceutical topic treatment to obtain a better scar.
OBJECTIVES
To update a possible role of cosmeceutical topic treatment to obtain a better scar.
METHODS
This is a preliminary supportive study. A total of 14 patients who went to the General Hospital of Mexico City, Mexico, between May and December 2020, for breast reconstruction were included in the current study. The biopsies were carried out to the scar area of the previous I° and II° surgery. The patients were thus divided into 2 groups: those who used Cicolea cream® as a treatment supplement and those who used only petrolatum.
RESULTS
Collagen fibers arranged in a regular pattern in the group treated with Cicolea compared to dispersed collagen fibers in the group treated with pure petrolatum. Furthermore, the patients who presented hypertrophic or keloid scars secondary to mastectomy, developed after insertion of breast expanders an organized scarring process, with improvement of scar if treated with Cicolea.
CONCLUSION
Based on our observations, it is possible to propose that the action of the polyphenols present in the different components of Cicolea® cream leads to a better evolution of the wound healing compared to the action of petrolatum composition.
Topics: Humans; Female; Breast Neoplasms; Cicatrix, Hypertrophic; Mastectomy; Wound Healing; Skin; Petrolatum; Collagen
PubMed: 36634956
DOI: 10.15537/smj.2023.44.1.20220556 -
Pediatric Allergy and Immunology :... Aug 2020
Topics: Eczema; Emollients; Humans; Immunoglobulin E; Immunoglobulin G; Paraffin; Petrolatum
PubMed: 32372469
DOI: 10.1111/pai.13253 -
International Wound Journal Apr 2023Split-thickness skin grafts (STSG) are widely used in wound reconstruction. However, donor site wounds are created as a result. Traditionally, moist wound healing and...
Comparison of skin graft donor site management using oxidised regenerated cellulose (ORC)/collagen/silver-ORC with absorptive silicone adhesive border and transparent film dressing vs semi-occlusive dressings.
Split-thickness skin grafts (STSG) are widely used in wound reconstruction. However, donor site wounds are created as a result. Traditionally, moist wound healing and transparent film dressings have been used to promote donor site wound healing. This retrospective study evaluated the use of oxidised regenerated cellulose (ORC)/collagen/silver-ORC dressing (ORC/C/Ag-ORC) with an absorptive silicone adhesive border dressing and transparent film dressing (treatment) compared with petrolatum-based gauze dressing (control) over donor site wounds. Patients underwent an STSG procedure between January and December 2020. Donor sites received treatment (n = 10) or control (n = 10) dressings. Dressing changes occurred as necessary. Time to epithelialisation, narcotic pain medication requirements, and the number of office/hospital visits were examined. Twenty patients were managed (9 males, 11 females, average age: 49.7 ± 13.9 y). Patient comorbidities included hypertension, diabetes, and hyperlipidemia. Wound types included traumatic and cancer excision. Time to epithelialisation was significantly reduced in the treatment group (11.1 ± 1.4 d vs 18 ± 2.4 d, P < 0.0001). The number of office visits for dressing changes was significantly lower in the treatment group (0.1 ± 0.3 vs 2 ± 0.7, P < 0.0001). No patients in the treatment group required a hospital visit, compared with 3 patients in the control group. One patient in the treatment group required narcotic pain medication, compared with 5 in the control group. In this patient population, the use of ORC/C/Ag-ORC, an absorptive silicone adhesive border dressing, and transparent film dressing resulted in a shorter time to epithelialisation and less analgesic requirement compared with petrolatum-based gauze dressing use.
Topics: Male; Female; Humans; Adult; Middle Aged; Occlusive Dressings; Silver; Skin Transplantation; Silicones; Retrospective Studies; Bandages; Collagen; Burns; Cellulose, Oxidized; Surgical Wound Infection; Petrolatum; Pain
PubMed: 36151766
DOI: 10.1111/iwj.13968 -
Yakugaku Zasshi : Journal of the... Oct 2019Compared to oral medication, the base plays a large role in the external preparation for skin, and dermatologists select the dosage form based on understanding of the...
[Clinical Research on the Effects of Differences in Properties of External Preparations for Skin on Application Amount: An Exploratory Investigation of the Relationship between the Base Usability and Application Amount by Questionnaire in Adult Subjects].
Compared to oral medication, the base plays a large role in the external preparation for skin, and dermatologists select the dosage form based on understanding of the effect of the base as well as according to skin symptoms and conditions, application site, age, season, etc. Further, in treatment with external preparations, it is important for patients to understand the application method and continue to apply an adequate amount to achieve the treatment goal. However, there is little evidence regarding the relationship between base properties or usability and the application amount. In this study, we investigated the usability and application amount of three bases with different properties (ointment base, cream base, and lotion base) in 62 adult subjects and exploratively examined the effect of the different base properties on the application amount. The results of this clinical study showed that the usability and preference for the base used for external preparations varies, and poor usability and low preference may lead to a reduction in the application amount. Even with good usability and high preference, there were many cases in which an adequate amount was not applied due to lack of specific instructions on external use. When selecting or changing the base in an external therapy, it is important for not only dermatologists but also pharmacists providing instructions on external use to be aware of the importance of the base and actively instruct patients to apply an adequate amount of the preparation.
Topics: Administration, Topical; Adult; Aged; Cross-Over Studies; Dermatologists; Female; Friction; Humans; Male; Middle Aged; Ointment Bases; Patient Education as Topic; Perception; Pharmacists; Sensation; Skin Cream; Skin Physiological Phenomena; Surveys and Questionnaires; Young Adult
PubMed: 31231102
DOI: 10.1248/yakushi.19-00091 -
Medicine Jan 2020The challenges with reconstruction of penile defects are plenty. In addition, no single and universally accepted reconstructive method exists for penile defect repair....
RATIONALE
The challenges with reconstruction of penile defects are plenty. In addition, no single and universally accepted reconstructive method exists for penile defect repair. Herein, we present the application of a circumferential penile shaft defect reconstruction using pull-up double-opposing keystone-designed perforator island flaps (KDPIFs) in one patient. This is the first case report of a circumferential penile shaft defect reconstruction using KDPIFs.
PATIENT CONCERNS
A 43-year-old man who injected petroleum jelly into his penis 10 years ago presented with multiple firm nodular mass-like lesions adherent to the overlying skin along the penile shaft. Our urologic surgeon removed the foreign bodies and performed a primary closure with undermining. However, wound dehiscence developed, and skin necrosis was exacerbated 5 days postoperatively.
DIAGNOSES
We performed debridement, and the final post-debridement defect was circumferential (5.5 × 12 cm) from the base of the glans to the midpoint of the penile shaft.
INTERVENTIONS
We covered the defect using pull-up double-opposing KDPIFs (10 × 13 cm each) based on the hot spots of the superficial external pudendal artery perforators on each side from the suprapubic area to the scrotum.
OUTCOMES
The flaps survived perfectly, with no postoperative complications. The patient was satisfied with the final outcome and had no erectile dysfunction or shortening of penile length after a 6-month follow-up.
LESSONS
We successfully reconstructed a circumferential penile defect with pull-up double-opposing KDPIFs both esthetically and functionally. Our technique can be a good alternative modality for extensive penile defect reconstruction.
Topics: Adult; Debridement; Foreign Bodies; Humans; Injections; Male; Penile Diseases; Petrolatum; Plastic Surgery Procedures; Surgical Flaps
PubMed: 32011463
DOI: 10.1097/MD.0000000000018762 -
Journal of the American Academy of... May 2020
Topics: Administration, Topical; Anti-Bacterial Agents; Antibiotic Prophylaxis; Biopsy; Dermatologic Surgical Procedures; Dermatologists; Drug Resistance, Microbial; Drug Utilization; Emollients; Humans; Petrolatum; Skin; Skin Diseases; Surgical Wound Infection
PubMed: 31927078
DOI: 10.1016/j.jaad.2019.12.060 -
Medicine Apr 2024Epistaxis is one of the common emergencies in otolaryngology. There are many causes of epistaxis, but reports of epistaxis due to nasal foreign bodies like leeches are...
RATIONALE
Epistaxis is one of the common emergencies in otolaryngology. There are many causes of epistaxis, but reports of epistaxis due to nasal foreign bodies like leeches are rare.
PATIENT CONCERNS
A 55-year-old male presented with "repeated epistaxis for over 20 days." Nasal endoscopy revealed a live leech in the olfactory area of the left nostril.
DIAGNOSES
The patient was diagnosed with epistaxis caused by a live leech in the nasal cavity.
INTERVENTIONS
Under nasal endoscopy, the leech was grasped with a vascular clamp and removed from the nasal cavity. The leech measured 8 cm in length. Hemostasis was achieved using a gelatin sponge at the wound site, and the nasal cavity was packed with Vaseline gauze.
OUTCOMES
The live leech was removed via nasal endoscopy. Two days later, the Vaseline gauze packing was removed, and the patient experienced no further nasal bleeding.
CONCLUSION
Live leeches in the nasal cavity can cause epistaxis. Nasal endoscopic removal of the live leech is an effective treatment.
LESSON
There are many causes of epistaxis, which are nonspecific and prone to missed or incorrect diagnosis. In patients with a history of fieldwork or direct contact with leeches who present with recurrent nasal bleeding, the possibility of epistaxis caused by a live leech should be considered, and timely and effective treatment should be provided.
Topics: Animals; Humans; Male; Middle Aged; Endoscopy; Epistaxis; Leeches; Nasal Cavity; Nose; Petrolatum
PubMed: 38579026
DOI: 10.1097/MD.0000000000037720 -
Dermatology Online Journal Dec 2020
Topics: Dermatitis, Contact; Eye Protective Devices; Humans; Masks; Petrolatum
PubMed: 33423432
DOI: No ID Found