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Skin Appendage Disorders Nov 2021The lesions of porokeratosis (PK) lead to skin atrophy and scarring as long as they spread centrifugally. PK affecting the nail unit is seldom described.
BACKGROUND
The lesions of porokeratosis (PK) lead to skin atrophy and scarring as long as they spread centrifugally. PK affecting the nail unit is seldom described.
OBJECTIVE
The aim was to revise the previously reported cases of ungual PK and to present 3 new cases.
METHODS
A PubMed search was performed with the keywords "nail" and "porokeratosis." Previously reported cases as well as 3 new cases are depicted in tables.
RESULTS
Only 11 cases of ungual PK were found; 3 new cases have been added. All patients presented with typical lesions of PK (Mibelli, isolated, segmental, or ostial eccrine types) that happened to affect nails due to nail matrix or nail bed compromise, resulting in mild to severe nail scarring, including irreversible anonychia. The present 3 case series contrast with the previous single case reports.
CONCLUSIONS
PK affecting the nails is exceedingly rare. Changes in nails affected by PK are irreversible, since, as on the skin, this is a chronic scarring process.
PubMed: 34901183
DOI: 10.1159/000516304 -
Indian Journal of Dermatology 2022We report a case of porokeratosis ptychotropica with a rare manifestation. Dermoscopy showed dotted vessels, cerebriform pattern, white scales, and brown and greyish...
We report a case of porokeratosis ptychotropica with a rare manifestation. Dermoscopy showed dotted vessels, cerebriform pattern, white scales, and brown and greyish white tracks in the periphery over a red-brown background. A skin biopsy confirmed the diagnosis from the presence of cornoid lamellae.
PubMed: 36998821
DOI: 10.4103/ijd.ijd_1145_20 -
International Journal of Women's... Dec 2021
PubMed: 35028392
DOI: 10.1016/j.ijwd.2021.07.009 -
Indian Journal of Dermatology 2021Porokeratosis ptychotropica (PP) is a rare variant of porokeratosis characterized by pruritic, symmetrical, red-brown verrucous papules, and plaques most commonly...
Porokeratosis ptychotropica (PP) is a rare variant of porokeratosis characterized by pruritic, symmetrical, red-brown verrucous papules, and plaques most commonly localized within the gluteal fold. Herein, we report the clinical, dermoscopy, and reflectance confocal microscopy (RCM) aspects of a case of PP in a 63-year-old Caucasian woman along with histopathological correlation. Both dermoscopy and RCM were able to recognize the , the histopathological clue shared by all clinical variants of porokeratosis. These non-invasive techniques may help in the differential diagnosis with other inflammatory/infectious and neoplastic disorders that may clinically resemble PP, but show distinct patterns.
PubMed: 35068510
DOI: 10.4103/ijd.ijd_894_20 -
Actas Dermo-sifiliograficas Jun 2023
Topics: Humans; Porokeratosis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imiquimod; Administration, Cutaneous; Cholesterol
PubMed: 36925100
DOI: 10.1016/j.ad.2022.06.025 -
Cureus Aug 2023Linear porokeratosis is a rare skin disorder that presents along dermatomal or Blashko lines. While the mechanism of linear porokeratosis formation is unknown, both...
Linear porokeratosis is a rare skin disorder that presents along dermatomal or Blashko lines. While the mechanism of linear porokeratosis formation is unknown, both disrupted cholesterol synthesis and mevalonate accumulation have been proposed as possible theories. There is a small chance of transforming into cutaneous malignancies, most commonly squamous cell carcinomas. The patient is a 61-year-old male with an unusual presentation of bilateral linear porokeratosis. His condition provided a unique opportunity to compare the efficacy of topical treatments in a single individual. A previous trial had successfully cleared the porokeratosis plaques with topical cholesterol 2%/lovastatin 2% on the patient's right arm. After a 12-week trial of topical lovastatin 2% monotherapy on the left arm, our current study demonstrated a comparable reduction of porokeratosis lesions. In our PubMed search, there has been a single reported case of disseminated superficial actinic porokeratosis successfully treated with topical lovastatin 2% monotherapy, but there have not been any reported cases of linear porokeratosis treated with this therapy. While topical lovastatin monotherapy for porokeratosis subvariants requires further studies, this case demonstrates similar efficacy of treating linear porokeratosis with topical lovastatin compared to cholesterol/lovastatin dual therapy. These findings support the theory of mevalonate accumulation as a more likely cause of linear porokeratosis compared to disruption of cholesterol synthesis.
PubMed: 37719543
DOI: 10.7759/cureus.43657 -
International Journal of Trichology 2022Porokeratosis (PK) is an epidermal disorder of keratinization, caused by a clone expansion of a mutated keratinocyte that generates a thin parakeratotic column: the...
Porokeratosis (PK) is an epidermal disorder of keratinization, caused by a clone expansion of a mutated keratinocyte that generates a thin parakeratotic column: the cornoid lamella (CL). Depending on the clinical presentation, we differentiate up to 6 different types of PK. Most frequent locations for the lesions are limbs and trunk, while scalp is rarely affected. The possible origin of the CL in the epidermal appendages has been proposed (ostia of the eccrine glands and infundibulum of the follicle). The first case of PK limited to the scalp with exclusive involvement of the hair follicles is presented in this manuscript. It helps identify the clinical description and especially the trichoscopy as a diagnostic key in follicular PK and also to elucidate if it is an incidental histological finding or a new different clinical variant of PK.
PubMed: 35300103
DOI: 10.4103/ijt.ijt_86_20 -
Indian Dermatology Online Journal 2021
PubMed: 34211921
DOI: 10.4103/idoj.IDOJ_419_20 -
The Australasian Journal of Dermatology Feb 2023Porokeratosis encompass a group of acquired and familial, preneoplastic, keratinization disorders, clinically characterized by atrophic macules or patches with a...
Porokeratosis encompass a group of acquired and familial, preneoplastic, keratinization disorders, clinically characterized by atrophic macules or patches with a peripheral keratotic rim, the cornoid lamella. Genetic background is recognized as crucial in its pathophysiology, while immunosuppression and ultraviolet radiation represent triggering factors. We report the case of a woman who developed disseminate superficial actinic porokeratosis following the intake of hydroxyurea for a polycythaemia vera. Clinical, dermoscopic and histopathology data are showed, and the role of drug as a second-hit mutation trigger is discussed.
Topics: Female; Humans; Porokeratosis; Hydroxyurea; Ultraviolet Rays; Keratosis, Actinic
PubMed: 36320094
DOI: 10.1111/ajd.13943 -
Clinical, Cosmetic and Investigational... 2024Porokeratosis (PK), characterized by keratotic lesions with an atrophic center and a prominent peripheral ridge, with a typical histological hallmark, namely, the...
Porokeratosis (PK), characterized by keratotic lesions with an atrophic center and a prominent peripheral ridge, with a typical histological hallmark, namely, the cornoid lamella, has two forms: disseminated and localized. While PK often converts into squamous cell carcinoma (SCC), conversion from disseminated superficial porokeratosis (DSP) alone is rarely reported except for one case in which DSP and LP coexisted and converted to SCC. Here, we report the case of a patient with SCC converted from DSP alone, presenting with coin-sized macules on the bottom right of his waist that developed into an ulcer at the center. The patient underwent radiation therapy, which effectively treated the SCC but did not resolve the PK. This article highlights regular follow-up and undergo comprehensive diagnosis, both of which are beneficial to enable early detection and management of DSP that has converted to into SCC; in addition, standardized medical treatment may help improve the treatment therapeutic effect of in similar diseases.
PubMed: 38827628
DOI: 10.2147/CCID.S463569