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BMJ Case Reports Mar 2021We present a rare case of single pulmonary arteriovenous malformation (PAVM) with multiple metal allergies, including for platinum. A 47-year-old woman presented to our...
We present a rare case of single pulmonary arteriovenous malformation (PAVM) with multiple metal allergies, including for platinum. A 47-year-old woman presented to our hospital without any symptoms. Enhanced computed tomography showed a single PAVM in S6 of the right lung. Interviews prompted us to suspect a history of palmoplantar pustulosis associated with metal dental filling. Dermatology patch tests for metal allergy were positive for platinum, cobalt, tin and potassium dichromate. The first choice of treatment for PAVM is endovascular treatment using a metal coil. Since the coil is composed of platinum alloy, we performed partial lung resection for PAVM without metal implants. Although metal allergy is rare for endovascular treatment, it causes an additional stress of removal of causative metal or long-term steroidal treatment. Therefore, for single PAVM with multiple metal allergies to the implants, surgical treatment without metal implants should be considered.
Topics: Arteriovenous Fistula; Arteriovenous Malformations; Female; Humans; Hypersensitivity; Middle Aged; Pulmonary Artery; Pulmonary Veins
PubMed: 33692060
DOI: 10.1136/bcr-2020-240275 -
Journal of Pharmaceutical Sciences Mar 2023Budesonide (BUD), a glucocorticoids drug, inhibits all steps in the inflammatory response. It can reduce and treat inflammation and other symptoms associated with acute...
Budesonide (BUD), a glucocorticoids drug, inhibits all steps in the inflammatory response. It can reduce and treat inflammation and other symptoms associated with acute lung injury such as COVID-19. Loading BUD into bilosomes could boost its therapeutic activity, and lessen its frequent administration and side effects. Different bilosomal formulations were prepared where the independent variables were lipid type (Cholesterol, Phospholipon 80H, L-alpha phosphatidylcholine, and Lipoid S45), bile salt type (Na cholate and Na deoxycholate), and drug concentration (10, 20 mg). The measured responses were: vesicle size, entrapment efficiency, and release efficiency. One optimum formulation (composed of cholesterol, Na cholate, and 10 mg of BUD) was selected and investigated for its anti-inflammatory efficacy in vivo using Wistar albino male rats. Randomly allocated rats were distributed into four groups: The first: normal control group and received intranasal saline, the second one acted as the acute lung injury model received intranasal single dose of 2 mg/kg potassium dichromate (PD). Whereas the third and fourth groups received the market product (Pulmicort® nebulising suspension 0.5 mg/ml) and the optimized formulation (0.5 mg/kg; intranasal) for 7 days after PD instillation, respectively. Results showed that the optimized formulation decreased the pro-inflammatory cytokines TNF-α, and TGF-β contents as well as reduced PKC content in lung. These findings suggest the potentiality of BUD-loaded bilosomes for the treatment of acute lung injury with the ability of inhibiting the pro-inflammatory cytokines induced COVID-19.
Topics: Rats; Animals; Budesonide; Rats, Wistar; COVID-19; Acute Lung Injury; Cytokines; Cholesterol
PubMed: 36228754
DOI: 10.1016/j.xphs.2022.10.001 -
Molecules (Basel, Switzerland) Mar 2024Geopolymers show great potential in complex wastewater treatment to improve water quality. In this work, general geopolymers, porous geopolymers and geopolymer...
Geopolymers show great potential in complex wastewater treatment to improve water quality. In this work, general geopolymers, porous geopolymers and geopolymer microspheres were prepared by the suspension curing method using three solid waste products, coal gangue, fly ash and blast furnace slag. The microstructure, morphology and surface functional groups of the geopolymers were studied by SEM, XRD, XRF, MIP, FTIR and XPS. It was found that the geopolymers possess good adsorption capacities for both organic and inorganic pollutants. With methylene blue and potassium dichromate as the representative pollutants, in order to obtain the best removal rate, the effects of the adsorbent type, dosage of adsorbent, concentration of methylene blue and potassium dichromate and pH on the adsorption process were studied in detail. The results showed that the adsorption efficiency of the geopolymers for methylene blue and potassium dichromate was in the order of general geopolymers < porous geopolymers < geopolymer microspheres, and the removal rates were up to 94.56% and 79.46%, respectively. Additionally, the competitive adsorption of methylene blue and potassium dichromate in a binary system was also studied. The mechanism study showed that the adsorption of methylene blue was mainly through pore diffusion, hydrogen bond formation and electrostatic adsorption, and the adsorption of potassium dichromate was mainly through pore diffusion and redox reaction. These findings demonstrate the potential of geopolymer microspheres in adsorbing organic and inorganic pollutants, and, through five cycles of experiments, it is demonstrated that MGP exhibits excellent recyclability.
PubMed: 38611839
DOI: 10.3390/molecules29071560 -
Indian Journal of Pharmacology 2021Stress exacerbates the pathophysiology of major neurodegenerative disorders. In this study, the zebrafish (Danio rerio), the frequently used model for experimental...
OBJECTIVE
Stress exacerbates the pathophysiology of major neurodegenerative disorders. In this study, the zebrafish (Danio rerio), the frequently used model for experimental studies of stress and other central nervous system disorders, was used to evaluate the anxiolytic potential of flavonoids, namely silibinin and naringenin on alleviating acute stress-induced anxiety.
MATERIALS AND METHODS
A molecular docking study with Molegro Virtual Docker software was done to assess the binding potential of flavonoids on serotonin and dopamine receptors. To determine the bioactivity and investigate the toxicity of the flavonoids, silibinin, and naringenin, brine shrimp lethality assay, and an acute toxicity study was conducted according to Organization for Economic Co-operation and Development (OECD) Test Guideline 203. The effect of silibinin and naringenin was assessed using behavioral tasks such as the novel tank assay and the light-dark test on the zebrafish model of acute stress.
RESULTS
Molecular docking studies showed a higher affinity of silibinin and naringenin for the serotonin and dopamine receptors. In comparison to the LC value, 13.15 μg/ml of the reference standard potassium dichromate, silibinin, and naringenin yielded higher LC values, 34.10 μg/ml and 91.33 μg/ml, respectively. The LC value of silibinin and naringenin was observed to be >100 mg/l from the acute toxicity study on adult zebrafish. After transferring to a novel tank, silibinin and naringenin-treated zebrafish groups were found to explore the upper level of the tank, similar to standard drugs, and spent a long time in the upper level of the tank compared to the control group (p < 0.01). Both silibinin and naringenin treatment group spent increased amounts of time in the tank's illuminated part in contrast to that of the dark side as evidenced by the number of zebrafish entering or remaining in the illuminated part of the tank through the light-dark test. Silibinin and naringenin treated groups were found to spend increased time in the light side significantly on the day 15 of evaluation as compared to the control group (p < 0.05 and p < 0.001, respectively).
CONCLUSION
The flavonoids, silibinin, and naringenin were found to mitigate acute stress-induced anxiety, owing to their anxiolytic properties in the zebrafish model and may be explored as the potential therapeutic agents for treating anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Artemia; Behavior, Animal; Citrus; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Flavanones; Inhibitory Concentration 50; Male; Silybum marianum; Molecular Docking Simulation; Phytotherapy; Random Allocation; Silybin; Zebrafish
PubMed: 34975133
DOI: 10.4103/ijp.IJP_18_20 -
Heliyon Aug 2023With the rapid development of industry, the increasing discharge of sewage causes the detection of water quality to be of increasing importance. Potassium dichromate...
With the rapid development of industry, the increasing discharge of sewage causes the detection of water quality to be of increasing importance. Potassium dichromate titration is one of the most important testing methods in water quality detection; the ability to accurately identify the titration end-point of potassium dichromate is currently a research challenge. To identify titration end-point quickly and accurately, this study proposes a ResNet14Attention network, which utilizes residual modules that focus on original image information and an attention mechanism that focuses highly on classification targets. The proposed ResNet14Attention network is compared with 12 convolutional neural networks such as ResNet series networks, VGG, and GoogLeNet. The results of comparison experiments reveal that only the proposed ResNet14Attention network has the highest training and testing accuracy of 100% among all convolutional neural networks in the comparison experiment; the proposed ResNet14Attention network has the highest training speed compared to all the networks that over 90% accuracy.
PubMed: 37609400
DOI: 10.1016/j.heliyon.2023.e18992 -
Frontiers in Endocrinology 2023Environmental pollution and infertility are two modern global challenges that agonize personal and public health. The causal relationship between these two deserves... (Meta-Analysis)
Meta-Analysis
Protective effects of melatonin against the toxic effects of environmental pollutants and heavy metals on testicular tissue: A systematic review and meta-analysis of animal studies.
BACKGROUND
Environmental pollution and infertility are two modern global challenges that agonize personal and public health. The causal relationship between these two deserves scientific efforts to intervene. It is believed that melatonin maintains antioxidant properties and may be utilized to protect the testicular tissue from oxidant effects caused by toxic materials.
METHODS
A systematic literature search was conducted in PubMed, Scopus, and Web of Science to identify the animal trial studies that evaluated melatonin therapy's effects on rodents' testicular tissue against oxidative stress caused by heavy metal and non-heavy metal environmental pollutants. Data were pooled, and standardized mean difference and 95% confidence intervals were estimated using the random-effect model. Also, the risk of bias was assessed using the Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) tool. (PROSPERO: CRD42022369872).
RESULTS
Out of 10039 records, 38 studies were eligible for the review, of which 31 were included in the meta-analysis. Most of them showed beneficial effects of melatonin therapy on testicular tissue histopathology. [20 toxic materials were evaluated in this review, including arsenic, lead, hexavalent chromium, cadmium, potassium dichromate, sodium fluoride, cigarette smoke, formaldehyde, carbon tetrachloride (CCl4), 2-Bromopropane, bisphenol A, thioacetamide, bisphenol S, ochratoxin A, nicotine, diazinon, Bis(2-ethylhexyl) phthalate (DEHP), Chlorpyrifos (CPF), nonylphenol, and acetamiprid.] The pooled results showed that melatonin therapy increased sperm count, motility, viability and body and testicular weights, germinal epithelial height, Johnsen's biopsy score, epididymis weight, seminiferous tubular diameter, serum testosterone, and luteinizing hormone levels, testicular tissue Malondialdehyde, glutathione peroxidase, superoxide dismutase, and glutathione levels. On the other hand, abnormal sperm morphology, apoptotic index, and testicular tissue nitric oxide were lower in the melatonin therapy arms. The included studies presented a high risk of bias in most SYRCLE domains.
CONCLUSION
In conclusion, our study demonstrated amelioration of testicular histopathological characteristics, reproductive hormonal panel, and tissue markers of oxidative stress. Melatonin deserves scientific attention as a potential therapeutic agent for male infertility.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/PROSPERO, identifier CRD42022369872.
Topics: Animals; Male; Melatonin; Environmental Pollutants; Semen; Testis; Antioxidants
PubMed: 36793277
DOI: 10.3389/fendo.2023.1119553 -
Contact Dermatitis Oct 2022Allergic contact dermatitis (ACD) to Compositae is caused by sensitisation to sesquiterpene lactones (SQLs) and subsequent exposure can occur from direct handling or...
BACKGROUND
Allergic contact dermatitis (ACD) to Compositae is caused by sensitisation to sesquiterpene lactones (SQLs) and subsequent exposure can occur from direct handling or from airborne transmission. Plants from the Compositae family are ubiquitous globally and their plant extracts are also used in various products.
OBJECTIVES
Investigation of contact allergy (CA) and allergic contact dermatitis (ACD) to Compositae at a single dermatology centre.
METHODS
A retrospective case review was performed on patients undergoing patch testing to Compositae between January 2011 and December 2020 in Melbourne, Australia.
RESULTS
Of 3679 patients, 44 (1.2%) patch tested positive to Compositae and 19 (43.2%) reactions were deemed relevant. Thirteen cases (68.4%) were from direct contact with Compositae plants, mostly in gardeners. Six cases (31.6%) were from personal products and all these patients were female. Involvement of the face was significant (p = 0.007). Simultaneous allergic reactions included SQL mix in eight (42.1%), fragrance mix in seven (36.8%), potassium dichromate in three (15.8%) and colophonium in two (10.5%) cases.
CONCLUSION
Contact with Compositae from gardening contributed most cases of ACD; however, personal products accounted almost one-third of cases. Treatment options remain limited and avoidance is the most important aspect of management.
Topics: Allergens; Asteraceae; Australia; Dermatitis, Allergic Contact; Humans; Patch Tests; Plants; Retrospective Studies; Sesquiterpenes
PubMed: 35603484
DOI: 10.1111/cod.14162 -
PeerJ 2020Deterioration of the ecological environment in recent years has led to increasing soil salinization, which severely affects the cultivation of agricultural crops. While...
BACKGROUND
Deterioration of the ecological environment in recent years has led to increasing soil salinization, which severely affects the cultivation of agricultural crops. While research has focused on improving soil environment through the application of pollution-free microbial fertilizers, there are relatively few plant growth-promoting bacteria suitable for saline-alkali environments. Although can adapt to saline-alkali environments to successfully colonize rhizosphere microenvironments, only a few studies have investigated its role in promoting crop growth. Its effect on the crop rhizosphere soil microenvironment is especially unclear.
METHODS
In this study, the biological function of and its colonization in maize seedling rhizosphere soil were studied in detail through selective media and ultraviolet spectrophotometry. The effects of on the rhizosphere soil microenvironment and the growth of maize seedlings in saline-alkali and neutral soils were systematically analysed using the colorimetric method, the potassium dichromate volumetric method, and the diffusion absorption method.
RESULTS
Our results showed that played a role in indole acetic acid, acetoin, ammonia, phosphorus, and potassium production, as well as in nitrogen fixation. A high level of colonization was observed in the rhizosphere soil of maize seedlings. Following the application of in neutral and saline-alkali soils, the nutrient composition of rhizosphere soil of maize seedlings increased in varying degrees, more notably in saline-alkali soil. The content of organic matter, alkali-hydrolysable nitrogen, available phosphorus, available potassium, alkaline phosphatase, sucrase, urease, and catalase increased by 64.22%, 117.39%, 175.64%, 28.63%, 146.08%, 76.77%, 86.60%, and 45.29%, respectively, insaline-alkalisoil.
CONCLUSION
, therefore, performed a variety of biological functions to promote the growth of maize seedlings and effectively improve the level of soil nutrients and enzymes in the rhizosphere of maize seedlings, undersaline-alkali stress conditions. It played an important role in enhancing the rhizosphere microenvironment of maize seedlings under saline-alkali stress.
PubMed: 32995084
DOI: 10.7717/peerj.9894 -
Annals of Parasitology 2021Gastrointestinal (GI) infection is predominant globally, especially in people with low socio-economic status with existing illiteracy, ignorance, poor housing and...
Gastrointestinal (GI) infection is predominant globally, especially in people with low socio-economic status with existing illiteracy, ignorance, poor housing and lifestyle, and the surrounding environment. It has been implicated as a significant public health concern in the rural parts of many developing countries like Nepal. This study aimed to determine the diversity and prevalence of GI parasites in the highly marginalized indigenous Chepang communities in central Nepal. One hundred fresh stool samples of Chepangs were collected and preserved in 2.5% potassium dichromate solution. The samples were analyzed by direct wet mount, sedimentation, flotation, and acid-fast techniques and examined under the microscope at the total magnifications of 100Å~, 400Å~, and 1000Å~. We detected 97% prevalence rates with eight protozoan and six helminth parasites. Considering the infection’s concurrency, mixed pattern of infection was found to be higher than single pattern. Mixed infections from two to seven parasitic species were differently recorded in different samples. We also found that people’s eating habits were associated with GI parasitism (p=0.0034). “One Health” Approach/Principle accompanied by the detailed molecular and epidemiologic studies of parasitic transmission is required to identify the causal evidence critical in controlling and preventing parasitic infections.
Topics: Animals; Cross-Sectional Studies; Feces; Humans; Intestinal Diseases, Parasitic; Nepal; Parasites; Prevalence; Risk Factors
PubMed: 34953115
DOI: 10.17420/ap6703.353 -
Veterinary Medicine (Auckland, N.Z.) 2022infection is one of the protozoal diseases of animals caused by various species of (intracellular parasite) and causes reduced productivity and mortality in ruminants,...
INTRODUCTION
infection is one of the protozoal diseases of animals caused by various species of (intracellular parasite) and causes reduced productivity and mortality in ruminants, especially in young ones. Despite the fact that the disease is one of the leading causes of economic losses, there is little information in Ethiopia on the occurrence of the infection in cattle and sheep.
METHODS
A cross-sectional study was conducted from December 2021 to April 2022 in and around Adama and Bishoftu towns with the objectives to estimate the prevalence of infection; identify circulating oocysts, the intensity/burden of infection and associated risk factors of infection in cattle and sheep. A total of 384 randomly selected (265 cattle and 119 sheep) fecal samples were collected from the rectum and examined by flotation technique using sheather's sugar solution to detect the oocysts of . A 2.5% potassium dichromate solution was added to the positive fecal samples for sporulation of the oocysts.
RESULTS AND DISCUSSION
The overall prevalence of 48.95% infection was recorded during the study. 45.0% and 58% prevalence of the infection was registered in cattle and sheep, respectively. There was a statistically significant difference (P ˂ 0.05) in infection between the study animal species, age of the animals, breed, farm hygiene and management system. However, there was no significant difference in infection (P > 0.05) in sex, body condition of the animals and fecal consistency. The maximum oocysts per gram of feces was found to be 10,000. infection is of great importance to livestock producers and requires serious control and prevention initiatives.
PubMed: 36110350
DOI: 10.2147/VMRR.S377017