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Nature Reviews. Microbiology Oct 2019Antimicrobial treatment failure threatens our ability to control infections. In addition to antimicrobial resistance, treatment failures are increasingly understood to... (Review)
Review
Antimicrobial treatment failure threatens our ability to control infections. In addition to antimicrobial resistance, treatment failures are increasingly understood to derive from cells that survive drug treatment without selection of genetically heritable mutations. Parasitic protozoa, such as Plasmodium species that cause malaria, Toxoplasma gondii and kinetoplastid protozoa, including Trypanosoma cruzi and Leishmania spp., cause millions of deaths globally. These organisms can evolve drug resistance and they also exhibit phenotypic diversity, including the formation of quiescent or dormant forms that contribute to the establishment of long-term infections that are refractory to drug treatment, which we refer to as 'persister-like cells'. In this Review, we discuss protozoan persister-like cells that have been linked to persistent infections and discuss their impact on therapeutic outcomes following drug treatment.
Topics: Antiprotozoal Agents; Biological Variation, Population; Chagas Disease; Drug Tolerance; Humans; Leishmania; Leishmaniasis; Malaria; Plasmodium; Toxoplasma; Toxoplasmosis; Treatment Failure; Trypanosoma cruzi
PubMed: 31444481
DOI: 10.1038/s41579-019-0238-x -
Trends in Parasitology Oct 2022The ability of the intraerythrocytic Plasmodium spp. to form spontaneous rosettes with uninfected red blood cells (URBCs) has been observed in the medically important... (Review)
Review
The ability of the intraerythrocytic Plasmodium spp. to form spontaneous rosettes with uninfected red blood cells (URBCs) has been observed in the medically important malaria parasites. Since the discovery of rosettes in the late 1980s, different formation mechanisms and pathobiological roles have been postulated for rosetting; most of which have focused on Plasmodium falciparum. Recent breakthroughs, including new data from Plasmodium vivax, have highlighted the multifaceted roles of rosetting in the immunopathobiology and the development of drug resistance in human malaria. Here, we provide new perspectives on the formation and the role of rosetting in malaria rheopathobiology.
Topics: Cell Adhesion; Erythrocytes; Humans; Malaria; Malaria, Falciparum; Plasmodium falciparum; Plasmodium vivax; Rosette Formation
PubMed: 36031553
DOI: 10.1016/j.pt.2022.08.001 -
Parasitology Research Dec 2021
Topics: Animals; Humans; One Health; Zoonoses
PubMed: 34142224
DOI: 10.1007/s00436-021-07221-9 -
Parasitology Dec 2022Fish (Elasmobranchia and Actinopterygii) inhabit the majority of aquatic habitats globally. They are crucial for human nutrition but they may be negatively affected by...
Fish (Elasmobranchia and Actinopterygii) inhabit the majority of aquatic habitats globally. They are crucial for human nutrition but they may be negatively affected by parasitic protists and metazoan parasites. Fish parasites are also an extraordinary group of animals because of their ecological and evolutionary importance and unique adaptations to parasitism. They also play a key role in ecosystem functioning. In the present special issue, 13 review and research articles on major groups of fish parasites are provided to document the current advancement in our understanding of different aspects of their biology, ecology and associations with their fish hosts. The existing gaps in our knowledge of these peculiar animals are mapped and future trends in their research outlined.
Topics: Animals; Humans; Parasites; Ecosystem; Host-Parasite Interactions; Fishes; Biological Evolution; Fish Diseases
PubMed: 36226653
DOI: 10.1017/S0031182022001433 -
Indian Journal of Dermatology,... 2022
Review
Topics: Animals; Dermatology; Humans; Sarcoptes scabiei; Scabies
PubMed: 35138065
DOI: 10.25259/IJDVL_718_2021 -
Trends in Parasitology Aug 2020Reptiles are reservoirs of a wide range of pathogens, including many protozoa, helminths, pentastomids, and arthropod parasitic species, some of which may be of public... (Review)
Review
Reptiles are reservoirs of a wide range of pathogens, including many protozoa, helminths, pentastomids, and arthropod parasitic species, some of which may be of public health concern. In this review we discuss the zoonotic risks associated with human-reptile interactions. Increased urbanization and introduction of exotic species of reptile may act as drivers for the transmission of zoonotic parasites through the environment. In addition, being a part of human diet, reptiles can be a source of life-threatening parasitoses, such as pentastomiasis or sparganosis. Finally, reptiles kept as pets may represent a risk to owners given the possibility of parasites transmitted by direct contact or fecal contamination. Awareness of reptile-borne zoonotic parasitoses is important to advocate control, prevention, and surveillance of these neglected diseases.
Topics: Animals; Food Parasitology; Humans; Parasites; Parasitic Diseases; Pets; Reptiles; Zoonoses
PubMed: 32448703
DOI: 10.1016/j.pt.2020.04.014 -
Journal of Parasitic Diseases :... Dec 2022The invention of CRISPR-Cas9 technology has opened a new era in which genome manipulation has become precise, faster, cheap and more accurate than previous genome... (Review)
Review
The invention of CRISPR-Cas9 technology has opened a new era in which genome manipulation has become precise, faster, cheap and more accurate than previous genome editing strategies. Despite the intricacies of the genomes associated with several protozoan parasites, CRISPR-Cas9 has made a substantial contribution to parasitology. The study of functional genomics through CRISPR-Cas9 mediated gene knockout, insertion, deletion and mutation has helped in understanding intrinsic parasite biology. The invention of CRISPR-dCas9 has helped in the programmable control of protozoan gene expression and epigenetic engineering. CRISPR and CRISPR-based alternatives will continue to thrive and may aid in the development of novel anti-protozoan strategies to tame the protozoan parasites in the imminent future.
PubMed: 36457766
DOI: 10.1007/s12639-022-01534-x -
Nature Communications May 2023Giardia lamblia (Giardia) is among the most common intestinal pathogens in children in low- and middle-income countries (LMICs). Although Giardia associates with...
Giardia lamblia (Giardia) is among the most common intestinal pathogens in children in low- and middle-income countries (LMICs). Although Giardia associates with early-life linear growth restriction, mechanistic explanations for Giardia-associated growth impairments remain elusive. Unlike other intestinal pathogens associated with constrained linear growth that cause intestinal or systemic inflammation or both, Giardia seldom associates with chronic inflammation in these children. Here we leverage the MAL-ED longitudinal birth cohort and a model of Giardia mono-association in gnotobiotic and immunodeficient mice to propose an alternative pathogenesis of this parasite. In children, Giardia results in linear growth deficits and gut permeability that are dose-dependent and independent of intestinal markers of inflammation. The estimates of these findings vary between children in different MAL-ED sites. In a representative site, where Giardia associates with growth restriction, infected children demonstrate broad amino acid deficiencies, and overproduction of specific phenolic acids, byproducts of intestinal bacterial amino acid metabolism. Gnotobiotic mice require specific nutritional and environmental conditions to recapitulate these findings, and immunodeficient mice confirm a pathway independent of chronic T/B cell inflammation. Taken together, we propose a new paradigm that Giardia-mediated growth faltering is contingent upon a convergence of this intestinal protozoa with nutritional and intestinal bacterial factors.
Topics: Mice; Animals; Giardia; Giardiasis; Inflammatory Bowel Diseases; Nutrients; Inflammation; Amino Acids
PubMed: 37202423
DOI: 10.1038/s41467-023-38363-2 -
MBio Feb 2023Parasite infections affect human and animal health significantly and contribute to a major burden on the global economy. Parasitic protozoan viruses (PPVs) affect the... (Review)
Review
Parasite infections affect human and animal health significantly and contribute to a major burden on the global economy. Parasitic protozoan viruses (PPVs) affect the protozoan parasites' morphology, phenotypes, pathogenicity, and growth rates. This discovery provides an opportunity to develop a novel preventive and therapeutic strategy for parasitic protozoan diseases (PPDs). Currently, there is greater awareness regarding PPVs; however, knowledge of viruses and their associations with host diseases remains limited. Parasite-host interactions become more complex owing to PPVs; however, few studies have investigated underlying viral regulatory mechanisms in parasites. In this study, we reviewed relevant studies to identify studies that investigated PPV development and life cycles, the triangular association between viruses, parasites, and hosts, and the effects of viruses on protozoan pathogenicity. This study highlights that viruses can alter parasite biology, and viral infection of parasites may exacerbate the adverse effects of virus-containing parasites on hosts or reduce parasite virulence. PPVs should be considered in the prevention of parasitic epidemics and outbreaks, although their effects on the host and the complexity of the triangular association between PPVs, protozoans, and hosts remain unclear. PPVs-based regulation of parasitic protozoa can provide a theoretical basis and direction for PPD prevention and control, although PPVs and PPV regulatory mechanisms remain unclear. In this review, we investigated the differences between PPVs and the unique properties of each virus regarding virus discovery, structures, and life cycles, focused on the Trichomonas vaginalis virus, Giardia lamblia virus, RNA virus, and the Cryptosporidium parvum virus 1. The triangular association between PPVs, parasitic protozoa, and hosts reveals the "double-edged sword" property of PPVs, which maintains a balance between parasitic protozoa and hosts in both positive and negative respects. These studies discuss the complexity of parasitic protozoa and their co-existence with hosts and suggest novel pathways for using PPVs as tools to gain a deeper understanding of protozoal infection and treatment.
Topics: Animals; Humans; Parasites; Cryptosporidiosis; Cryptosporidium; Viruses; Protozoan Infections; RNA Viruses
PubMed: 36633419
DOI: 10.1128/mbio.02642-22 -
Annals of Parasitology 2023In recent years, there has been more and more new research on the therapeutic effects of plants and their positive impact on the fight against parasitic diseases. It is... (Review)
Review
In recent years, there has been more and more new research on the therapeutic effects of plants and their positive impact on the fight against parasitic diseases. It is of great importance, as it gives the opportunity to use this knowledge for phytotherapy, which is cheaper than pharmacological treatment, and as numerous studies have shown, it can be equally effective. Scientists are still looking for newer and newer chemicals that can be isolated from plants around us, and the current medicine is more and more willing to use natural medicines. In the following work, we present an overview of the most common parasitic diseases caused by protozoa, flatworms, roundworms, as well as by arachnids and fleas. We also presented alternative methods of treating these diseases using phytotherapy, which uses extracts of, among others, mint, tea tree, garlic, ginger, pumpkin seeds, annual mugwort, musk cosmos, walnuts, cocoa, grapes or black cumin.
Topics: Phytotherapy; Plant Extracts; Garlic; Parasitic Diseases; Antioxidants
PubMed: 38281734
DOI: 10.17420/ap6903/4.513