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Dermatology Online Journal Apr 2021Palpable migratory arciform erythema (PMAE) is an uncommon T cell pseudolymphoma characterized by erythematous, annular-to-arciform papules and plaques. Although the...
Palpable migratory arciform erythema (PMAE) is an uncommon T cell pseudolymphoma characterized by erythematous, annular-to-arciform papules and plaques. Although the eruption is self-limited in most cases, recurrences are routine. Diagnosis requires attention to clinical history as well as histopathologic analysis, which allow for differentiation from other T cell pseudolymphomas and gyrate erythemas. A common triggering factor has not been identified. We report a 60-year-old man who developed PMAE after IVIg infusion. Interestingly, although the individual eruptions were self-limited and resolved after several weeks, subsequent infusions predictably resulted in recurrence of PMAE, confirming the association. To our knowledge, this is the first reported case of recurrent PMAE in association with IVIg infusions.
Topics: Diagnosis, Differential; Erythema; Humans; Immunoglobulins, Intravenous; Male; Middle Aged; Myasthenia Gravis; Pseudolymphoma; Recurrence; Skin; T-Lymphocytes
PubMed: 33999580
DOI: No ID Found -
JAAD Case Reports Apr 2020
PubMed: 32211493
DOI: 10.1016/j.jdcr.2016.07.008 -
Anais Brasileiros de Dermatologia 2024Primary cutaneous CD4 small/medium-sized pleomorphic T-Cell lymphoproliferative disorder (PC-SMTLD) has been considered as a controversial dermatological disease that...
BACKGROUND
Primary cutaneous CD4 small/medium-sized pleomorphic T-Cell lymphoproliferative disorder (PC-SMTLD) has been considered as a controversial dermatological disease that has been included in cutaneous T-cell lymphoma group, presenting most commonly as a solitary nodule and/or plaque with a specific and characteristic head and neck predilection. Due to the considerable overlap between PC-SMTLD and pseudolymphoma (PL), the differential diagnosis is often challenging. Methylation of DNA at position 5 of cytosine, and the subsequent reduction in intracellular 5-hydroxymethylcytosine (5-hmC) levels, is a key epigenetic event in several cancers, including systemic lymphomas. However, it has rarely been studied in cutaneous lymphomas.
OBJECTIVES
The authors aimed to explore the role of differential 5-hmC immunostaining as a useful marker to distinguish PC-SMTLD from PL.
METHODS
Retrospective case series study with immunohistochemical and immunofluorescence analysis of 5-hmC was performed in PL and PC-SMTLD.
RESULTS
Significant decrease of 5-hmC nuclear staining was observed in PC-SMTLD when compared with PL (p < 0.0001). By semi-quantitative grade integration, there were statistical differences in the final 5-hmC scores in the two study groups. The IF co-staining of 5-hmC with CD4 revealed a decrease of 5-hmC in CD4 lymphocytes of PC-SMTLD.
STUDY LIMITATIONS
The small clinical sample size of the study.
CONCLUSIONS
The immunorreactivity of 5-hmC in CD4 lymphocytes was highly suggestive of a benign process as PL. Furthermore, the decrease of 5-hmC nuclear staining in PC-SMTLD indicated its lymphoproliferative status and helped to make the differential diagnosis with PL.
Topics: Humans; Retrospective Studies; CD4-Positive T-Lymphocytes; Lymphoma, T-Cell, Cutaneous; Skin Neoplasms; Pseudolymphoma
PubMed: 37657958
DOI: 10.1016/j.abd.2023.01.003 -
Journal of Nippon Medical School =... 2020A 39-year-old Japanese woman presented with a pruritic infiltrated erythematous plaque on the right cheek. Histopathologic analysis of the erythema showed dermal edema,...
A 39-year-old Japanese woman presented with a pruritic infiltrated erythematous plaque on the right cheek. Histopathologic analysis of the erythema showed dermal edema, separation of collagen bundles, and nodular perivascular and periadnexal infiltration of lymphocytes in the whole dermis, without epidermal changes. Alcian blue staining intensity was elevated between the collagen bundles, indicating dermal mucinosis. The nodular infiltrates consisted of CD3+ T cell clusters and CD20+ B cell clusters (ratio, approximately 3:1) and included numerous CD123+ cells, indicative of plasmacytoid dendritic cells. Blood analysis revealed serum antinuclear antibody at a titer of 1:160 (homogeneous, speckled pattern). Lupus erythematosus tumidus with pseudolymphomatous infiltrates was diagnosed. Hydroxychloroquine treatment partially improved symptoms; however, the addition of prednisolone was required for complete resolution. Lupus erythematosus tumidus is sometimes accompanied by pseudolymphomatous infiltrates. Dermal mucinosis and the presence of numerous plasmacytoid dendritic cells are useful in differentiating lupus erythematosus tumidus from pseudolymphoma.
Topics: Adult; Antigens, CD20; B-Lymphocytes; CD3 Complex; Female; Humans; Hydroxychloroquine; Interleukin-3 Receptor alpha Subunit; Lupus Erythematosus, Systemic; Pseudolymphoma; T-Lymphocytes
PubMed: 32418941
DOI: 10.1272/jnms.JNMS.2020_87-208 -
Indian Journal of Dermatology,... 2023
Topics: Humans; Pseudolymphoma; Gold; Patch Tests
PubMed: 37067105
DOI: 10.25259/IJDVL_1230_2021 -
JFMS Open Reports 2022A female neutered domestic longhair cat, aged 1 year and 5 months, presented with lymphadenomegaly and anaemia following therapy with phenobarbital for idiopathic...
CASE SUMMARY
A female neutered domestic longhair cat, aged 1 year and 5 months, presented with lymphadenomegaly and anaemia following therapy with phenobarbital for idiopathic epilepsy. Physical examination revealed pale pink mucous membranes and peripheral lymphadenomegaly. Haematology showed a regenerative anaemia (haematocrit 19.3%, reticulocyte count 118.08 ×10/l), and saline agglutination was positive. Infectious disease screening was negative and lymph node cytology was consistent with reactive lymphoid hyperplasia. A diagnosis of phenobarbital-induced reactive lymphoid hyperplasia and immune-mediated anaemia was suspected. Complete resolution of the lymphadenomegaly and anaemia was documented within 4 weeks of phenobarbital discontinuation.
RELEVANCE AND NOVEL INFORMATION
There are limited case reports of phenobarbital-induced haematological changes and lymphadenomegaly; however, the combination has not previously been reported in cats and is similar to the rare but significant syndrome in humans known as 'anticonvulsant hypersensitivity syndrome'. Anticonvulsant hypersensitivities should be considered as a potentially serious, yet reversible, sequela to phenobarbital treatment that may be mistaken for more severe illness such as neoplasia.
PubMed: 35281675
DOI: 10.1177/20551169221079238 -
Journal of Hematology & Oncology Jun 2020Hippo-Yes-associated protein (YAP) signaling is a key regulator of organ size and tumorigenesis, yet the underlying molecular mechanism is still poorly understood. At...
BACKGROUND
Hippo-Yes-associated protein (YAP) signaling is a key regulator of organ size and tumorigenesis, yet the underlying molecular mechanism is still poorly understood. At present, the significance of the Hippo-YAP pathway in diffuse large B-cell lymphoma (DLBCL) is ill-defined.
METHODS
The expression of YAP in DLBCL was determined in public database and clinical specimens. The effects of YAP knockdown, CRISPR/Cas9-mediated YAP deletion, and YAP inhibitor treatment on cell proliferation and the cell cycle were evaluated both in vitro and in vivo. RNA sequencing was conducted to detect dysregulated RNAs in YAP-knockout DLBCL cells. The regulatory effects of insulin-like growth factor-1 receptor (IGF-1R) on Hippo-YAP signaling were explored by targeted inhibition and rescue experiments.
RESULTS
High expression of YAP was significantly correlated with disease progression and poor prognosis. Knockdown of YAP expression suppressed cell proliferation and induced cell cycle arrest in DLBCL cells. Verteporfin (VP), a benzoporphyrin derivative, exerted an anti-tumor effect by regulating the expression of YAP and the downstream target genes, CTGF and CYR61. In vitro and in vivo studies revealed that deletion of YAP expression with a CRISPR/Cas9 genome editing system significantly restrained tumor growth. Moreover, downregulation of IGF-1R expression led to a remarkable decrease in YAP expression. In contrast, exposure to IGF-1 promoted YAP expression and reversed the inhibition of YAP expression induced by IGF-1R inhibitors.
CONCLUSIONS
Our study highlights the critical role of YAP in the pathogenesis of DLBCL and uncovers the regulatory effect of IGF-1R on Hippo-YAP signaling, suggesting a novel therapeutic strategy for DLBCL.
Topics: Adaptor Proteins, Signal Transducing; Aged; Animals; Apoptosis; B-Lymphocytes; CRISPR-Cas Systems; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; Hippo Signaling Pathway; Humans; Insulin-Like Growth Factor I; Lymphoma, Large B-Cell, Diffuse; Male; Mice; Mice, SCID; Middle Aged; Neoplasm Proteins; Podophyllotoxin; Protein Serine-Threonine Kinases; Pseudolymphoma; RNA Interference; RNA, Small Interfering; Random Allocation; Receptor, IGF Type 1; Signal Transduction; Transcription Factors; Tyrphostins; Verteporfin; Xenograft Model Antitumor Assays; YAP-Signaling Proteins
PubMed: 32546241
DOI: 10.1186/s13045-020-00906-1 -
Indian Journal of Ophthalmology Dec 2019: To present histopathological and immunohistochemical analysis of idiopathic inflammatory diseases of orbit and ocular adnexa.
PURPOSE
: To present histopathological and immunohistochemical analysis of idiopathic inflammatory diseases of orbit and ocular adnexa.
METHODS
Design- A retrospective laboratory-based study. The study was carried out in an ocular pathology laboratory in a tertiary institute of northeast India where analysis of 93 cases was done in 5 years, during the period from 2011 to 2016. Hematoxylin--eosin and special stains were done for the diagnoses. Immunohistochemistry (IHC) panel was also carried out. For infectious pathology, Grocott's methenamine silver (GMS) stain for fungus, tissue Gram's stain for bacteria's, and acid-fast stains for tubercular bacilli were done. IHC panels were done for CD 20 (B-cells), CD-3 (T-cells), CD-45 (Leukocyte common antigen, LCA), BCL-2, CD-138 (Plasma cells), Kappa, Lambda, IgG-4 in tissue, IgG-4 in serum, etc. IHCs were done using kit methods (standardized) and adequate controls were taken for each sample.
RESULTS
93 cases of nonspecific orbital inflammation were reported out of 1,467 specimens. Orbital pseudotumors (idiopathic orbital inflammatory disease, IOID) were seen in 27 cases (sclerosing variety-6); benign lymphoid hyperplasia in two cases; reactive lymphoid hyperplasia in 10 cases; atypical plasma lymphoproliferative reactive (polyclonal immunophenotypically, IgG4 negative) lesions in four cases; IgG-4 related disease in one case; nonspecific inflammatory reactions (conjunctiva, sclera, and lid) in 49 cases. In all the diagnoses, infections and lymphomas were excluded.
CONCLUSION
Biopsy supported study on nonspecific orbital inflammation was important to know the pattern.
Topics: Adult; Aged; Antigens, CD; B-Lymphocytes; Blepharitis; Conjunctivitis; Female; Humans; Immunohistochemistry; Male; Middle Aged; Orbital Cellulitis; Orbital Myositis; Orbital Pseudotumor; Pseudolymphoma; Retrospective Studies; Scleritis; T-Lymphocytes
PubMed: 31755435
DOI: 10.4103/ijo.IJO_2120_18 -
Acta Dermato-venereologica Oct 2019
Topics: Anti-Bacterial Agents; Borrelia burgdorferi Group; Breast Diseases; Child, Preschool; Diagnosis, Differential; Humans; Male; Nipples; Penicillins; Pseudolymphoma
PubMed: 31304558
DOI: 10.2340/00015555-3266 -
The Indian Journal of Radiology &... Jul 2021Chronic follicular cholecystitis (CFC) is a rare pathology characterized by prominent lymphoid follicles in the lamina propria distributed throughout the gallbladder...
Chronic follicular cholecystitis (CFC) is a rare pathology characterized by prominent lymphoid follicles in the lamina propria distributed throughout the gallbladder wall. It has also been mentioned in the literature as lymphoid hyperplasia and pseudolymphoma. CFC represents less than 2% of cholecystectomies. Its etiopathology is mostly unknown. Most reports are based on histopathological findings, with little or no imaging analysis. We describe a case involving a 66-year-old man radiologically diagnosed as xanthogranulomatous cholecystitis (XGC) versus malignancy, revealing CFC with surrounding inflammatory changes in the cholecystectomy specimen.
PubMed: 34790317
DOI: 10.1055/s-0041-1736163