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International Journal of Environmental... Dec 2021Standard polysomnographic analysis of sleep has not provided evidence of an objective measure of sleep quality; however, factors such as sleep duration and sleep... (Review)
Review
Standard polysomnographic analysis of sleep has not provided evidence of an objective measure of sleep quality; however, factors such as sleep duration and sleep efficiency are those more consistently associated with the subjective perception of sleep quality. Sleep reduction as currently occurs in our 24/7 society has had a profound impact on sleep quality; the habitual sleep period should fit within what is a limited nighttime window and may not be sufficient to satisfy the whole sleep process; moreover, the use of artificial light during the evening and early night hours can delay and disturb the circadian rhythms, especially affecting REM sleep. The correct phase relationship of the sleep period with the circadian pacemaker is an important factor to guarantee adequate restorative sleep duration and sleep continuity, thus providing the necessary background for a good night's sleep. Due to the fact that REM sleep is controlled by the circadian clock, it can provide a window-like mechanism that defines the termination of the sleep period when there is still the necessity to complete the sleep process (not only wake-related homeostasis) and to meet the circadian end of sleep timing. An adequate amount of REM sleep appears necessary to guarantee sleep continuity, while periodically activating the brain and preparing it for the return to consciousness.
Topics: Brain; Circadian Rhythm; Sleep; Sleep Quality; Sleep, REM
PubMed: 34948586
DOI: 10.3390/ijerph182412976 -
Neuropsychopharmacology : Official... Jan 2020Vigilant attention is a major component of a wide range of cognitive performance tasks. Vigilant attention is impaired by sleep deprivation and restored after rest... (Review)
Review
Vigilant attention is a major component of a wide range of cognitive performance tasks. Vigilant attention is impaired by sleep deprivation and restored after rest breaks and (more enduringly) after sleep. The temporal dynamics of vigilant attention deficits across hours and days are driven by physiologic, sleep regulatory processes-a sleep homeostatic process and a circadian process. There is also evidence of a slower, allostatic process, which modulates the sleep homeostatic setpoint across days and weeks and is responsible for cumulative deficits in vigilant attention across consecutive days of sleep restriction. There are large inter-individual differences in vulnerability to sleep loss, and these inter-individual differences constitute a pronounced human phenotype. However, this phenotype is multi-dimensional; vulnerability in terms of vigilant attention impairment can be dissociated from vulnerability in terms of other cognitive processes such as attentional control. The vigilance decrement, or time-on-task effect-a decline in performance across the duration of a vigilant attention task-is characterized by progressively increasing response variability, which is exacerbated by sleep loss. This variability, while crucial to understanding the impact of sleep deprivation on performance in safety-critical tasks, is not well explained by top-down regulatory mechanisms, such as the homeostatic and circadian processes. A bottom-up, neuronal pathway-dependent mechanism involving use-dependent, local sleep may be the main driver of response variability. This bottom-up mechanism may also explain the dissociation between cognitive processes with regard to trait vulnerability to sleep loss.
Topics: Arousal; Attention; Brain; Humans; Sleep Deprivation; Wakefulness
PubMed: 31176308
DOI: 10.1038/s41386-019-0432-6 -
Nature Neuroscience Aug 2022Sleep has a complex micro-architecture, encompassing micro-arousals, sleep spindles and transitions between sleep stages. Fragmented sleep impairs memory consolidation,...
Sleep has a complex micro-architecture, encompassing micro-arousals, sleep spindles and transitions between sleep stages. Fragmented sleep impairs memory consolidation, whereas spindle-rich and delta-rich non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep promote it. However, the relationship between micro-arousals and memory-promoting aspects of sleep remains unclear. In this study, we used fiber photometry in mice to examine how release of the arousal mediator norepinephrine (NE) shapes sleep micro-architecture. Here we show that micro-arousals are generated in a periodic pattern during NREM sleep, riding on the peak of locus-coeruleus-generated infraslow oscillations of extracellular NE, whereas descending phases of NE oscillations drive spindles. The amplitude of NE oscillations is crucial for shaping sleep micro-architecture related to memory performance: prolonged descent of NE promotes spindle-enriched intermediate state and REM sleep but also associates with awakenings, whereas shorter NE descents uphold NREM sleep and micro-arousals. Thus, the NE oscillatory amplitude may be a target for improving sleep in sleep disorders.
Topics: Animals; Arousal; Electroencephalography; Mice; Norepinephrine; Sleep; Sleep Stages; Sleep, REM
PubMed: 35798980
DOI: 10.1038/s41593-022-01102-9 -
Sensors (Basel, Switzerland) Jun 2021The use of heart rate variability (HRV) in research has been greatly popularized over the past decades due to the ease and affordability of HRV collection, coupled with... (Review)
Review
The use of heart rate variability (HRV) in research has been greatly popularized over the past decades due to the ease and affordability of HRV collection, coupled with its clinical relevance and significant relationships with psychophysiological constructs and psychopathological disorders. Despite the wide use of electrocardiograms (ECG) in research and advancements in sensor technology, the analytical approach and steps applied to obtain HRV measures can be seen as complex. Thus, this poses a challenge to users who may not have the adequate background knowledge to obtain the HRV indices reliably. To maximize the impact of HRV-related research and its reproducibility, parallel advances in users' understanding of the indices and the standardization of analysis pipelines in its utility will be crucial. This paper addresses this gap and aims to provide an overview of the most up-to-date and commonly used HRV indices, as well as common research areas in which these indices have proven to be very useful, particularly in psychology. In addition, we also provide a step-by-step guide on how to perform HRV analysis using an integrative neurophysiological toolkit, NeuroKit2.
Topics: Electrocardiography; Heart Rate; Psychophysiology; Reproducibility of Results
PubMed: 34207927
DOI: 10.3390/s21123998 -
Neurosciences (Riyadh, Saudi Arabia) Apr 2023Although not fully understood, sleep is accepted as a vital and organized sequence of events that follows a regular cyclic program each night to ensure the human body... (Review)
Review
Although not fully understood, sleep is accepted as a vital and organized sequence of events that follows a regular cyclic program each night to ensure the human body can perform at its optimum. A lack of sleep, or sleep deprivation (SD), is a widespread phenomenon that can induce adverse changes in cognitive performance. This review focused on the biological explanation as well as the research investigating the numerous effects that SD can have on cognition. A reduction in sleep does not occur independently of the effects on memory, attention, alertness, judgment, decision-making, and overall cognitive abilities in the brain, resulting in decreased function and impaired cognitive performance.
Topics: Humans; Sleep Deprivation; Psychomotor Performance; Cognition; Attention; Sleep
PubMed: 37045455
DOI: 10.17712/nsj.2023.2.20220108 -
Nature Communications Apr 2023The parasubthalamic nucleus (PSTN) is considered to be involved in motivation, feeding and hunting, all of which are highly depending on wakefulness. However, the roles...
The parasubthalamic nucleus (PSTN) is considered to be involved in motivation, feeding and hunting, all of which are highly depending on wakefulness. However, the roles and underlying neural circuits of the PSTN in wakefulness remain unclear. Neurons expressing calretinin (CR) account for the majority of PSTN neurons. In this study in male mice, fiber photometry recordings showed that the activity of PSTN neurons increased at the transitions from non-rapid eye movement (non-REM, NREM) sleep to either wakefulness or REM sleep, as well as exploratory behavior. Chemogenetic and optogenetic experiments demonstrated that PSTN neurons were necessary for initiating and/or maintaining arousal associated with exploration. Photoactivation of projections of PSTN neurons revealed that they regulated exploration-related wakefulness by innervating the ventral tegmental area. Collectively, our findings indicate that PSTN circuitry is essential for the induction and maintenance of the awake state associated with exploration.
Topics: Mice; Male; Animals; Wakefulness; Calbindin 2; Neurons; Arousal; Sleep, REM; Sleep
PubMed: 37095092
DOI: 10.1038/s41467-023-37797-y -
International Journal of Environmental... Mar 2021Heart Rate Variability Biofeedback (HRVB) is a treatment in which patients learn self-regulation of a physiological dysregulated vagal nerve function. While the... (Review)
Review
BACKGROUND
Heart Rate Variability Biofeedback (HRVB) is a treatment in which patients learn self-regulation of a physiological dysregulated vagal nerve function. While the therapeutic approach of HRVB is promising for a variety of disorders, it has not yet been regularly offered in a mental health treatment setting.
AIM
To provide a systematic review about the efficacy of HRV-Biofeedback in treatment of anxiety, depression, and stress related disorders.
METHOD
Systematic review in PubMed and Web of Science in 2020 with terms HRV, biofeedback, Post-Traumatic Stress Disorder (PTSD), depression, panic disorder, and anxiety disorder. Selection, critical appraisal, and description of the Random Controlled Trials (RCT) studies. Combined with recent meta-analyses.
RESULTS
The search resulted in a total of 881 studies. After critical appraisal, nine RCTs have been selected as well as two other relevant studies. The RCTs with control groups treatment as usual, muscle relaxation training and a "placebo"-biofeedback instrument revealed significant clinical efficacy and better results compared with control conditions, mostly significant. In the depression studies average reduction at the Beck Depression Inventory (BDI) scale was 64% (HRVB plus Treatment as Usual (TAU) versus 25% (control group with TAU) and 30% reduction (HRVB) at the PSQ scale versus 7% (control group with TAU). In the PTSD studies average reduction at the BDI-scale was 53% (HRV plus TAU) versus 24% (control group with TAU) and 22% (HRVB) versus 10% (TAU) with the PTSD Checklist (PCL). In other systematic reviews significant effects have been shown for HRV-Biofeedback in treatment of asthma, coronary artery disease, sleeping disorders, postpartum depression and stress and anxiety.
CONCLUSION
This systematic review shows significant improvement of the non-invasive HRVB training in stress related disorders like PTSD, depression, and panic disorder, in particular when combined with cognitive behavioral therapy or different TAU. Effects were visible after four weeks of training, but clinical practice in a longer daily self-treatment of eight weeks is more promising. More research to integrate HRVB in treatment of stress related disorders in psychiatry is warranted, as well as research focused on the neurophysiological mechanisms.
Topics: Anxiety; Anxiety Disorders; Autonomic Nervous System; Biofeedback, Psychology; Depression; Female; Heart Rate; Humans; Self-Control; Stress Disorders, Post-Traumatic
PubMed: 33804817
DOI: 10.3390/ijerph18073329 -
Revista Da Associacao Medica Brasileira... Mar 2021Stress and burnout can result in errors, reduction in patient safety, and decreased productivity. They can cause absenteeism, depression, destructive behavior, alcohol,...
Stress and burnout can result in errors, reduction in patient safety, and decreased productivity. They can cause absenteeism, depression, destructive behavior, alcohol, drug abuse, and even suicide. Several factors lead to professional stress, many of which are out of one's control, thus making intervention impossible. Physicians often neglect their health and ignore stress and burnout. They often deny the existence of stress as a way of adapting to it, which is an ineffective method of coping with this problem that can lead to negative coping strategies. For managing stress and burnout, it is paramount to recognize situations/conditions that may trigger them, identify their signs, and invest in well-being strategies. In this article, well-being promotion is addressed with a focus on strategies that can be used at the individual level. Topics such as stress management and resilience should be valued in medical training and profession. As long as they form a part of the "hidden curriculum", well-being will continue to be undervalued, when in fact it should be seen as fundamental to the health of professionals and patients.
Topics: Adaptation, Psychological; Burnout, Professional; Burnout, Psychological; Humans; Occupational Stress; Physicians; Stress, Psychological
PubMed: 34468595
DOI: 10.1590/1806-9282.20200785 -
The Permanente Journal Dec 2020
Topics: Burnout, Professional; Burnout, Psychological; Child; Child Abuse; Compassion Fatigue; Humans
PubMed: 33482966
DOI: 10.7812/TPP/20.011.1 -
Psychological Research Sep 2021Although many people listen to music while performing tasks that require sustained attention, the literature is inconclusive about its effects. The present study...
Although many people listen to music while performing tasks that require sustained attention, the literature is inconclusive about its effects. The present study examined performance on a sustained-attention task and explored the effect of background music on the prevalence of different attentional states, founded on the non-linear relationship between arousal and performance. Forty students completed a variation of the Psychomotor Vigilance Task-that has long been used to measure sustained attention-in silence and with their self-selected or preferred music in the background. We collected subjective reports of attentional state (specifically mind-wandering, task-focus and external distraction states) as well as reaction time (RT) measures of performance. Results indicated that background music increased the proportion of task-focus states by decreasing mind-wandering states but did not affect external distraction states. Task-focus states were linked to shorter RTs than mind-wandering or external distraction states; however, background music did not reduce RT or variability of RT significantly compared to silence. These findings show for the first time that preferred background music can enhance task-focused attentional states on a low-demanding sustained-attention task and are compatible with arousal mediating the relationship between background music and task-performance.
Topics: Arousal; Attention; Humans; Music; Reaction Time; Task Performance and Analysis
PubMed: 32748062
DOI: 10.1007/s00426-020-01400-6