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BioRxiv : the Preprint Server For... Aug 2023Hemispherectomy is a surgical procedure in which an entire hemisphere of a patient's brain is resected or functionally disconnected to manage seizures in individuals...
Hemispherectomy is a surgical procedure in which an entire hemisphere of a patient's brain is resected or functionally disconnected to manage seizures in individuals with drug-resistant epilepsy. Despite the extensive loss of input from both ventral and dorsal visual pathways of one hemisphere, pediatric patients who have undergone hemispherectomy show a remarkably high degree of perceptual function across many domains. In the current study, we sought to understand the extent to which functions of the ventral and dorsal visual pathways reorganize to the contralateral hemisphere following childhood hemispherectomy. To this end, we collected fMRI data from an equal number of left and right hemispherectomy patients who completed tasks that typically elicit lateralized responses from the ventral or the dorsal pathway, namely, word (left ventral), face (right ventral), tool (left dorsal), and global form (right dorsal) perception. Overall, there was greater evidence of functional reorganization in the ventral pathway than in the dorsal pathway. Importantly, because ventral and dorsal reorganization was tested in the very same patients, these results cannot be explained by idiosyncratic factors such as disease etiology, age at the time of surgery, or age at testing. These findings suggest that because the dorsal pathway may mature earlier, it may have a shorter developmental window of plasticity than the ventral pathway and, hence, be less malleable.
PubMed: 37577633
DOI: 10.1101/2023.08.03.551494 -
BMC Surgery Dec 2022Ventral hernia repair is one of the most common surgical procedures performed worldwide. Despite the large volume, consensus is lacking regarding indications for repair...
BACKGROUND AND AIMS
Ventral hernia repair is one of the most common surgical procedures performed worldwide. Despite the large volume, consensus is lacking regarding indications for repair or choice of surgical method used for reconstruction. The aim of this study was to explore the risk for major complications and mortality in ventral hernia repair using data from a nationwide patient register.
METHOD
Patient data of individuals over 18 years of age who had a ventral hernia procedure between 2004 and 2014 were retrieved from the Patient Register kept by the Swedish National Board of Health and Welfare. After exclusion of patients with concomitant bowel surgery, 45 676 primary surgical admissions were included. Procedures were dichotomised into laparoscopic and open surgery, and stratified for primary and incisional hernias.
RESULTS
A total of 45 676 admissions were analysed. The material comprised 36% (16 670) incisional hernias and 64% (29 006) primary hernias. Women had a higher risk for reoperation during index admission after primary hernia repair (OR 1.84 (1.29-2.62)). Forty-three patients died of complications within 30 days of index surgery. Patients aged 80 years and older had a 2.5 times higher risk for a complication leading to reoperation, and a 12-fold higher mortality risk than patients aged 70-79 years.
CONCLUSION
Age is the dominant mortality risk factor in ventral hernia repair. Laparoscopic surgery was associated with a lower risk for reoperation during index admission. Reoperation seems to be a valid outcome variable, while registration of complications is generally poor in this type of cohort.
Topics: Humans; Female; Adolescent; Adult; Herniorrhaphy; Incisional Hernia; Cohort Studies; Sweden; Recurrence; Hernia, Ventral; Laparoscopy; Surgical Mesh
PubMed: 36514042
DOI: 10.1186/s12893-022-01873-9 -
Biology Nov 2022Dinophiliformia is a newly revealed clade within Annelida that is a sister group to Pleistoannelida. is a representative of this clade that has fascinated scientists...
Dinophiliformia is a newly revealed clade within Annelida that is a sister group to Pleistoannelida. is a representative of this clade that has fascinated scientists with its high degree of sexual dimorphism. Both males and females are small, worm-like creatures that have specific ciliary structures: anterior ventral, posterior ventral, and dorsal ciliary fields in males, and prototroch, metatroch, and ventral ciliary fields in females. There are data on the morphology and development of the nervous system in Oweniidae, Sipunculida, Pleistoannelida, and even Dinophiliformia. However, data on the neuromorphology and development of dwarf males are limited. Here, we present data on the distribution of cilia, sensory neurons, and the 5-HT-like immunoreactive system in 3D reconstructions and cross-sections. Immunochemical labeling with anti-acetylated tubulin and anti-5-HT antibodies and confocal microscopy were used to visualize the ciliary structures and neurons. The male has three ciliary fields: anterior ventral, posterior ventral, and dorsal. These include frontal ganglia, five commissures, two ventral and two dorsal bundles, and penial nerves. A total of fifty-seven neurons and only five 5-HT-like immunoreactive cells were described. Although the sensory neurons were not 5-HT-like immunoreactive, they had 5-HT innervation, which may indicate the role of 5-HT in perception. There may be homology between male and female ciliary structures. The dwarf male of may have a reduced apical organ consisting of two sensory neurons and a 5-HT-like immunoreactive cell.
PubMed: 36421388
DOI: 10.3390/biology11111674 -
Journal of Neurophysiology Oct 2021The connectivity among architectonically defined areas of the frontal, parietal, and temporal cortex of the macaque has been extensively mapped through tract-tracing...
The connectivity among architectonically defined areas of the frontal, parietal, and temporal cortex of the macaque has been extensively mapped through tract-tracing methods. To investigate the statistical organization underlying this connectivity, and identify its underlying architecture, we performed a hierarchical cluster analysis on 69 cortical areas based on their anatomically defined inputs. We identified 10 frontal, four parietal, and five temporal hierarchically related sets of areas (clusters), defined by unique sets of inputs and typically composed of anatomically contiguous areas. Across the cortex, clusters that share functional properties were linked by dominant information processing circuits in a topographically organized manner that reflects the organization of the main fiber bundles in the cortex. This led to a dorsal-ventral subdivision of the frontal cortex, where dorsal and ventral clusters showed privileged connectivity with parietal and temporal areas, respectively. Ventrally, temporofrontal circuits encode information to discriminate objects in the environment, their value, emotional properties, and functions such as memory and spatial navigation. Dorsal parietofrontal circuits encode information for selecting, generating, and monitoring appropriate actions based on visual-spatial and somatosensory information. This organization may reflect evolutionary antecedents, in which the vertebrate pallium, which is the ancestral cortex, was defined by a ventral and lateral olfactory region and a medial hippocampal region. The study of cortical connectivity is crucial for understanding brain function and disease. We show that temporofrontal and parietofrontal networks in the macaque can be described in terms of circuits among clusters of areas that share similar inputs and functional properties. The resulting overall architecture described a dual subdivision of the frontal cortex, consistent with the main cortical fiber bundles and an evolutionary trend that underlies the organization of the cortex in the macaque.
Topics: Animals; Cluster Analysis; Frontal Lobe; Macaca; Nerve Net; Parietal Lobe; Temporal Lobe
PubMed: 34379536
DOI: 10.1152/jn.00092.2021 -
Cureus Oct 2023Spigelian hernia, also known as lateral ventral hernia, is a type of hernia arising through the Spigelian aponeurosis. Unlike many other ventral hernias that occur...
Spigelian hernia, also known as lateral ventral hernia, is a type of hernia arising through the Spigelian aponeurosis. Unlike many other ventral hernias that occur beneath the layer of fat and abdominal skin, Spigelian hernia is situated within the abdominal wall muscles. Spigelian hernia often presents with few symptoms and may exist for a long time without being diagnosed or detected. We report a case of Spigelian hernia causing an intestinal obstruction treated with surgical emergency abdominal wall reconstruction using the sublay technique. Identification and evaluation of cases with the potential for hernia occurrence are crucial for the safety of patients undergoing surgery. Spigelian hernia accounts for 1%-2% of all ventral hernia cases. Currently, there are no reports on Spigelian hernia in Vietnam. However, a few reports on surgical management of Spigelian hernia have been published worldwide, with approaches including laparoscopic and open surgery, and these reports have indicated that abdominal wall reconstruction using the sublay technique is feasible as it is associated with fewer postoperative complications and shorter hospital stays. Here, we describe the case of an 87-year-old woman presenting with swelling and pain in the lower left quadrant of the abdomen. A preoperative diagnosis of Spigelian hernia causing intestinal obstruction was established, and we proceeded with abdominal wall reconstruction using the sublay technique. The patient was discharged three days after surgery without any postoperative complications.
PubMed: 37933366
DOI: 10.7759/cureus.46589 -
Developmental Cognitive Neuroscience Dec 2023Hemispherectomy is a surgical procedure in which an entire hemisphere of a patient's brain is resected or functionally disconnected to manage seizures in individuals...
Hemispherectomy is a surgical procedure in which an entire hemisphere of a patient's brain is resected or functionally disconnected to manage seizures in individuals with drug-resistant epilepsy. Despite the extensive loss of both ventral and dorsal visual pathways in one hemisphere, pediatric patients who have undergone hemispherectomy show a remarkably high degree of perceptual function across many domains. In the current study, we sought to understand the extent to which functions of the ventral and dorsal visual pathways reorganize to the contralateral hemisphere following childhood hemispherectomy. To this end, we collected fMRI data from an equal number of left and right hemispherectomy patients who completed tasks that typically elicit lateralized responses from the ventral or the dorsal pathway, namely, word (left ventral), face (right ventral), tool (left dorsal), and global form (right dorsal) perception. Overall, there was greater evidence of functional reorganization in the ventral pathway than in the dorsal pathway. Importantly, because ventral and dorsal reorganization was tested within the very same patients, these results cannot be explained by idiosyncratic factors such as disease etiology, age at the time of surgery, or age at testing. These findings suggest that because the dorsal pathway may mature earlier, it may have a shorter developmental window of plasticity than the ventral pathway and, hence, be less malleable after perturbation.
Topics: Humans; Child; Hemispherectomy; Visual Pathways; Brain; Magnetic Resonance Imaging
PubMed: 37976921
DOI: 10.1016/j.dcn.2023.101323 -
Frontiers in Synaptic Neuroscience 2020Functional diversification along the longitudinal axis of the hippocampus is a rapidly growing concept. Modulation of synaptic transmission by neurotransmitter receptors...
Functional diversification along the longitudinal axis of the hippocampus is a rapidly growing concept. Modulation of synaptic transmission by neurotransmitter receptors may importantly contribute to specialization of local intrinsic network function along the hippocampus. In the present study, using transverse slices from the dorsal and the ventral hippocampus of adult rats and recordings of evoked field postsynaptic excitatory potentials (fEPSPs) from the CA1 stratum radiatum, we aimed to compare modulation of synaptic transmission between the dorsal and the ventral hippocampus. We found that transient heterosynaptic depression (tHSD, <2 s), a physiologically relevant phenomenon of regulation of excitatory synaptic transmission induced by paired stimulation of two independent inputs to stratum radiatum of CA1 field, has an increased magnitude and duration in the ventral hippocampus, presumably contributing to increased input segregation in this segment of the hippocampus. GABA receptors, GABA receptors, adenosine A1 receptors and L-type voltage-gated calcium channels appear to contribute differently to tHSD in the two hippocampal segments; GABARs play a predominant role in the ventral hippocampus while both GABARs and A1Rs play important roles in the dorsal hippocampus. Activation of GABA receptors by an exogenous agonist, baclofen, robustly and reversibly modulated both the initial fast and the late slow components of excitatory synaptic transmission, expressed by the fEPSPslope and fEPSP decay time constant (fEPSP), respectively. Specifically, baclofen suppressed fEPSP slope more in the ventral than in the dorsal hippocampus and enhanced fEPSP more in the dorsal than in the ventral hippocampus. Also, baclofen enhanced paired-pulse facilitation in the two hippocampal segments similarly. Blockade of GABA receptors did not affect basal paired-pulse facilitation in either hippocampal segment. We propose that the revealed dorsal-ventral differences in modulation of synaptic transmission may provide a means for specialization of information processing in the local neuronal circuits, thereby significantly contributing to diversifying neuronal network functioning along the dorsal-ventral axis of hippocampus.
PubMed: 32625076
DOI: 10.3389/fnsyn.2020.00024 -
NeuroImage Feb 2021Neurophysiological and anatomical data suggest the existence of several functionally distinct regions in the lower arcuate sulcus and adjacent postarcuate convexity of...
Neurophysiological and anatomical data suggest the existence of several functionally distinct regions in the lower arcuate sulcus and adjacent postarcuate convexity of the macaque monkey. Ventral premotor F5c lies on the postarcuate convexity and consists of a dorsal hand-related and ventral mouth-related field. The posterior bank of the lower arcuate contains two additional premotor F5 subfields at different anterior-posterior levels, F5a and F5p. Anterior to F5a, area 44 has been described as a dysgranular zone occupying the deepest part of the fundus of the inferior arcuate. Finally, area GrFO occupies the most rostral portion of the fundus and posterior bank of inferior arcuate and extends ventrally onto the frontal operculum. Recently, data-driven exploratory approaches using resting-state fMRI data have been suggested as a promising non-invasive method for examining the functional organization of the primate brain. Here, we examined to what extent partitioning schemes derived from data-driven clustering analysis of resting-state fMRI data correspond with the proposed organization of the fundus and posterior bank of the macaque arcuate sulcus, as suggested by invasive architectonical, connectional and functional investigations. Using a hierarchical clustering analysis, we could retrieve clusters corresponding to the dorsal and ventral portions of F5c on the postarcuate convexity, F5a and F5p at different antero-posterior locations on the posterior bank of the lower arcuate, area 44 in the fundus, as well as part of area GrFO in the most anterior portion of the fundus. Additionally, each of these clusters displayed distinct whole-brain functional connectivity, in line with previous anatomical tracer and seed-based functional connectivity investigations of F5/44 subdivisions. Overall, our data suggests that hierarchical clustering analysis of resting-state fMRI data can retrieve a fine-grained level of cortical organization that resembles detailed parcellation schemes derived from invasive functional and anatomical investigations.
Topics: Animals; Brain Mapping; Cluster Analysis; Female; Image Processing, Computer-Assisted; Macaca mulatta; Magnetic Resonance Imaging; Male; Motor Cortex; Neural Pathways
PubMed: 33338618
DOI: 10.1016/j.neuroimage.2020.117647 -
Scientific Reports Jun 2022This study aimed to explore the feasibility of Phase I percutaneous spinal endoscopy with a 270° single incision in the ventral and dorsal dura mater for decompression...
This study aimed to explore the feasibility of Phase I percutaneous spinal endoscopy with a 270° single incision in the ventral and dorsal dura mater for decompression treatment of thoracic spinal stenosis (TSS). Phase I percutaneous spinal endoscopy with a two-path (posterior and posterolateral approaches) single incision with a 270° decompression was performed in four cases of TSS with compression in the ventral and dorsal dura mater. The affected intervertebral space was located during the surgery, and the ossified ligamentum flavum in the ventral and dorsal dura mater was removed via laminectomy, which formed a decompression space in the thoracic cord. Next, posterolateral transforaminal expansion and plasty were performed to remove the ventral intervertebral disk. The visual analogue scale (VAS) score, thoracic spinal cord function score of the Japanese Orthopaedic Association (JOA) (11-point method), and Oswestry Disability Index (ODI) scores were used to evaluate the clinical efficacy. No dura mater or thoracic nerve injury occurred during the surgery. The symptoms of weakness in the lower extremities improved after the surgery. The postoperative magnetic resonance imaging and computed tomography examinations showed compression removal and dura mater bulging. The postoperative VAS, JOA, and ODI scores improved compared with the preoperative scores. Two surgical trajectories, posterior and posterolateral approaches, were established by a single incision using thoracic spinal canal decompression with Phase I 270° single-incision percutaneous spinal endoscopy. The posterior approach was performed mainly by translaminar unilateral fenestration and bilateral decompression in the ventral and dorsal dura mater, whereas the posterolateral approach was performed by decompression in the ventral dura mater to the midline of the vertebrae. This surgical method could be applied as a safe and feasible minimally invasive treatment for TSS with compression on both the ventral and dorsal dura mater.
Topics: Decompression, Surgical; Endoscopy; Endoscopy, Gastrointestinal; Feasibility Studies; Humans; Lumbar Vertebrae; Retrospective Studies; Spinal Canal; Spinal Stenosis; Thoracic Diseases; Treatment Outcome
PubMed: 35676323
DOI: 10.1038/s41598-022-13666-4 -
Proceedings of the National Academy of... Mar 2020The striatal complex of basal ganglia comprises two functionally distinct districts. The dorsal district controls motor and cognitive functions. The ventral district...
The striatal complex of basal ganglia comprises two functionally distinct districts. The dorsal district controls motor and cognitive functions. The ventral district regulates the limbic function of motivation, reward, and emotion. The dorsoventral parcellation of the striatum also is of clinical importance as differential striatal pathophysiologies occur in Huntington's disease, Parkinson's disease, and drug addiction disorders. Despite these striking neurobiologic contrasts, it is largely unknown how the dorsal and ventral divisions of the striatum are set up. Here, we demonstrate that interactions between the two key transcription factors Nolz-1 and Dlx1/2 control the migratory paths of striatal neurons to the dorsal or ventral striatum. Moreover, these same transcription factors control the cell identity of striatal projection neurons in both the dorsal and the ventral striata including the D1-direct and D2-indirect pathways. We show that Nolz-1, through the I12b enhancer, represses , allowing normal migration of striatal neurons to dorsal and ventral locations. We demonstrate that deletion, up-regulation, and down-regulation of and can produce a striatal phenotype characterized by a withered dorsal striatum and an enlarged ventral striatum and that we can rescue this phenotype by manipulating the interactions between Nolz-1 and Dlx1/2 transcription factors. Our study indicates that the two-tier system of striatal complex is built by coupling of cell-type identity and migration and suggests that the fundamental basis for divisions of the striatum known to be differentially vulnerable at maturity is already encoded by the time embryonic striatal neurons begin their migrations into developing striata.
Topics: Animals; Basal Ganglia; Cell Differentiation; Corpus Striatum; Female; Homeodomain Proteins; Interneurons; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Nucleus Accumbens; Transcription Factors; Ventral Striatum
PubMed: 32170006
DOI: 10.1073/pnas.1921007117