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Journal of Comparative Effectiveness... Jun 2023With no head-to-head studies comparing the effectiveness of lanadelumab and berotralstat for prevention of hereditary angioedema (HAE) attacks, this network... (Meta-Analysis)
Meta-Analysis
With no head-to-head studies comparing the effectiveness of lanadelumab and berotralstat for prevention of hereditary angioedema (HAE) attacks, this network meta-analysis (NMA) aimed to indirectly compare the effectiveness of these treatments. The NMA, using the published data from Phase III trials, was performed using a frequentist weighted regression-based approach following Rücker Efficacy outcomes of interest were HAE attack rate per 28 days and ≥90% reduction in monthly HAE attacks. In this NMA, lanadelumab 300 mg administered every 2 weeks or every 4 weeks was associated with statistically significantly higher effectiveness versus berotralstat 150 mg once daily (q.d.) or 110 mg q.d. for both efficacy outcomes assessed.
Topics: Humans; Angioedemas, Hereditary; Network Meta-Analysis; Antibodies, Monoclonal, Humanized
PubMed: 37218553
DOI: 10.57264/cer-2022-0188 -
Seminars in Plastic Surgery Nov 2022Despite being relatively uncommon in the general population, thumb amputations cause severe disability. More than 3,300 thumb amputations occurred in the United States.... (Review)
Review
Despite being relatively uncommon in the general population, thumb amputations cause severe disability. More than 3,300 thumb amputations occurred in the United States. The thumb makes up around 40% of the function of the hand. Therefore, losing it would result in significant medical, hospital, and societal costs. Thumb reconstruction surgery's primary goal is to restore grip strength, including the range of motion, fine and tripod pinch, power grasp, strength, and sensibility, while secondary goals include restoring hand aesthetics. In cases of thumb replantation, like-for-like replacement is possible; however, when thumb replantation is not possible, great toe-to-hand transplantation is the best available reconstruction. When compared with other reconstructive options such as osteoplastic thumb reconstruction, pollicization, second toe transplantation, and the use of a thumb prosthesis, great toe transplantation provides superior function and aesthetics. For restoring pinch, sensitivity, strength, and aesthetics of the hand with well-tolerated donor site morbidity, toe to thumb transplantation is regarded as the gold standard.
PubMed: 36561428
DOI: 10.1055/s-0042-1758689 -
Seminars in Plastic Surgery Nov 2022Phalloplasty in the female to male transgender patient is a complex operation aimed at creating a functional and aesthetic phallus, external genitalia, and perineum.... (Review)
Review
Phalloplasty in the female to male transgender patient is a complex operation aimed at creating a functional and aesthetic phallus, external genitalia, and perineum. Functional goals include standing micturition and sexual function with erogenous and tactile sensation as well as the ability to participate in penetrative intercourse. Functional genital reconstruction relies on creating of a fully lengthened urethra from local tissues as well as the provision for additional length via tissue transplantation. This manuscript will review techniques for the creation of perineal urethral segment as well as primary flaps available for the creation of neophallus. Particular emphasis is given to our preferred method of reconstruction: single-stage urethral lengthening with radial forearm flap phalloplasty including a review of surgical techniques and complications.
PubMed: 36561429
DOI: 10.1055/s-0042-1758226 -
CMAJ : Canadian Medical Association... Nov 2021
Topics: Alzheimer Disease; Antibodies, Monoclonal, Humanized; Canada; Drug Approval; Drug Costs; Humans; Immunologic Factors; Infusions, Intravenous; Randomized Controlled Trials as Topic; Treatment Outcome; United States; United States Food and Drug Administration
PubMed: 34725122
DOI: 10.1503/cmaj.211134-f -
Frontiers in Psychology 2019
PubMed: 31798493
DOI: 10.3389/fpsyg.2019.02514 -
Cold Spring Harbor Perspectives in... Jun 2022Fibroblasts are the main cell type in the dermis. They are responsible for the synthesis and deposition of structural proteins such as collagen and elastin, which are...
Fibroblasts are the main cell type in the dermis. They are responsible for the synthesis and deposition of structural proteins such as collagen and elastin, which are integrated into the extracellular matrix (ECM). Mouse and human studies using flow cytometry, cell culture, skin reconstitution, and lineage tracing experiments have shown the existence of different subpopulations of fibroblasts, including papillary fibroblasts, reticular fibroblasts, and fibroblasts comprising the dermal papilla at the base of the hair follicle. In recent years, the technological advances in single-cell sequencing have allowed researchers to study the repertoire of cells present in full-thickness skin including the dermis. Multiple groups have confirmed that distinct fibroblast populations can be identified in mouse and human dermis on the basis of differences in the transcriptional profile. Here, we discuss the current state of knowledge regarding dermal fibroblast heterogeneity in healthy mouse and human skin, highlighting the similarities and differences between mouse and human fibroblast subpopulations. We also discuss how fibroblast heterogeneity may provide insights into physiological wound healing and its dysfunction in pathological states such as hypertrophic and keloid scars.
PubMed: 35667795
DOI: 10.1101/cshperspect.a041238 -
CMAJ : Canadian Medical Association... Jan 2024
Topics: Humans; Alzheimer Disease; Canada; Antibodies, Monoclonal, Humanized
PubMed: 38286492
DOI: 10.1503/cmaj.230595-f -
Epidemics Sep 2022
Topics: Forecasting; Pandemics
PubMed: 36030185
DOI: 10.1016/j.epidem.2022.100621