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European Journal of Vascular and... Oct 2016Experimental animal models have been used to investigate the formation, development, and progression of abdominal aortic aneurysms (AAAs) for decades. New models are... (Review)
Review
OBJECTIVE
Experimental animal models have been used to investigate the formation, development, and progression of abdominal aortic aneurysms (AAAs) for decades. New models are constantly being developed to imitate the mechanisms of human AAAs and to identify treatments that are less risky than those used today. However, to the authors' knowledge, there is no model identical to the human AAA. The objective of this systematic review was to assess the different types of animal models used to investigate the development, progression, and treatment of AAA and to highlight their advantages and limitations.
METHODS
A search protocol was used to perform a systematic literature search of PubMed and Embase. A total of 2,830 records were identified. After selection of the relevant articles, 564 papers on animal AAA models were included.
RESULTS
The most common models in rodents, including elastase, calcium chloride, angiotensin II, xenograft, and transgenic models, and the most common models in non-rodents, including chemically induced, graft models, and patch models, all have limitations with regard to the pathological interpretation of human AAA.
CONCLUSION
Although findings from animal models of AAAs cannot be directly translated to human AAAs, the identification and awareness of animal models of AAA will provide knowledge for further investigation and insight into human AAA disease.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Models, Animal; Feasibility Studies; Humans; Species Specificity
PubMed: 27543385
DOI: 10.1016/j.ejvs.2016.07.004 -
PloS One 2018Abdominal aortic calcification (AAC) has a pretty high incidence in dialysis patients and may be associated with their prognosis. AAC can be assessed by abdominal CT or... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Abdominal aortic calcification (AAC) has a pretty high incidence in dialysis patients and may be associated with their prognosis. AAC can be assessed by abdominal CT or X-ray. We determined to investigate whether the occurrence of AAC is associated with all-cause mortality and cardiovascular (CV) events in dialysis patients through this meta-analysis and systematic review.
METHODS
A comprehensive literature search was conducted using the PubMed, Cochrane library, Embase, Medline databases to collect cohort studies investigating whether AAC is associated with all-cause mortality and CV events of patients, and we also searched gray articles and conferences abstracts. Meta-analysis was performed by STATA software. Pooled results were expressed as hazard ratio (HR) with corresponding 95% confidence intervals (CI). Fixed-effect models were used to pool the HR of each trial.
RESULTS
10 studies (2,724 dialysis patients) were identified. The presence of AAC was associated with increased risk for all-cause mortality among dialysis patients (HR, 2.84; 95% CI, 2.03-3.98; I2 = 9.8%; P = 0.354). Meanwhile, there was an association between AAC and increased risk for all CV events (fatal and non-fatal) in patients (HR, 2.04; 95% CI, 1.51-2.76, I2 = 44.6%; P = 0.125). 3 studies presented their endpoint as CV mortality, and the pooled HR was 2.46 (95%CI 1.38-4.40; I2 = 0.0%; P = 0.952). There were also 2 studies that reported their primary endpoint as all-cause mortality and CV events, and the pooled HR was 5.72 (95% CI 3.24-10.10; I2 = 0.0%; P = 0.453).
CONCLUSIONS
Among patients treated with dialysis, AAC is associated with adverse outcomes, including all-cause mortality and CV events (fatal and non-fatal). The abdominal X-ray or CT scan can be used as a useful added method to evaluate the patient's calcification. This may provide reasonable data for estimating the risk of adverse events in dialysis patients, which is helpful in guiding clinical treatment and improving the prognosis of dialysis patients.
Topics: Aorta, Abdominal; Cardiovascular Diseases; Humans; Prognosis; Renal Dialysis; Vascular Calcification
PubMed: 30240443
DOI: 10.1371/journal.pone.0204526 -
European Journal of Vascular and... Dec 2016Despite technical advances of fenestrated and branched endografts, endovascular exclusion of aneurysms involving renal, visceral, and/or supra-aortic branches remains a... (Review)
Review
OBJECTIVE
Despite technical advances of fenestrated and branched endografts, endovascular exclusion of aneurysms involving renal, visceral, and/or supra-aortic branches remains a challenge. In situ fenestration (ISF) of standard endografts represents another endovascular means to maintain perfusion to such branches. This study aimed to review current indications, technical descriptions, and results of ISF.
METHOD
A review of the English language literature was performed in Medline databases, Cochrane Database, Web of Science, and Scopus using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Sixty-seven relevant papers were selected. Thirty-three papers were excluded, leaving 34 articles as the basis of the present review.
RESULTS
Most experimental papers evaluated ISF feasibility and assessed the consequences of ISF on graft fabric. Regarding clinical papers, 73 ISF procedures have been attempted in 58 patients, including 26 (45%) emergent and three (5%) bailout cases. Sixty-five (89%) ISF were located at the level of the arch, and eight (11%) in the abdominal aorta. Graft perforation was performed by physical, mechanical, or unspecified means in 33 (45%), 38 (52%), and two vessels (3%), respectively. ISF was technically successful in 68/73 (93%) arteries. At 30 days, two (3.4%) patients died in the setting of an aorto-bronchial fistula and an aorto-oesophageal fistula, respectively. No post-operative death, major complication, or endoleak was described as secondary to the ISF procedure. With follow-up between 0 and 72 months, four (6.9%) late deaths were noted, unrelated to the aorta. One (1.7%) LSA stent was stenosed without symptoms.
CONCLUSIONS
Although there may be publication bias, multiple techniques were described to perform ISF with satisfactory short-term results. Long-term data remain scarce. Aortic endograft ISF is an off-label procedure that should not be used outside emergent bailout techniques or investigational studies. A comparison with alternative techniques of preserving aortic side branches is needed.
Topics: Animals; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Endovascular Procedures; Humans; Postoperative Complications; Prosthesis Design; Risk Factors; Stents; Time Factors; Treatment Outcome
PubMed: 27843111
DOI: 10.1016/j.ejvs.2016.10.001 -
The Cochrane Database of Systematic... Jan 2010Surgery on the abdominal aorta to treat aneurysms or occlusive disease is a major undertaking which requires intensive physiological support and fluid management. Blood... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Surgery on the abdominal aorta to treat aneurysms or occlusive disease is a major undertaking which requires intensive physiological support and fluid management. Blood products are often used but the main fluid replacement is with crystalloids or colloids. For years there has been controversy over which fluid is optimal and a number of studies have examined the subject. This is an update of a Cochrane review first published in 2000 and previously updated in 2002.
OBJECTIVES
To determine the effectiveness of different non-blood replacement fluids used in abdominal aorta procedures with a view to identifying the optimal fluid for use.
SEARCH STRATEGY
The Cochrane Peripheral Vascular Diseases Group searched their Specialised Register (August 2009) and the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2009, Issue 3) for publications describing randomised controlled trials of non-blood replacement fluids in abdominal aortic surgery. In addition, the reference lists from retrieved trials were screened for further information about trials.
SELECTION CRITERIA
Randomised controlled trials assessing the effects of at least one specific non-blood fluid used for replacement therapy in operations on, and confined to, the abdominal aorta.
DATA COLLECTION AND ANALYSIS
Data were extracted and then entered into the Review Manager software where statistical analyses were performed.
MAIN RESULTS
Thirty-eight trials involving 1589 patients were included. Patients undergoing aortic surgery had various physiological parameters measured before and after their operation (these were cardiac, respiratory, haematological, and biochemical). Patients were randomised to a fluid type. This review demonstrated that no single fluid affects any outcome measure significantly more than another fluid across a range of outcomes. The death rate in these studies was 2.45% (39 patients).
AUTHORS' CONCLUSIONS
Despite the confirmed beneficial effects of colloids in this review, further studies are still required. There are no studies examining the effects of combination fluid therapy. The primary research outcome was death, for which results were limited; therefore, future studies should pay more attention to short-term outcomes such as minimising the need for allogenic blood transfusion, complications (organ failure), and length of stay in both the intensive care unit and hospital.
Topics: Aorta, Abdominal; Aortic Aneurysm, Abdominal; Arteriosclerosis; Blood Loss, Surgical; Colloids; Fluid Therapy; Humans; Randomized Controlled Trials as Topic; Solutions
PubMed: 20091510
DOI: 10.1002/14651858.CD000991.pub2 -
BMC Pregnancy and Childbirth Jan 2019Severe obstetric hemorrhage caused by placenta accreta results in significant maternal morbidity and mortality. As a new technology, abdominal aortic balloon occlusion... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Severe obstetric hemorrhage caused by placenta accreta results in significant maternal morbidity and mortality. As a new technology, abdominal aortic balloon occlusion (AABO) is becoming an important treatment for patients with placenta accreta. To evaluate the safety and efficacy of AABO, we conducted a systematic review and meta-analysis of previous studies.
METHODS
We used a three-check subset including placenta accreta (placenta previa, percreta, increta, etc.), balloon, and aortic (aortas, aorta, etc.) to form a retrieval formula and searched in MEDLINE, EMBASE, the Cochrane Library, clinicaltrials.gov and Web of Science. All articles regarding placenta previa or placenta accreta and including the use of abdominal aortic balloon occlusion were included in our screening. Two researchers selected articles and extracted data independently. Finally, the Newcastle-Ottawa Quality Assessment Scale was used for quality assessments.
RESULTS
We retrieved 776 articles and eventually included 11 clinical studies. Meta-analysis showed that AABO significantly reduced the blood loss volume (MD - 1480 ml, 95% CI -1806 to - 1154 ml, P < 0.001) and blood transfusion volume (MD - 1125 ml, 95% CI -1264 to - 987 ml, P < 0.001). Similarly, obvious reductions in the hysterectomy rate (OR 0.30, 95% CI 0.19 to 0.48, P < 0.001), hospitalization duration (MD - 1.35 days, 95% CI -2.40 to - 0.31 days, P = 0.01), and operative time (MD - 29.23 min, 95% CI -46.04 to - 12.42 min, P < 0.001) were observed in the AABO group.
CONCLUSION
The prophylactic use of AABO in patients with placenta accreta is safe and effective.
Topics: Adult; Aorta, Abdominal; Balloon Occlusion; Blood Loss, Surgical; Blood Transfusion; Female; Humans; Length of Stay; Operative Time; Placenta Accreta; Postpartum Hemorrhage; Pregnancy; Treatment Outcome
PubMed: 30646863
DOI: 10.1186/s12884-019-2175-0 -
European Journal of Vascular and... Aug 2012A recent GWAS demonstrated an association between low density lipoprotein receptor related protein 1 (LRP1) and abdominal aortic aneurysm (AAA). This review aims to... (Review)
Review
OBJECTIVES
A recent GWAS demonstrated an association between low density lipoprotein receptor related protein 1 (LRP1) and abdominal aortic aneurysm (AAA). This review aims to identify how LRP1 may be involved in the pathogenesis of abdominal aortic aneurysm.
DESIGN AND MATERIALS
A systematic review of the English language literature was undertaken in order to determine whether LRP1 and associated pathways were plausible candidates for contributing to the development and/or progression of AAA.
METHODS AND RESULTS
A comprehensive literature search of MEDLINE (since 1948), Embase (since 1980) and Health and Psychological Instruments (since 1985) was conducted in January 2012 identified 50 relevant articles. These studies demonstrate that LRP1 has a diverse range of biological functions and is a plausible candidate for playing a central role in aneurysmogenesis. Importantly, LRP1 downregulates MMP (matrix metalloproteinase) activity in vascular smooth muscle cells and regulates other key pathways involved in extracellular matrix remodelling and vascular smooth muscle migration and proliferation. Crucially animal studies have shown that LRP1 depletion leads to progressive destruction of the vascular architecture and aneurysm formation.
CONCLUSIONS
Published evidence suggests that LRP1 may play a key role in the development of AAA.
Topics: Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Disease Progression; Genetic Predisposition to Disease; Humans; Low Density Lipoprotein Receptor-Related Protein-1; Phenotype; Polymorphism, Single Nucleotide; Protein Conformation
PubMed: 22658609
DOI: 10.1016/j.ejvs.2012.05.009 -
Journal of Vascular and Interventional... Oct 2013Little is known regarding the outcomes of endovascular and surgical treatment of penetrating ulcers in the abdominal aorta. The potential benefit of conservative... (Meta-Analysis)
Meta-Analysis Review
Little is known regarding the outcomes of endovascular and surgical treatment of penetrating ulcers in the abdominal aorta. The potential benefit of conservative management of asymptomatic disease is also debatable. A systematic review of the literature was undertaken to investigate these issues.
Topics: Aorta, Abdominal; Aortic Diseases; Endovascular Procedures; Evidence-Based Medicine; Female; Humans; Male; Prevalence; Radiography; Risk Factors; Treatment Outcome; Ulcer; Vascular Surgical Procedures
PubMed: 23932417
DOI: 10.1016/j.jvir.2013.05.067 -
Annals of Anatomy = Anatomischer... May 2021The inferior phrenic artery is a paired artery that supplies the diaphragm from its inferior aspect. It may arise as a common trunk, the common inferior phrenic artery... (Meta-Analysis)
Meta-Analysis
INTRODUCTION
The inferior phrenic artery is a paired artery that supplies the diaphragm from its inferior aspect. It may arise as a common trunk, the common inferior phrenic artery (CIPA), or as two individual arteries, the right and left inferior phrenic arteries (RIPA and LIPA, respectively). The aim of this study was to perform a systematic review and meta-analysis to create pooled prevalence data on the various origins of the inferior phrenic arteries and to discuss their clinical importance.
METHODS
Major electronic medical databases were reviewed to identify articles with anatomical prevalence data on the origin of the inferior phrenic arteries. Data on the origin of the left, right and common inferior phrenic arteries were extracted and quantitatively synthesized.
RESULTS
The CIPA was present in 24.2% of cases and most commonly originated from the aorta, with a pooled prevalence 57.2% (95% CI 52.4-62.0%), and the coeliac trunk, with a pooled prevalence of 41.3% (95% CI 36.8-45.9%). Other origins were much less common (1.00% (95% CI 0.28-1.71%)). Independent origin of the RIPA and LIPA were present in 75.8%. The RIPA arose from the aorta (49.6%, 95% CI 43.2%-55.9%), coeliac trunk (35.7%, 95% CI 28.7-42.6%), right renal artery (10.3%, 95% CI 7.27-13.3%) and left gastric artery (2.07%, 95% CI 0.97-3.16%). Other less common origins had a pooled prevalence of 2.07% (95% CI 0.97-3.16%). The LIPA arose from the aorta (46.8%, 95% CI 39.1-54.6%), coeliac trunk (46.1%, 95 CI 38.6-53.5%), left renal artery (1.47%, 95% CI 0.78-2.15%) and left gastric artery (1.07%, 95% CI 0.25-1.89%). Other less common origins had a pooled prevalence of 1.29% (95% CI 0.44-2.14%).
CONCLUSION
The inferior phrenic arteries express a wide range of variations in origin. Knowledge of their origins are important in interventional radiology, gastroenterology, surgery and traumatology.
Topics: Aorta, Abdominal; Celiac Artery; Diaphragm; Renal Artery
PubMed: 33516785
DOI: 10.1016/j.aanat.2021.151679 -
Annali Italiani Di Chirurgia 2017Laparoscopic surgery (LS) is the minimally invasive alternative to open surgery and endovascular approach for treating major aortic diseases. Only few reports in the... (Review)
Review
UNLABELLED
Laparoscopic surgery (LS) is the minimally invasive alternative to open surgery and endovascular approach for treating major aortic diseases. Only few reports in the literature describe the long-term outcomes of the laparoscopic approach for major vascular diseases. Furthermore, the widespread use of endovascular techniques has limited the use of LS to wellselected patients. This review evaluated the results of LS for aortic disease and compared the clinical outcomes of laparoscopic technique with those of open and endovascular surgery. A systematic review was performed by using the MEDLINE database, along with a meta-analysis of the reported studies on the treatment of abdominal aortic aneurysm (AAA) and/or aorto-iliac occlusive disease (AIOD). Forty-three studies were analyzed (17 for AAA and 26 for AIOD), with a total of 1197 patients with AAA and 1307 patients with AIOD. Laparoscopic surgery, when performed in experienced centers, is a feasible and safe technique for the treatment of AAA and AIOD in patients unfit for open and endovascular repair. Assisted laparoscopic approach has shown better outcomes than totally laparoscopic repair, with a lower rate of mortality and morbidity. Endovascular repair, however, remains the gold standard in the treatment of AAA.
KEY WORDS
Abdominal aortic aneurysm, Aorta, Aneurysm, Aorto-iliac occlusive disease, Endovascular aneurysm repair, EVAR, Laparoscopy, Endovascular, Repair, Laparoscopic Assisted, Laparoscopy Vascular, Laparoscopic surgery, Totally.
Topics: Aortic Aneurysm, Abdominal; Aortic Diseases; Arterial Occlusive Diseases; Blood Vessel Prosthesis Implantation; Endovascular Procedures; Evidence-Based Medicine; Feasibility Studies; Humans; Iliac Artery; Laparoscopy; Length of Stay; Patient Selection; Severity of Illness Index; Treatment Outcome
PubMed: 28604376
DOI: No ID Found -
British Journal of Anaesthesia May 2018Cerebrospinal-fluid (CSF) drainage is recommended by current guidelines for spinal protection during open and endovascular repairs of thoracic and thoraco-abdominal... (Meta-Analysis)
Meta-Analysis
Cerebrospinal-fluid drain-related complications in patients undergoing open and endovascular repairs of thoracic and thoraco-abdominal aortic pathologies: a systematic review and meta-analysis.
BACKGROUND
Cerebrospinal-fluid (CSF) drainage is recommended by current guidelines for spinal protection during open and endovascular repairs of thoracic and thoraco-abdominal aortic aneurysms. In the published literature, great variability exists in the rate of CSF-related complications and morbidity. Herein, we perform a systematic review and meta-analysis on the incidence of CSF drainage-related complications, and compare the complication rates between open and endovascular repairs.
METHODS
The systematic review was conducted according to the Meta-Analysis of Observational Studies in Epidemiology guidelines. Thirty-four studies (4714 patients) were included in the quantitative analysis. The CSF drainage-related complications were categorised as mild, moderate, and severe. Pooled event rates for each complication category were estimated using a random-effect model. Random-effect uni- and multivariable meta-regression analyses were used to assess the effect of aortic-repair approach (open vs endovascular) and the CSF drainage criteria on CSF drainage-related complications.
RESULTS
The pooled event rates were 6.5% [95% confidence interval (CI): 4.3-9.8%] for overall complications, 2% (95% CI: 1.1-3.4%) for minor complications, 3.7% (95% CI: 2.5-5.6%) for moderate complications, and 2.5% (95% CI: 1.6-3.8%) for severe complications. The drainage-related-mortality pooled event rate was 0.9% (95% CI: 0.6-1.4%). The uni- and multivariable meta-regression analyses showed no difference in complication rates between the open and endovascular approaches, or between the different CSF drainage protocols.
CONCLUSION
The complication rate for CSF drainage is not negligible. Our results help define a more accurate risk-benefit ratio for CSF drain placement at the time of repair of thoracic and thoraco-abdominal aneurysms.
Topics: Aorta, Thoracic; Aortic Aneurysm, Thoracic; Drainage; Endovascular Procedures; Humans; Postoperative Complications; Treatment Outcome
PubMed: 29661408
DOI: 10.1016/j.bja.2017.12.045