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BMJ Clinical Evidence Jul 2010Mammalian bites are usually caused by dogs, cats, or humans, and are more prevalent in children (especially boys) than in adults. Animal bites are usually caused by the... (Review)
Review
INTRODUCTION
Mammalian bites are usually caused by dogs, cats, or humans, and are more prevalent in children (especially boys) than in adults. Animal bites are usually caused by the person's pet and, in children, frequently involve the face. Human bites tend to occur in children as a result of playing or fighting, while in adults they are usually the result of physical or sexual abuse. Mixed aerobe and anaerobe infection is the most common type of infection, and can occur in up to half of human bites.
METHODS AND OUTCOMES
We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of interventions to prevent complications of mammalian bites? What are the effects of treatments for infected mammalian bites? We searched: Medline, Embase, The Cochrane Library, and other important databases up to October 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
RESULTS
We found five systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
CONCLUSIONS
In this systematic review we present information relating to the effectiveness and safety of the following interventions: antibiotic prophylaxis (human bites, non-human bites), antibiotics, debridement, decontamination, irrigation, primary wound closure, and tetanus vaccination (after mammalian bites).
Topics: Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bites and Stings; Bites, Human; Debridement; Evidence-Based Medicine; Humans; Incidence
PubMed: 21418668
DOI: No ID Found -
International Journal of Exercise... 2021This review aims to 1) be the first systematic review and meta-analysis of the literature examining the physiology and assessment of goaltenders, and 2) present a... (Review)
Review
This review aims to 1) be the first systematic review and meta-analysis of the literature examining the physiology and assessment of goaltenders, and 2) present a physiological profile of ice-hockey goaltenders. It will 1) highlight physiological differences between goaltenders and players at other positions, 2) determine strengths and weaknesses of ice hockey goaltenders, and 3) offer possible guidelines for strength and conditioning coaches. Six electronic databases were systematically searched in October 2019 using the PRISMA model. A total of twelve scientific articles published in peer-reviewed journals were included. Professional male (PM) goaltenders had the following profile for age (A) 26.8 ± 2.5 years, body weight (BW) 85.64 ± 3.79 kg, height (H) 184.38 ± 2.79 cm, body fat % (BF%) 11.9 ± 2.22, VOmax 49.9 ± 4.45 ml/kg/min, anaerobic power (AP) 12.78 ± 1.63 W/kg, and combined hand grip strength (GS) 120.7 ± 15 kg. Amateur male (AM) goaltenders presented the following: A: 18.2 ± 0.75, BW: 83.85 ± 4.51, H: 184.96 ± 2.06, BF%: 10.51 ± 1.61, VOmax: 55.73 ± 4.57, AP: 10.9 ± 1.2 and GS: 109.08 ± 14.06. Amateur female (AF) goaltenders presented the following: A: 21.04 ± 1.84, BW: 63.4 ± 5.14, H: 164.86 ± 5.73, BF%: 22.12 ± 2.27 and VOmax: 42.84 ± 3.59. Overall, PM goaltenders are heavier, have a higher BF%, and exhibit greater GS and abdominal muscular endurance than AM, while AM goaltenders are heavier, taller, leaner, and can generate greater lower-body muscular power than AF goaltenders. In the current literature, there were a small number of studies on women players and a lack of distinction between player position in reported results. Specific physiological assessments during NHL Combines should be developed for goaltenders in accordance with their specific positional demands.
PubMed: 34567379
DOI: No ID Found -
Journal of Strength and Conditioning... Nov 2021Ulupınar, S, Özbay, S, Gençoğlu, C, and İnce, İ. Performance differences between Greco-Roman and freestyle wrestlers: a systematic review and meta-analysis. J... (Meta-Analysis)
Meta-Analysis
Ulupınar, S, Özbay, S, Gençoğlu, C, and İnce, İ. Performance differences between Greco-Roman and freestyle wrestlers: a systematic review and meta-analysis. J Strength Cond Res 35(11): 3270-3279, 2021-This systematic review and meta-analysis aims to summarize evidence on performance differences between Greco-Roman (GR) and freestyle (Fr) wrestlers. Eleven studies met the inclusion criteria (91 individual data and a total of 752 wrestlers). The analysis of handgrip strength comprised 9 outcomes from 5 studies with no significant difference between GR and Fr wrestlers. The analysis of isometric (back or leg) strength comprised 15 outcomes from 6 studies with a significant effect favoring GR wrestlers. The analysis of muscle power comprised 15 outcomes from 5 studies with a significant effect favoring GR wrestlers. The analysis of strength endurance comprised 4 outcomes from 3 studies with no significant difference between GR and Fr wrestlers. The analysis of anaerobic capacity and power comprised 6 outcomes from 3 studies with no significant difference between GR and Fr wrestlers. The analysis of speed comprised 19 outcomes from 7 studies with a significant effect favoring GR wrestlers. The analysis of flexibility comprised 20 outcomes from 6 studies with a significant effect favoring Fr wrestlers. This study indicated that GR wrestlers had greater isometric strength, muscle power, and speed performance, but Fr wrestlers had greater flexibility. Given the significant effect sizes favoring GR wrestlers, it is possible that they focused on training strategies to improve physical strength-power performance. However, considering the significant effect size favoring Fr wrestlers, it is possible that they focused on training strategies to improve flexibility because Fr wrestling techniques require a larger range of motion during both attack and defense.
Topics: Hand Strength; Humans; Range of Motion, Articular; Wrestling
PubMed: 34474431
DOI: 10.1519/JSC.0000000000004129 -
Antibiotics (Basel, Switzerland) Aug 2022is a genus comprising Gram-positive, rod-shaped, spore-forming, anaerobic bacteria that cause a variety of diseases. However, there is a shortage of information... (Review)
Review
is a genus comprising Gram-positive, rod-shaped, spore-forming, anaerobic bacteria that cause a variety of diseases. However, there is a shortage of information regarding antibiotic resistance in the genus in Saudi Arabia. This comprehensive analysis of research results published up until December 2021 intends to highlight the incidence of antibiotic resistance in species in Saudi Arabia. PubMed, Google Scholar, Web of Science, SDL, and ScienceDirect databases were searched using specific keywords, and ten publications on antibiotic resistance in species in Saudi Arabia were identified. We found that the rates of resistance of to antibiotics were as follows: 42% for ciprofloxacin, 83% for gentamicin, 28% for clindamycin, 25% for penicillin, 100% for levofloxacin, 24% for tetracycline, 77% for nalidixic acid, 50% for erythromycin, 72% for ampicillin, and 28% for moxifloxacin; whereas those of were: 21% for metronidazole, 83% for ceftiofur, 39% for clindamycin, 59% for penicillin, 62% for erythromycin, 47% for oxytetracycline, and 47% for lincomycin. The current findings suggest that ceftiofur, erythromycin, lincomycin, and oxytetracycline should not be used in infection treatments in humans or animals in Saudi Arabia.
PubMed: 36139945
DOI: 10.3390/antibiotics11091165 -
Haemophilia : the Official Journal of... Jan 2009In haemophiliacs, the physical condition, muscular strength, aerobic resistance, anaerobic resistance and proprioception have all diminished. Muscle atrophy and... (Review)
Review
In haemophiliacs, the physical condition, muscular strength, aerobic resistance, anaerobic resistance and proprioception have all diminished. Muscle atrophy and instability, being more vulnerable to stressful motor demands, increase the risk of lesion and establish a vicious circle that is hard to break: pain, immobility, atrophy, articular instability and repeated bleeding episodes. In haemophilia, physical and/or sporting activities were not recommended until the seventies. Nowadays, the overall policy is to recommend certain physical activities, especially swimming, to improve the patient's quality of life, thanks to prophylaxis programmes. The objective of this study is to perform a systematic review of the exercise and sporting activities recommended for haemophiliacs. Experimental and observational studies and clinical assays about rehabilitation for haemophiliacs with exercise and sporting activities have been included. The relevant studies were identified in Medline, Cinahl, Embase and SportDiscus, and key words were: haemophilia, exercise and sport (with no language restrictions). Works were independently analysed by reviewers and the following were identified: of 3603 studies, 103 were included in this review: 29 (28.15%) were experimental, 27 (26.21%) were observational and 47 (45.63%) were clinical. Physiotherapy, physical activity and sport are basic elements to improve quality of life and the physical condition, increase strength and resistance and to reduce the risk of musculoskeletal lesions and to prevent haemophilic atrophy. In general, professionals in haemophilia believe that regular exercise and rehabilitation with physiotherapy is fundamental, particularly in countries where replacement therapy is not readily available.
Topics: Exercise; Hemarthrosis; Hemophilia A; Humans; Male; Physical Therapy Modalities; Sports
PubMed: 18721151
DOI: 10.1111/j.1365-2516.2008.01867.x -
Sleep & Breathing = Schlaf & Atmung Jun 2023Circadian rhythm affects maximal short-term performance, and it is an important determinant of the training component. This review aimed to summarise the influence of... (Review)
Review
PURPOSE
Circadian rhythm affects maximal short-term performance, and it is an important determinant of the training component. This review aimed to summarise the influence of circadian rhythm on peak and mean power output of muscle, fatigue index, and blood lactate levels.
METHODS
English language articles were searched through the following databases: PubMed, Web of Science, Science Direct, and Google Scholar, and pertinent randomized control trials were scrutinized.
RESULTS
The search revealed 17,481 articles, and 29 were included in this systematic review based on inclusion and exclusion criteria. Randomized control trials were selected, and the methodological validity of articles was evaluated using the 'Cochrane risk of bias tool'. Findings suggest that outcome variables muscle peak power output (p < 0.0001, Z = 7.22, I = 57.42, SMD = - 0.91, 95% confidence interval CI = - 1.16, - 0.67), muscle mean power output (p < 0.0001, Z = 5.66, I = 83.85, SMD = - 0.75, 95% CI = - 1.01, - 0.49), and fatigue index (p = 0.02, Z = 2.41, I = 2.49, SMD = - 0.39, 95% CI = - 0.72, - 0.07) were higher in the evening while the level of blood lactate was higher in the morning (p = 0.79, Z = 0.27, I = 0.73, SMD = - 0.05, 95% CI = - 0.46, - 0.35).
CONCLUSION
The results show that diurnal variation affects both peak and mean power output of muscle as well as fatigue index. However, there is no remarkable effect of circadian rhythm on blood lactate level. A major factor attributed to this finding was the variation in the training experience of participants. For an effective training prescription, it is very important to consider the effect of the biological clock on muscle power output since anaerobic exercise performance is discernibly influenced by the time of the day.
Topics: Humans; Anaerobiosis; Circadian Rhythm; Fatigue; Lactates
PubMed: 35904663
DOI: 10.1007/s11325-022-02662-7 -
Expert Opinion on Drug Safety Sep 2021Dalbavancin is a semisynthetic lipoglycopeptide antimicrobial agent with activity against Gram-positive bacteria including anaerobes. (Comparative Study)
Comparative Study Meta-Analysis
BACKGROUND
Dalbavancin is a semisynthetic lipoglycopeptide antimicrobial agent with activity against Gram-positive bacteria including anaerobes.
RESEARCH DESIGN AND METHODS
Meta-analysis of randomized control trials and large case series (more than 20 patients), were identified by searching Pubmed and Cochrane databases through 14 December 2020.
RESULTS
3,073 patients from 6 RCTs met the inclusion criteria. Treatment emergent adverse effects were described in 30.6% dalbavancin patients, and 38.1% patients with other treatments. Our meta-analysis supports favorable results for dalbavancin treatment (OR 0.79; 95%CI 0.66-0.94; p = 0.01). 2.74% dalbavancin patients had to discontinue treatment versus 2.49% patients on other antibiotics. 4.80% dalbavancin patients versus 5.30% patients with other treatments had severe adverse events. 0.31% in the dalbavancin group and 0.95% receiving other antibiotics died. There was no statistically significant difference in severe adverse effects with OR 0.77; 95% CI 0.52-1.14; p = 0.19. Dalbavancin therapy was shown to have statistically significant lower mortality rate (OR 0.26; 95% CI 0.07-0.90; p = 0.03). Observational studies reported few side effects but included a heterogeneous population of patients concerning their diagnosis and the duration of antibiotic treatment.
CONCLUSIONS
Dalbavancin has comparable safety profile relative to other antibiotics and is well-tolerated.
Topics: Anti-Bacterial Agents; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Randomized Controlled Trials as Topic; Teicoplanin
PubMed: 34042549
DOI: 10.1080/14740338.2021.1935864 -
Transfusion Medicine Reviews Jul 2021Septic reactions from platelet transfusions are one of the leading causes of transfusion-associated mortality. The FDA guidance for platelet bacterial risk control... (Meta-Analysis)
Meta-Analysis Review
Septic reactions from platelet transfusions are one of the leading causes of transfusion-associated mortality. The FDA guidance for platelet bacterial risk control includes bacterial culture using both aerobic and anaerobic bottles. Several studies have reported false positive rates (FPR) of culture, but these data have not been summarized or influencing factors analyzed. A systematic review and meta-analysis was performed according to published guidelines to assess the false positive rate and influencing factors. Eighteen studies were included for analysis. The combined aerobic/anaerobic FPR was 2.4 events per thousand (EPT) with a prediction interval of 0.5 to 5.7, while the aerobic FPR rate was 1.0 EPT (prediction interval: 0.2-2.2) and the anaerobic rate was 1.8 EPT. Estimates were based on a total of almost 5 million units tested. The rate of false positives due to instrument error was between 0.5-1.7 EPT, while it was between 0.3-1.0 EPT for sampling contamination based on whether only aerobic, anaerobic, or aerobic/anaerobic cultures were performed. The FPR is approximately 2 to 5 times higher than the literature reported true positive rate of 0.5 EPT.
Topics: Anaerobiosis; Bacteria; Blood Platelets; Humans; Platelet Transfusion; Quality Control
PubMed: 34158212
DOI: 10.1016/j.tmrv.2021.05.001 -
Journal of Sports Science & Medicine Dec 2022To identify and evaluate current scientific literature concerning the effect of strength, power and speed training on relevant physiological and biomechanical... (Review)
Review
To identify and evaluate current scientific literature concerning the effect of strength, power and speed training on relevant physiological and biomechanical characteristics and performance of competitive cross-country skiers (XCS), the databases Scopus and PubMed were searched systematically for original articles in peer-reviewed journals. Of the 599 studies retrieved, 12 met the inclusion criteria (i.e., assessment of outcome measures with relevance for XCS performance; involvement of traditional resistance training; application of external resistance to the body; intervention longer than 4 weeks; randomized controlled trial). The methodological rigor of each study was assessed using the PEDro scale, which were mostly poor-to-fair, with good methodological quality in only two articles. All of the strength/power/speed interventions improved 1RM (0.8-6.8 ES), but findings with respect to jump performance, ability to generate force rapidly and body composition were mixed. Interventions demonstrated moderate-to-high ES on XCS specific performance compared with control (mean ES = 0.56), but the pattern observed was not consistent. None of the interventions changed anaerobic capacity, while in most studies VO was either unchanged or increased. Work economy or efficiency was enhanced by most of the interventions. In conclusion, present research indicates that strength training improves general strength, with moderate effects on XCS performance, and inconclusive effects on work economy and VO/VO. Strength training with high loads, explosive strength training, or sprint interval training seem to be promising tools for modern XCS training. Future investigations should include long-term (e.g., >6 months) strength training to allow sufficient time for increased strength and speed to influence actual XCS performance. Moreover, they should include both sexes, as well as upper- and lower-body muscles (trained separately and together) and employ free weights and core training. Methodological differences and limitations highlighted here may explain discrepancies in findings and should be taken into consideration in future research in this area.
Topics: Male; Female; Humans; Muscle Strength; Resistance Training; High-Intensity Interval Training
PubMed: 36523891
DOI: 10.52082/jssm.2022.555 -
Nutrients Sep 2023To summarize available evidence in the literature on the impacts of CoQ supplementation on metabolic, biochemical, and performance outcomes in athletes. (Review)
Review
BACKGROUND
To summarize available evidence in the literature on the impacts of CoQ supplementation on metabolic, biochemical, and performance outcomes in athletes.
METHODS
Six databases, Cochrane Library (33 articles), PubMed (90 articles), Scopus (55 articles), Embase (60 articles), SPORTDiscus (1056 articles), and Science Direct (165 articles), were researched. After applying the eligibility criteria, articles were selected for peer review independently as they were identified by June 2022. The protocol for this systematic review was registered on PROSPERO (CRD42022357750).
RESULTS
Of the 1409 articles found, 16 were selected for this systematic review. After CoQ supplementation, a decrease in oxidative stress markers was observed, followed by higher antioxidant activity. On the other hand, lower levels of liver damage markers (ALT); Aspartate aminotransferase (AST); and Gamma-glutamyl transpeptidase (γGT) were identified. Finally, we found a reduction in fatigue indicators such as Creatine Kinase (CK) and an increase in anaerobic performance.
CONCLUSIONS
This systematic review concludes that supplementation with orally administered CoQ (30-300 mg) was able to potentiate plasma antioxidant activity and anaerobic performance, reducing markers linked to oxidative stress and liver damage in athletes from different modalities aged 17 years old and older.
PubMed: 37764774
DOI: 10.3390/nu15183990