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The Science of the Total Environment Jan 2024The COVID-19 pandemic presents unprecedented challenge for global public health systems and exacerbates existing health disparities. Epidemiological evidence suggested a... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
The COVID-19 pandemic presents unprecedented challenge for global public health systems and exacerbates existing health disparities. Epidemiological evidence suggested a potential linkage between particulate and gaseous pollutants and COVID-19 mortality. We aimed to summarize the overall risk of COVID-19 mortality associated with ambient air pollutants over the short- and long-term.
METHODS
For the systematic review and meta-analysis, we searched five databases for studies evaluating the risk of COVID-19 mortality from exposure to air pollution. Inclusion of articles was assessed independently on the basis of research topic and availability of effect estimates. The risk estimates (relative risk) for each pollutant were pooled with a random-effect model. Potential heterogeneity was explored by subgroup analysis. Funnel plots and trim-and-fill methods were employed to assess and adjust for publication bias.
FINDINGS
The systematic review retrieved 2059 records, and finally included 43 original studies. PM (RR: 1.71, 95 % CI: 1.40-2.08, per 10 μg/m increase), NO (RR: 1.33, 1.07-1.65, per 10 ppb increase) and O (RR: 1.61, 1.00-2.57, per 10 ppb increase) were positively associated with COVID-19 mortality for long-term exposures. Accordingly, a higher risk of COVID-19 mortality was associated with PM (1.05, 1.02-1.08), PM (1.05, 1.01-1.08), and NO (1.40, 1.04-1.90) for short-term exposures. There was some heterogeneity across subgroups of income level and geographical areas.
CONCLUSION
Both long-term and short-term exposures to ambient air pollution may increase the risk of COVID-19 mortality. Future studies utilizing individual-level information on demographics, exposures, outcome ascertainment and confounders are warranted to improve the accuracy of estimates.
Topics: Humans; Nitrogen Dioxide; Pandemics; Environmental Exposure; COVID-19; Air Pollution; Air Pollutants; Dust; Particulate Matter
PubMed: 37797765
DOI: 10.1016/j.scitotenv.2023.167542 -
International Archives of Occupational... Jan 2017To conduct a systematic review of epidemiologic studies on risk of cancer from exposure to silicon carbide (SiC). (Meta-Analysis)
Meta-Analysis Review
PURPOSE
To conduct a systematic review of epidemiologic studies on risk of cancer from exposure to silicon carbide (SiC).
METHODS
We followed established guidelines to search electronic databases for studies on populations exposed to SiC. We conducted meta-analyses when the data justified it.
RESULTS
We identified two studies of SiC production workers and several studies of users. The studies of production workers indicated an increased risk of lung cancer. The increased risk was restricted to workers with elevated dust exposure and, in the most informative study from Norway, was linked to estimated cristobalite exposure, a form of crystalline silica. Increased risk was not linked to SiC particles, once cristobalite exposure was controlled for. Studies of SiC users in various industries did not reveal an increased risk of lung cancer.
CONCLUSIONS
The increased risk of lung cancer detected in the SiC production industry appears to be associated with high exposure levels to total dust, including crystalline silica and cristobalite which occurred in this industry in the past decades. It may not persist under current exposure circumstances, characterized by lower levels and use of personal protection equipment. Commercial users of SiC-based products were not affected.
Topics: Carbon Compounds, Inorganic; Dust; Humans; Lung Neoplasms; Manufacturing Industry; Occupational Diseases; Occupational Exposure; Risk Factors; Silicon Compounds; Silicon Dioxide
PubMed: 27628329
DOI: 10.1007/s00420-016-1169-8 -
Occupational and Environmental Medicine Jul 2017Lung function is a predictor of morbidity and mortality, and the chronic nature of lung function decline allows for preventive initiatives. Proinflammatory constituents... (Meta-Analysis)
Meta-Analysis Review
Lung function is a predictor of morbidity and mortality, and the chronic nature of lung function decline allows for preventive initiatives. Proinflammatory constituents of organic dust are considered a possible cause of compromised respiratory health. The aim of this systematic review was to reveal the impact of organic dust exposure on long-term change in lung function. The literature search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. Predefined criteria concerned study design: longitudinal, ≥1 year follow-up, ≥50 exposed; exposure measures: organic dust, measured or estimated, in different occupational settings; and outcome measures: change in lung function measured by spirometry. Based on these criteria, 1580 potentially relevant publications were narrowed down to 20 included publications. Quality was evaluated and discussed based on six objectively defined criteria. Overall, 14 studies found some type of association between exposure to organic dust and long-term change in lung function. However, the results were inconsistent and no specific work exposure showed more clear associations to change in lung function. Meta-analysis revealed an overall small significant excess loss in forced expiratory volume in the 1st s for exposed compared with controls of 4.92 mL/year (95% CI 0.14 to 9.69). No significant association was seen overall for forced vital capacity. 12 studies revealed a significant exposure-response relation between organic dust and change in lung function. The results were inconsistent across varying study design and different exposure measures and outcomes. We therefore conclude that there is limited evidence of a causal association between general exposure to organic dust and long-term excess decline in lung function.
Topics: Air Pollutants, Occupational; Dust; Endotoxins; Environmental Monitoring; Forced Expiratory Volume; Humans; Longitudinal Studies; Lung; Lung Diseases; Occupational Diseases; Occupational Exposure; Respiratory Function Tests; Spirometry
PubMed: 28404791
DOI: 10.1136/oemed-2016-103963 -
Journal of Education and Health... 2021New epidemiological studies acknowledge the detrimental effects of dust storms on health. The aim of this study was to systematically review the effects of dust storms... (Review)
Review
New epidemiological studies acknowledge the detrimental effects of dust storms on health. The aim of this study was to systematically review the effects of dust storms on the morbidity and mortality rates of cardiovascular and respiratory diseases. The results of this study were obtained based on articles published in English-language journals. For the purpose of this study, all articles published until the end of 2020 based on the search in the "Scopus," "Web of Science," and "PubMed" databases were selected. Articles were searched independently by two trained researchers. Dust storms are the cause of many diseases and health-related complications, of which cardiovascular and respiratory diseases are common. It is necessary to recognize and investigate the harmful effects of dust storms to prevent serious harms to human societies. In the reviewed articles, the impact of dust storms on several diseases, including cardiovascular and respiratory diseases, has been analyzed. Most of these articles acknowledge the effect of dust storms on increasing the incidence and mortality rate of these diseases, although in some articles this effect is not statistically significant. Many studies conducted around the world confirm the harmful effects of dust storms on cardiovascular and respiratory diseases, including increase in the number and duration of hospitalizations, as well as increase in mortality and exacerbation of these diseases. However, some studies do not consider the harmful effects of dust storms on the above diseases to be statistically significant.
PubMed: 34250125
DOI: 10.4103/jehp.jehp_1272_20 -
Toxicology Reports Dec 2023Heavy metals in street dust are one of the most important sources of pollutants in urban areas. This urban dust can be caused by industrial activities, traffic, erosion... (Review)
Review
BACKGROUND
Heavy metals in street dust are one of the most important sources of pollutants in urban areas. This urban dust can be caused by industrial activities, traffic, erosion of buildings, and fossil fuels. The aim of this systematic review is to evaluate the ecological risk of heavy metals in the dust of Iran's provinces.
METHODS
This study was conducted in February 2023 in order to investigate the environmental risks associated with heavy metals associated with dust particles in Iran. The present study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Finally, 9 studies were extracted from the search databases.
RESULTS
The ecological risk of heavy metals in the present study was as follows: Cd (258.26؛ CI: 83.53, 433) >Pb (52.58؛ CI: 37.15, 68.02) >Cu (24.44؛ CI: 16.74, 32.14)>Ni (14.75؛ CI: 12.68, 16.82)>As (13.53؛ CI: 10.20, 16.85)>Zn (6.32؛ CI: 3.76, 8.87)>V (3.18؛ CI: 2.65, 3.72)>Cr (2.73؛ CI: 2.19, 3.27)>Co (1.94؛ CI: 1.13, 2.74). The mean ranking of the studied Pb ecological risk is as follows: Shiraz.> Tehran > Ahvaz > Ilam > Abadan > Dezful.
CONCLUSION
The ecological risk potential of Cd in Tehran was also much higher than the standard. Therefore, Tehran was the most polluted city studied in terms of the ecological risk potential of Cd (1611.41؛ CI: 1605.98, 1616.84) and Pb (86.54؛ CI: 71.46, 101.62). The average concentration as well as the ecological risk of Cr, Co, and V metals were lower than the standard. Therefore, controlling the sources of heavy metal emissions (especially lead and cadmium) is highly recommended.
PubMed: 38075013
DOI: 10.1016/j.toxrep.2023.11.007 -
Journal of Indian Prosthodontic Society 2021This systematic review aims to identify and interpret results of studies that evaluated the changes in the color stability of maxillofacial prosthetic materials due to... (Meta-Analysis)
Meta-Analysis Review
AIM
This systematic review aims to identify and interpret results of studies that evaluated the changes in the color stability of maxillofacial prosthetic materials due to chemical instability of silicones and pigments and the effect of exposure to environmental conditions and aging factors on the same.
SETTINGS AND DESIGN
This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines (PRISMA).
MATERIALS AND METHODS
Relevant articles written in English only, before November 15, 2019, were identified using an electronic search in the PubMed/Medline conducted to identify pertinent articles. The relevancy of the articles was verified by screening the title, abstract, and full text, if they met the inclusion criteria. A total of 42 articles satisfied the criteria, from which data were extracted for qualitative synthesis. This review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO registration number CRD42019124562).
STATISTICAL ANALYSIS USED
Since considerable data heterogenicity was present in all studies except the ones on incorporation of TiO2 for which meta-analysis using random effects model was performed.
RESULTS
The database search resulted in 234 studies, of which 202 articles were excluded due to lack of relevance, duplication, and unavailability of data. The remaining 32 fulltext articles were assessed for eligibility, out of which 2 articles were excluded. Twelve articles were yielded by manual search. A total of 42 studies were included in the present systematic review. Due to heterogeneous data, meta-analysis could be only carried out with the effect of TiO nano particle on color stability.
CONCLUSIONS
Although there has been extensive amount of research in this field, an ideal maxillofacial silicone exhibiting good color stability in various human and environmental aging conditions is yet to be identified. Human and environmental aging conditions have an adverse effect on the color stability and addition of TiO nano particle seems to improve the same.
Topics: Humans; Silicone Elastomers
PubMed: 33938863
DOI: 10.4103/jips.jips_253_19 -
BioMed Research International 2021Evidence on the carcinogenicity of coalmine dust in occupational settings is still conflicting. Therefore, we conducted this research to evaluate the mortality risk of... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Evidence on the carcinogenicity of coalmine dust in occupational settings is still conflicting. Therefore, we conducted this research to evaluate the mortality risk of lung cancer for coalminers exposed to occupational dust when compared to population with no or low dust exposure.
METHODS
Databases of PubMed and Chinese National Knowledge Infrastructure as well as reference lists were searched updated to September 18, 2020. The enrolled articles should report lung cancer mortality risk for coalminers exposed to occupational dust. Basic information was extracted such as the author and publication year, area and ethnicity, the type and estimates of outcome, duration of follow-up, and the study design. The checklists from Agency for Healthcare Research and Quality and the Newcastle-Ottawa Scale were used for the assessment of quality and bias risk for descriptive studies, cohort studies, and case control studies, respectively. The overall relative risks were calculated while Begg's and Egger's tests and sensitivity analysis were performed to explore potential heterogeneity sources. Metaregression and subgroup analyses were also conducted to give more detailed information for the correlation between dust exposure and lung cancer mortality.
RESULTS
A total of 19 articles with 22 different studies (descriptive study, case control study, and cohort study) including 8909 observed deaths from 1964 to 2017 were enrolled with a significant heterogeneity ( = 95%, < 0.001). The pooled relative risk of mortality from lung cancer was 1.16 (1.03-1.30) for coalminers. Results of metaregression analysis indicated that the high heterogeneity among these enrolled studies might be caused by the ethnicity differences ( = 0.011). Subgroup analysis also indicated that the pooled estimate for Asian population in China was 4.94 (3.95-6.17) with = 39.3% and = 0.192. All these results suggested that exposure to occupational dust would significantly increase the mortality risk of lung cancer, especially for Asian population in China, which should be measured and controlled more strictly. . This systematic review and meta-analysis provides high-quality evidence that exposure to occupational dust might increase the mortality risk of lung cancer, especially for Asian populations in China. The magnitude of this effect is of major public health importance in view of the ubiquitous existence of coalmining industry in China and even in the world. However, these pooled estimates should be interpreted cautiously because of the high heterogeneity among these publications. . This study was supported by the National Key Research and Development Program of China (Grant No. 2016YFC1302501).
Topics: Coal; Coal Mining; Dust; Humans; Lung Neoplasms; Occupational Diseases; Occupational Exposure
PubMed: 33763477
DOI: 10.1155/2021/6624799 -
Chemosphere Dec 2023In recent years, the indoor exposure of organophosphate esters (OPEs) and novel brominated flame retardants (NBFRs) has received widespread attention worldwide. Using... (Review)
Review
Organophosphate esters (OPEs) and novel brominated flame retardants (NBFRs) in indoor dust: A systematic review on concentration, spatial distribution, sources, and human exposure.
In recent years, the indoor exposure of organophosphate esters (OPEs) and novel brominated flame retardants (NBFRs) has received widespread attention worldwide. Using published data on 6 OPEs in 23 countries (n = 1437) and 2 NBFRs in 18 countries (n = 826) in indoor dust, this study systematically reviewed the concentrations, spatial distribution, sources and exposure risk of 8 flame retardants (FRs) worldwide. Tris(chloroisopropyl)phosphate (TCIPP) is the predominant FR with a median concentration of 1050 ng g ΣCl-OPEs are significantly higher than Σnon-Cl-OPEs (p < 0.05). ΣOPEs in indoor dust from industrially-developed countries are higher than those from the countries lacking industrial development. Household appliances, electronics and plastic products are the main sources of non-Cl-OPEs and NBFRs, while interior decorations and materials contribute abundant Cl-OPEs in indoor dust. The mean hazard index (HI) of TCIPP for children is greater than 1, possibly posing non-cancer risk for children in some countries. The median ILCRs for 3 carcinogenic OPEs are all less than 10, suggesting no cancer risk induced by these compounds for both adults and children. This review helps to understand the composition, spatial pattern and human exposure risk of OPEs and NBFRs in indoor dust worldwide.
Topics: Child; Adult; Humans; Environmental Monitoring; Flame Retardants; Dust; Air Pollution, Indoor; Organophosphates; Esters; Environmental Exposure
PubMed: 37898464
DOI: 10.1016/j.chemosphere.2023.140560 -
BMC Public Health May 2021While the association between occupational inhalation of silica dust and pulmonary tuberculosis has been known for over a century, there has never been a published... (Meta-Analysis)
Meta-Analysis
BACKGROUND
While the association between occupational inhalation of silica dust and pulmonary tuberculosis has been known for over a century, there has never been a published systematic review, particularly of experience in the current era of less severe silicosis and treatable tuberculosis. We undertook a systematic review of the evidence for the association between (1) silicosis and pulmonary tuberculosis, and (2) silica exposure and pulmonary tuberculosis controlling for silicosis, and their respective exposure-response gradients.
METHODS
We searched PUBMED and EMBASE, and selected studies according to a priori inclusion criteria. We extracted, summarised and pooled the results of published case-control and cohort studies of silica exposure and/or silicosis and incident active tuberculosis. Study quality was assessed on the Newcastle-Ottawa Scale. Where meta-analysis was possible, effect estimates were pooled using inverse-variance weighted random-effects models. Otherwise narrative and graphic synthesis was undertaken. Confidence regarding overall effect estimates was assessed using the GRADE schema.
RESULTS
Nine studies met the inclusion criteria. Meta-analysis of eight studies of silicosis and tuberculosis yielded a pooled relative risk of 4.01 (95% confidence interval (CI) 2.88, 5.58). Exposure-response gradients were strong with a low silicosis severity threshold for increased risk. Our GRADE assessment was high confidence in a strong association. Meta-analysis of five studies of silica exposure controlling for or excluding silicosis yielded a pooled relative risk of 1.92 (95% CI 1.36, 2.73). Exposure-response gradients were observable in individual studies but not finely stratified enough to infer an exposure threshold. Our GRADE assessment was low confidence in the estimated effect owing to inconsistency and use of proxies for silica exposure.
CONCLUSIONS
The evidence is robust for a strongly elevated risk of tuberculosis with radiological silicosis, with a low disease severity threshold. The effect estimate is more uncertain for silica exposure without radiological silicosis. Research is needed, particularly cohort studies measuring silica exposure in different settings, to characterise the effect more accurately as well as the silica exposure threshold that could be used to prevent excess tuberculosis risk.
Topics: Dust; Humans; Occupational Exposure; Risk Factors; Silicon Dioxide; Silicosis
PubMed: 34016067
DOI: 10.1186/s12889-021-10711-1 -
The Science of the Total Environment Feb 2024A severe health crisis has been well-documented regarding dust particle exposure. We aimed to present the risk of all-cause, cardiovascular, and respiratory mortality... (Meta-Analysis)
Meta-Analysis Review
A severe health crisis has been well-documented regarding dust particle exposure. We aimed to present the risk of all-cause, cardiovascular, and respiratory mortality due to particulate matter (PM) exposure during non-dust and dust storm events by performing a meta-analysis. A systematic review of the literature was conducted by an online search of the databases (Google Scholar, Web of Science, Scopus, and PubMed) with no restrictions according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines until December 2022. We performed a random-effects model to compute the pooled rate ratio (RR) of mortality with 95 % confidence intervals (CI). The Office of Health Assessment and Translation (OHAT) risk of bias rating tool was prepared to assess the quality of the individual study. The registration number in PROSPERO was CRD42023423212. We found a 16 % (95 % CI: 0.7 %, 24 %) increase in all-cause, 25 % (95 % CI: 14 %, 37 %) increase in cardiovascular, and 18 % (95 % CI: 13 %, 22 %) increase in respiratory mortality per 10 μg/m increment in dust exposure. Furthermore, the RRs per 10 μg/m increment in PM were 1.046 (95 % CI: 1.019, 1.072)¸ 1.085 (95 % CI: 1.045, 1.0124), and 1.089 (95 % CI: 0.939, 1.24) for all-cause, cardiovascular, and respiratory mortality, respectively. PM during dust days significantly increased the all-cause (1.013, 95 % CI: 1.007, 1.018) cardiovascular mortality risk (1.014, 95 % CI: 1.009, 1.02). We also found significant evidence for all-cause, cardiovascular, and respiratory mortality among females and the elderly age group due to dust particle (PM and PM) exposure. Our results provided significant evidence about high concentrations of PM and PM during dust storm events related to mortality risk.
Topics: Humans; Air Pollutants; Air Pollution; Dust; Environmental Exposure; Mortality; Particulate Matter; Respiratory Tract Diseases
PubMed: 38042201
DOI: 10.1016/j.scitotenv.2023.168945