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Vaccine Jan 2008A review was conducted of all identified literature evaluating Moraxella bovis vaccines efficacy in preventing pinkeye in beef calves. From 292 publications identified... (Review)
Review
Assessment of methodological quality and sources of variation in the magnitude of vaccine efficacy: a systematic review of studies from 1960 to 2005 reporting immunization with Moraxella bovis vaccines in young cattle.
A review was conducted of all identified literature evaluating Moraxella bovis vaccines efficacy in preventing pinkeye in beef calves. From 292 publications identified by the search, data on 123 unique vaccine-to-control comparisons were extracted from 38 studies published in English from 1960 to 2005. Descriptive analysis was performed and an analysis of sources of variation evaluated. Use of methods to control bias such as randomization and blinding were associated with decreased vaccine efficacy. Only 15 trials reported using randomization and blinding. The authors conclude that when designing and reporting veterinary vaccination studies, researchers must include methodological quality information necessary to judge the evidence produced from the study.
Topics: Animals; Bacterial Vaccines; Cattle; Cattle Diseases; Drug Evaluation; Moraxella bovis; Moraxellaceae Infections
PubMed: 18054816
DOI: 10.1016/j.vaccine.2007.10.014 -
Animal Health Research Reviews Jun 2016Infectious bovine keratoconjunctivitis (IBK) is a common and important disease of calves. Without effective vaccines, antibiotic therapy is often implemented to minimize... (Meta-Analysis)
Meta-Analysis Review
Infectious bovine keratoconjunctivitis (IBK) is a common and important disease of calves. Without effective vaccines, antibiotic therapy is often implemented to minimize the impact of IBK. This review updates a previously published systematic review regarding comparative efficacy for antibiotic treatments of IBK. Available years of Centre for Biosciences and Agriculture International and MEDLINE databases were searched, including non-English results. Also searched were the American Association of Bovine Practitioners and World Buiatrics Congress conference proceedings from 1996 to 2016, reviews since 2013, reference lists from relevant trials, and U.S. Food and Drug Administration New Animal Drug Application summaries. Eligible studies assessed antibiotic treatment of naturally-occurring IBK in calves randomly allocated to group at the individual level. Outcomes of interest were clinical score, healing time, unhealed ulcer risk, and ulcer surface area. A mixed-effects model comparing active drug with placebo was employed for all outcomes. Heterogeneity was assessed visually and using Cochran's Q-test. Thirteen trials assessing nine treatments were included. Compared with placebo, most antibiotic treatments were effective. There was evidence that the treatment effect differed by day of outcome measurement. Visually, the largest differences were observed 7-14 days post-treatment. These results indicate improved IBK healing with many antibiotics and suggest the need for randomized trials comparing different antibiotic treatments.
Topics: Animals; Anti-Bacterial Agents; Bias; Cattle; Cattle Diseases; Keratoconjunctivitis, Infectious; Moraxella bovis; Moraxellaceae Infections
PubMed: 27427193
DOI: 10.1017/S1466252316000050