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Parasites & Vectors Mar 2021Schistosomiasis is a highly prevalent parasitic disease that can lead to adverse maternal and perinatal outcomes. To our knowledge, there has been no systematic review... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Schistosomiasis is a highly prevalent parasitic disease that can lead to adverse maternal and perinatal outcomes. To our knowledge, there has been no systematic review and meta-analysis of schistosomiasis during pregnancy.
METHODS
We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Relevant published studies were searched in international databases (PubMed, Science Direct, Scopus, Web of Science, and Google Scholar), from their inception until May 31, 2020. The retrieved studies were assessed for quality using the Modified Newcastle-Ottawa Scale. OpenMeta Analyst software was used for the statistical analysis.
RESULTS
Thirty-two studies enrolling 21024 pregnant women were included in this meta-analysis. All 32 of these studies were conducted in Africa. Of these studies, 19, 11, and 2 investigated S. mansoni, S. haematobium, and combined S. mansoni and S. haematobium infections, respectively. The pooled prevalence estimate of schistosomiasis during pregnancy was 13.2% (95 CI 11.0-15.4). A random model was used because of high heterogeneity (Q = 99.14; P < 0.001). In subgroup analyses, the pooled prevalence estimate of S. haematobium was significantly higher than the pooled prevalence estimates of S. mansoni [22.5% (95% CI 1.6-43.5) vs 8.7% (95% CI 6.0-11.3, P = 0.016), respectively]. The results of meta-regression analyses showed a non-significant difference in the prevalence of schistosomiasis during pregnancy according to the study sample sizes and year of publication. Only six studies evaluated the association between schistosomiasis during pregnancy and anemia. Schistosomiasis was associated with anemia in these six studies (OR = 3.02, 95% = 1.25‒7.28, P = 0.014).
CONCLUSION
The present meta-analysis suggests that schistosomiasis during pregnancy is an existing health problem. This meta-analysis also highlights the lack of data on the determinants and outcomes of schistosomiasis during pregnancy. Preventive measures are needed and could be part of antenatal care in areas endemic with schistosomiasis.
Topics: Africa; Anemia; Female; Humans; Pregnancy; Prevalence; Schistosomiasis; Schistosomiasis haematobia
PubMed: 33653391
DOI: 10.1186/s13071-021-04642-4 -
Microbial Pathogenesis Mar 2021Blastocystis is one of the most common pathogens of the human intestine, caused by an emerging parasite, which can lead to severe symptoms and even death in... (Meta-Analysis)
Meta-Analysis
Blastocystis is one of the most common pathogens of the human intestine, caused by an emerging parasite, which can lead to severe symptoms and even death in immunocompromised patients. We aimed to determine the global prevalence of Blastocystosis infection in people with immunodeficiency. A systematic literature search was conducted on Web of Science, Scopus, Google scholar, Science Direct and MEDLINE databases to select all observational studies reporting the prevalence of Blastocystosis infection in Worldwide, based on different diagnostic methods in immunocompromised patients of any age and published from inception to February 2019. Pooled estimates and 95% confidence intervals (95% CIs) were calculated using random effects models and in addition, the I statistic was calculated. The geographic distribution of studies was evaluated and the diagnosis of Blastocystis was compared by various techniques. Electronic databases were reviewed for Blastocystosis infection in HIV/AIDS, cancer and other immunocompromised patients, and meta-analyses were conducted to calculate the overall estimated prevalence. Total68 eligible studies were included. The estimated pooled prevalence rate of Blastocystosis infection in immunocompromised patients was overall 10% (95% CI, 7-13%; I 96.04%) (P < 0.001), of whom 21% [18-25] were in Australia, 12% [4-24] in America, 11% [6-17] in Europe and 10% [5-15], 7% [3-13] in Asia and Africa, respectively. It was calculated that the estimated pooled prevalence rate of Blastocystosis infection in immunocompromised patients was overall 10% and the prevalence estimates ranged from 0.44 to 72.39. Also, overall the prevalence of parasites co-infection in immunocompromised patients was detected as 0.024%. Our finding showed that immunocompromised people show a high prevalence of Blastocystosis infection compared to the control population. Adequate information on the prevalence rate is still missing from many countries. However, current information underscore that Blastocystis should not be neglected.
Topics: Africa; Animals; Asia; Australia; Blastocystis; Europe; Humans; Immunocompromised Host; Parasites; Prevalence
PubMed: 33246090
DOI: 10.1016/j.micpath.2020.104615 -
Veterinary Parasitology, Regional... Apr 2022Cryptosporidiosis is an infection caused by a protozoon that inhabits the gastrointestinal tract. More than forty valid species have been described in the genus... (Meta-Analysis)
Meta-Analysis Review
Cryptosporidiosis is an infection caused by a protozoon that inhabits the gastrointestinal tract. More than forty valid species have been described in the genus Cryptosporidium, infecting a broad range of hosts around the world, some with zoonotic transmission and others with predominant anthroponotic transmission. Prevalence studies conducted in Latin American countries have been specific, without consolidating information on species prevalences. Thus, the aim of this study was to perform a systematic review and meta-analysis addressing the prevalence of Cryptosporidium species in animals in Latin America. The estimated pooled prevalence rate for cryptosporidiosis in animals, by means of meta-analysis with a random-effects model, based on species identification, was 18.0% (95% CI 11.0%-27.0%) with high heterogeneity. The estimated overall prevalence was 20.3% (36/177) in pets, 19.9% (1309/6573) in livestock animals and 23.9% (954/3995) in exotic/captive animals. Evidence of circulation of 16 Cryptosporidium species was found in five Latin American countries: Brazil, Colombia, Chile, Argentina and Mexico. Through meta-analysis with a random-effects model, the pooled prevalence rate for Cryptosporidium parvum was 0.7% (95% CI 0.2%-2.4%). Cryptosporidium felis (8.5%) was the most prevalent species in pets, C. parvum (10.3%) in livestock animals and Cryptosporidium galli (17.6%) in exotic/captive animals. C. parvum was the species with the greatest geographical dispersion, which can be explained by its eurixenic and zoonotic potential. Few studies on cryptosporidiosis in animals in Latin America were found, which shows that there is a need for investment in and expansion of studies on this parasite. The pooled prevalence of C. parvum in Latin America and its wide circulation are similar to what has been observed in other developing regions, which reaffirms the importance of this species as the cause of a neglected, emerging and zoonotic parasitosis.
Topics: Animals; Cryptosporidiosis; Cryptosporidium; Genotype; Latin America; Livestock
PubMed: 35256118
DOI: 10.1016/j.vprsr.2022.100690 -
Pathogens (Basel, Switzerland) Jan 2022Filth flies, cockroaches, and dung beetles have been close neighbors with humans and animals throughout our joint histories. However, these insects can also serve as... (Review)
Review
Filth flies, cockroaches, and dung beetles have been close neighbors with humans and animals throughout our joint histories. However, these insects can also serve as vectors for many zoonotic enteric parasites (ZEPs). Zoonoses by ZEPs remain a paramount public health threat due to our close contact with animals, combined with poor water, sanitation, and hygiene access, services, and behaviors in many global regions. Our objective in this systematic review was to determine which ZEPs have been documented in these vectors, to identify risk factors associated with their transmission, and to provide effectual One Health recommendations for curbing their spread. Using PRISMA guidelines, a total of 85 articles published from 1926 to 2021 were reviewed and included in this study. Qualitative analysis revealed that the most common parasites associated with these insects included, but were not limited to: spp., spp., spp., and spp. Additionally, prominent risk factors discovered in the review, such as poor household and community WASH services, unsafe food handling, and exposure to domestic animals and wildlife, significantly increase parasitic transmission and zoonoses. The risk of insect vector transmission in our shared environments makes it critically important to implement a One Health approach in reducing ZEP transmission.
PubMed: 35056038
DOI: 10.3390/pathogens11010090 -
Vector Borne and Zoonotic Diseases... Jun 2013Urban Norway and black rats (Rattus norvegicus and Rattus rattus) are the source of a number of pathogens responsible for significant human morbidity and mortality in... (Review)
Review
Urban Norway and black rats (Rattus norvegicus and Rattus rattus) are the source of a number of pathogens responsible for significant human morbidity and mortality in cities around the world. These pathogens include zoonotic bacteria (Leptospira interrogans, Yersina pestis, Rickettsia typhi, Bartonella spp., Streptobacillus moniliformis), viruses (Seoul hantavirus), and parasites (Angiostrongylus cantonensis). A more complete understanding of the ecology of these pathogens in people and rats is critical for determining the public health risks associated with urban rats and for developing strategies to monitor and mitigate those risks. Although the ecology of rat-associated zoonoses is complex, due to the multiple ways in which rats, people, pathogens, vectors, and the environment may interact, common determinants of human disease can still be identified. This review summarizes the ecology of zoonoses associated with urban rats with a view to identifying similarities, critical differences, and avenues for further study.
Topics: Animals; Bacterial Infections; Cities; Disease Reservoirs; Ecology; Humans; Male; Parasitic Diseases; Public Health; Rats; Risk Factors; Rodent Diseases; Virus Diseases; Zoonoses
PubMed: 23590323
DOI: 10.1089/vbz.2012.1195 -
Veterinary Parasitology, Regional... Sep 2022Trichostrongylid nematodes can cause serious loss in the livestock economy; nevertheless, infections with these ubiquitous nematodes in animals from developing countries... (Meta-Analysis)
Meta-Analysis Review
Trichostrongylid nematodes can cause serious loss in the livestock economy; nevertheless, infections with these ubiquitous nematodes in animals from developing countries are largely neglected. The present paper provides a systematic review and meta-analysis to evaluate the status of trichostrongyle infections in domestic ruminants from Egypt. Out of 626 collected publications, 118 were defined suitable for inclusion in this review and represented trichostrongyle infections in 5 ruminant species (sheep, goats, cattle, buffaloes and camels) from Egypt. Published surveys have mostly focused on sheep, which had the highest (44.8%) pooled prevalence of trichostrongyle infections based on 95% confidence interval (35.9-53.6%) with no significant variations among sheep in different Egyptian regions. Goats had lower infection prevalence (31.2%, 21.5-40.8%) in comparison to sheep, and no significant regional differences were also found. The management and marketing practices likely account for the wide distribution of infection among small ruminants across Egypt. Variable trichostrongyle infection rates were estimated for camels (38.8%, 28.9-48.7%), cattle (27.4%, 14.4-40.3%) and buffaloes (12.2%, 8.0-16.4%). The prevalence of infection was significantly high during winter (52.1%, 32.2-72.1%), which provide favorable conditions for development and survival of larvae on pastures. The most common trichostrongyle identified in infected animals was Haemonchus contortus. The parasite was detected in 38.8% (29.9-47.6%) of infected sheep, 35.3% (24.8-45.7%) of infected goats and in 40.6% (18.6-62.5%) of infected camels. Clinical infections have been reported in a limited number of studies. Analysis of fecal egg counts (FECs) revealed that more than half (52.7%, 30.4-75.0%) of the tested sheep had low counts (<500 eggs per gram EPG), whereas only a few sheep (6.1%, 3.5-8.7%) had high counts >2000 EPG, implying that subclinical infections are common; however, the clinical infections cannot be completely ruled out. Anthelmintic resistance does not appear to be serious in trichostrongyle populations infecting ruminants from Egypt; nonetheless there have been a few cases of albendazole resistance in trichostrongyles infecting sheep. This paper contributes to a better understanding of the epidemiology and economic implications of trichostrongyle infections in ruminants from Egypt, which is crucial for establishing effective control strategies against these ubiquitous nematodes.
Topics: Animals; Bison; Buffaloes; Camelus; Cattle; Cattle Diseases; Egypt; Goat Diseases; Goats; Nematoda; Sheep; Sheep Diseases
PubMed: 36041796
DOI: 10.1016/j.vprsr.2022.100761 -
Parasites & Vectors Nov 2012Toxoplasmosis is a disease caused by Toxoplasma gondii and at least one-third of the world's population has detectable T. gondii antibodies. The seroprevalence of... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Toxoplasmosis is a disease caused by Toxoplasma gondii and at least one-third of the world's population has detectable T. gondii antibodies. The seroprevalence of T.gondii ranges from 15% to 50% among the Mexican general population. The aim of this work was to determine the mean prevalence and weighted mean prevalence of T. gondii infection, and to evaluate the epidemiological transition of infection in Mexico.
METHODS
Pub Med, Lilacs, Medline, Latindex, Google Scholar data bases were searched to retrieve reports from 1951 up to 2012 regarding prevalence data, diagnostic tests and risk factors of infection among the adult population. Data collection and criteria eligibility was established in order to determine the crude prevalence (proportion of positive cases) of each study, together with weighted population prevalence according to individual research group categories to limit the bias that may impose the heterogeneous nature of the reports. A Forest Plot chart and linear regression analysis were performed by plotting the prevalence of infection reported from each study over a period of sixty years.
RESULTS
A total of 132 studies were collected from 41 publications that included 70,123 individuals. The average mean prevalence was 27.97%, and weighted mean prevalence was 19.27%. Comparisons among different risk groups showed that the weighted prevalence was higher in women with miscarriages (36.03%), immunocompromised patients (28.54%), mentally-ill patients (38.52%) and other risk groups (35.13%). Toxoplasma infection among the Mexican population showed a downward trend of 0.1%/year over a period of sixty years that represents a 5.8% reduction in prevalence.
CONCLUSIONS
This analysis showed a downward trend of infection; however, there are individuals at high risk for infection such as immunocompromised patients, mentally-ill patients and pregnant women. Further research is required to provide better prevention strategies, effective diagnostic testing and medical management of patients. Educational efforts are required to avoid the transmission of infection in populations that cannot be controlled by drugs alone.
Topics: Abortion, Spontaneous; Antibodies, Protozoan; Databases, Factual; Female; Humans; Immunocompromised Host; Male; Mental Disorders; Mexico; Pregnancy; Pregnancy Complications, Parasitic; Prevalence; Risk Factors; Seroepidemiologic Studies; Toxoplasma; Toxoplasmosis
PubMed: 23181616
DOI: 10.1186/1756-3305-5-271 -
Acta Tropica Jan 2023Giardia is an ubiquitous protozoa that infect a broad range of vertebrate hosts, including domestic and wild animals as well as humans. Giardia duodenalis is one of the... (Review)
Review
Giardia is an ubiquitous protozoa that infect a broad range of vertebrate hosts, including domestic and wild animals as well as humans. Giardia duodenalis is one of the most common parasite in humans and mammals worldwide. Human giardiasis is highly prevalent in the countries that make up from Amazon. The identification of genotypes in humans and animals improves the understanding of transmission routes and the control strategies. Thus, we carried out a systematic review on Giardia in animals from Amazon region/South American, following the PRISMA guidelines. Studies up to September, 2022 were searched for in public database. A total of seven out of 432 articles were selected: four, two and one from Brazil, Colombia and Peru, respectively. Based on these articles it is seen that the G. duodenalis cosmopolitan assemblages A and B prevail within domestic and wild animals in the Amazon. Moreover, a Giardia microscopic screening in aquatic animals from this biome showed its prevalence among aquatic mammals including the endangered species Trichechus inunguis (manatee). Therefore, a yet not accessed number of susceptible hosts, new G. duodenalis assemblages and species can be occurring in this huge hotspot of biodiversity that is Amazon region.
Topics: Animals; Humans; Giardia lamblia; Animals, Wild; Feces; Giardiasis; Giardia; Genotype; Prevalence; Gastropoda; Mammals
PubMed: 36195184
DOI: 10.1016/j.actatropica.2022.106708 -
Environmental Pollution (Barking, Essex... Nov 2018Toxocariasis is a neglected tropical disease of humans. Although many studies have indicated or shown that environmental contamination with Toxocara species eggs is a... (Meta-Analysis)
Meta-Analysis Review
Toxocariasis is a neglected tropical disease of humans. Although many studies have indicated or shown that environmental contamination with Toxocara species eggs is a major risk factor for toxocariasis in humans, there has been no comprehensive analysis of published data or information. Here, we conducted the first systematic review and meta-analysis of current literature to assess the global prevalence of Toxocara eggs in public places (including beaches, parks and playgrounds). We conducted searches of the PubMed, Embase, Scopus and Science Direct databases for relevant studies published until 20 April 2018, and assessed the prevalence rates of Toxocara eggs in public places. We used the random effects model to calculate pooled prevalence estimates, with 95% confidence intervals (CIs), and analysed data in relation to WHO geographical regions. Subgroup analysis and meta-regressions regarding the geographical and environmental variables were also performed. Of 2384 publications identified, 109 studies that tested 42,797 soil samples in 40 countries were included in the meta-analysis. The pooled global prevalence of Toxocara eggs in public places was 21% (95% CI, 16-27%; 13,895/42,797). The estimated prevalence rates in the different WHO regions ranged from 13% to 35%: Western Pacific (35%; 95% CI, 15-58%), Africa (27%; 95% CI, 11-47%), South America (25%; 95% CI, 13-33%), South-East Asia (21%; 95% CI, 3-49%), Middle East and North Africa (18%; 95% CI, 11-24%), Europe (18%; 95% CI, 14-22%), and North and Central Americas (13%; 95% CI, 8-23%). A high prevalence was significantly associated with high geographical longitude (P = 0.04), low latitude (P = 0.02) and high relative environmental humidity (P = 0.04). This meta-analysis of data from published records indicates that public places are often heavily contaminated with eggs of Toxocara. This finding calls for measures to reduce the potential risk of infection and disease in humans.
Topics: Animals; Environmental Microbiology; Environmental Monitoring; Parasite Egg Count; Soil; Soil Pollutants; Toxocara
PubMed: 30142562
DOI: 10.1016/j.envpol.2018.07.087 -
Parasitology Research Jan 2015Toxoplasmosis, a cosmopolitan parasitic infection caused by Toxoplasma gondii, is frequently found in meat-producing animals and human beings. This review and... (Meta-Analysis)
Meta-Analysis Review
Toxoplasmosis, a cosmopolitan parasitic infection caused by Toxoplasma gondii, is frequently found in meat-producing animals and human beings. This review and meta-analysis study was performed to evaluate the overall prevalence of T. gondii infection among sheep and goats in Iran. Data were systematically collected from 1977 to 2012 in Iran on the following electronic databases: PubMed, Google Scholar, Science Direct, Scopus, Web of Science, Magiran, Irandoc, IranMedex, and Scientific Information Database (SID). Additionally, abstracts of national scientific congresses and dissertations were included. A total of 34 articles in field of sheep and 18 articles about goat toxoplasmosis, totalizing to the examination of 14,372 sheep and 3,120 goats, reporting prevalence of toxoplasmosis from different regions of Iran fulfilled our eligibility criteria. The overall prevalence rate of toxoplasmosis in Iran was estimated to be 31% (95% confidence interval (CI) = 0.259825 to 0.352382) in sheep and 27% (95% CI = 0.140097 to 0.424782) in goats, respectively. There was no significant difference in infection rate between males and females among sheep (odds ratio (OR) = 1.002, 95% CI = 0.59 to 1.696) and goats (OR = 1.027, 95% CI = 0.685 to 1.541). Analysis revealed that infection rate in sheep over than 1 year old was 2.4 times more than that in less than 1 year old (OR = 2.396, 95% CI = 1.050 to 5.467). This systematic review and meta-analysis study revealed that infection is widespread in Iran. Further studies are required to improve strategies for controlling infection among flocks and consequently in human population.
Topics: Animals; Female; Goat Diseases; Goats; Iran; Male; Prevalence; Sheep; Sheep Diseases; Toxoplasma; Toxoplasmosis, Animal
PubMed: 25378258
DOI: 10.1007/s00436-014-4176-2