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International Archives of Occupational... Aug 2022The aim of this study was to determine the effectiveness of educational interventions aimed at agricultural workers' knowledge, behaviour, and risk perception for... (Meta-Analysis)
Meta-Analysis Review
The effectiveness of educational interventions aimed at agricultural workers' knowledge, behaviour, and risk perception for reducing the risk of pesticide exposure: a systematic review and meta-analysis.
AIM
The aim of this study was to determine the effectiveness of educational interventions aimed at agricultural workers' knowledge, behaviour, and risk perception for reducing the risk of pesticide exposure.
METHOD
All studies published in the English language between the years 2000 and 2020 were screened on relevant databases. The study protocol was registered on PROSPERO. Randomised controlled studies (RCTs) and quasi-experimental studies meeting the inclusion and exclusion criteria according to the PICOS criteria were included. In line with the PRISMA flow diagram, 38 studies were included in the systematic review and meta-analysis. Risk of bias was assessed with the Cochrane risk-of-bias assessment tool. A random-effects model was applied and Hedge's g was used to calculate effect size.
FINDINGS
Five of the included studies are RCTs, two are cluster RCTs, 17 are quasi-experimental studies with experimental and control groups, and 14 have single-group pretest-posttest study designs. Educational interventions had a large effect on knowledge level (Hedge's g = 0.890), a medium effect on behaviour level (Hedge's g = 0.707), and a small effect on risk perception (Hedge's g = 0.377). No publication bias was detected. The largest effect of educational interventions on both knowledge and behaviour levels belonged to studies grounded on a theoretical basis and carried out between the years 2011 and 2020.
CONCLUSION
It was determined that educational interventions are an appropriate method for reducing the pesticide exposure risks of agricultural workers. To increase the effectiveness of these interventions, it is recommended that consideration is given to a theoretical basis, the use of multiple education components, and evidence-based practices.
Topics: Bias; Farmers; Humans; Perception; Pesticides
PubMed: 35103845
DOI: 10.1007/s00420-022-01838-8 -
Current Diabetes Reviews 2020Organophosphate (OP) pesticides are extremely poisonous and they affect the glucose breakdown in numerous and mechanism. There are higher evidence of stimulating...
Organophosphate (OP) pesticides are extremely poisonous and they affect the glucose breakdown in numerous and mechanism. There are higher evidence of stimulating diabetes mellitus through OP pesticides especially the type II diabetes. The upsurge in the level of glucose (hyperglycemia), and insulin resistance along with their related outcomes are discussed in this review. The data related to investigational and clinical techniques endorse a connection amid such molecular mechanism and compounds of OPs. Numerous studies conducted till March 2018 have reported OP' exposures and diabetes-related outcomes. The acute and chronic exposure in case of these insecticides and diabetesrelated outcomes are defined in this study. Initially, it was declared that OPs prompt to hyperglycemia. Then, a high association of glucose in blood beside insulin was found out. The affirmation from some clinical as well as investigational studies supported a connection amid exposure to OP and diabetes, yet in maximum number of instances, non-specific diabetes occurs.
Topics: Diabetes Mellitus, Type 2; Humans; Hydrocarbons, Chlorinated; Hyperglycemia; Insulin Resistance; Lipid Metabolism; Obesity; Organophosphates; Pancreas; Pesticides
PubMed: 31544698
DOI: 10.2174/1573399815666190712192844 -
Neurotoxicology Oct 2012It has been suggested that exposure to pesticides might be involved in the etiology of Parkinson's disease (PD). We conducted an updated systematic review of the... (Review)
Review
It has been suggested that exposure to pesticides might be involved in the etiology of Parkinson's disease (PD). We conducted an updated systematic review of the epidemiologic literature over the past decade on the relationship between pesticide exposure and PD, using the MEDLINE database. Despite methodological differences, a significantly increased PD risk was observed in 13 out of 23 case-control studies that considered overall exposure to pesticides (risk estimates of 1.1-2.4) and in 10 out of 12 studies using other research designs (risk estimates of 2 or higher). Various studies found stronger associations in genetically susceptible individuals. Among a growing number of studies on the effects of exposure to specific pesticides (n=20), an increased PD risk has been associated with insecticides, especially chlorpyrifos and organochlorines, in six studies (odds ratios of 1.8-4.4), and with the herbicide paraquat, the fungicide maneb or the combination of both. Findings considerably strengthen the evidence that exposure to pesticides in well water may contribute to PD, whereas studies of farming and rural residence found inconsistent or little association with the disease. Taken together, this comprehensive set of results suggests that the hypothesis of an association between pesticide exposure and PD cannot be ruled out. However, inadequate data on consistent responses to exposure hinder the establishment of a causal relationship with PD. Given the extensive worldwide use of many pesticides, further studies are warranted in larger populations that include detailed quantitative data on exposure and determination of genetic polymorphisms.
Topics: Databases, Factual; Environmental Exposure; Humans; Occupational Diseases; Parkinson Disease; Pesticides
PubMed: 22627180
DOI: 10.1016/j.neuro.2012.05.011 -
Critical Reviews in Analytical Chemistry 2023Brazil annually produces around 43 million tons of fruits and vegetables. Therefore, large amounts of pesticides are needed to grow these foods. The use of unauthorized... (Review)
Review
Brazil annually produces around 43 million tons of fruits and vegetables. Therefore, large amounts of pesticides are needed to grow these foods. The use of unauthorized or indiscriminate pesticides can lead to the adherence of residues of these compounds to the product in a concentration above the maximum residue limit (MRL). Pesticide residues (PRs) monitoring is a continuous challenge due to several factors influencing the detection of these compounds in the food matrix. Currently, several adaptations to conventional techniques have been developed to minimize these problems. This systematic review presents the main information obtained from 52 research articles, taken from five databases, on changes and advances in Brazil in sample preparation methods for determining PRs in fruits and vegetables in the last nine years. We cover the preexisting ones and some others that might be suitable alternatives approaches. In addition, we present a brief discussion on the monitoring of PRs in different Brazilian regions, and we found that residues belonging to the organophosphate and pyrethroid classes were detected more frequently. Approximately 67% of the residues detected are of irregular use in 28 types of fruits and vegetables commonly consumed and exported by Brazil.
Topics: Pesticide Residues; Vegetables; Fruit; Brazil; Pesticides; Food Contamination
PubMed: 34908509
DOI: 10.1080/10408347.2021.2013157 -
BMC Public Health Jun 2016A study in frog and chicken embryos, and reports of a high incidence of birth defects in regions of intensive GM-soy planting have raised concerns on the teratogenic... (Review)
Review
BACKGROUND
A study in frog and chicken embryos, and reports of a high incidence of birth defects in regions of intensive GM-soy planting have raised concerns on the teratogenic potential of glyphosate-based herbicides. These public concerns prompted us to conduct a systematic review of the epidemiological studies testing hypotheses of associations between glyphosate exposure and adverse pregnancy outcomes including birth defects.
METHODS
A systematic and comprehensive literature search was performed in MEDLINE, TOXLINE, Bireme-BVS and SCOPUS databases using different combinations of exposure and outcome terms. A case-control study on the association between pesticides and congenital malformations in areas of extensive GM soy crops in South America, and reports on the occurrence of birth defects in these regions were reviewed as well.
RESULTS
The search found ten studies testing associations between glyphosate and birth defects, abortions, pre-term deliveries, small for gestational date births, childhood diseases or altered sex ratios. Two additional studies examined changes of time-to-pregnancy in glyphosate-exposed populations. Except for an excess of Attention Deficit Hyperactivity Disorder - ADHD (OR = 3.6, 1.3-9.6) among children born to glyphosate appliers, no significant associations between this herbicide and adverse pregnancy outcomes were described. Evidence that in South American regions of intensive GM-soy planting incidence of birth defects is high remains elusive.
CONCLUSIONS
Current epidemiological evidence, albeit limited to a few studies using non-quantitative and indirect estimates and dichotomous analysis of exposures, does not lend support to public concerns that glyphosate-based pesticides might pose developmental risks to the unborn child. Nonetheless, owing to methodological limitations of existing analytical observational studies, and particularly to a lack of a direct measurement (urine and/or blood levels), or an indirect estimation of exposure that has proven valid, these negative findings cannot be taken as definitive evidence that GLY, at current levels of occupational and environmental exposures, brings no risk for human development and reproduction.
Topics: Abortion, Spontaneous; Agriculture; Case-Control Studies; Congenital Abnormalities; Environmental Exposure; Epidemiologic Studies; Female; Glycine; Herbicides; Humans; Incidence; Infant, Newborn; Male; Pregnancy; Pregnancy Outcome; South America; Glyphosate
PubMed: 27267204
DOI: 10.1186/s12889-016-3153-3 -
Environmental Health Perspectives Oct 2009We conducted a systematic review and meta-analysis of childhood leukemia and parental occupational pesticide exposure. (Meta-Analysis)
Meta-Analysis Review
OBJECTIVES
We conducted a systematic review and meta-analysis of childhood leukemia and parental occupational pesticide exposure.
DATA SOURCES
Searches of MEDLINE (1950-2009) and other electronic databases yielded 31 included studies.
DATA EXTRACTION
Two authors independently abstracted data and assessed the quality of each study.
DATA SYNTHESIS
Random effects models were used to obtain summary odds ratios (ORs) and 95% confidence intervals (CIs). There was no overall association between childhood leukemia and any paternal occupational pesticide exposure (OR = 1.09; 95% CI, 0.88-1.34); there were slightly elevated risks in subgroups of studies with low total-quality scores (OR = 1.39; 95% CI, 0.99-1.95), ill-defined exposure time windows (OR = 1.36; 95% CI, 1.00-1.85), and exposure information collected after offspring leukemia diagnosis (OR = 1.34; 95% CI, 1.05-1.70). Childhood leukemia was associated with prenatal maternal occupational pesticide exposure (OR = 2.09; 95% CI, 1.51-2.88); this association was slightly stronger for studies with high exposure-measurement-quality scores (OR = 2.45; 95% CI, 1.68-3.58), higher confounder control scores (OR = 2.38; 95% CI, 1.56-3.62), and farm-related exposures (OR = 2.44; 95% CI, 1.53-3.89). Childhood leukemia risk was also elevated for prenatal maternal occupational exposure to insecticides (OR = 2.72; 95% CI, 1.47-5.04) and herbicides (OR = 3.62; 95% CI, 1.28-10.3).
CONCLUSIONS
Childhood leukemia was associated with prenatal maternal occupational pesticide exposure in analyses of all studies combined and in several subgroups. Associations with paternal occupational pesticide exposure were weaker and less consistent. Research needs include improved pesticide exposure indices, continued follow-up of existing cohorts, genetic susceptibility assessment, and basic research on childhood leukemia initiation and progression.
Topics: Child; Child, Preschool; Environmental Exposure; Female; Humans; Leukemia; Male; Maternal Exposure; Occupational Exposure; Paternal Exposure; Pesticides
PubMed: 20019898
DOI: 10.1289/ehp.0900582 -
Mutation Research. Reviews in Mutation... 2019Glyphosate is the most widely used broad-spectrum systemic herbicide in the world. Recent evaluations of the carcinogenic potential of glyphosate-based herbicides (GBHs)... (Meta-Analysis)
Meta-Analysis
Glyphosate is the most widely used broad-spectrum systemic herbicide in the world. Recent evaluations of the carcinogenic potential of glyphosate-based herbicides (GBHs) by various regional, national, and international agencies have engendered controversy. We investigated whether there was an association between high cumulative exposures to GBHs and increased risk of non-Hodgkin lymphoma (NHL) in humans. We conducted a new meta-analysis that includes the most recent update of the Agricultural Health Study (AHS) cohort published in 2018 along with five case-control studies. Using the highest exposure groups when available in each study, we report the overall meta-relative risk (meta-RR) of NHL in GBH-exposed individuals was increased by 41% (meta-RR = 1.41, 95% confidence interval, CI: 1.13-1.75). For comparison, we also performed a secondary meta-analysis using high-exposure groups with the earlier AHS (2005), and we calculated a meta-RR for NHL of 1.45 (95% CI: 1.11-1.91), which was higher than the meta-RRs reported previously. Multiple sensitivity tests conducted to assess the validity of our findings did not reveal meaningful differences from our primary estimated meta-RR. To contextualize our findings of an increased NHL risk in individuals with high GBH exposure, we reviewed publicly available animal and mechanistic studies related to lymphoma. We documented further support from studies of malignant lymphoma incidence in mice treated with pure glyphosate, as well as potential links between glyphosate / GBH exposure and immunosuppression, endocrine disruption, and genetic alterations that are commonly associated with NHL or lymphomagenesis. Overall, in accordance with findings from experimental animal and mechanistic studies, our current meta-analysis of human epidemiological studies suggests a compelling link between exposures to GBHs and increased risk for NHL.
Topics: Carcinogens; Glycine; Herbicides; Humans; Lymphoma, Non-Hodgkin; Risk; Glyphosate
PubMed: 31342895
DOI: 10.1016/j.mrrev.2019.02.001 -
The Science of the Total Environment Feb 2021Fish cholinesterases (ChEs) - like acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) - are common biomarkers of environmental contamination due to their... (Meta-Analysis)
Meta-Analysis
Fish cholinesterases (ChEs) - like acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) - are common biomarkers of environmental contamination due to their sensitivity to a variety of toxicants. To understand pesticide effects on fish ChEs mean activity and variability, we conducted a systematic review and meta-analyses. Our goal was to verify (i) if brain and muscle ChEs responded differently to pesticide exposure; (ii) how fish size and life stage (i.e., juvenile and adult) influence ChEs variability and mean activity; (iii) what type of pesticides (i.e., herbicide, insecticide, and fungicide) has the strongest effect, and if the analytical-grade compounds differ from commercial formulations; (iv) if increasing concentrations combined with prolonged exposure leads to stronger ChEs inhibition; and (v) how each class of pesticide affects these enzymes. We validated ChEs reliability as biomarkers and identified factors influencing their response. Regardless of tissue, BChE response was more variable than AChE, and no difference between their average activity was detected. The size of juvenile fish is an important factor affecting ChEs mean activity and variability, whereas pesticide had no significant effect on adult fish ChEs. Insecticides were stronger inhibitors compared to herbicides and fungicides. Analytical-grade compounds decreased ChEs mean activity to a higher degree than commercial formulations. The combined effect of concentration and time was only significant for fungicides and insecticides. Among classes, organophosphorus insecticides had the strongest effect on ChEs, followed by carbamates, organochlorines, and pyrethroids. Organophosphorus herbicides and oxazolidinones were the only herbicides to decrease ChEs mean activity significantly, and their effects were similar from those of pyrethroids and organochlorines. Additionally, our results identified research gaps, such as the small number of studies on fungicides, neonicotinoids and other relevant pesticides. These findings suggest future directions, which might help researchers identify robust cause-effect relationships between fish ChEs and pesticides.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Insecticides; Pesticides; Reproducibility of Results
PubMed: 33248758
DOI: 10.1016/j.scitotenv.2020.143829 -
Environmental Health : a Global Access... Nov 2023Early life exposure to lead, mercury, polychlorinated biphenyls (PCBs), polybromide diphenyl ethers (PBDEs), organophosphate pesticides (OPPs), and phthalates have been... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Early life exposure to lead, mercury, polychlorinated biphenyls (PCBs), polybromide diphenyl ethers (PBDEs), organophosphate pesticides (OPPs), and phthalates have been associated with lowered IQ in children. In some studies, these neurotoxicants impact males and females differently. We aimed to examine the sex-specific effects of exposure to developmental neurotoxicants on intelligence (IQ) in a systematic review and meta-analysis.
METHOD
We screened abstracts published in PsychINFO and PubMed before December 31st, 2021, for empirical studies of six neurotoxicants (lead, mercury, PCBs, PBDEs, OPPs, and phthalates) that (1) used an individualized biomarker; (2) measured exposure during the prenatal period or before age six; and (3) provided effect estimates on general, nonverbal, and/or verbal IQ by sex. We assessed each study for risk of bias and evaluated the certainty of the evidence using Navigation Guide. We performed separate random effect meta-analyses by sex and timing of exposure with subgroup analyses by neurotoxicant.
RESULTS
Fifty-one studies were included in the systematic review and 20 in the meta-analysis. Prenatal exposure to developmental neurotoxicants was associated with decreased general and nonverbal IQ in males, especially for lead. No significant effects were found for verbal IQ, or postnatal lead exposure and general IQ. Due to the limited number of studies, we were unable to analyze postnatal effects of any of the other neurotoxicants.
CONCLUSION
During fetal development, males may be more vulnerable than females to general and nonverbal intellectual deficits from neurotoxic exposures, especially from lead. More research is needed to examine the nuanced sex-specific effects found for postnatal exposure to toxic chemicals.
Topics: Child; Pregnancy; Humans; Male; Female; Polychlorinated Biphenyls; Lead; Sex Characteristics; Halogenated Diphenyl Ethers; Mercury; Insecticides; Organophosphorus Compounds; Prenatal Exposure Delayed Effects
PubMed: 37978510
DOI: 10.1186/s12940-023-01029-z -
Journal of the European Academy of... Sep 2022
Meta-Analysis
Topics: Humans; Occupational Exposure; Pemphigus; Pesticides
PubMed: 35607897
DOI: 10.1111/jdv.18258