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Acta Neuropsychiatrica Apr 2021The present study was designed to test the hypothesis that there is a reduction in the activity of the enzyme cytochrome c oxidase (Cox) in Alzheimer's disease (AD). (Comparative Study)
Comparative Study Meta-Analysis
OBJECTIVE
The present study was designed to test the hypothesis that there is a reduction in the activity of the enzyme cytochrome c oxidase (Cox) in Alzheimer's disease (AD).
METHODS
Systematic review of literature and meta-analysis were used with data obtained from the PubMed, Scopus, MEDLINE, Lilacs, Eric and Cochrane. The keywords were Alzheimer's AND Cox AND mitochondria; Alzheimer's AND Cox AND mitochondria; Alzheimer's AND complex IV AND mitochondria. A total of 1372 articles were found, 23 of them fitting the inclusion criteria. The data were assembled in an Excel spreadsheet and analysed using the RevMan software. A random effects model was adopted to the estimative of the effect.
RESULTS
The data shows a significant decrease in the activity of the Cox AD patients and animal models.
CONCLUSION
Cox enzyme may be an important molecular component involved in the mechanisms underlying AD. Therefore, this enzyme may represent a possible new biomarker for the disease as a complementary diagnosis and a new treatment target for AD.
Topics: Alzheimer Disease; Animals; Colorimetry; Electron Transport Complex IV; Humans; Mice; Mitochondria; Models, Animal; Polarography; Rats; Software; Spectrophotometry
PubMed: 33256871
DOI: 10.1017/neu.2020.43