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Frontiers in Psychology 2021Studies of creativity emerging from cultural psychology and social psychology perspectives challenge individualist conceptions of creativity to argue that social...
Studies of creativity emerging from cultural psychology and social psychology perspectives challenge individualist conceptions of creativity to argue that social interaction, communication, and collaboration are key elements in creativity. In recent work creative collaboration has been proposed to be "distributed" between audiences, materials, embodied actions, and the historico-socio-cultural affordances of the creative activity and environment, thus expanding the potentialities of creative collaboration beyond instances of direct human interaction and engagement. Music performance, improvisation and composition may be viewed as exemplary "laboratories" of creative collaboration through the combined elements of audiences, materials, embodied actions and historico-socio-cultural affordances and constraints. This article reports the findings of a systematic literature review of creative collaboration and collaborative creativity in music. We sought to identify what has been currently investigated in relation to these terms and concepts in music, with what methodologies and in what settings. Findings indicate that studies were undertaken in higher education, professional development and professional practice predominantly, leading to an emergent phenomenon of interest, collaborative creative learning. Musical genres were jazz, popular, western classical, contemporary and world musics across the musical processes of composing, improvising and performing. Studies in higher education and professional development settings focused on identifying those practices that supported learning rather than the nature of collaborative creative approaches or the outcomes of creative collaboration. Participants were primarily male, with small sample sizes. Methodologies were largely qualitative with an emphasis on case study using observation, interview and reflective diary methods. Further areas for research include: the investigation of gendered approaches to creative collaboration, collaborative creativity, and collaborative creative learning; the use of more diverse research methodologies and methods and techniques including large-scale quantitative studies and arts-based and arts-led approaches; and the investigation of more diverse music settings.
PubMed: 34434151
DOI: 10.3389/fpsyg.2021.713445 -
Critical Reviews in Oncology/hematology Apr 2021Glioblastoma, the most common primary brain malignancy, is an exceptionally fatal cancer. Lack of suitable biomarkers and efficient treatment largely contribute to the... (Review)
Review
Glioblastoma, the most common primary brain malignancy, is an exceptionally fatal cancer. Lack of suitable biomarkers and efficient treatment largely contribute to the therapy failure. Cytoskeletal proteins are crucial proteins in glioblastoma pathogenesis and can potentially serve as biomarkers and therapeutic targets. Among them, GFAP, has gained most attention as potential diagnostic biomarker, while vimentin and microtubules are considered as prospective therapeutic targets. Microtubules represent one of the best anti-cancer targets due to their critical role in cell proliferation. Despite testing in clinical trials, the efficiency of taxanes, epothilones, vinca-domain binding drugs, colchicine-domain binding drugs and γ-tubulin binding drugs remains to be confirmed. Moreover, tumor treating field that disrupts microtubules draw attention because of its high efficiency and is called "the fourth cancer treatment modality". Thereby, because of the involvement of cytoskeleton in key physiological and pathological processes, its therapeutic potential in glioblastoma is currently extensively investigated.
Topics: Biomarkers; Cytoskeletal Proteins; Glioblastoma; Humans; Prospective Studies; Tubulin
PubMed: 33667657
DOI: 10.1016/j.critrevonc.2021.103283 -
Brazilian Journal of Otorhinolaryngology 2018Caffeine can be considered the most consumed drug by adults worldwide, and can be found in several foods, such as chocolate, coffee, tea, soda and others. Overall,... (Meta-Analysis)
Meta-Analysis Review
INTRODUCTION
Caffeine can be considered the most consumed drug by adults worldwide, and can be found in several foods, such as chocolate, coffee, tea, soda and others. Overall, caffeine in moderate doses, results in increased physical and intellectual productivity, increases the capacity of concentration and reduces the time of reaction to sensory stimuli. On the other hand, high doses can cause noticeable signs of mental confusion and error induction in intellectual tasks, anxiety, restlessness, muscle tremors, tachycardia, labyrinthine changes, and tinnitus.
OBJECTIVE
Considering that the vestibular evoked myogenic potential is a clinical test that evaluates the muscular response of high intensity auditory stimulation, the present systematic review aimed to analyze the effects of caffeine on vestibular evoked myogenic potential.
METHODS
This study consisted of the search of the following databases: MEDLINE, CENTRAL, ScienceDirect, Scopus, Web of Science, LILACS, SciELO and ClinicalTrials.gov. Additionally, the gray literature was also searched. The search strategy included terms related to intervention (caffeine or coffee consumption) and the primary outcome (vestibular evoked myogenic potential).
RESULTS
Based on the 253 potentially relevant articles identified through the database search, only two full-text publications were retrieved for further evaluation, which were maintained for qualitative analysis.
CONCLUSION
Analyzing the articles found, caffeine has no effect on vestibular evoked myogenic potential in normal individuals.
Topics: Caffeine; Central Nervous System Stimulants; Humans; Vestibular Evoked Myogenic Potentials
PubMed: 29361437
DOI: 10.1016/j.bjorl.2017.11.003 -
Journal of Clinical Nursing Oct 2008To synthesise the evidence regarding honey's role in health care and to identify whether this evidence applies more specifically to cancer care. (Review)
Review
AIM
To synthesise the evidence regarding honey's role in health care and to identify whether this evidence applies more specifically to cancer care.
DESIGN
Systematic review.
METHODS
The inclusion and exclusion criteria were agreed by two reviewers and a keyword strategy was developed. EMBASE, CINAHL, AMED, MEDLINE, COCHRANE and PUBMED databases were screened to identify suitable articles. The citation list from each included study was also screened for potentially suitable papers. The key findings from each study were entered onto a data extraction sheet.
RESULTS
In total, 43 studies were included in the systematic review, which included studies in relation to wounds (n = 19), burns (n = 11), skin (n = 3), cancer (n = 5) and others (n = 5). In addition, a systematic review regarding honey use in wound care was also included. While the majority of studies noted the efficacy of honey in clinical use, five studies found honey to be equally as effective as the comparator and three found honey to be less effective than the comparator treatment. Other research did not illustrate any significant difference between standard treatment regimes vs. honey treatment. Studies were generally poor in quality because of small sample sizes, lack of randomisation and absence of blinding.
CONCLUSIONS
Honey was found to be a suitable alternative for wound healing, burns and various skin conditions and to potentially have a role within cancer care.
RELEVANCE TO CLINICAL PRACTICE
In the cancer setting, honey may be used for radiation-induced mucositis, radiotherapy-induced skin reactions, hand and foot skin reactions in chemotherapy patients and for oral cavity and external surgical wounds.
Topics: Antineoplastic Agents; Honey; Humans; Neoplasms; Radiotherapy; Wound Healing
PubMed: 18808626
DOI: 10.1111/j.1365-2702.2008.02304.x -
JAMA Neurology Jan 2015Perioperative stroke is a persistent complication of carotid endarterectomy (CEA) for patients with symptomatic carotid stenosis (CS). (Meta-Analysis)
Meta-Analysis Review
IMPORTANCE
Perioperative stroke is a persistent complication of carotid endarterectomy (CEA) for patients with symptomatic carotid stenosis (CS).
OBJECTIVE
To evaluate whether changes in somatosensory evoked potential (SSEP) during CEA are diagnostic of perioperative stroke in patients with symptomatic CS.
DESIGN, SETTING, AND PARTICIPANTS
We searched PubMed and the World Science Database for reference lists of retrieved studies and/or experiments on SSEP use in postoperative outcomes following CEA in patients with symptomatic CS from January 1, 1950, through January 1, 2013. We independently screened all titles and abstracts to identify studies that met the inclusion criteria and extracted relevant articles in a uniform manner. Inclusion criteria included randomized clinical trials, prospective studies, or retrospective cohort reviews; population of symptomatic CS; use of intraoperative SSEP monitoring during CEA; immediate postoperative assessment and/or as long as a 3-month follow-up; a total sample size of 50 or more patients; studies with adult humans 18 years or older; and studies published in English.
MAIN OUTCOME AND MEASURE
Whether intraoperative SSEP changes were diagnostic of perioperative stroke indicated by postoperative neurological examination.
RESULTS
Four-hundred sixty-four articles were retrieved, and 15 prospective and retrospective cohort studies were included in the data analysis. A 4557-patient cohort composed the total sample population for all the studies, 3899 of whom had symptomatic CS. A change in SSEP exhibited a strong pooled mean specificity of 91% (95% CI, 86-94) but a weaker pooled mean sensitivity of 58% (95% CI, 49-68). A pooled diagnostic odds ratio for individual studies of patients with neurological deficit with changes in SSEPs was 14.39 (95% CI, 8.34-24.82), indicating that the odds of observing an SSEP change among those with neurologic deficits were 14 times higher than in individuals without neurologic deficit.
CONCLUSIONS AND RELEVANCE
Intraoperative SSEP is a highly specific test in predicting neurological outcome following CEA. Patients with perioperative neurological deficits are 14 times more likely to have had changes in SSEPs during the procedure. The use of SSEPs to design prevention strategies is valuable in reducing perioperative cerebral infarctions during CEA.
Topics: Carotid Stenosis; Databases, Bibliographic; Endarterectomy, Carotid; Evoked Potentials, Somatosensory; Humans; Postoperative Complications; Stroke
PubMed: 25383418
DOI: 10.1001/jamaneurol.2014.3071 -
Brain and Neuroscience Advances 2020Repeated maternal separation is the most widely used pre-clinical approach to investigate the relationship between early-life chronic stress and its neuropsychiatric and... (Review)
Review
Repeated maternal separation is the most widely used pre-clinical approach to investigate the relationship between early-life chronic stress and its neuropsychiatric and physical consequences. In this systematic review, we identified 46 studies that conducted repeated maternal separation or single-episode maternal separation and reported measurements of interleukin-1b, interleukin-6, interleukin-10, tumour necrosis factor-alpha, or microglia activation and density. We report that in the short-term and in the context of later-life stress, repeated maternal separation has pro-inflammatory immune consequences in diverse tissues. Repeated maternal separation animals exhibit greater microglial activation and elevated pro-inflammatory cytokine signalling in key brain regions implicated in human psychiatric disorders. Notably, repeated maternal separation generally has no long-term effect on cytokine expression in any tissue in the absence of later-life stress. These observations suggest that the elevated inflammatory signalling that has been reported in humans with a history of early-life stress may be the joint consequence of ongoing stressor exposure together with potentiated neural and/or immune responsiveness to stressors. Finally, our findings provide detailed guidance for future studies interrogating the causal roles of early-life stress and inflammation in disorders such as major depression.
PubMed: 33447663
DOI: 10.1177/2398212820978049 -
Journal of Cancer Research and... 2023Oral malignant and potentially malignant conditions affect several people worldwide each year. The early diagnoses of these conditions play an important role in... (Meta-Analysis)
Meta-Analysis Review
Oral malignant and potentially malignant conditions affect several people worldwide each year. The early diagnoses of these conditions play an important role in prevention and recovery. Vibrational spectroscopy techniques such as Raman spectroscopy (RS) and Fourier-transform infrared (FTIR) spectroscopy are used in the early, non-invasive, label-free diagnosis of malignant and pre-malignant conditions, and are areas of active research. However, there is no conclusive evidence suggesting the translatability of these methods into clinical practice. This systematic review and meta-analysis presents pooled evidence for RS and FTIR methods in the detection of malignant and potentially malignant conditions of the oral cavity. Electronic databases were searched for published literature on RS and FTIR in the diagnosis of oral malignant and potentially malignant conditions. The pooled sensitivity, specificity, diagnostic accuracy, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), pre-test, and post-test probability were then calculated using the random-effects model. A subgroup analysis was conducted separately for RS and FTIR methods. A total of 12 studies were included (8 of RS; 4 of FTIR) as per the eligibility criteria. The pooled sensitivity and specificity of the vibrational spectroscopy methods were calculated to be 0.99 (95% confidence interval [CI]: 0.90, 1.00) and 0.94 (95% CI: 0.85, 0.98), respectively. The area under the curve (AUC) for the summary receiving operator characteristic curve was found to be 0.99 (0.98-1.00). Therefore, the results obtained in this study suggest that the RS and FTIR methods offer great potential to be used in the early diagnosis of oral malignant and pre-malignant conditions.
Topics: Humans; Spectrum Analysis, Raman; Area Under Curve; Databases, Factual; Mouth; Odds Ratio; Syndrome
PubMed: 37313896
DOI: 10.4103/jcrt.jcrt_2275_21 -
Spine Oct 2016Systematic review. (Review)
Review
Diagnostic Accuracy of Combined Multimodality Somatosensory Evoked Potential and Transcranial Motor Evoked Potential Intraoperative Monitoring in Patients With Idiopathic Scoliosis.
STUDY DESIGN
Systematic review.
OBJECTIVE
The aim of the study was to determine the predictive value of combined multimodality somatosensory evoked potential (SSEP) and transcranial motor evoked potential (TcMEP) monitoring in detecting impending neurological injury during surgery for idiopathic scoliosis.
SUMMARY OF BACKGROUND DATA
The diagnostic of motor evoked potential monitoring and SSEP monitoring have been established. However, the predictive value of combined multimodality SSEP and TcMEP monitoring in detecting impending neurological injury during surgery for idiopathic scoliosis has not been evaluated.
METHODS
A systematic literature search was performed using PubMed/MEDLINE, Web of Science, and EMBASE from 1974 to January 2015. All titles and abstracts were independently reviewed by the authors. We included all studies that were (1) randomized controlled trials, prospective or retrospective cohort studies; (2) included patients with idiopathic scoliosis undergoing scoliosis correction surgery; (3) included multimodality SSEP and TcMEP monitoring during spinal surgery; (4) included immediate postoperative neurological assessment; (5) idiopathic scoliosis patient population n ≥25; and (6) published in English.
RESULTS
Seven studies comprising a total of 2052 patients with idiopathic scoliosis were included in our meta-analysis. The incidence of neurological deficit in this cohort was 0.93%. The pooled sensitivity, specificity, and Diagnostic Odds Ratio were 82.6% (95% CI 56.7%-94.5%), 94.4% (95% CI 85.1%-98.0%), and 106.16 (95% CI 24.952-451.667), respectively. The area under the curve was 0.928, indicating excellent discriminatory ability.
CONCLUSION
Idiopathic scoliosis corrective surgery patients who experience a new neurological deficit are 106.16 times more likely to have had an SSEP and/or TcMEP change during corrective procedures. The results of this meta-analysis demonstrate that combined multimodality SSEP and TcMEP monitoring possess some advantage over use of each alone, and that intraoperative neurophysiological monitoring may provide a valuable biomarker in detection of impending neurological injury.
LEVEL OF EVIDENCE
2.
Topics: Evoked Potentials, Motor; Evoked Potentials, Somatosensory; Humans; Intraoperative Neurophysiological Monitoring; Neurosurgical Procedures; Orthopedic Procedures; Scoliosis
PubMed: 27172278
DOI: 10.1097/BRS.0000000000001678 -
Frontiers in Neurology 2019Epilepsy is one of the most prevalent chronic brain diseases worldwide and is often accompanied by cognitive impairment. Event-related potentials (ERPs) are an...
Epilepsy is one of the most prevalent chronic brain diseases worldwide and is often accompanied by cognitive impairment. Event-related potentials (ERPs) are an objectively non-invasive approach for studying information processing and cognitive functions in the brain. The P300 is an important and extensively explored late component of ERPs that has been widely applied to assess cognitive function in epilepsy in previous studies. However, consistent conclusions have not yet been reached for various reasons. We conducted a comprehensive systematic review and meta-analysis of P300-related studies to assess the latency and amplitude of the P300 in epileptic patients. PubMed, EMBASE, and Cochrane Library databases were systematically searched for eligible studies. The standard mean difference (SMD) and the 95% confidence interval (CI) were calculated as the effect size of the P300 component. The main results of the present meta-analysis indicated that epileptic patients have a longer P300 latency and a lower P300 amplitude than controls. Subgroup analysis based on age group demonstrated that these differences can be observed in both children and adult patients compared with healthy controls. In addition, the P300 latency was longer in patients with the five main types of epileptic seizures than in controls. This study revealed that epileptic patients have abnormalities in the P300 component, which may reflect deficits in cognitive function. Thus, the P300 may be a potential objective approach for evaluating cognitive function in epileptic patients.
PubMed: 31543861
DOI: 10.3389/fneur.2019.00943 -
Advanced Emergency Nursing Journal 2017Postoperative residual neuromuscular blockade is associated with an increased risk of respiratory insufficiency, aspiration, and potential pulmonary complications. The... (Review)
Review
Postoperative residual neuromuscular blockade is associated with an increased risk of respiratory insufficiency, aspiration, and potential pulmonary complications. The standard of care for reversal of residual block centers on anticholinesterases such as neostigmine. However, these medications provide inconsistent or inadequate effect while being associated with potentially severe adverse effects. Sugammadex, a modified γ-cyclodextrine compound, is a recently approved agent for the reversal of blockade with aminosterodial neuromuscular blockers. Randomized controlled trials, in addition to a meta-analysis and a systematic review, have published results indicating faster and more consistent reversal of blockade while leading to fewer adverse events.
Topics: Humans; Neuromuscular Blockade; Neuromuscular Nondepolarizing Agents; Sugammadex; gamma-Cyclodextrins
PubMed: 29095176
DOI: 10.1097/TME.0000000000000170