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Zhonghua Nan Ke Xue = National Journal... Jun 2021During the spermatogenesis of fertile men, an incidental meiosis mistake could induce the generation of aneuploid sperm, which may further cause the aneuploidy of... (Review)
Review
During the spermatogenesis of fertile men, an incidental meiosis mistake could induce the generation of aneuploid sperm, which may further cause the aneuploidy of embryos, miscarriage and chromosome abnormality of the offspring. Sex chromosomes of sperm have a higher tendency to be aneuploid than autosomes, though the mechanisms of sperm sex chromosome aneuploidy are not yet thoroughly understood. It may be attributed to the fact that the synapsis of sex chromosomes is confined to the pseudoautosomal region and that only one subsequent crossover is formed there. In addition, gene mutation, advanced age, lifestyle and environmental pollution may induce the segregation errors of sex chromosomes or failure of the meiosis checkpoint, and thus increase the incidence of sperm sex chromosome aneuploidy. With a systematic review of the relevant literature, this paper illustrated the generation mechanisms of sperm sex chromosome aneuploidy in men with normal and abnormal karyotypes, aiming to shed some new light on the studies of sperm sex chromosome aneuploidy.
Topics: Aneuploidy; Chromosome Aberrations; Humans; Male; Meiosis; Sex Chromosomes; Spermatozoa
PubMed: 34914297
DOI: No ID Found -
Acta Haematologica 2014Sweet's syndrome (SS) is an acute febrile neutrophilic dermatosis. It can occur as an idiopathic, drug-induced or malignancy-associated entity. SS is also seen in... (Review)
Review
Initially lymphocytic Sweet's syndrome in male patients with myelodysplasia: a distinguished clinicopathological entity? Case report and systematic review of the literature.
BACKGROUND
Sweet's syndrome (SS) is an acute febrile neutrophilic dermatosis. It can occur as an idiopathic, drug-induced or malignancy-associated entity. SS is also seen in patients with myelodysplastic syndrome (MDS) where it may present atypically, both clinically and histologically. In a few rare cases of MDS, lymphocytic infiltrates are the presenting feature of SS.
METHODS
MEDLINE and Scopus were the data sources for our review.
RESULTS
A clinicopathological subsetemerged of 12 male SS patients with MDS and a mean age of 67.3 years in which the initial SS lesions were lymphocytic infiltrates. However, from 0.5 to 8 years later, sequential biopsies revealed neutrophilic dermal infiltration typical of SS.
CONCLUSION
Initially lymphocytic infiltrates in this subset could be attributed either to an early timing of the biopsy concerning the age of the lesion or to the dysgranulopoiesis syndrome. A possible relationship between the dysfunction of the receptor of the granulocyte-macrophage colony stimulating factor, the gene of which is located on the pseudoautosomal X-Y region, may exist in MDS patients with initially lymphocytic SS. This could explain the male gender of this subset and might establish initially lymphocytic SS as a distinguished clinicopathological entity for predicting the occurrence and even the prognosis of MDS.
Topics: Aged; Anemia, Refractory, with Excess of Blasts; Biopsy; Chromosomes, Human, X; Chromosomes, Human, Y; Disease Progression; Humans; Lymphocytes; Male; Middle Aged; Models, Immunological; Myelodysplastic Syndromes; Neutrophil Infiltration; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; Sex Factors; Skin; Sweet Syndrome
PubMed: 24714374
DOI: 10.1159/000357933