-
Journal of Family Medicine and Primary... Mar 2023One of the causes of dissatisfaction between couples is sexual dysfunction that sometimes leads to divorce. The present systematic study was conducted to evaluate the... (Review)
Review
INTRODUCTION
One of the causes of dissatisfaction between couples is sexual dysfunction that sometimes leads to divorce. The present systematic study was conducted to evaluate the factors affecting sexual dysfunction and divorce in Iran.
METHOD
A comprehensive search, including keywords of sexual dysfunction, emotional divorce, breakaway, separation, conflict, and Iran, was conducted on the databases of Scopus, MEDLINE/PubMed, CINAHL, Web of Science, Magiran, IranMedex, and SID. Out of the total number of reviewed articles, 16 articles met the inclusion criteria. No time limit was considered for our research and all published articles up to November 2021 were reviewed.
RESULTS
Based on the results of the present study, in all of the reviewed articles, sexual problems and dissatisfaction were among the effective factors in the occurrence or request of a formal divorce or an emotional divorce. The data also demonstrated that weakness in arousal and sexual desire, weakness in sexual function, sexual disorders, orgasm problems, and pain were among the problems of people on the verge of divorce.
CONCLUSION
Due to the importance of this issue, recognizing the effective and influential factors of divorce is one of the priorities of mental health. Dissatisfaction with sexual relations in both or one of the spouses is found to be one of the most important factors involved in divorce. If there are problems such as sexual dysfunction between the couples, they may still live together due to cultural and social conditions; however, they may experience emotional divorce. Therefore, there is an urgent need for effective counseling and treatment programs in this regard.
PubMed: 37122645
DOI: 10.4103/jfmpc.jfmpc_991_22 -
Integrative Cancer Therapies 2023Sleep disturbances are common and bothersome among cancer and noncancer populations. () is commonly used to improve sleep, yet its efficacy and safety are unclear. (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Sleep disturbances are common and bothersome among cancer and noncancer populations. () is commonly used to improve sleep, yet its efficacy and safety are unclear.
METHODS
We systematically searched PubMed, Cochrane Library, and EMBASE from inception through October 5, 2021, to identify randomized trials of . We included randomized trials comparing to placebo, medications, cognitive behavioral therapy (CBT), or usual care for improving sleep outcomes in cancer and noncancer patients with insomnia or sleep disturbance. We performed a risk of bias analysis following Cochrane guidelines. Depending on heterogeneity, we pooled studies with similar comparators using fixed- and random-effects models.
RESULTS
We included participants with insomnia disorder (N = 785) or sleep disturbance (N = 120) from 9 trials. Compared with placebo, led to significant subjective sleep quality improvements in participants with insomnia and patients with sleep disturbance combined (standard mean difference -0.58, 95% CI -1.04, -0.11; < .01); Compared with benzodiazepines or CBT, was associated with a significant decrease in insomnia severity (mean difference -2.68 points, 95% CI -5.50, -0.22; = .03) at 4 weeks in the general population and cancer patients. The long-term effects of were mixed among trials. did not increase the incidence of major adverse events. The placebo-controlled studies had a low risk of bias.
CONCLUSION
is associated with short-term patient-reported sleep quality improvements among individuals with insomnia or sleep disturbance. Due to the small sample size and variable study quality, the clinical benefits and harms of , particularly in the long term, should be further assessed in a sufficiently powered randomized trial.
REGISTRATION
PROSPERO CRD42021281943.
Topics: Humans; Sleep Initiation and Maintenance Disorders; Quality Improvement; Seeds; Sleep; Drugs, Chinese Herbal; Sleep Wake Disorders; Plants, Medicinal; Randomized Controlled Trials as Topic
PubMed: 37014010
DOI: 10.1177/15347354231162080 -
Communications Medicine Oct 2023Monogenic diabetes presents opportunities for precision medicine but is underdiagnosed. This review systematically assessed the evidence for (1) clinical criteria and...
BACKGROUND
Monogenic diabetes presents opportunities for precision medicine but is underdiagnosed. This review systematically assessed the evidence for (1) clinical criteria and (2) methods for genetic testing for monogenic diabetes, summarized resources for (3) considering a gene or (4) variant as causal for monogenic diabetes, provided expert recommendations for (5) reporting of results; and reviewed (6) next steps after monogenic diabetes diagnosis and (7) challenges in precision medicine field.
METHODS
Pubmed and Embase databases were searched (1990-2022) using inclusion/exclusion criteria for studies that sequenced one or more monogenic diabetes genes in at least 100 probands (Question 1), evaluated a non-obsolete genetic testing method to diagnose monogenic diabetes (Question 2). The risk of bias was assessed using the revised QUADAS-2 tool. Existing guidelines were summarized for questions 3-5, and review of studies for questions 6-7, supplemented by expert recommendations. Results were summarized in tables and informed recommendations for clinical practice.
RESULTS
There are 100, 32, 36, and 14 studies included for questions 1, 2, 6, and 7 respectively. On this basis, four recommendations for who to test and five on how to test for monogenic diabetes are provided. Existing guidelines for variant curation and gene-disease validity curation are summarized. Reporting by gene names is recommended as an alternative to the term MODY. Key steps after making a genetic diagnosis and major gaps in our current knowledge are highlighted.
CONCLUSIONS
We provide a synthesis of current evidence and expert opinion on how to use precision diagnostics to identify individuals with monogenic diabetes.
PubMed: 37794142
DOI: 10.1038/s43856-023-00369-8 -
PloS One 2023Military healthcare studies have reported a wide range of mental health issues amongst military personnel. Globally, mental health issues are one of the main causes of...
INTRODUCTION
Military healthcare studies have reported a wide range of mental health issues amongst military personnel. Globally, mental health issues are one of the main causes of ill health. Military personnel have a greater prevalence of mental health issues than that of the general population. The impact of mental health issues can be wide and far reaching for family and carers. This systematic narrative review explores the military spouse experience of living alongside their serving or veteran partner with a mental health issue.
METHODS
The systematic review performed was based on the PRISMA guide for searching, screening, selecting papers for data extraction and evaluation. Studies were identified from CINHAL, ASSIA, Proquest Psychology, Proquest Nursing & Allied Health source, Proquest Dissertations & Theses, ETHOS, PsychArticles, Hospital collection, Medline, Science Direct Freedom Collection and hand searching of citations and reference lists.
RESULTS
Twenty-seven studies were included in the narrative synthesis. Five overarching themes from the experiences of military spouses' living alongside their serving/veteran partners mental health issue were identified: caregiver burden, intimate relationships, psychological/psychosocial effects on the spouse, mental health service provision and spouse's knowledge and management of symptoms.
CONCLUSIONS
The systematic review and narrative synthesis identified that the majority of studies focused on spouses of veterans, very few were specific to serving military personnel, but similarities were noted. Findings suggest that care burden and a negative impact on the intimate relationship is evident, therefore highlight a need to support and protect the military spouse and their serving partner. Likewise, there is a need for greater knowledge, access and inclusion of the military spouse, in the care and treatment provision of their serving partner's mental health issue.
Topics: Humans; Veterans; Military Personnel; Mental Health; Spouses; Mental Health Services
PubMed: 37200312
DOI: 10.1371/journal.pone.0285714 -
Frontiers in Public Health 2023Subjective cognitive decline (SCD) is considered a preclinical stage of Alzheimer's disease. However, reliable prevalence estimates of SCD in the Chinese population are... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Subjective cognitive decline (SCD) is considered a preclinical stage of Alzheimer's disease. However, reliable prevalence estimates of SCD in the Chinese population are lacking, underscoring the importance of such metrics for policymakers to formulate appropriate healthcare strategies.
OBJECTIVE
To systematically evaluate SCD prevalence among older Chinese adults.
METHODS
PubMed, Web of Science, The Cochrane Library, Embase, CNKI, Wanfang, VIP, CBM, and Airiti Library databases were searched for studies on SCD in older Chinese individuals published before May 2023. Two investigators independently screened the literature, extracted the information, and assessed the bias risk of the included studies. A meta-analysis was then conducted using Stata 16.0 software via a random-effects model to analyze SCD prevalence in older Chinese adults.
RESULTS
A total of 17 studies were included (n = 31,782). The SCD prevalence in older Chinese adults was 46.4% (95% CI, 40.6-52.2%). Further, subgroup analyzes indicated that SCD prevalence was 50.8% in men and 58.9% among women. Additionally, SCD prevalence in individuals aged 60-69, 70-79, and ≥ 80 years was 38.0, 45.2, and 60.3%, respectively. Furthermore, SCD prevalence in older adults with BMI <18.5, 18.5-24.0, and > 24.0 was 59.3, 54.0, and 52.9%, respectively. Geographically, SCD prevalence among older Chinese individuals was 41.3% in North China and 50.0% in South China. In terms of residence, SCD prevalence was 47.1% in urban residents and 50.0% among rural residents. As for retired individuals, SCD prevalence was 44.2% in non-manual workers and 49.2% among manual workers. In the case of education, individuals with an education level of "elementary school and below" had an SCD prevalence rate of 62.8%; "middle school, "52.4%; "high school, "55.0%; and "college and above, "51.3%. Finally, SCD prevalence was lower among married individuals with surviving spouses than in single adults who were divorced, widowed, or unmarried.
CONCLUSION
Our systematic review and meta-analysis identified significant and widespread SCD prevalence in the older population in China. Therefore, our review findings highlight the urgent requirement for medical institutions and policymakers across all levels to prioritize and rapidly develop and implement comprehensive preventive and therapeutic strategies for SCD.: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023406950, identifier: CRD42023406950.
Topics: Aged; Female; Humans; Male; Middle Aged; China; Cognitive Dysfunction; Prevalence; Schools; East Asian People; Aged, 80 and over
PubMed: 38106895
DOI: 10.3389/fpubh.2023.1277995 -
International Journal of Gynaecology... Jun 2016Intimate partner violence (IPV) has a detrimental impact on the lives of women worldwide. Several studies have examined the effect IPV has on adverse birth outcomes when... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Intimate partner violence (IPV) has a detrimental impact on the lives of women worldwide. Several studies have examined the effect IPV has on adverse birth outcomes when it occurs during pregnancy.
OBJECTIVES
To explore the association between IPV and selected adverse birth outcomes.
SEARCH STRATEGY
Multiple databases were searched to identify studies investigating the association between IPV and low birth weight (LBW), preterm birth, and/or intrauterine growth restriction (IUGR).
SELECTION CRITERIA
Included studies defined the perpetrator of violence as an intimate partner, the type of violence as physical and/or sexual, and the study outcomes as LBW, preterm birth, or IUGR, with violence preceding delivery.
DATA COLLECTION AND ANALYSIS
Random-effects meta-analysis was used to calculate adjusted/unadjusted odds ratios (ORs). Subanalyses explored the effect of emotional/psychological violence on birth outcomes.
MAIN RESULTS
Nineteen studies met the inclusion criteria (15 LBW, 12 preterm birth, 4 IUGR). IPV was associated with LBW (OR 1.18, 95% confidence interval 1.05-1.31; I(2)=0.70, P<0.001) and preterm birth (OR 1.42, 95% confidence interval 1.21-1.63; I(2)=0.20, P<0.001). No statistically significant association was found for IUGR.
CONCLUSIONS
There are associations between IPV and LBW and preterm birth that could be causal.
Topics: Female; Fetal Growth Retardation; Humans; Infant, Low Birth Weight; Infant, Newborn; Odds Ratio; Physical Abuse; Pregnancy; Pregnancy Complications; Premature Birth; Sex Offenses; Spouse Abuse
PubMed: 27039053
DOI: 10.1016/j.ijgo.2015.10.023 -
Bulletin of the World Health... Oct 2017To provide an estimate of the burden of postpartum depression in Indian mothers and investigate some risk factors for the condition. (Meta-Analysis)
Meta-Analysis Review
OBJECTIVE
To provide an estimate of the burden of postpartum depression in Indian mothers and investigate some risk factors for the condition.
METHODS
We searched PubMed®, Google Scholar and Embase® databases for articles published from year 2000 up to 31 March 2016 on the prevalence of postpartum depression in Indian mothers. The search used subject headings and keywords with no language restrictions. Quality was assessed via the Newcastle-Ottawa quality assessment scale. We performed the meta-analysis using a random effects model. Subgroup analysis and meta-regression was done for heterogeneity and the Egger test was used to assess publication bias.
FINDINGS
Thirty-eight studies involving 20 043 women were analysed. Studies had a high degree of heterogeneity ( = 96.8%) and there was evidence of publication bias (Egger bias = 2.58; 95% confidence interval, CI: 0.83-4.33). The overall pooled estimate of the prevalence of postpartum depression was 22% (95% CI: 19-25). The pooled prevalence was 19% (95% CI: 17-22) when excluding 8 studies reporting postpartum depression within 2 weeks of delivery. Small, but non-significant differences in pooled prevalence were found by mother's age, geographical location and study setting. Reported risk factors for postpartum depression included financial difficulties, presence of domestic violence, past history of psychiatric illness in mother, marital conflict, lack of support from husband and birth of a female baby.
CONCLUSION
The review shows a high prevalence of postpartum depression in Indian mothers. More resources need to be allocated for capacity-building in maternal mental health care in India.
Topics: Child; Depression, Postpartum; Domestic Violence; Female; Humans; India; Infant, Newborn; Mothers; Pregnancy; Social Support; Socioeconomic Factors; Spouses
PubMed: 29147043
DOI: 10.2471/BLT.17.192237 -
Acta Obstetricia Et Gynecologica... Dec 2022The objective of this study was to evaluate the association between caffeine and alcohol consumption and in vitro fertilization (IVF) and intracytoplasmic sperm... (Meta-Analysis)
Meta-Analysis Review
INTRODUCTION
The objective of this study was to evaluate the association between caffeine and alcohol consumption and in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) outcomes.
MATERIAL AND METHODS
The protocol was registered in the PROSPERO database on May 23, 2021 (registration number: CRD42021256649), and updated on August 4, 2022. Two researchers performed a literature search in the PubMed, Embase, and MEDLINE databases for articles published before July 15, 2022 independently. Studies investigating the association between caffeine and alcohol consumption and IVF/ICSI outcomes were included, and studies reporting the consumption amount were analyzed using a one-stage robust error meta-regression-based method to explore potential dose-response relation. Funnel plot was used to assess publication bias if more than 10 studies were included.
RESULTS
Twelve studies on caffeine consumption and 14 studies on alcohol consumption were included in the systematic review, of which seven and nine were eligible for the meta-analysis. These studies included 26 922 women and/or their spouses who underwent IVF/ICSI treatment. Women's and men's caffeine consumption was not significantly associated with the pregnancy rate (odds ratio [OR] 0.97, 95% confidence interval [CI] 0.85-1.12; OR 0.93, 95% CI 0.75-1.14; respectively) and the live birth rate (OR 0.98, 95% CI 0.89-1.08; OR 0.98, 95% CI 0.86-1.12; respectively) of IVF/ICSI. Maternal alcohol consumption was negatively associated with pregnancy after IVF/ICSI treatment (OR 0.83, 95% CI 0.69-1.01). Paternal alcohol consumption was negatively associated with partner's live birth after IVF/ICSI treatment (OR 0.88, 95% CI 0.79-0.99). Compared with abstainers, the chance of achieving a pregnancy after IVF/ICSI treatment decreased by 7% for women who consumed 84 g alcohol per week (OR 0.93, 95% CI 0.90-0.98), and the chance of partners achieving a live birth decreased by 9% for men who consumed 84 g alcohol per week (OR 0.91, 95% CI 0.88-0.94).
CONCLUSIONS
There was no association between caffeine consumption and pregnancy or live birth rate of IVF/ICSI. Women's alcohol consumption was associated with decreased pregnancy rate after IVF/ICSI treatment when weekly consumption was greater than 84 g. Men's alcohol consumption was associated with decreased live birth rate after IVF/ICSI treatment when weekly consumption was greater than 84 g.
Topics: Pregnancy; Male; Female; Humans; Sperm Injections, Intracytoplasmic; Caffeine; Semen; Pregnancy Rate; Fertilization in Vitro; Live Birth; Alcohol Drinking
PubMed: 36259227
DOI: 10.1111/aogs.14464 -
Ecotoxicology and Environmental Safety Aug 2021Studies investigating the association between pesticide exposure and colorectal cancer (CRC) risk have been inconclusive.
BACKGROUND
Studies investigating the association between pesticide exposure and colorectal cancer (CRC) risk have been inconclusive.
OBJECTIVES
Investigate the association between pesticide exposure and CRC risk through a systematic literature review.
METHODS
CRC has the fourth-highest rate of cancer-caused death in the US after lung cancer, breast cancer in women, and prostate cancer in men. Here we have conducted a systematic literature search on studies examining the association between any pesticide exposure and CRC risk using PubMed, MEDLINE via EBSCO host, and Embase according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist.
RESULTS
Following the review, 139 articles were included for qualitative evaluation. Study participants were farmers, pesticide applicators, pesticide manufacturers, spouses of pesticide applicators, farm residents, Korean veterans of the Vietnam War, rural communities, and those who consumed food with pesticide residues. The studies' results were split between those with significant positive (39 significant results) and inverse (41 significant results) associations when comparing pesticide exposure and CRC risk.
DISCUSSION
From our literature review, we have identified a similar number of significant positive and inverse associations of pesticide exposure with CRC risk and therefore cannot conclude whether pesticide exposure has a positive or inverse association with CRC risk overall. However, certain pesticides such as terbufos, dicamba, trifluralin, S-ethyl dipropylthiocarbamate (EPTC), imazethapyr, chlorpyrifos, carbaryl, pendimethalin, and acetochlor are of great concern not only for their associated elevated risk of CRC, but also for the current legal usage in the United States (US). Aldicarb and dieldrin are of moderate concern for the positive associations with CRC risk, and also for the illegal usage or the detection on imported food products even though they have been banned in the US. Pesticides can linger in the soil, water, and air for weeks to years and, therefore, can lead to exposure to farmers, manufacturing workers, and those living in rural communities near these farms and factories. Approximately 60 million people in the US live in rural areas and all of the CRC mortality hotspots are within the rural communities. The CRC mortality rate is still increasing in the rural regions despite the overall decreasing of incidence and mortality of CRC elsewhere. Therefore, the results from this study on the relationship between pesticide exposure and CRC risk will help us to understand CRC health disparities.
Topics: Adult; Colorectal Neoplasms; Farmers; Female; Herbicides; Humans; Incidence; Male; Middle Aged; Occupational Exposure; Pesticide Residues; Pesticides
PubMed: 34029839
DOI: 10.1016/j.ecoenv.2021.112327 -
BMJ (Clinical Research Ed.) Oct 2010To evaluate the efficacy and relative adverse effects of tricyclic antidepressants in the treatment of migraine, tension-type, and mixed headaches. (Comparative Study)
Comparative Study Meta-Analysis Review
OBJECTIVE
To evaluate the efficacy and relative adverse effects of tricyclic antidepressants in the treatment of migraine, tension-type, and mixed headaches.
DESIGN
Meta-analysis.
DATA SOURCES
Medline, Embase, the Cochrane Trials Registry, and PsycLIT. Studies reviewed Randomised trials of adults receiving tricyclics as only treatment for a minimum of four weeks.
DATA EXTRACTION
Frequency of headaches (number of headache attacks for migraine and number of days with headache for tension-type headaches), intensity of headache, and headache index.
RESULTS
37 studies met the inclusion criteria. Tricyclics significantly reduced the number of days with tension-type headache and number of headache attacks from migraine than placebo (average standardised mean difference -1.29, 95% confidence interval -2.18 to -0.39 and -0.70, -0.93 to -0.48) but not compared with selective serotonin reuptake inhibitors (-0.80, -2.63 to 0.02 and -0.20, -0.60 to 0.19). The effect of tricyclics increased with longer duration of treatment (β=-0.11, 95% confidence interval -0.63 to -0.15; P<0.0005). Tricyclics were also more likely to reduce the intensity of headaches by at least 50% than either placebo (tension-type: relative risk 1.41, 95% confidence interval 1.02 to 1.89; migraine: 1.80, 1.24 to 2.62) or selective serotonin reuptake inhibitors (1.73, 1.34 to 2.22 and 1.72, 1.15 to 2.55). Tricyclics were more likely to cause adverse effects than placebo (1.53, 95% confidence interval 1.11 to 2.12) and selective serotonin reuptake inhibitors (2.22, 1.52 to 3.32), including dry mouth (P<0.0005 for both), drowsiness (P<0.0005 for both), and weight gain (P<0.001 for both), but did not increase dropout rates (placebo: 1.22, 0.83 to 1.80, selective serotonin reuptake inhibitors: 1.16, 0.81 to 2.97).
CONCLUSIONS
Tricyclic antidepressants are effective in preventing migraine and tension-type headaches and are more effective than selective serotonin reuptake inhibitors, although with greater adverse effects. The effectiveness of tricyclics seems to increase over time.
Topics: Adult; Antidepressive Agents, Tricyclic; Headache Disorders; Humans; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Time Factors; Treatment Outcome
PubMed: 20961988
DOI: 10.1136/bmj.c5222