-
International Journal of Geriatric... Jul 2021Most studies have been concerned with the experiences and needs of spouses/partners and adult children of people with dementia. In this review, children and young...
OBJECTIVES
Most studies have been concerned with the experiences and needs of spouses/partners and adult children of people with dementia. In this review, children and young people's lived experience of parental dementia was investigated. Findings will inform both researchers and professionals in the area of dementia care.
DESIGN
A systematic literature search was performed in CINAHL, PsychINFO, PubMed, Scopus, and Web of Science. A rigorous screening process was followed, and a checklist for qualitative and observational studies was used to evaluate the methodological quality of the studies. Narrative synthesis of the selected articles was carried out.
RESULTS
Twenty-one studies were included and a synthesis of the literature revealed six themes. The first theme concerned the difficulties in dealing with the diagnosis which was often preceded by a long period characterized by uncertainty, confusion, family distress, and conflicts. The second theme discussed changes in family relationships in terms of the role of children and young people in supporting both parents and keeping family together. The third theme described the impact of caring on children and young people who struggled to balance caring tasks and developmental needs. The fourth theme showed consequences on children and young people's personal lives in terms of education/career and life planning. The fifth theme illustrated main adaptation models and coping strategies. The last theme discussed the need for appropriate support and services based on a "whole family" approach.
CONCLUSIONS
The included studies provide the basis for knowledge and awareness about the experience of children and young people with a parent with dementia and the specific needs of support for this population.
Topics: Adaptation, Psychological; Adolescent; Dementia; Humans; Parents; Qualitative Research
PubMed: 33826166
DOI: 10.1002/gps.5542 -
BMC Medicine Jan 2014Diabetes history in biologically-related individuals increases diabetes risk. We assessed diabetes concordance in spouses (that is, biologically unrelated family... (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
Diabetes history in biologically-related individuals increases diabetes risk. We assessed diabetes concordance in spouses (that is, biologically unrelated family members) to gauge the importance of socioenvironmental factors.
METHODS
We selected cross-sectional, case-control and cohort studies examining spousal association for diabetes and/or prediabetes (impaired fasting glucose or impaired glucose tolerance), indexed in Medline, Embase or Scopus (1 January 1997 to 28 February 2013). Effect estimates (that is, odds ratios, incidence rate ratios, and so on) with body mass index (BMI) adjustment were pooled separately from those without BMI adjustment (random effects models) to distinguish BMI-dependent and independent concordance.
RESULTS
Searches yielded 2,705 articles; six were retained (n = 75,498 couples) for systematic review and five for meta-analysis. Concordance was lowest in a study that relied on women's reports of diabetes in themselves and their spouses (effect estimate 1.1, 95% CI 1.0 to 1.30) and highest in a study with systematic assessment of glucose tolerance (2.11, 95% CI 1.74 to 5.10). The random-effects pooled estimate adjusted for age and other covariates but not BMI was 1.26 (95% CI 1.08 to 1.45). The estimate with BMI adjustment was lower (1.18, 95% CI 0.97 to 1.40). Two studies assessing between-spouse associations of diabetes/prediabetes determined by glucose testing reported high concordance (OR 1.92, 95% CI 1.55 to 2.37 without BMI adjustment; 2.32, 95% CI 1.87 to 3.98 with BMI adjustment). Two studies did not distinguish type 1 and type 2 diabetes. However given that around 95% of adults is type 2, this is unlikely to have influenced the results.
CONCLUSIONS
Our pooled estimate suggests that a spousal history of diabetes is associated with a 26% diabetes risk increase. Recognizing shared risk between spouses may improve diabetes detection and motivate couples to increase collaborative efforts to optimize eating and physical activity habits.
Topics: Body Mass Index; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Humans; Life Style; Male; Risk Factors; Spouses
PubMed: 24460622
DOI: 10.1186/1741-7015-12-12 -
Human Reproduction Update Jan 2018Early pregnancy complications, defined as miscarriage, recurrent miscarriage or ectopic pregnancy, affect the physical and psychological well-being of intended parents.... (Review)
Review
BACKGROUND
Early pregnancy complications, defined as miscarriage, recurrent miscarriage or ectopic pregnancy, affect the physical and psychological well-being of intended parents. Research in this field so far has focused mainly on improving accuracy of diagnostic tests and safety and effectiveness of therapeutic management. An overview of aspects of care valued by women and/or their partners is missing.
OBJECTIVE AND RATIONALE
This systematic review aims to provide an overview of aspects of care valued by women and/or their partners faced with early pregnancy complications and to identify potential targets for improvement in early pregnancy healthcare.
SEARCH METHODS
We searched five electronic databases for empirical quantitative or qualitative studies on patients' perspectives of early pregnancy care in July 2017. We first identified aspects of early pregnancy care valued by women and/or their partners based on qualitative and quantitative data and organized these aspects of care according to the eight dimensions of patient-centered care. Second, we extracted the assessment of service quality from women and/or their partners on each of these aspects of care based on quantitative data. Third, we combined the findings on patients' values with the findings of service quality assessment to identify potential targets for improvement in five groups according to how likely these targets are to require improvement.
OUTCOMES
The search yielded 6240 publications, of which 27 studies were eligible for inclusion in this review. All included studies focused on miscarriage or recurrent miscarriage care. We identified 24 valued aspects of care, which all covered the eight dimensions of patient-centered care. The most frequently reported valued aspect was 'being treated as an individual person experiencing a significant life event rather than a common condition'. Assessment of service quality from women and/or their partners was available for 13 of the 24 identified aspects of care. Quantitative studies all documented service quality as problematic for these 13 aspects of care. We thus identified 13 potential targets for improvement in the patient-centeredness of miscarriage and recurrent miscarriage care of which none were very likely, four were likely, six were unlikely and three were very unlikely, to require improvement. The four likely potential targets for improvement were 'Understandable information provision about the etiology of pregnancy', 'Staff discussing patients' distress', 'Informing patients on pregnancy loss in the presence of a friend or partner' and 'Staff performing follow-up phone calls to support their patients after a miscarriage'.
WIDER IMPLICATIONS
It is important for clinicians to realize that women and their partners undergoing a miscarriage experience a significant live event and appreciate an individual approach. Future qualitative studies are needed to explore the identified potential targets for improvement of (recurrent) miscarriage care and to explore patients' perspectives in women suspected and treated for ectopic pregnancy.
Topics: Abortion, Habitual; Female; Humans; Male; Parents; Patient-Centered Care; Perception; Pregnancy; Prenatal Care; Quality of Health Care; Spouses
PubMed: 29040571
DOI: 10.1093/humupd/dmx030 -
BMJ (Clinical Research Ed.) Mar 2011To determine the comparative effects of the thiazolidinediones (rosiglitazone and pioglitazone) on myocardial infarction, congestive heart failure, and mortality in... (Meta-Analysis)
Meta-Analysis Review
OBJECTIVE
To determine the comparative effects of the thiazolidinediones (rosiglitazone and pioglitazone) on myocardial infarction, congestive heart failure, and mortality in patients with type 2 diabetes.
DESIGN
Systematic review and meta-analysis of observational studies.
DATA SOURCES
Searches of Medline and Embase in September 2010.
STUDY SELECTION
Observational studies that directly compared the risk of cardiovascular outcomes for rosiglitazone and pioglitazone among patients with type 2 diabetes mellitus were included.
DATA EXTRACTION
Random effects meta-analysis (inverse variance method) was used to calculate the odds ratios for cardiovascular outcomes with thiazolidinedione use. The I(2 )statistic was used to assess statistical heterogeneity.
RESULTS
Cardiovascular outcomes from 16 observational studies (4 case-control studies and 12 retrospective cohort studies), including 810,000 thiazolidinedione users, were evaluated after a detailed review of 189 citations. Compared with pioglitazone, use of rosiglitazone was associated with a statistically significant increase in the odds of myocardial infarction (n = 15 studies; odds ratio 1.16, 95% confidence interval 1.07 to 1.24; P < 0.001; I(2) = 46%), congestive heart failure (n = 8; 1.22, 1.14 to 1.31; P < 0.001; I(2) = 37%), and death (n = 8; 1.14, 1.09 to 1.20; P < 0.001; I(2) = 0%). Numbers needed to treat to harm (NNH), depending on the population at risk, suggest 170 excess myocardial infarctions, 649 excess cases of heart failure, and 431 excess deaths for every 100,000 patients who receive rosiglitazone rather than pioglitazone.
CONCLUSION
Among patients with type 2 diabetes, use of rosiglitazone is associated with significantly higher odds of congestive heart failure, myocardial infarction, and death relative to pioglitazone in real world settings.
Topics: Diabetes Mellitus, Type 2; Heart Failure; Humans; Hypoglycemic Agents; Myocardial Infarction; Pioglitazone; Prognosis; Publication Bias; Risk Factors; Rosiglitazone; Thiazolidinediones
PubMed: 21415101
DOI: 10.1136/bmj.d1309 -
PloS One 2024As theoretical models suggest, work addiction has several adverse correlates and consequences, such as unfavorable personality traits, physical and psychological... (Meta-Analysis)
Meta-Analysis
As theoretical models suggest, work addiction has several adverse correlates and consequences, such as unfavorable personality traits, physical and psychological symptoms, and social conflicts. Both early and recent concepts emphasize that individuals with work addiction have more problematic social life due to obsessive overwork. This includes negative impacts on family, workplace, and other relationships. The present study aimed to systematically review and meta-analyze all the empirical studies that examined the association between work addiction and any dimension of social life, as such an analysis has never been conducted before. Studies published from 1995 to 2022 were identified through a systematic search. 102 eligible studies were included in the review, with 75 studies contributing to five different meta-analyses. The results indicated significant associations between work addiction and: (1) lower work-life balance, (2) reduced social functioning, and increased difficulties in (3) family relationships, (4) intimate relationships, and (5) relationships with the community, friends, and colleagues. The associations were found to be independent of gender and age. The meta-analytic study highlights research gaps in the field and suggests future directions, including exploring attachment styles and early social relationships in work addiction, investigating the association between social and emotional competencies and work addiction, examining the role of escape motivation, and exploring the characteristics of the partners (spouses) of workaholics. Since the quality of social relationships and social support are crucial factors in physical and mental health, the prevention and intervention of work addiction should be prioritized in organizational and clinical settings.
Topics: Humans; Behavior, Addictive; Interpersonal Relations; Work-Life Balance; Social Support; Workplace
PubMed: 38833505
DOI: 10.1371/journal.pone.0303563 -
BMJ (Clinical Research Ed.) Aug 2010To investigate the independent effects of intake of fruit and vegetables on incidence of type 2 diabetes. (Meta-Analysis)
Meta-Analysis Review
OBJECTIVE
To investigate the independent effects of intake of fruit and vegetables on incidence of type 2 diabetes.
DESIGN
Systematic review and meta-analysis.
DATA SOURCES
Medline, Embase, CINAHL, British Nursing Index (BNI), and the Cochrane library were searched for medical subject headings and keywords on diabetes, prediabetes, fruit, and vegetables. Expert opinions were sought and reference lists of relevant articles checked.
STUDY SELECTION
Prospective cohort studies with an independent measure of intake of fruit, vegetables, or fruit and vegetables and data on incidence of type 2 diabetes.
RESULTS
Six studies met the inclusion criteria; four of these studies also provided separate information on the consumption of green leafy vegetables. Summary estimates showed that greater intake of green leafy vegetables was associated with a 14% (hazard ratio 0.86, 95% confidence interval 0.77 to 0.97) reduction in risk of type 2 diabetes (P=0.01). The summary estimates showed no significant benefits of increasing the consumption of vegetables, fruit, or fruit and vegetables combined.
CONCLUSION
Increasing daily intake of green leafy vegetables could significantly reduce the risk of type 2 diabetes and should be investigated further.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Diet; Epidemiologic Methods; Female; Fruit; Humans; Male; Middle Aged; Prospective Studies; Publication Bias; Vegetables
PubMed: 20724400
DOI: 10.1136/bmj.c4229 -
British Journal of Cancer Oct 2005We performed a systematic review of 28 case-control, 17 cohort and seven twin studies of the relationship between family history and risk of lung cancer and a... (Review)
Review
We performed a systematic review of 28 case-control, 17 cohort and seven twin studies of the relationship between family history and risk of lung cancer and a meta-analysis of risk estimates. Data from both case-control and cohort studies show a significantly increased lung cancer risk associated with having an affected relative. Risk appears to be greater in relatives of cases diagnosed at a young age and in those with multiple affected family members. Increased lung cancer risk was observed in association with an affected spouse and twin studies, while limited, favour shared environmental exposures. The limitations of the currently published epidemiological studies to infer genetic susceptibility are discussed.
Topics: Case-Control Studies; Cohort Studies; Environmental Exposure; Family; Genetic Predisposition to Disease; Humans; Lung Neoplasms; Risk Factors; Twin Studies as Topic
PubMed: 16160696
DOI: 10.1038/sj.bjc.6602769 -
Heliyon Jan 2022This study aimed to estimate the pooled prevalence and factors associated with postpartum modern contraceptive use in Ethiopia. (Review)
Review
OBJECTIVE
This study aimed to estimate the pooled prevalence and factors associated with postpartum modern contraceptive use in Ethiopia.
DESIGN
Systematic Reviews and Meta-Analysis.
METHOD
PubMed, MEDLINE, EMBASE, Hinari, Google Scholar, direct Google search, African Journal Online (AJOL), an online repository, and gray kinds of literature were used for searching. This meta-analysis included eighteen cross-sectional studies. The quality appraisal criterion of the Joanna Briggs Institute (JBI) was employed to critically appraise papers. The I2 statistics were used to test heterogeneity and subgroup analysis was computed with the evidence of heterogeneity. The Egger test with funnel plot was used to investigate publication bias. The "generate" command in STATA was used to calculate the logarithm and standard error of the odds ratio (OR) for each included study. Then odds ratio (OR) with a 95% confidence interval (CI) was presented.
RESULT
Eighteen studies were included in the systematic review and meta-analysis. The pooled prevalence of modern postpartum family planning utilization among postnatal women in Ethiopia was 45.44% (95%CI: 31.47, 59.42).Prenatal family planning counseling (AOR = 3.80; 95%CI: 2.70, 5.34), postnatal care utilization (AOR = 3.07; 95%CI: 1.39, 6.77), spouse communication on family planning (AOR = 1.86; 95%CI:1.36,2.54), resumption of menses (AOR = 4.20; 95%CI: 2.95, 5.99), and resumption of sexual activity (AOR = 3.98; 95%CI: 2.34, 6.79) were associated factors to uptake modern postpartum family planning among postnatal women.
CONCLUSION
The pooled prevalence of postpartum modern contraceptive use was low. The most common factors significantly associated with postpartum modern contraceptive use were prenatal family planning counseling, postnatal care utilization, spouse communication on family planning, resumption of menses, and resumption of sexual activity were the commonest factors significantly associated with postpartum modern contraceptive use.
PubMed: 35036604
DOI: 10.1016/j.heliyon.2021.e08712 -
Patient Related Outcome Measures 2019Parkinson's is an incurable, neuro-degenerative condition with multiple symptoms substantially impacting on living conditions and quality of life (QoL) for people with... (Review)
Review
BACKGROUND
Parkinson's is an incurable, neuro-degenerative condition with multiple symptoms substantially impacting on living conditions and quality of life (QoL) for people with Parkinson's (PwP), most whom are older adults, and their families. The study aimed to undertake a literature review of studies conducted in the UK that quantify the direct or indirect impact of Parkinson's on people with the condition, their families, and society in terms of out-of-pocket payments and financial consequences.
METHODS
Literature was searched for Parkinson's-related terms plus condition impact (eg, financial, employment, pension, housing, health care costs, and QoL) in the UK setting. The strategy probed several electronic databases with all retrieved papers screened for relevancy. The instruments used to measure patient-related outcomes were then examined for their relevancy in justifying the results.
RESULTS
The initial search retrieved 2,143 papers of which 79 were shortlisted through title and abstract screening. A full-text reading indicated 38 papers met the inclusion and quality criteria. Summary data extracted from the articles on focus, design, sample size, and questionnaires/instruments used were presented in four themes: (a) QoL and wellbeing of PwP, (b) QoL and wellbeing of caregivers and family members, (c) employment and living conditions, and (d) direct and indirect health care and societal cost.
CONCLUSION
UK results substantiated global evidence regarding the deterioration of QoL of PwP as the condition progressed, utilizing numerous measures to demonstrate change. Many spouses and family accept care responsibilities, affecting their QoL and finances too. The review highlighted increased health care and privately borne costs with condition progression, although UK evidence was limited on societal costs of Parkinson's in terms of loss of employment, reduced work hours, premature retirement of PwP and caregivers that directly affected their household budget.
PubMed: 31695537
DOI: 10.2147/PROM.S160843 -
Journal of Affective Disorders May 2024Psychiatric disorders differ in their prevalence, symptom profiles, and disease courses in men and women. However, sex differences in psychiatric disorders have not...
BACKGROUND
Psychiatric disorders differ in their prevalence, symptom profiles, and disease courses in men and women. However, sex differences in psychiatric disorders have not received enough attention to guide treatment recommendations. This systematic review aims to summarize sex differences in the treatment responses and adverse effects of mood stabilizers and antipsychotics transdiagnostically.
METHODS
We conducted a systematic review following the PRISMA 2020 statement (CRD42020212478). A literature search was conducted using MEDLINE, Embase, Cochrane Central, PsycINFO, Web of Science Core Collection, and Scopus databases. Studies comparing mood stabilizer or antipsychotic treatment outcomes in men and women were included. JBI critical appraisal checklists were used to assess bias risk.
RESULTS
Out of 4866 records, 129 reports (14 on mood stabilizers, 115 on antipsychotics) with varying designs were included. Sample sizes ranged from 17 to 22,774 participants (median = 147). The most common psychiatric diagnoses were schizophrenia spectrum (n = 109, 84.5 %) and bipolar disorders (n = 38, 29.5 %). Only four studies explored sex differences in mood stabilizer treatment response. In 40 articles on antipsychotic treatment response, 18 indicated no sex difference, while 16 showed females had better outcomes. Women had more adverse effects with both mood stabilizers and antipsychotics. The risk of bias was low in 84 (65.1 %) of studies.
LIMITATIONS
Substantial heterogeneity among the studies precluded performing a meta-analysis.
CONCLUSION
Number of studies focusing on sex differences in treatment outcomes of mood stabilizers is limited. Women may respond better to antipsychotics than men, but also experience more side effects. The impact of pharmacokinetics on sex differences warrants more attention.
Topics: Female; Humans; Male; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Sex Characteristics
PubMed: 38367709
DOI: 10.1016/j.jad.2024.02.038