-
Annals of Clinical and Laboratory... 1985The adrenogenital syndrome is a result of the deficiency of one of the enzymes involved in the pathway leading to the synthesis of cortisol by the adrenal cortex....
The adrenogenital syndrome is a result of the deficiency of one of the enzymes involved in the pathway leading to the synthesis of cortisol by the adrenal cortex. Laboratory evaluation of the adrenogenital syndrome involves measurement of hormones and metabolites accumulated prior to the enzymic block as well as hormones whose synthesis is affected by deficiency of a specific enzyme. Laboratory measurements of hormone metabolites in urine, because of their nonspecificity, lack of sensitivity, and multiple assay steps resulting in poor yield, have been supplanted by specific and sensitive radioimmunoassays of steroid hormones in plasma. In the laboratory evaluation of the adrenogenital syndrome, problems involved in some of the immunoassays of selected hormones should be addressed. Variables owing to specimen collection, storage and handling, and the assay itself should be minimized and controlled.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenal Hyperplasia, Congenital; Cholesterol Side-Chain Cleavage Enzyme; Humans; Radioimmunoassay; Specimen Handling
PubMed: 3873204
DOI: No ID Found -
Chicago Medicine Mar 1961
Topics: Adrenal Hyperplasia, Congenital; Adrenocortical Hyperfunction; Adrenogenital Syndrome; Cushing Syndrome
PubMed: 13706420
DOI: No ID Found -
American Journal of Diseases of... Sep 1963
Topics: Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Child; Humans; Male; Pathology; Testis
PubMed: 14057603
DOI: 10.1001/archpedi.1963.02080050245001 -
Annales Paediatriae Fenniae 1961
Topics: Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Child; Infant
PubMed: 13907202
DOI: No ID Found -
Fel'dsher I Akusherka 1981
Topics: Adrenal Hyperplasia, Congenital; Adult; Female; Humans; Pregnancy; Pregnancy Complications
PubMed: 6914965
DOI: No ID Found -
American Journal of Obstetrics and... Feb 1963
Topics: Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Delivery, Obstetric; Female; Humans; Pregnancy; Pregnancy Complications; Vagina
PubMed: 13996257
DOI: 10.1016/s0002-9378(16)35445-x -
Acta Endocrinologica Apr 1955
Topics: Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome
PubMed: 14375668
DOI: 10.1530/acta.0.0180512 -
Journal. Iowa State Medical Society Mar 1963
Topics: Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Hyponatremia; Sodium Chloride; Sodium Chloride, Dietary
PubMed: 13981462
DOI: No ID Found -
Medical Bulletin (Ann Arbor, Mich.) Apr 1959
Topics: Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Female; Humans; Virilism
PubMed: 13669183
DOI: No ID Found -
Pediatrics Jul 1952
Topics: Adrenal Cortex; Adrenal Cortex Diseases; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Child; Humans; Hypertrophy; Male; Wilms Tumor
PubMed: 12983105
DOI: No ID Found