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Klinicka Onkologie : Casopis Ceske a... 2022Meigs syndrome is defined by the presence of a benign ovarian tumor, ascites, and pleural effusion (predominantly on the right side). A characteristic sign of Meigs...
BACKGROUND
Meigs syndrome is defined by the presence of a benign ovarian tumor, ascites, and pleural effusion (predominantly on the right side). A characteristic sign of Meigs syndrome is the complete disappearance of exudate after surgical resection of the ovarian tumor.
CASE REPORT
We present a case report of a 58-year-old patient admitted for an advanced ovarian tumor with pleural effusion, ascites, and tumor marker elevation typical for ovarian cancer. Cytological examination of ascites and pleural effusion was repeatedly negative for malignancy. Histopathological examination of the bio-psied tissue was concluded as low-grade mesenchymal neoplasia. The second opinion of histopathological examination was concluded as low grade fibroblastic pelvic tumor without the possibility of exact specification. Dia-gnoses of desmoid fibromatosis and low-grade fibromyxiod sarcoma (less likely) were considered. Surgical resection was indicated, and a large tumor with numerous adhesions to the uterus, bladder, and thin loops with a noticeably thickened peritoneum were perioperatively described. Histologically, left ovarian fibroma with productive peritonitis and sanguine-induced ascites was dia-gnosed. Due to the clinical findings and the result of the histopathological examination, the case was classified as Meigs syndrome. Two months after the surgery, the ascites and pleural effusion disappeared, and the tumor marker levels normalized.
CONCLUSION
The present case report documents that it is always necessary to consider diseases other than those most likely at the outset, as the treatment algorithm and prognosis of these rare diseases may differ significantly.
Topics: Ascites; Biomarkers, Tumor; Female; Fibroma; Humans; Meigs Syndrome; Middle Aged; Ovarian Neoplasms; Pleural Effusion
PubMed: 35760576
DOI: 10.48095/ccko2022232 -
The New England Journal of Medicine Jun 2024
Topics: Humans; Meigs Syndrome; Female; Male
PubMed: 38856181
DOI: 10.1056/NEJMicm2313447 -
BMJ Case Reports Feb 2021
Topics: Female; Humans; Meigs Syndrome
PubMed: 33541974
DOI: 10.1136/bcr-2020-241337 -
Kardiologiia Oct 2019The article presents an overview of the data related to Demons-Meigs syndrome and the clinical situation associated with a complex differential diagnosis between... (Review)
Review
The article presents an overview of the data related to Demons-Meigs syndrome and the clinical situation associated with a complex differential diagnosis between myocarditis with the formation of secondary cardiomyopathy and Demons-Meigs syndrome. A variety of clinical symptom complexes that are associated with Demons-Meigs syndrome is discussed. The concepts of classical and non-classical, full and incomplete Demons-Meigs syndrome are considered. The current views on the pathogenesis of the syndrome and the mechanism of the formation of ascites and pleural effusion are given.
Topics: Ascites; Cardiomyopathies; Diagnosis, Differential; Female; Humans; Meigs Syndrome; Pleural Effusion
PubMed: 31995727
DOI: 10.18087/10.18087/cardio.n447 -
Journal of Obstetrics and Gynaecology... Apr 2012
Topics: Ascites; Female; Fibroma; Humans; Hysterectomy; Meigs Syndrome; Middle Aged; Ovarian Neoplasms; Ovariectomy; Ovary; Pleural Effusion; Salpingectomy
PubMed: 22472326
DOI: 10.1016/s1701-2163(16)35204-5 -
Pediatric Blood & Cancer Jun 2023
Topics: Female; Humans; Child; Meigs Syndrome; Dysgerminoma; Ovarian Neoplasms; Ascites; Diagnosis, Differential
PubMed: 36721998
DOI: 10.1002/pbc.30224 -
Medicine Dec 2015Although Meigs' syndrome is regarded as a well-defined entity, contradictory data on pleural fluid characteristics have been presented, with some papers classifying it... (Review)
Review
Although Meigs' syndrome is regarded as a well-defined entity, contradictory data on pleural fluid characteristics have been presented, with some papers classifying it as a transudate, whereas others stating that it is an exudate.The aims of the study were: (1) to evaluate pleural fluid characteristics in patients with Meigs' syndrome and (2) to analyze the prevalence of transudative and exudative pleural effusion in relation to the applied definition of the syndrome.We performed a search through medical databases (MEDLINE, EMBASE, SCOPUS, and GOOGLE SCHOLAR) to identify papers on Meigs' syndrome published between 1940 and 2013. Two authors independently reviewed each paper searching for prespecified data: (1) signs and symptoms, (2) tumor characteristics, (3) clinical and laboratory data on ascites, (4) clinical, radiological, and laboratory data on pleural fluid, (5) clinical course after tumor removal. All case reports were reclassified according to a new unequivocal classification of Meigs' syndrome-related entities.A total of 653 papers were initially identified, and 454 articles reporting 541 patients were included in the final analysis. After reclassification according to our case definitions, there were 196, 113, and 108 patients defined as classic Meigs' syndrome, nonclassic Meigs' syndrome, and pseudo-Meigs' syndrome, respectively. Significantly more patients presented with right-sided than left-sided and bilateral pleural effusions (P < 0.001). Median volume of withdrawn pleural fluid was 2950 (1500-6000) mL. The classification of pleural effusion with the use of Light's criteria was possible in only 7 patients. In 6 of these patients pleural effusion met the criteria for an exudate. When the protein concentration > 3.0 g/dL was applied as a criterion of pleural exudate, 88.8% (80/90) of effusions were classified as exudates. Increasing the cut-off level to 3.5 g/dL resulted in only a modest decrease in the percentage of exudative effusions (81%, 73/90).Surprisingly few reports on Meigs' syndrome present data reliably defining the character of pleural effusion. The available data indicate, however, that the majority of pleural effusions in patients with this entity are exudates. This finding may be a prerequisite for the verification of some earlier presented concepts.
Topics: Female; Humans; Meigs Syndrome; Pleural Effusion; Prevalence
PubMed: 26656338
DOI: 10.1097/MD.0000000000002114 -
Annali Italiani Di Chirurgia Jul 2022Meigs syndrome is a rare disease defined by the coexistence of benign ovarian neoplasm, ascites and hydrothorax, which mainly affects women over the age of 30. This... (Review)
Review
Meigs syndrome is a rare disease defined by the coexistence of benign ovarian neoplasm, ascites and hydrothorax, which mainly affects women over the age of 30. This clinical condition refers only to cases in which the ovarian neoformation is a fibroid, a thecoma, a granulosa cell tumor or a Brenner tumor with disappearance of symptoms and effusions after removal of the neoplasm. Meigs syndrome is most frequently characterized by the presence of an ovarian fibroid, which in childhood is very rare and not commonly associated with the disease. In this article we report the case of an 11- year-old girl who came to our observation for a high fever for five days accompanied by cough and abdominal pain; imaging methods revealed bilateral hydrothorax, ascites, and a voluminous expansive right ovarian formation. On histological examination, the mass showed a cellular fibroid and the diagnosis of Meigs syndrome was made. Furthermore, we present a review of the literature aimed at detecting the state of knowledge on this disease in pediatric age, giving particular emphasis to the condition for which, in the presence of pleural effusion and ascites, an ovarian neoformation is not necessarily malignant. KEY WORDS: CT, Meigs syndrome, Pediatric, Pelvic mass, Ultrasounds.
Topics: Female; Child; Humans; Meigs Syndrome; Ascites; Hydrothorax; Early Detection of Cancer; Ovarian Neoplasms; Leiomyoma
PubMed: 36606361
DOI: No ID Found -
JAMA May 1971
Topics: Eponyms; Female; Humans; Meigs Syndrome; Terminology as Topic
PubMed: 5108250
DOI: 10.1001/jama.1971.03180320078024 -
Medicina Clinica Jul 2015
Topics: Aged; Cystadenoma, Mucinous; Female; Humans; Meigs Syndrome; Tomography, X-Ray Computed
PubMed: 25662723
DOI: 10.1016/j.medcli.2014.12.007