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Sao Paulo Medical Journal = Revista... Sep 2003Meigs' syndrome consists of a benign ovarian tumor accompanied by ascites and hydrothorax. Elevated serum CA 125 levels in postmenopausal women with solid adnexal...
CONTEXT
Meigs' syndrome consists of a benign ovarian tumor accompanied by ascites and hydrothorax. Elevated serum CA 125 levels in postmenopausal women with solid adnexal masses, ascites and pleural effusion are highly suggestive for malignant ovarian tumor. However, patients with Meigs' syndrome can also have elevated serum CA 125 levels. The authors report a case of Meigs' syndrome with elevated CA 125 level.
OBJECTIVE
This is a case report of Meigs' syndrome with elevated CA 125 level.
CASE REPORT
A 65-year-old Brazilian woman had presented progressive dyspnea, weight loss and decline in general condition over the 7 months preceding admission to our service. In another hospital, the patient had been submitted to thoracic drainage due to pleural effusion. With recurrence of the pleural effusion and increase in abdominal volume due to ascites and a pelvic mass, the patient sought our service. Transvaginal ultrasound showed an extensive adnexal solid mass of 16.4 x 10.8 cm located in the pelvis without exact limits, and the serum CA 125 level was elevated. With a preoperative diagnosis of ovarian carcinoma, the patient was submitted to exploratory laparotomy, which revealed a left ovarian tumor. The frozen section diagnosis was thecoma. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. The histology of the specimen confirmed the diagnosis of thecoma. The patient was asymptomatic with a normal serum CA 125 level 20 months after the operation.
Topics: Aged; CA-125 Antigen; Female; Humans; Meigs Syndrome; Thecoma
PubMed: 14666294
DOI: 10.1590/s1516-31802003000500007 -
BMC Pulmonary Medicine May 2016Meigs' syndrome is defined as the presence of a benign ovarian tumor with pleural effusion and ascites that resolve after removal of the tumor. The pathogenesis of the...
BACKGROUND
Meigs' syndrome is defined as the presence of a benign ovarian tumor with pleural effusion and ascites that resolve after removal of the tumor. The pathogenesis of the production of ascites and pleural effusion in this syndrome remains unknown. Aside from pleural effusion and ascites, pericardial effusion is rarely observed in Meigs' syndrome. Here, we report the first case of Meigs' syndrome with preceding pericardial effusion in advance of pleural effusion.
CASE PRESENTATION
An 84-year-old Japanese non-smoking woman with a history of lung cancer, treated by surgery, was admitted due to gradual worsening of dyspnea that had occurred over the previous month. She had asymptomatic and unchanging pericardial effusion and a pelvic mass, which had been detected 3 and 11 years previously, respectively. The patient was radiologically followed-up without the need for treatment. Two months before admission, the patient underwent a right upper lobectomy for localized lung adenocarcinoma and intraoperative pericardial fenestration confirmed that the pericardial effusion was not malignant. However, she began to experience dyspnea on exertion leading to admission. A chest, abdomen, and pelvis computed tomography scan confirmed the presence of right-sided pleural and pericardial effusion and ascites with a left ovarian mass. Repeated thoracentesis produced cultures that were negative for any microorganism and no malignant cells were detected in the pleural effusions. Pleural fluid accumulation persisted despite a tube thoracostomy for pleural effusion drainage. With a suspicion of Meigs' syndrome, the patient underwent surgical resection of the ovarian mass and histopathological examination of the resected mass showed ovarian fibroma. Pleural and pericardial effusion as well as ascites resolved after tumor resection, confirming a diagnosis of Meigs' syndrome. This clinical course suggests a strong association between pericardial effusion and ovarian fibroma, as well as pleural and peritoneal fluid.
CONCLUSIONS
In female patients with unexplained pericardial effusion and an ovarian tumor, clinicians should consider the possibility of Meigs' syndrome. Although a malignant disease should be suspected in all patients with undiagnosed pleural and/or pericardial effusion, Meigs' syndrome is curable by tumor resection and should be differentiated from malignancy.
Topics: Aged, 80 and over; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Meigs Syndrome; Pericardial Effusion; Pleural Effusion; Tomography, X-Ray Computed
PubMed: 27160723
DOI: 10.1186/s12890-016-0241-1 -
Nihon Rinsho. Japanese Journal of... 1977
Topics: Adult; Aged; Child; Female; Humans; Meigs Syndrome; Middle Aged
PubMed: 613035
DOI: No ID Found -
Rassegna Internazionale Di Clinica E... Sep 1957
Topics: Female; Humans; Meigs Syndrome; Neoplasms; Ovarian Neoplasms; Ovary
PubMed: 13494737
DOI: No ID Found -
Prensa Medica Argentina Jan 1955
Topics: Female; Humans; Meigs Syndrome; Neoplasms; Ovarian Neoplasms; Ovary
PubMed: 14371413
DOI: No ID Found -
L' Hopital May 1950
Topics: Female; Humans; Meigs Syndrome; Neoplasms; Ovary
PubMed: 15415023
DOI: No ID Found -
Laval Medical Dec 1962
Topics: Female; Fibroma; Humans; Meigs Syndrome; Ovarian Neoplasms
PubMed: 14018379
DOI: No ID Found -
Ugeskrift For Laeger Sep 1951
Topics: Female; Humans; Meigs Syndrome; Neoplasms; Ovarian Neoplasms; Ovary
PubMed: 14893553
DOI: No ID Found -
Belgisch Tijdschrift Voor Geneeskunde Jun 1950
Topics: Ascites; Female; Humans; Meigs Syndrome; Neoplasms; Ovary
PubMed: 15420144
DOI: No ID Found -
Bulletin de La Federation Des Societes... 1950
Topics: Female; Humans; Meigs Syndrome; Ovary
PubMed: 14812196
DOI: No ID Found