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Oral Surgery, Oral Medicine, Oral... Jul 2009The aim was to investigate the diagnostic imaging characteristics of Mikulicz disease (MD), especially sonographic ones, and to clarify the differences between them and... (Comparative Study)
Comparative Study
OBJECTIVE
The aim was to investigate the diagnostic imaging characteristics of Mikulicz disease (MD), especially sonographic ones, and to clarify the differences between them and those in Sjögren syndrome (SS), based on new criteria of MD.
STUDY DESIGN
The sonographic and sialographic images, as well as clinical, histopathologic, and serologic findings of 9 patients satisfying the new criteria of MD were analyzed and compared with those in SS.
RESULTS
All swollen submandibular glands showed bilateral nodal hypoechoic areas with high vascularization on sonograms and a parenchymal defect on sialograms, whereas parotid glands showed normal or slight change on both images. Nodal areas in submandibular gland sonograms were unclear on computerized tomography and on magnetic resonance imaging, but showed accumulation on gallium scintigraphy.
CONCLUSION
Mikulicz disease showed a high rate of bilateral nodal change in submandibular glands, which was completely different from SS. For detection and follow-up of these changes, sonography may be the best imaging modality.
Topics: Adult; Aged; Biopsy; Diagnosis, Differential; Female; Gallium Radioisotopes; Humans; Immunoglobulin G; Lymphocytes; Magnetic Resonance Imaging; Male; Middle Aged; Mikulicz' Disease; Parotid Diseases; Radiopharmaceuticals; Retrospective Studies; Saliva; Sialography; Sjogren's Syndrome; Submandibular Gland Diseases; Tomography, X-Ray Computed; Ultrasonography
PubMed: 19451003
DOI: 10.1016/j.tripleo.2009.02.032 -
Annales de Pathologie Nov 2012
Review
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Diagnosis, Differential; Humans; Hypergammaglobulinemia; Immunoglobulin G; Lymph Nodes; Male; Middle Aged; Mikulicz' Disease; Nephritis, Interstitial; Pancreatitis; Plasma Cells; Retroperitoneal Fibrosis; Sclerosis
PubMed: 23127945
DOI: 10.1016/j.annpat.2012.07.015 -
Rheumatology (Oxford, England) Jan 2015
Topics: Age Factors; Female; Glucocorticoids; Humans; Immunoglobulin G; Male; Mikulicz' Disease; Prednisolone; Sex Factors
PubMed: 25065016
DOI: 10.1093/rheumatology/keu282 -
Quantitative Imaging in Medicine and... Dec 2023
PubMed: 38106322
DOI: 10.21037/qims-23-563 -
Reumatologia Clinica 2013
Topics: Biomarkers; Diagnosis, Differential; Humans; Immunoglobulin G; Mikulicz' Disease; Sjogren's Syndrome
PubMed: 23570964
DOI: 10.1016/j.reuma.2013.02.003 -
Journal of Oral and Maxillofacial... Nov 1985
Topics: Aged; Diagnosis, Differential; Female; History, 19th Century; History, 20th Century; Humans; Lacrimal Apparatus Diseases; Lymph Nodes; Lymphoma; Mikulicz' Disease; Salivary Gland Neoplasms; Submandibular Gland Neoplasms
PubMed: 3903084
DOI: 10.1016/0278-2391(85)90231-9 -
Ceskoslovenska Stomatologie 1952
Topics: Humans; Mikulicz' Disease
PubMed: 12998075
DOI: No ID Found -
Revista de La Sociedad de Pediatria Del... 1945
Topics: Humans; Mikulicz' Disease
PubMed: 21028310
DOI: No ID Found -
Modern Rheumatology Feb 2012IgG4-related disease (IgG4RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by... (Review)
Review
IgG4-related disease (IgG4RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. IgG4RD may be present in a certain proportion of patients with a wide variety of diseases, including Mikulicz's disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, interstitial nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pseudotumor. Although IgG4RD forms a distinct, clinically independent disease category and is attracting strong attention as a new clinical entity, many questions and problems still remain to be elucidated, including its pathogenesis, the establishment of diagnostic criteria, and the role of IgG4. Here we describe the concept of IgG4RD and up-to-date information on this emerging disease entity.
Topics: Autoimmune Diseases; Female; Guidelines as Topic; Humans; Immunoglobulin G; Male; Mikulicz' Disease; Organ Specificity; Pancreatitis; Plasma Cells; Terminology as Topic
PubMed: 21881964
DOI: 10.1007/s10165-011-0508-6 -
Oral Surgery, Oral Medicine, Oral... Sep 2005To remove the confusion surrounding the terms "Mikulicz's disease" and "Mikulicz's syndrome" by discovering the nature of the disease that Mikulicz described.
OBJECTIVE
To remove the confusion surrounding the terms "Mikulicz's disease" and "Mikulicz's syndrome" by discovering the nature of the disease that Mikulicz described.
STUDY DESIGN
Investigation of the original 1892 publication by Mikulicz in the light of current knowledge.
RESULTS
Mikulicz described bilateral painless swellings of the lacrymal, major salivary, and minor salivary glands that were present for 14 months without a reduction in salivary flow before the patient, a man of 42 years, died. A print of a microscopical field of one of the submandibular glands contains a uniform lymphocytic infiltrate of centrocyte-like cells typical of MALT lymphoma, which is strongly supported by the reported clinical features.
CONCLUSION
Mikulicz published the first case report of a MALT lymphoma of salivary glands, and the terms "Mikulicz's disease" and "Mikulicz's syndrome" should no longer be used.
Topics: Adult; Diagnosis, Differential; Fatal Outcome; Humans; Lymphoma, B-Cell, Marginal Zone; Male; Mikulicz' Disease; Salivary Gland Neoplasms; Syndrome; Terminology as Topic
PubMed: 16122662
DOI: 10.1016/j.tripleo.2005.01.016