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Pediatric Blood & Cancer Aug 2022Lymphedema in children is rare; however, it is usually a progressive and chronic condition. Accurate diagnosis of lymphedema in the pediatric population often takes... (Review)
Review
Lymphedema in children is rare; however, it is usually a progressive and chronic condition. Accurate diagnosis of lymphedema in the pediatric population often takes several months and sometimes is delayed for years. Lymphedema can be isolated or associated with genetic syndromes, thus it is very important to identify the correct diagnosis, to select carefully which patients to refer for genetic testing, and to initiate appropriate treatment in a timely fashion. In this article, we review key information about diagnosis of lymphedema, associated conditions and syndromes, and current treatment modalities.
Topics: Child; Humans; Lymphedema; Syndrome
PubMed: 36070213
DOI: 10.1002/pbc.29908 -
Pediatric Blood & Cancer Aug 2022Lymphedema in children is rare; however, it is usually a progressive and chronic condition. Accurate diagnosis of lymphedema in the pediatric population often takes... (Review)
Review
Lymphedema in children is rare; however, it is usually a progressive and chronic condition. Accurate diagnosis of lymphedema in the pediatric population often takes several months and sometimes is delayed for years. Lymphedema can be isolated or associated with genetic syndromes, thus it is very important to identify the correct diagnosis, to select carefully which patients to refer for genetic testing, and to initiate appropriate treatment in a timely fashion. In this article, we review key information about diagnosis of lymphedema, associated conditions and syndromes, and current treatment modalities.
Topics: Child; Humans; Lymphedema; Physical Therapy Modalities; Syndrome
PubMed: 35404535
DOI: 10.1002/pbc.29611 -
CA: a Cancer Journal For Clinicians 2009
Topics: Humans; Lymphedema
PubMed: 19147866
DOI: 10.3322/caac.20007 -
Cardiovascular Research Jul 2021Vascular endothelial growth factor receptors (VEGFRs) are part of the evolutionarily conserved VEGF signalling pathways that regulate the development and maintenance of... (Review)
Review
Vascular endothelial growth factor receptors (VEGFRs) are part of the evolutionarily conserved VEGF signalling pathways that regulate the development and maintenance of the body's cardiovascular and lymphovascular systems. VEGFR3, encoded by the FLT4 gene, has an indispensable and well-characterized function in development and establishment of the lymphatic system. Autosomal dominant VEGFR3 mutations, that prevent the receptor functioning as a homodimer, cause one of the major forms of hereditary primary lymphoedema; Milroy disease. Recently, we and others have shown that FLT4 variants, distinct to those observed in Milroy disease cases, predispose individuals to Tetralogy of Fallot, the most common cyanotic congenital heart disease, demonstrating a novel function for VEGFR3 in early cardiac development. Here, we examine the familiar and emerging roles of VEGFR3 in the development of both lymphovascular and cardiovascular systems, respectively, compare how distinct genetic variants in FLT4 lead to two disparate human conditions, and highlight the research still required to fully understand this multifaceted receptor.
Topics: Animals; Cardiovascular System; Disease Models, Animal; Gene Expression Regulation, Developmental; Heart Defects, Congenital; Humans; Lymphatic System; Lymphedema; Mice, Transgenic; Morphogenesis; Mutation; Signal Transduction; Vascular Endothelial Growth Factor Receptor-3
PubMed: 33067626
DOI: 10.1093/cvr/cvaa291 -
Lymphatic Research and Biology Dec 2014Patients, health care providers, and payers depend on practical, efficient, and useful tests that can be performed in a clinical setting in order to measure accurately... (Review)
Review
Patients, health care providers, and payers depend on practical, efficient, and useful tests that can be performed in a clinical setting in order to measure accurately and to diagnose lymphedema. Accurate measures are also necessary to monitor progression or regression of the disease, as well as treatment effects. This article reviews clinical measures of lymphedema that are currently being utilized. In addition, this article proposes an alternative objective measure, different from limb volume, that quantifies tissue texture.
Topics: Humans; Lymphedema; Neoplasms; Prognosis
PubMed: 25317946
DOI: 10.1089/lrb.2014.0019 -
Boletin Cultural E Informativo -... Nov 1953
Topics: Disease; Edema; Humans; Leg; Lymphedema
PubMed: 13160128
DOI: No ID Found -
Annals of Vascular Surgery Jan 1996
Topics: Drainage; Humans; Lymphedema; Physical Therapy Modalities
PubMed: 8688303
DOI: 10.1007/BF02002347 -
Experientia 1976
Review
Topics: Animals; Disease Models, Animal; Humans; Lymphedema; Vasa Vasorum
PubMed: 782901
DOI: 10.1007/BF02003702 -
JAMA May 1976The clinical recognition and evaluation of congenital lymphedema of the lower extremities with abrupt onset in a 51-year-old man are reviewed. A rational, systematic...
The clinical recognition and evaluation of congenital lymphedema of the lower extremities with abrupt onset in a 51-year-old man are reviewed. A rational, systematic approach is outlined and exemplifies the use of an interdisciplinary effort to achieve accurate diagnosis through readily available diagnostic procedures.
Topics: Age Factors; Diagnosis, Differential; Humans; Lymphatic System; Lymphedema; Lymphography; Male; Middle Aged
PubMed: 946512
DOI: No ID Found -
Krankenpflege Journal May 1983
Topics: Elephantiasis; Humans; Lymphatic System; Lymphedema
PubMed: 6552319
DOI: No ID Found