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Medecine Sciences : M/S Feb 2022
Topics: Humans; Precision Medicine; Sjogren's Syndrome
PubMed: 35179468
DOI: 10.1051/medsci/2021258 -
Best Practice & Research. Clinical... Jun 2004Sjögren's syndrome is an autoimmune disease characterized by inflammation of the exocrine glands, leading to impaired function. Here, I review the relatively short... (Review)
Review
Sjögren's syndrome is an autoimmune disease characterized by inflammation of the exocrine glands, leading to impaired function. Here, I review the relatively short history of the syndrome and explain why it is frequently underdiagnosed, undertreated and under-researched. Attempts to provide classification criteria have culminated in the revised American-European Consensus Criteria, which provide a sound basis for both clinical management and research. The recognition that Sjögren's syndrome is a disease of considerable morbidity has led to a more aggressive approach to therapy ranging from topical therapies to systemic treatment with secretagogues such as pilocarpine and cemiveline, and immunomodulatory drugs such as hydroxychloroquine and interferon-alpha. The central role of the glandular epithelial cell is identified as the key to understanding the pathogenesis of the disease. Hypofunction rather than destruction of these cells is now regarded as the main mechanism of secretory failure in Sjögren's syndrome.
Topics: Humans; Sjogren's Syndrome
PubMed: 15158743
DOI: 10.1016/j.berh.2004.02.010 -
International Journal of Rheumatic... Oct 2017
Review
Topics: Age of Onset; Asia; Asian People; Humans; Incidence; Prevalence; Prognosis; Risk Factors; Sjogren's Syndrome
PubMed: 29027763
DOI: 10.1111/1756-185X.13201 -
Acta Medica Portuguesa Oct 1994This paper consists the theorical review and the current concepts of the subject and the second includes the casuistry of the Stomatology Department of the Pulido... (Review)
Review
This paper consists the theorical review and the current concepts of the subject and the second includes the casuistry of the Stomatology Department of the Pulido Valente Hospital. From April 1989 to 1991 (2 years), a study was made on Sjögren Syndrome (Primary and Secondary) of multiple character with the particular co-operation of the Portuguese Institute of Rheumatology. With this paper we wish to point out the importance of the oral evaluation of the study of the plurisystemic diseases as well as to establish criterions of diagnosis for the Portuguese population. Eighty cases of suspected Sjögren's Syndrome have been assessed, 66 of which have been fully. The reason for the consultation was dry mouth, dry eyes and enlargement of parotid glands. The symptoms were isolated or in association with other pathologies after other causes had been excluded. We had to establish the salivary reference values for the Portuguese population in 22 healthy volunteers. The xerostomia was evaluated by the Sialochemistry, Sialography, Cintigraphy and biopsies of the lower lip and of the sublingual gland. The ophthalmologic examination took place in the Ophthalmology Department of Santo António dos Capuchos Hospital by means of Shirmer test, Rosa Bengala and B.U.T. In spite of Sjögren's Syndrome being, up to now, so remotely determined in connection with the treatment, these patients need medical care and Stomatology plays a fundamental role as far as the diagnosis and the therapeutic points of view are concerned. We maintain the notion that the Syndrome is not as infrequent as one would believe and the evaluation of the oral field is important to establish the degree of the disease and its treatment.
Topics: Female; Humans; Male; Middle Aged; Sjogren's Syndrome
PubMed: 7856465
DOI: No ID Found -
JAAPA : Official Journal of the... Nov 2012
Topics: Humans; Sjogren's Syndrome
PubMed: 23620927
DOI: 10.1097/01720610-201211000-00014 -
Postgraduate Medicine Sep 2020Health care has become increasingly fragmented, partly due to advancing medical technology. Patients are often managed by various specialty teams when presenting with... (Review)
Review
Health care has become increasingly fragmented, partly due to advancing medical technology. Patients are often managed by various specialty teams when presenting with symptoms that could be manifestations of different diseases. Approximately one third of them are referred to specialists, at over half for outpatient appointments. Fatigue, pain, depression, dry mouth, headaches, and arthralgia are common complaints and frequently require referral to specialist physicians. Differential diagnoses include fibromyalgia (FM), Sjogren's syndrome (SS), and depression. Evaluations involve various sub-specialist especially physicians like those practicing pain management, rheumatology, and psychiatry. Thresholds for referring vary. Patients sometime feel lost in a 'medical maze'. Disagreement is frequent between specialties regarding management. Each discipline has its own diagnostic and treatment protocols and there is little consensus about shared decision-making. Communication between doctors could improve continuity. There are many differences and similarities in the pathophysiology, symptomatology, diagnosis, and treatment of fibromyalgia, Sjogren's syndrome, and depression. Understanding the associations between fibromyalgia, Sjogren's syndrome and depression should improve clinical outcome via a common holistic approach.
Topics: Depression; Diagnosis, Differential; Fatigue; Fibromyalgia; Humans; Severity of Illness Index; Sjogren's Syndrome
PubMed: 32314938
DOI: 10.1080/00325481.2020.1758426 -
Arthritis Research & Therapy Feb 2024Sjögren's disease is a heterogeneous autoimmune disorder that may be associated with systemic manifestations such as pulmonary or articular involvement. Systemic... (Review)
Review
Sjögren's disease is a heterogeneous autoimmune disorder that may be associated with systemic manifestations such as pulmonary or articular involvement. Systemic complications have prognostic implications and need to be identified and managed in a timely manner. Treatment should be tailored to the type and severity of organ involvement, ideally based on multidisciplinary evaluation.
Topics: Humans; Sjogren's Syndrome; Autoimmune Diseases
PubMed: 38331820
DOI: 10.1186/s13075-024-03262-4 -
Archives of Medical Research Nov 2006The term Sjögren's syndrome refers to keratoconjunctivitis sicca and xerostomia due to lymphocytic infiltrates of lachrymal and salivary glands. The current used... (Review)
Review
The term Sjögren's syndrome refers to keratoconjunctivitis sicca and xerostomia due to lymphocytic infiltrates of lachrymal and salivary glands. The current used criteria for diagnosis of primary Sjögren's syndrome is the American-European consensus. Primary Sjögren's syndrome is an autoimmune disorder characterized by lymphocytic infiltrates and destruction of the salivary and lachrymal glands and systemic production of autoantibodies to the ribonucleoprotein particles SS-A/Ro and SS-B/La. The infiltrating cells (T- and B-cells, dendritic cells) interfere with glandular function at several points: destruction of glandular elements by cell-mediated mechanisms; secretion of cytokines that activate pathways bearing the signature of type 1 and 2 interferons; production of autoantibodies that interfere with muscarinic receptors; and secretion of metalloproteinases (MMPs) that interfere with the interaction of the glandular cell with its extracellular matrix, which is necessary for efficient glandular function. As the process progresses, the mucosal surfaces become sites of chronic inflammation and the start of a vicious circle. Despite extensive study of the underlying cause of Sjögren's syndrome, the pathogenesis remains obscure. In broad terms, pathogenesis is multifactorial; environmental factors are thought to trigger inflammation in individuals with a genetic predisposition to the disorder.
Topics: Biomarkers; Environment; Humans; Sjogren's Syndrome
PubMed: 17045106
DOI: 10.1016/j.arcmed.2006.08.002 -
Current Rheumatology Reviews 2018The association of primary Sjogren´s Syndrome (SS) and amyloidosis has been recognized but scarcely assessed. (Review)
Review
BACKGROUND
The association of primary Sjogren´s Syndrome (SS) and amyloidosis has been recognized but scarcely assessed.
OBJECTIVE
Herein we analyzed the literature regarding this association in order to describe a SS phenotype prone to both conditions.
METHODS
PubMed and CINAHL databases were searched from inception until April 2016 for the keywords: Amyloidosis, amyloid, Sjögren's syndrome and their combinations.
RESULTS
Most of the cases corresponded to localized amyloidosis mainly at skin and lung, whereas only three cases were systemic. Other places of localized amyloidosis were the kidney, tracheobronchial, tongue, breast, salivary gland and vocal cord. Most of the localized forms corresponded to AL type, whereas AA amyloidosis was uncommon. The diagnosis of amyloidosis followed the SS onset (1-25 years) and in the majority of patients the presence of B cell hyperactivity traduced by hypergammaglobulinemia, positive rheumatoid factor and/or anti-Ro/SSA and anti-La/SSB antibodies were observed. In seven patients, an associated lymphoma was also documented.
CONCLUSION
The spectrum of lymphoid proliferation associated with SS extends beyond the classical B cell lymphoma. Localized or systemic amyloidosis might coexist with primary SS. Localized amyloidosis should be suspected in patients with consistently high serologic activity and suggestive lesions.
Topics: Adult; Aged; Amyloidosis; Autoimmunity; Biomarkers; Cell Proliferation; Humans; Lung; Lymphocytes; Middle Aged; Phenotype; Sjogren's Syndrome; Skin
PubMed: 28049394
DOI: 10.2174/1573397113666170103152537 -
Wiadomosci Lekarskie (Warsaw, Poland :... 2014Sjögren's syndrome (SS--Sjögren's Syndrom) is an autoimmune systemic disease of connective tissue. The aim of this study was to present the contemporary literature on... (Review)
Review
Sjögren's syndrome (SS--Sjögren's Syndrom) is an autoimmune systemic disease of connective tissue. The aim of this study was to present the contemporary literature on the basis of the pathophysiology of the Sjögren's syndrome, with particular reference to the pathogenesis of the damage to the salivary glands. It also discusses the criteria for classification, aetiology and pathogenesis of the SS, as well as the clinical symptoms of the disease in the oral cavity and its influence on the composition of the saliva. The knowledge of the Sjbgren's syndrome is important for the diagnosis and treatment of this disease.
Topics: Humans; Salivary Gland Diseases; Sjogren's Syndrome
PubMed: 26030959
DOI: No ID Found