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Journal Der Deutschen Dermatologischen... Jan 2021Clear cell acanthoma is a rarely diagnosed tumor with variable clinical morphology that is usually only recognized by its histopathological features. The primary lesion... (Review)
Review
Clear cell acanthoma is a rarely diagnosed tumor with variable clinical morphology that is usually only recognized by its histopathological features. The primary lesion is a red papule a few millimeters in diameter that often occurs as a single lesion on the lower extremities. In dermoscopy, resemblance of the vessels to a string of pearls is a largely specific finding of clear cell acanthoma. In contrast to the initially uncharacteristic clinical findings, histopathology of clear cell acanthomas is characterized by a typical compact, well-demarcated acanthosis consisting of pale-staining, PAS-reactive keratinocytes. As etiology and pathogenesis are both unclear, nosology of clear cell acanthoma is also controversial, with an ongoing debate as to its classification as cutaneous neoplasia or reactive inflammatory dermatosis.
Topics: Acanthoma; Dermoscopy; Humans; Keratinocytes; Keratosis; Skin Neoplasms
PubMed: 32989899
DOI: 10.1111/ddg.14270 -
Journal Der Deutschen Dermatologischen... Feb 2015
Review
Topics: Acanthoma; Diagnosis, Differential; Humans; Knee; Male; Middle Aged; Porokeratosis; Skin Neoplasms
PubMed: 25631132
DOI: 10.1111/ddg.12447 -
Journal of the European Academy of... Apr 2022
Topics: Acanthoma; Humans; Nail Diseases; Skin Neoplasms
PubMed: 34753213
DOI: 10.1111/jdv.17800 -
Dermatopathology (Basel, Switzerland) Aug 2020Degos and Civatte first described clear cell acanthoma (CCA) in 1962 and later in a review article found that, in most instances, the lesion was a solitary red-brown... (Review)
Review
Degos and Civatte first described clear cell acanthoma (CCA) in 1962 and later in a review article found that, in most instances, the lesion was a solitary red-brown dome-shaped papule that involved the distal lower extremity. The first morphologic variant of CCA was reported as a "giant form of the acanthoma of Degos" which measured 45 × 40 mm, about twice the size of the largest CCA documented earlier. Since then, many variants of CCA have been described, including polypoid, pigmented and atypical. Herein, we describe a new variant of CCA and add another example of the polypoid variant to the literature. The new variant exhibits cellular features of trichilemmoma but architecturally differs from it. We also attempt to broaden the list of CCA variants summarized by Tempark and Shwayder by adding ours and a few more examples of CCA. The new variants of CCA include verrucous, linear, subungual and trichilemmal.
PubMed: 32854184
DOI: 10.3390/dermatopathology7020005 -
European Journal of Dermatology : EJD Jun 2017
Review
Topics: Acanthoma; Aged, 80 and over; Buttocks; Female; Humans; Sebaceous Glands; Skin Neoplasms
PubMed: 28492170
DOI: 10.1684/ejd.2017.2996 -
Clinical and Experimental Dermatology Dec 2012Clear cell acanthoma (CCA), is an asymptomatic benign lesion of unknown origin and aetiology, which typically presents as a red to brown, dome-shaped papule on the leg.... (Review)
Review
Clear cell acanthoma (CCA), is an asymptomatic benign lesion of unknown origin and aetiology, which typically presents as a red to brown, dome-shaped papule on the leg. We discuss the case of a patient with an irregular plaque of hypopigmented papules whose diagnosis of CCA was only made by biopsy, and review the characteristic presentation, uncommon variants, locations and associated conditions of this lesion. The diagnosis is based on histopathology and/or immunohistochemistry, but the variable clinical presentation may make diagnosis difficult. The differential diagnosis includes skin tumours and inflammatory and pigmentary dermatoses. The lesions do not regress spontaneously, and excisional removal is the preferred treatment.
Topics: Abdominal Wall; Acanthoma; Child, Preschool; Diagnosis, Differential; Humans; Immunohistochemistry; Male; Nevus, Pigmented; Skin Neoplasms
PubMed: 23171155
DOI: 10.1111/j.1365-2230.2012.04428.x -
The American Journal of Dermatopathology Jul 2021Eosinophilic hyaline inclusions (EHIs) or globules have been reported in various cutaneous tumors including vascular lesions, myoepithelial neoplasms, and basal cell...
Eosinophilic hyaline inclusions (EHIs) or globules have been reported in various cutaneous tumors including vascular lesions, myoepithelial neoplasms, and basal cell carcinoma. In basal cell carcinoma, the presence of intracytoplasmic inclusions is reportedly associated with myoepithelial differentiation. In this regard, EHI has not been conclusively documented in a cutaneous lesion of genuine squamous cell lineage without aberrant differentiation. In the current case, a biopsy from the right thigh of a 71-year-old male patient demonstrated a relatively well-demarcated intraepidermal squamous lesion featured an admixture of predominantly enlarged keratinocytes harboring distinct eccentric intracytoplasmic EHI and a smaller population of keratinocytes displaying pale cytoplasm. Cytologic atypia, mitotic activity, and inflammatory cells were not identified. The intracytoplasmic EHI stained red with Masson's trichrome and were negative with periodic-acid Schiff with and without diastase. Immunologically, the lesion was strongly and diffusely positive for various cytokeratins but negative for ubiquitin and myoepithelial markers. Only cytokeratin AE1 revealed a differential staining pattern as the suprabasal lesional cells displayed significantly stronger immunoreactivity in comparison with the adjacent normal keratinocytes. Polymerase chain reaction for low-risk and high-risk human papillomavirus was negative. Molecular studies did not reveal any mutations commonly encountered in seborrheic or lichenoid keratoses. As an analogous lesion has not previously reported in the literature, the term hyaline inclusion acanthoma is proposed for this peculiar lesion.
Topics: Acanthoma; Aged; Biomarkers, Tumor; Biopsy; Humans; Hyalin; Immunohistochemistry; Keratinocytes; Male; Skin Neoplasms
PubMed: 33606370
DOI: 10.1097/DAD.0000000000001927 -
JAAD Case Reports May 2021
PubMed: 33912638
DOI: 10.1016/j.jdcr.2021.03.018 -
Actas Dermo-sifiliograficas Dec 2022
Topics: Humans; Acanthoma; Skin Neoplasms; Sebaceous Glands
PubMed: 36543467
DOI: 10.1016/j.ad.2021.08.010