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Mini Reviews in Medicinal Chemistry Jan 2009This paper is a general overview that contributes for the knowledge systematization concerning the characteristics of the acne in the adult, its prevalence, causes,... (Review)
Review
This paper is a general overview that contributes for the knowledge systematization concerning the characteristics of the acne in the adult, its prevalence, causes, diagnosis, classification and drugs available for treatment. The reference therapy is the combination between topical retinoids and oral antibiotics. Oral isotretinoin is still the only available therapy that may modify the different acne physiopathologic factors and therefore it is the standard treatment for severe acne. The importance of the acne treatment in the adult should be enhanced as it can also lead to symptoms of serious depression and anxiety.
Topics: Acne Vulgaris; Adult; Anti-Bacterial Agents; Anti-Infective Agents, Local; Humans; Retinoids
PubMed: 19149656
DOI: 10.2174/138955709787001730 -
The Medical Letter on Drugs and... Feb 2024
Topics: Humans; Acne Vulgaris
PubMed: 38294764
DOI: 10.58347/tml.2024.1695a -
Pediatrics in Review Nov 2013
Review
Topics: Acne Vulgaris; Dermatologic Agents; Humans; United States
PubMed: 24187141
DOI: 10.1542/pir.34-11-479 -
Skin Pharmacology and Physiology 2014Acne in the adult female often presents as a chronic condition that can have a considerable negative psychological, social and emotional impact on the affected... (Review)
Review
Acne in the adult female often presents as a chronic condition that can have a considerable negative psychological, social and emotional impact on the affected individual. Estimated prevalence rates of adult female acne vary widely according to study type. Case reports and clinical examinations estimate the prevalence of clinical acne at 10-12%, while survey estimates of physiological disease states are as high as 54%. Two subtypes of adult female acne may be defined according to time of onset: 'persistent' and 'late-onset', accounting for approximately 80 and 20% of cases, respectively. Postadolescent acne is generally mild-to-moderate in severity and presents with more inflammatory lesions and fewer comedones compared to adolescent acne. Furthermore, the impact of acne on the quality of life is often greater in adult females than in younger individuals. Despite these important differences, the key principles of acne treatment in the adult female do not differ significantly from those of other age groups. However, specific characteristics relating to the adult female should be considered when selecting a treatment regimen.
Topics: Acne Vulgaris; Adult; Female; Humans; Prevalence
PubMed: 24280643
DOI: 10.1159/000354887 -
Boletin Medico Del Hospital Infantil de... 2021Neonatal acne (NA) is a transitory dermatosis that occurs between the second and fourth weeks of life in 20% of children. This condition is more frequent in males, with...
Neonatal acne (NA) is a transitory dermatosis that occurs between the second and fourth weeks of life in 20% of children. This condition is more frequent in males, with a male-female ratio of 4.5:1. Present primary skin lesions are open and closed comedones which can evolve into papules, erythematous pustules and, in rare cases, nodules and cysts. NA topography includes the forehead, cheeks, chin, and eyelids, but occasionally it spreads to the scalp, neck, and trunk. NA occurs due to an elevated production of placental and neonatal androgens (of adrenal origin in both sexes and of testicular origin in males) which cause enlargement of the sebaceous glands and increases the production of sebum. Most cases are mild and transient, but if NA is severe and long-lasting, clinical and paraclinical examination will be necessary to find congenital adrenal hyperplasia or a virilizing tumor of adrenal or gonadal origin. The diagnosis of NA is clinical; its main differential -diagnoses are neonatal cephalic pustulosis, other neonatal vesiculopustular dermatoses, infectious diseases, and acneiform reactions. The resolution of NA is spontaneous. In most cases, the use of a mild dermal cleanser and water will be sufficient. For comedogenic lesions (open and closed comedones), topical retinoids or 20% azelaic acid may be used, as well as some topical antibiotics for inflammatory lesions.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Child; Diagnosis, Differential; Female; Humans; Infant, Newborn; Male; Placenta; Pregnancy; Skin Diseases
PubMed: 34571513
DOI: 10.24875/BMHIM.20000327 -
Journal of the Royal College of... 1997
Review
Topics: Acne Vulgaris; Adolescent; Adult; Anti-Bacterial Agents; Female; Humans; Infant; Keratolytic Agents; Male; Prognosis; Retinoids; Treatment Outcome
PubMed: 9263960
DOI: No ID Found -
Journal of the Royal Society of Health Apr 1991
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Journal Der Deutschen Dermatologischen... Mar 2008Acne inversa is a chronic inflammatory skin disease featuring cutaneous and subcutaneous nodular inflammation, fistula formation and discharge of foul-smelling... (Review)
Review
Acne inversa is a chronic inflammatory skin disease featuring cutaneous and subcutaneous nodular inflammation, fistula formation and discharge of foul-smelling secretions. The disease can lead to functional impairment and psychological problems. There is inflammation of the terminal hair follicles in intertriginous regions, especially perianal, axillary and inguinal areas. Less often there is submammary, periumbilical, retroauricular or nuchal involvement. Without treatment the disease is chronic and progressive. The causes of acne inversa are multifactorial and pathogenesis is still not well understood. Besides a positive family history, obesity and cigarette smoking are trigger factors. Early diagnosis and therapy of acne inversa saves the patient years of suffering. The most effective treatment is undoubtedly the radical wide excision of the affected areas. Local measures such as radiotherapy, photodynamic therapy and cryotherapy have provided little benefit; the same is true for systemic antibiotic treatment or hormonal therapy with anti-androgens. TNF-alpha antagonists seem to have a promising influence on the disease. Further studies investigating the effect of these substances on acne inversa are warranted.
Topics: Acne Vulgaris; Germany; Humans; Practice Guidelines as Topic; Practice Patterns, Physicians'
PubMed: 18093218
DOI: 10.1111/j.1610-0387.2007.06492.x -
Journal of the European Academy of... Nov 2017Acne has been estimated to affect the majority of people at some point in their life and is common in Middle Eastern countries. While acne is frequently perceived to be... (Review)
Review
Acne has been estimated to affect the majority of people at some point in their life and is common in Middle Eastern countries. While acne is frequently perceived to be a self-limited disease of adolescence, there is an increasing population of adults with acne. Information about the management of acne in the Middle East is somewhat sparse; however, several studies have recently been conducted and will be discussed in this supplement.
Topics: Acne Vulgaris; Adolescent; Adult; Diagnosis, Differential; Female; Humans; Male; Middle East; Patient Education as Topic; Risk Factors; Young Adult
PubMed: 28990222
DOI: 10.1111/jdv.14491 -
Mymensingh Medical Journal : MMJ Jan 2014Sebum production is stimulated by androgens and is the key in the development of acne vulgaris. Several investigators have looked for direct relationships between serum... (Review)
Review
Sebum production is stimulated by androgens and is the key in the development of acne vulgaris. Several investigators have looked for direct relationships between serum androgen levels, sebum secretion rate and the presence of acne. The presence of acne in prepubertal girls and sebum production in both sexes correlate with serum dehydroepiandrosterone sulfate (DHEAS) levels. Although increased serum androgen levels correlate with the presence of severe nodular acne in men and women, these levels are often within the normal range in mild to moderate acne. This raises the question of whether there is an increased local production of androgens within the sebaceous gland of patients with acne vulgaris that leads to increased sebum secretion.
Topics: Acne Vulgaris; Androgens; Female; Humans; Male
PubMed: 24584396
DOI: No ID Found