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Skin Therapy Letter Jan 2024The treatment of acne vulgaris traditionally consists of a combination of topical and oral medications. The use of lasers to treat this condition has been an area of... (Review)
Review
The treatment of acne vulgaris traditionally consists of a combination of topical and oral medications. The use of lasers to treat this condition has been an area of increasing research, and several types have previously been used in the treatment of acne. New 1726 nm lasers specifically target the sebaceous gland, which is known to be pivotal in acne pathophysiology. This laser wavelength demonstrates substantial potential as a safe and effective therapeutic option for moderate to severe acne without the risks of systemic therapy. This paper reviews the 1726 nm lasers for acne vulgaris.
Topics: Humans; Acne Vulgaris; Sebaceous Glands; Lasers; Light; Treatment Outcome
PubMed: 38271552
DOI: No ID Found -
Clinical Medicine (London, England) 2005
Review
Topics: Acne Vulgaris; Anti-Bacterial Agents; Dermatology; Education, Medical, Continuing; Humans; Isotretinoin
PubMed: 16411353
DOI: 10.7861/clinmedicine.5-6-569 -
Dermatologic Clinics Oct 2005Acne is a common disorder that may have a considerable psychologic impact including anxiety and depression. Depression and suicide occur frequently in adolescents and... (Review)
Review
Acne is a common disorder that may have a considerable psychologic impact including anxiety and depression. Depression and suicide occur frequently in adolescents and young adults. Although case reports suggest an association between isotretinoin and depression and suicide, more rigorous observational studies and epidemiologic studies, using different designs, have not shown any effect of isotretinoin use in increasing the occurrence of depression and suicide. It is prudent for the practitioner to continue to use isotretinoin to treat severe acne, while at the same time informing patients and their relatives that depressive symptoms should be actively assessed at each visit and, if necessary, referral to a psychiatrist and a discontinuation of isotretinoin should be considered.
Topics: Acne Vulgaris; Adolescent; Adult; Australia; Depressive Disorder; Dermatologic Agents; Europe; Female; Humans; Isotretinoin; Male; Suicide; United States
PubMed: 16112443
DOI: 10.1016/j.det.2005.05.008 -
The Western Journal of Medicine Dec 1979The cause of acne is still obscure, but genetic predisposition, sebaceous overactivity, overgrowth of bacterial flora and exposure to comedogenic substances are all...
The cause of acne is still obscure, but genetic predisposition, sebaceous overactivity, overgrowth of bacterial flora and exposure to comedogenic substances are all significant factors. Acne lesions occur mainly in sebaceous follicles, which are characterized by deep follicular canals and large sebaceous glands. The associated seborrhea is not due to a circulatory excess of androgens but may be caused by a local amplification of androgenic activity. This, in turn, may be due to large numbers of androgen receptors and a high concentration of enzymes such as 17beta-hydroxysteroid dehydrogenase, within the sebaceous gland itself. Hyperkeratosis of the retention type in the pilary infrainfundibulum obstructs the outflow of sebum and keratin flakes. This favors the proliferation of Propionibacterium acnes which may initiate inflammation in microcomedos and lead to formation of pustules, papules or nodules. Topical therapy with tretinoin, benzoyl peroxide and antibiotics such as clindamycin is widely used today. Oral tetracyclines and other chemotherapeutic agents remain necessary in severe cases.
Topics: Acne Vulgaris; Adolescent; Adult; Female; Humans; Male; Vitamin A
PubMed: 161830
DOI: No ID Found -
Best Practice & Research. Clinical... Feb 2003Acne and body hair are both cutaneous responses to androgenic stimulation. They are normal events in adolescent girls. There is considerable variation in the evolution... (Review)
Review
Acne and body hair are both cutaneous responses to androgenic stimulation. They are normal events in adolescent girls. There is considerable variation in the evolution of the two conditions. The sebaceous gland is exquisitely sensitive to androgens, and acne appears with the onset of puberty, peaks in prevalence in the teenage years and gradually improves thereafter. Hair growth on the face, trunk and limbs develops more slowly and generally peaks in the 20s. Indications for endocrine investigation include very severe acne, onset of acne and hirsuties in the very early stage of puberty (Tanner stage 3) and systemic virilism. Treatment for acne and hirsuties can be either topical or systemic. The choice of therapy is based on the severity of the disease rather than the results of endocrine investigation. Further, since PCO is related to impaired glucose tolerance, advice relating to lifestyle changes should be offered to prevent the development of diabetes.
Topics: Acne Vulgaris; Adolescent; Endocrine System Diseases; Female; Hair; Hirsutism; Humans; Male
PubMed: 12758231
DOI: 10.1053/ybeog.2003.0348 -
Dermatologic Clinics Apr 2016The prevalence and emotional impact of acne scarring are underestimated by the medical community. Dermatology providers should be able to evaluate the acne scar patient... (Review)
Review
The prevalence and emotional impact of acne scarring are underestimated by the medical community. Dermatology providers should be able to evaluate the acne scar patient and discuss treatment options. Important aspects of the patient history include current treatments, prior acne scar procedures, and the patient's goals for treatment. During the physical examination, the scars are assessed and classified by scar morphology and overall severity of scarring. Finally, a treatment plan is developed in which the most appropriate procedures are matched with the scars that will work the best. Helping the patient understand likely expectations for improvement will increase overall satisfaction.
Topics: Acne Vulgaris; Cicatrix; Dermatology; Humans; Severity of Illness Index
PubMed: 27015781
DOI: 10.1016/j.det.2015.11.009 -
Cutis Jan 2024Acne vulgaris is a common condition that routinely affects females of childbearing age. Taking into consideration the reproductive journey of women when treating acne is... (Review)
Review
Acne vulgaris is a common condition that routinely affects females of childbearing age. Taking into consideration the reproductive journey of women when treating acne is of paramount importance given the safety concerns to both the mother and the fetus associated with certain medications. Therefore, careful consideration of therapeutic choices during pregnancy is crucial. Herein, we summarize the safety of acne treatments during pregnancy and offer practical clinical pearls for routine dermatology practice.
Topics: Pregnancy; Female; Humans; Acne Vulgaris
PubMed: 38478945
DOI: 10.12788/cutis.0951 -
International Journal of Dermatology Jun 1990
Review
Topics: Acne Vulgaris; Androgens; Fatty Acids; Female; Humans; Inflammation; Neutrophils; Sebum
PubMed: 2141829
DOI: 10.1111/j.1365-4362.1990.tb04749.x -
JAAPA : Official Journal of the... Aug 2022Acne vulgaris is a prevalent chronic skin disease caused by obstruction and/or inflammation of pilosebaceous follicles. Each year, about 50 million people in the United... (Review)
Review
Acne vulgaris is a prevalent chronic skin disease caused by obstruction and/or inflammation of pilosebaceous follicles. Each year, about 50 million people in the United States are affected. The use of topical and oral antibiotics to manage acne has been associated with the development of bacterial resistance. This article reviews concerns about antimicrobial use, current treatment recommendations, and emerging research in unconventional treatments.
Topics: Acne Vulgaris; Anti-Bacterial Agents; Chronic Disease; Humans
PubMed: 35881716
DOI: 10.1097/01.JAA.0000840500.37136.e5 -
Journal of Pediatric and Adolescent... Oct 2021Acne vulgaris is a common skin condition encountered in specialties outside of dermatology, including obstetrics and gynecology. The pathophysiology of acne is complex... (Review)
Review
Acne vulgaris is a common skin condition encountered in specialties outside of dermatology, including obstetrics and gynecology. The pathophysiology of acne is complex and includes disruption of the cutaneous microbiome, abnormal keratinization, inflammation, and hormonal influences. Various topical and systemic treatment modalities target each component of acne pathophysiology. Clinically, acne can be broken down into noninflammatory, inflammatory, or mixed subtypes. The age of the patient at presentation and signs and symptoms of hormonal imbalance might prompt workup for underlying disorders. The severity as well as type of acne dictates the type of treatment.
Topics: Acne Vulgaris; Adolescent; Child; Gynecology; Humans; Skin; Treatment Outcome
PubMed: 33727191
DOI: 10.1016/j.jpag.2021.03.002