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Eye, Ear, Nose & Throat Monthly Jun 1946
Topics: Cochlear Nerve; Cranial Nerve Neoplasms; Humans; Neoplasms; Neuroma
PubMed: 20991967
DOI: No ID Found -
Journal of Neurology, Neurosurgery, and... Nov 1950
Topics: Cochlear Nerve; Humans; Neoplasms; Neuroma; Neuroma, Acoustic; Vestibulocochlear Nerve
PubMed: 14795242
DOI: 10.1136/jnnp.13.4.277 -
The West Virginia Medical Journal Sep 1953
Topics: Cochlear Nerve; Humans; Neoplasms; Neurofibroma
PubMed: 13090645
DOI: No ID Found -
Archives of Pathology & Laboratory... Nov 2003Lipochoristomas (lipomatous choristomas) are rare tumors of the acoustic nerve (cranial nerve VIII/vestibulocochlear nerve) within the internal acoustic canal and...
CONTEXT
Lipochoristomas (lipomatous choristomas) are rare tumors of the acoustic nerve (cranial nerve VIII/vestibulocochlear nerve) within the internal acoustic canal and sometimes the cerebellopontine angle, and are histogenetically believed to be congenital malformations. Their clinically indolent behavior has recently prompted a more conservative management protocol in a quest for maximal nerve/hearing preservation. This approach contrasts sharply with that for the common internal acoustic canal/cerebellopontine angle tumors, the neuroepithelial neoplasms (acoustic schwannomas and meningiomas), which behave more aggressively and have more prominent clinical manifestations. Owing to their rarity, the clinicopathologic features of cranial nerve VIII lipochoristomas have been obtained mainly through case reports.
OBJECTIVE
We present the clinicopathologic features of 11 cases of lipochoristomas of cranial nerve VIII.
DESIGN
The 11 cases were documented between 1992 and 2003. We performed complete clinical reviews with histologic, histochemical, and immunohistochemical analyses of formalin-fixed, paraffin-embedded tumor samples.
RESULTS
The patients were 8 men and 3 women with hearing loss of the right ear (5 patients) or the left ear (6 patients). No patient had bilateral tumors. All lipochoristomas histologically possessed mature adipose tissue admixed with varied amounts of mature fibrous tissue, tortuous thick-walled vessels, smooth muscle bundles, and skeletal muscle fibers, the latter verified with immunohistochemistry.
CONCLUSIONS
The histomorphologic and immunophenotypic evidence showed that these tumors are better characterized as choristomas than as simple "lipomas," as they have been labeled in the past. Their overall nonaggressive clinical nature in addition to the characteristic radiologic and histomorphologic findings are important clinicopathologic features for the pathologist to recognize and differentiate, especially during frozen section evaluations, in order to direct the neurosurgeon to a more appropriate conservative therapeutic intervention.
Topics: Adult; Cerebellar Neoplasms; Cerebellopontine Angle; Cochlear Nerve; Cranial Nerve Neoplasms; Female; Follow-Up Studies; Formaldehyde; Hearing Loss; Humans; Immunohistochemistry; Lipoma; Magnetic Resonance Imaging; Male; Middle Aged; Paraffin Embedding; Tissue Fixation; Tomography, X-Ray Computed; Vestibulocochlear Nerve
PubMed: 14567720
DOI: 10.5858/2003-127-1475-LLTOTA -
Archives of Otolaryngology (Chicago,... Sep 1965
Review
Topics: Cochlear Nerve; Deafness; Hearing Loss, Noise-Induced; Hearing Loss, Sensorineural; Hearing Tests; Humans; Peripheral Nervous System Diseases
PubMed: 14327040
DOI: 10.1001/archotol.1965.00760010324024 -
The Journal of Comparative Neurology Nov 1976The maturation of the stato-acoustic nerve in the cat was studied by light and electron microscopy from the fetal stage to the adult. Measurement of the outer diameter... (Comparative Study)
Comparative Study
The maturation of the stato-acoustic nerve in the cat was studied by light and electron microscopy from the fetal stage to the adult. Measurement of the outer diameter of the fibers and the study of the myelination process revealed that myelination begins earlier for the vestibular nerve than for the cochlear nerve: by the fifty-third day of gestation 64% of the vestibular fibres have already passed the promyelin stage whereas for the cochlear nerve this promyelin stage begins for the majority of fibers on the fifty-seventh gestation day. Afterward, maturation proceeds more rapidly for the cochlear nerve. In the case of both nerves, maturation is still incomplete at two months of age. Concerning the relationship between the thickness of the myelin sheath and the axoplasmic diameter, there is already a good correlation by the fifty-seventh day of gestation in the vestibular nerve, whereas it appears several days after birth in the cochlear nerve.
Topics: Age Factors; Animals; Biometry; Cats; Cell Count; Cochlear Nerve; Myelin Sheath; Nerve Fibers; Schwann Cells; Vestibular Nerve; Vestibulocochlear Nerve
PubMed: 977813
DOI: 10.1002/cne.901700102 -
Medicine Jan 2015Atypical teratoid/rhabdoid tumors (AT/RTs) are rare, highly malignant central nervous system tumors that predominantly occur in young children. A 22-year-old woman... (Review)
Review
Atypical teratoid/rhabdoid tumors (AT/RTs) are rare, highly malignant central nervous system tumors that predominantly occur in young children. A 22-year-old woman presented with a 4-year history of relapsing tinnitus and gradual hearing loss. Neuroimaging revealed an enhanced intrinsic left internal auditory canal mass. The patient underwent radiotherapy treatment. Three years later, the tumor size continued to increase, as observed by imaging, and ultimately evolved into the left cerebellopontine angle. As a consequence, a total tumor resection was performed, and a pathological diagnosis of AT/RT was made. Aggressive radiotherapy and chemotherapy treatment continued; however, the tumor recurred within 11 months after the total tumor resection. The patient died within 4 months of the second operation. Histopathologically, the tumor contained characteristic rhabdoid cells with areas that resembled a classical primitive neuroectodermal tumor. Immunostaining showed loss of INI1 protein expression in tumor cells, and fluorescence in situ hybridization showed a hemizygous deletion of the hSNF5/INI1 gene region on 22q11.2. This is the first report of an AT/RT that arised from the acoustic nerve in a young adult. Despite manifold diagnostic and therapeutic advances, the prognosis of patients with AT/RT remains poor.
Topics: Chemotherapy, Adjuvant; Cochlear Nerve; Cranial Nerve Neoplasms; Fatal Outcome; Female; Hearing Loss; Humans; Radiotherapy, Adjuvant; Reoperation; Rhabdoid Tumor; Teratoma; Tinnitus; Vestibulocochlear Nerve Diseases; Young Adult
PubMed: 25634176
DOI: 10.1097/MD.0000000000000439 -
Science (New York, N.Y.) Nov 1962In silver-stained preparations of the rat auditory system large neurons were distributed over the whole length of the acoustic nerve. These neurons received many...
In silver-stained preparations of the rat auditory system large neurons were distributed over the whole length of the acoustic nerve. These neurons received many synaptic endings which arose from collaterals of the acoustic fibers. The axons of the neurons ascended toward the cochlear nuclei. Similar neurons were found in the mouse, but not in the bat or cat.
Topics: Animals; Axons; Cats; Cochlear Nerve; Mice; Neurons; Rats
PubMed: 13952991
DOI: 10.1126/science.138.3543.893 -
Acta Oto-laryngologica 1964
Topics: Audiometry; Cochlear Nerve; Deafness; Electrophysiology; Hearing Tests; Humans; Labyrinth Diseases; Peripheral Nervous System Diseases
PubMed: 14140518
DOI: 10.3109/00016486409137076 -
Acta Oto-laryngologica 1964
Topics: Audiometry; Brain Diseases; Cochlea; Cochlear Nerve; Fenestration, Labyrinth; Humans; Otitis Media; Otosclerosis; Pathology; Pons; Stapes Surgery; Vestibular Nerve
PubMed: 14109457
DOI: 10.3109/00016486409136942