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Clinical Rheumatology Jan 2017Acro-osteolysis is an osteolysis of the distal phalanges of the hands and feet and can affect the terminal tuft or the shaft of the distal phalanx (transverse or band... (Review)
Review
Acro-osteolysis is an osteolysis of the distal phalanges of the hands and feet and can affect the terminal tuft or the shaft of the distal phalanx (transverse or band acro-osteolysis). It is often associated with distal digital ischemia, digital calcinosis, or severe sensory neuropathy. Acro-osteolysis has been associated with a heterogeneous group of disorders, including occupational activities, infections, rheumatic disorders (systemic sclerosis, psoriatic arthritis), endocrinopathies, genetic disorders, and lysosomal storage disorders. Plain radiography is the gold standard for the detection of acro-osteolysis.
Topics: Acro-Osteolysis; Finger Phalanges; Fingers; Hajdu-Cheney Syndrome; Hand; Humans; Hyperparathyroidism; Ischemia; Leprosy; Lysosomal Storage Diseases; Mutation; Osteolysis; Rheumatic Diseases; Rheumatology; Scleroderma, Systemic
PubMed: 27796661
DOI: 10.1007/s10067-016-3459-7 -
Skeletal Radiology Jan 2023Acro-osteolysis is the osseous destruction of the hand or foot distal phalanges. The categories of the disease include terminal tuft, midshaft, or mixed types.... (Review)
Review
Acro-osteolysis is the osseous destruction of the hand or foot distal phalanges. The categories of the disease include terminal tuft, midshaft, or mixed types. Recognition of acro-osteolysis is straightforward on radiographs, but providing an accurate differential diagnosis and appropriately recommending advanced imaging or invasive tissue diagnosis can be more elusive. A radiologist's ability to provide advanced assessment can greatly aid clinicians in expedient diagnosis and management of the array of diseases presenting with acro-osteolysis.
Topics: Humans; Diagnosis, Differential; Acro-Osteolysis; Finger Phalanges; Hand; Radiography; Osteolysis
PubMed: 35969258
DOI: 10.1007/s00256-022-04145-y -
European Journal of Rheumatology Apr 2019
PubMed: 30308144
DOI: 10.5152/eurjrheum.2018.18087 -
Journal of Clinical Rheumatology :... Apr 2023
Topics: Humans; Acro-Osteolysis; Fingers
PubMed: 36870083
DOI: 10.1097/RHU.0000000000001943 -
BMJ Case Reports Mar 2021Sarcoidosis is characterised by the formation of noncaseating granulomas classically affecting lungs, lymph nodes and skin. Osteoarticular involvement affects up to 15%...
Sarcoidosis is characterised by the formation of noncaseating granulomas classically affecting lungs, lymph nodes and skin. Osteoarticular involvement affects up to 15% of patients; however, acro-osteolysis, destruction involving distal phalanges of fingers and toes, associated with sarcoidosis, is extremely rare. A 44-year-old woman with a history of biopsy-proven sarcoidosis managed with prednisone and methotrexate presented with swelling and pain in the distal fingers of her right hand without skin manifestations. Radiographic imaging showed erosion of distal phalanges on second, third and fifth fingers and bone resorption in bilateral toes. A biopsy of the finger lesions showed noncaseating granulomas consistent with sarcoidosis. She was diagnosed with sarcoid acro-osteolysis and started on adalimumab with clinical and radiographic improvement. While most cases of osteoarticular sarcoidosis are asymptomatic and respond to standard immunosuppression, we present a case with progressive and refractory clinical course. This is the first reported case of sarcoid acro-osteolysis affecting the toes.
Topics: Acro-Osteolysis; Adult; Female; Fingers; Hand; Humans; Sarcoidosis; Toes
PubMed: 33653863
DOI: 10.1136/bcr-2020-240828 -
Mayo Clinic Proceedings Oct 2023
Topics: Humans; Acro-Osteolysis; Fingers
PubMed: 37793727
DOI: 10.1016/j.mayocp.2023.05.015 -
Clinical Rheumatology May 2024
PubMed: 38767709
DOI: 10.1007/s10067-024-06988-3 -
ACR Open Rheumatology Oct 2019
PubMed: 31777834
DOI: 10.1002/acr2.11072 -
Pediatric Rheumatology Online Journal Jul 2021Acro-osteolysis is a radiographic finding which refers to bone resorption of the distal phalanges. Acro-osteolysis is associated with various conditions and its presence... (Review)
Review
INTRODUCTION
Acro-osteolysis is a radiographic finding which refers to bone resorption of the distal phalanges. Acro-osteolysis is associated with various conditions and its presence should prompt the clinician to search for the underlying etiology. The aim of this review is to discuss disorders with which acro-osteolysis is associated and their distinguishing features, with a focus on the pediatric population.
METHODS
A targeted literature review was performed using the term "acro-osteolysis" in combination with other key terms. The primary search results were supplemented using reference citations. Articles published prior to the year 2000 were included if they described additional associations not encountered in the more recent literature.
RESULTS
Genetic disorders (particularly primary hypertrophic osteoarthropathy and skeletal dysplasias) and rheumatic diseases (particularly psoriatic arthritis and systemic sclerosis) are the most frequently encountered conditions associated with acro-osteolysis in children. Hyperparathyroidism, neuropathy, local trauma and thermal injury, and spinal dysraphism should also be included in the differential diagnosis.
CONCLUSION
Although acro-osteolysis is uncommon, its presence should prompt the clinician to consider a differential diagnosis based on clinical and radiographic features.
Topics: Acro-Osteolysis; Child; Diagnosis, Differential; Humans; Pediatrics; Rheumatology
PubMed: 34261502
DOI: 10.1186/s12969-021-00596-0 -
The American Journal of Roentgenology,... Jul 1965
Topics: Acro-Osteolysis; Adolescent; Bone Resorption; Fingers; Genetics, Medical; Humans; Joint Diseases; Kyphosis; Platybasia; Radiography; Skull; Toes
PubMed: 14303950
DOI: No ID Found