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QJM : Monthly Journal of the... Feb 2022
Topics: Acro-Osteolysis; Calcinosis; Humans; Scleroderma, Systemic
PubMed: 34963011
DOI: 10.1093/qjmed/hcab331 -
Lancet (London, England) Sep 2012
Topics: Acro-Osteolysis; Aged; Hand Bones; Humans; Male; Radiography; Raynaud Disease
PubMed: 22658741
DOI: 10.1016/S0140-6736(12)60275-X -
The Journal of Foot Surgery 1985Acro-osteolysis is a common radiographic finding in the upper or lower extremity. It may be idiopathic, part of a primary osteolysis syndrome, associated with a systemic...
Acro-osteolysis is a common radiographic finding in the upper or lower extremity. It may be idiopathic, part of a primary osteolysis syndrome, associated with a systemic disorder, traumatically induced, or caused by environmental toxins. Recognition of this process and its associated disorders is essential for complete patient care. This paper discusses the definition, etiologies, pathogenesis, and radiographic findings of acro-osteolysis.
Topics: Arm; Bone Resorption; Humans; Leg; Osteolysis; Radiography
PubMed: 4045123
DOI: No ID Found -
Rheumatology (Oxford, England) Oct 2021
Topics: Female; Finger Phalanges; Humans; Middle Aged; Osteolysis; Radiography; Scleroderma, Systemic
PubMed: 33493313
DOI: 10.1093/rheumatology/keab031 -
Clinical and Experimental Rheumatology 2021Acro-osteolysis is often associated with systemic sclerosis (SSc). However, the severity of acro-osteolysis and its clinical association among SSc patients is limited....
OBJECTIVES
Acro-osteolysis is often associated with systemic sclerosis (SSc). However, the severity of acro-osteolysis and its clinical association among SSc patients is limited. Our aims were to assess the prevalence of acro-osteolysis and the clinical association with acro-osteolysis among SSc patients at early onset of the disease.
METHODS
A cross-sectional study of 120 newly diagnosed SSc patients with the onset of less than 4 years were evaluated on clinical characteristics and hand radiographs. Acro-osteolysis was graded on a 0-4-point scale based on the severity and the patients were subdivided into mild, moderate and severe.
RESULTS
Among all SSc patients enrolled, 62.5% were females, 56.1% dcSSc and the vast majority of them (84.1%) were positive for anti-topoisomerase I antibody (anti-topo I). The mean disease duration was 2.0±1.3 years. Acro-osteolysis was noted in 77 patients with a prevalence of 64.1% (95%CI 54.9-72.7), of which 16.7% were defined as severe acro-osteolysis. Logistic regression analysis revealed that acro-osteolysis was positively associated with anti-topo I (OR 13.96), hand deformity (OR 3.81) and dysphagia (OR 6.66), but negatively associated with oedematous skin (OR 0.05). Analysis stratified by severity of acro-osteolysis showed significant differences between subgroup in terms of the presence of digital gangrene (p=0.02), ischaemic ulcer (p=0.001), oedematous skin (p=0.001), and hand deformities (p=0.01).
CONCLUSIONS
Acro-osteolysis was common in SSc at the early onset of disease. While the presence of anti-topo I, hand deformity and esophageal involvement were strongly associated with acro-osteolysis, oedematous skin was the protective factor for acro-osteolysis.
Topics: Acro-Osteolysis; Cross-Sectional Studies; Female; Humans; Prevalence; Scleroderma, Diffuse; Scleroderma, Systemic
PubMed: 33427611
DOI: 10.55563/clinexprheumatol/vggbdq -
Rheumatology (Oxford, England) Jul 2022
Topics: Acro-Osteolysis; Arthritis, Psoriatic; Humans; Nail Diseases
PubMed: 34613366
DOI: 10.1093/rheumatology/keab727 -
Journal of Clinical Rheumatology :... Aug 2023
Topics: Humans; Mixed Connective Tissue Disease; Acro-Osteolysis; Fingers
PubMed: 36944417
DOI: 10.1097/RHU.0000000000001959 -
BMJ Case Reports Mar 2019
Topics: Acro-Osteolysis; Diagnosis, Differential; Female; Fingers; Humans; Middle Aged; Occupational Diseases
PubMed: 30914415
DOI: 10.1136/bcr-2018-229054 -
European Journal of Case Reports in... 2020We describe a case of systemic sclerosis (SS) with acro-osteolysis associated with cutaneous mucinosis, usually characterized by mucin deposition in the skin. The main...
OBJECTIVES
We describe a case of systemic sclerosis (SS) with acro-osteolysis associated with cutaneous mucinosis, usually characterized by mucin deposition in the skin. The main differential diagnosis was multicentric reticulohistiocytosis due to the presentation of papulonodular skin lesions.
MATERIALS AND METHODS
A physical examination, imaging studies and laboratory tests were performed.
RESULTS
Distal bone resorption was evident on plain radiographs, and skin biopsy confirmed mucinosis. The SS diagnosis was based on the clinical features, high levels of antinucleolar antibodies and typical nailfold capillaroscopy findings.
CONCLUSION
To the best of our knowledge, this is the first description of cutaneous mucinosis accompanying SS with acro-osteolysis.
LEARNING POINTS
Cutaneous mucinosis is rarely associated with systemic sclerosis.Systemic sclerosis with cutaneous mucinosis may resemble multicentric reticulohistiocytosis.
PubMed: 32789122
DOI: 10.12890/2020_001568 -
Deutsche Medizinische Wochenschrift... Nov 1956
Topics: Bone Diseases; Disease; Foot; Foot Diseases; Hand; Humans
PubMed: 13384109
DOI: 10.1055/s-0028-1115229