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Mykosen Aug 1982
Topics: Diagnosis, Differential; Humans; Male; Mycetoma; Nocardia; Sporotrichosis; Tetracyclines
PubMed: 7133047
DOI: 10.1111/j.1439-0507.1982.tb01959.x -
The Journal of Antibiotics Sep 1997
Topics: Actinomycetales; Carbazoles; Excitatory Amino Acid Antagonists; Molecular Structure
PubMed: 9360623
DOI: 10.7164/antibiotics.50.770 -
Annales de Dermatologie Et de... Jan 2003Mycetoma is a pathological process in which eumycotic (fungal) or actinomycotic causative agents from exogenous source produce grains. It follows penetrating injury...
BACKGROUND
Mycetoma is a pathological process in which eumycotic (fungal) or actinomycotic causative agents from exogenous source produce grains. It follows penetrating injury inoculating soil organisms, occurring preferentially in rural areas usually among labourers who work barefoot. Mycetoma is a localized chronic, and deforming infectious disease of subcutaneous tissues, skin and bones. We report 130 cases of mycetoma in Senegal from 1983 to 2000.
PATIENTS AND METHODS
There were 130 patients with mycetoma. Clinical diagnosis of mycetoma was based on open tract sinuses, tumefaction or discharge of grain. Diagnosis confirmation was based on mycology and histology. An X-ray was preformed to detect bone lesions. Treatment was medical for actinomycetoma and surgical for eumycetoma.
RESULTS
We observed 76 actinomycetoma and 54 eumycetoma (Sex ratio M/F=6.6; mean age=34.7 +/- 14.8 years). The mean duration before the first medical evaluation was 4.8 +/- 5.6 years. Actinomycetoma was due to Actinomadura pelletieri, (54 cases), Actinomadura madurae (17 cases) and Streptomyces somaliensis (5 cases). Eumycetoma was due to Madurella mycetomatis (38 cases), Leptospahria senegalensis (9 cases), Pseudoallescheria boydii (6 cases) and Rhinoclediella atrovirens (1 case). Clinical inflammatory features significantly associated with actinomyces (p<0.001 OR=2.64) were predominant (85 cases). Tumoral and cystic features were found in the others forms. Lesions were located on the foot in 81 patients. Bone lesions, depending on the duration, were observed in 68 patients. Neurological damage occurred in 3 patients with dorsolumbar actinomycetoma. Sixty-six patients with actinomycetoma were cured by medical treatment.
DISCUSSION
The 130 cases of mycetoma were remarkable by the long duration of the disease before the first medical evaluation. Pain and tumor were the two main symptoms which brought the patients to the hospital and had appeared after 5 years duration and the predominance of actinomadura pelletieri actinomycetoma was responsible for 41.3 p. 100 of our cases. In Niger and Mauritania, mycetoma were actinomycetoma in respectively 71.2 p. 100 and 25 p. 100 of cases. The geographic distribution of pathogenic mycetoma agents was determined by the annual rainfall. Distinction between eumycetoma and actinomycetoma is very important for the treatment.
Topics: Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Mycetoma; Retrospective Studies
PubMed: 12605151
DOI: No ID Found -
Transactions of the Royal Society of... 1983Sera from 160 individuals resident in the Gezira, and 40 living in Khartoum, Sudan, were screened for antibodies to Streptomyces somaliensis and Actinomadura madurae...
Sera from 160 individuals resident in the Gezira, and 40 living in Khartoum, Sudan, were screened for antibodies to Streptomyces somaliensis and Actinomadura madurae using enzyme linked immunosorbent assay (ELISA). Antibodies were detected in 11.2% of those from the Gezira (6.8% to S. somaliensis, 4.3% to A. madurae, and 0.6% to both) compared to 2.5% of those resident in Khartoum. The ratio of men with antibodies compared to women was about 2:1 in those from Gezira. The results encouraged further epidemiological surveys are mycetoma in Sudan using ELISA.
Topics: Actinomycetales Infections; Adult; Antibodies, Bacterial; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Mycetoma; Nocardia; Nocardia Infections; Sex Factors; Streptomyces; Sudan
PubMed: 6679364
DOI: 10.1016/0035-9203(83)90011-1 -
Mycopathologia Dec 2018Mycetoma is a chronic inflammatory process caused either by fungi (eumycetoma) or bacteria (actinomycetoma). In this retrospective study, we report epidemiologic and...
BACKGROUND
Mycetoma is a chronic inflammatory process caused either by fungi (eumycetoma) or bacteria (actinomycetoma). In this retrospective study, we report epidemiologic and histopathological data of mycetoma observed in the Lome Hospital, Togo in a 25-year period (1992-2016).
METHODOLOGY
This is a retrospective study, over a period of 25 years, to analyze epidemiological and etiological findings of mycetomas seen in the single laboratory of pathological anatomy of the Lomé, Togo.
RESULTS
A total of 61 cases were retrieved from which only 33 cases were included which where clinically and microbiologically confirmed. The mean age of the patients was 29.7 ± 1.34 and a sex ratio (M/F) of 1.5. The majority of patients were farmers (n = 23 cases; 69.7%). Diagnosed etiologic agents were fungal in 24 cases (72.7%) and actinomycotic cases in 9 cases (27.3%). The fungal mycetomas consisted of Madurella mycetomatis (black grains) and Falcifomispora senegaliensis (black grains). The actinomycotic agents were represented by Actinomadura madurae (white grains), Actinomadurae pelletieri (red grains) and Nocardia sp. (yellow grains).
CONCLUSION
This report represents a single-center study which provides epidemiologic and histopathological data of mycetoma cases in Togo.
Topics: Actinobacteria; Adolescent; Adult; Aged; Child; Cross-Sectional Studies; Female; Fungi; Histocytochemistry; Hospitals; Humans; Male; Middle Aged; Mycetoma; Retrospective Studies; Togo; Young Adult
PubMed: 29557534
DOI: 10.1007/s11046-018-0260-y -
Bulletin of the Calcutta School of... Jan 1973
Topics: Actinomycetaceae; Actinomycetales Infections; Adult; Foot Diseases; Humans; Male
PubMed: 4807201
DOI: No ID Found -
Zentralblatt Fur Bakteriologie :... Jan 1997Thirty-one strains received either as Actinomadura madurae or Actinomadura pelletieri were assigned to four phena, clusters 1 to 4, in a numerical phenetic survey of the...
Thirty-one strains received either as Actinomadura madurae or Actinomadura pelletieri were assigned to four phena, clusters 1 to 4, in a numerical phenetic survey of the genus Actinomadura. Clusters 2 and 4 corresponded to the validly described species A. madurae and A. pelletieri whereas clusters 1 and 3 encompassed strains received as A. madurae and A. pelletieri, respectively. The two clusters that contained A. madurae strains formed a single taxon when a dataset lacking the antibiotic sensitivity entries was examined. Results from pyrolysis mass spectrometric and DNA amplification fingerprinting analyses underpinned the taxonomic status of clusters 2, 3 and 4 and suggested that the A. madurae strains accounted for a relatively wide range of variation. It is proposed that the cluster 3 strains be given species status within the genus Actinomadura given the congruence found between the chemical, molecular and numerical phenetic data. The name Actinomadura latina is proposed for the new taxon. The type strain is DSM 43382.
Topics: Actinomycetales; DNA, Bacterial; Gene Amplification; Humans; Mass Spectrometry
PubMed: 9060154
DOI: 10.1016/s0934-8840(97)80029-1 -
The Journal of General and Applied... Dec 2008The taxonomic position of one soil isolate 13-12(50)(T) was clarified by a polyphasic study. The organism showed a combination of chemotaxonomic and morphological...
The taxonomic position of one soil isolate 13-12(50)(T) was clarified by a polyphasic study. The organism showed a combination of chemotaxonomic and morphological properties typical of the genus Actinomadura. It formed a distinct phyletic line in the Actinomadura 16S rRNA gene tree and was closely associated with Actinomadura mexicana (sequence similarity 99.5%), Actinomadura glauciflava, Actinomadura citrea (sequence similarity 99.4%) and Actinomadura madurae (sequence similarity 99.2%). The result of DNA-DNA hybridizations between 13-12(50)(T) and Actinomadura mexicana was 49.9%. On the basis of the phenotypic, chemotaxonomic and genotypic properties, the isolate was differentiated from its closest phylogenetic relatives. It is proposed that the organism be classified as a novel species of the genus Actinomadura. The name proposed for the new taxa are Actinomadura maheshkhaliensis sp. nov. [(13-12(50)(T)=JCM 13934(T) =MTCC 8055(T)].
Topics: Actinomycetales; Bacterial Typing Techniques; Bangladesh; DNA, Bacterial; DNA, Ribosomal; Genes, rRNA; Genotype; Molecular Sequence Data; Nucleic Acid Hybridization; Phenotype; Plant Roots; RNA, Ribosomal, 16S; Rhizophoraceae; Sequence Analysis, DNA; Soil Microbiology
PubMed: 19164876
DOI: 10.2323/jgam.54.335 -
International Journal of Systematic... Jan 1990A new species of the genus Actinomadura which belongs to the Actinomadura madurae group of Goodfellow et al. was isolated from soil collected in Togo, West Africa.... (Comparative Study)
Comparative Study
A new species of the genus Actinomadura which belongs to the Actinomadura madurae group of Goodfellow et al. was isolated from soil collected in Togo, West Africa. Traditional taxonomic methods plus contemporary fatty acid analysis techniques were used to establish the position of this species. Both physiological characteristics and fatty acid composition differentiate this strain from previously described species. This culture produces a new polyether antibiotic. It is characterized by the production of white to pink aerial hyphae on a limited number of media. The aerial hyphae appear asporogenous, forming thick fibers and projections instead of true spores. The reverse side is a distinctive reddish orange. This organism is resistant to 5% NaCl and grows at temperatures between 20 and 45 degrees C. Whole cells contain meso-diaminopimelic acid, galactose, glucose, mannose, madurose, phosphatidylinositol, and diphosphatidylglycerol. The menaquinones detected were MK-9(H6) and minor amounts of MK-9(H8). The name proposed for this new species is Actinomadura fibrosa; the type strain is strain NRRL 18348.
Topics: Actinomycetales; Soil Microbiology; Species Specificity; Togo
PubMed: 2223595
DOI: 10.1099/00207713-40-1-28 -
Mykosen Jun 1983
Topics: Aged; Female; Foot Diseases; Humans; Italy; Mycetoma
PubMed: 6888420
DOI: No ID Found