-
Emerging Infectious Diseases Dec 2003We describe two immunosuppressed female patients with fever and Actinomyces odontolyticus bacteremia, a combination documented once previously in an immunocompetent male... (Review)
Review
We describe two immunosuppressed female patients with fever and Actinomyces odontolyticus bacteremia, a combination documented once previously in an immunocompetent male patient. The patients were treated with doxycycline and clindamycin; these drugs, with beta-lactams, are effective treatment for A. odontolyticus infections.
Topics: Actinomyces; Actinomycosis; Aged; Anti-Infective Agents; Bacteremia; Female; Humans; Immunocompromised Host; Middle Aged
PubMed: 14720410
DOI: 10.3201/eid0912.020646 -
Archives of Iranian Medicine Jun 2022
Topics: Actinomyces; Empyema, Pleural; Humans; Lung Abscess
PubMed: 35943021
DOI: 10.34172/aim.2022.65 -
Cellular and Molecular Gastroenterology... 2024
Topics: Humans; Actinomyces; Actinomycetaceae; Colorectal Neoplasms
PubMed: 38403274
DOI: 10.1016/j.jcmgh.2024.02.009 -
BMC Infectious Diseases Jun 2023The combined infection of actinomyces odontolyticus sepsis and cryptococcal encephalitis is rare in routine clinical practice. Thus, we presented this case report and... (Review)
Review
BACKGROUND
The combined infection of actinomyces odontolyticus sepsis and cryptococcal encephalitis is rare in routine clinical practice. Thus, we presented this case report and literature review to provide clues to improve such patients' diagnoses and treatment processes.
CASE PRESENTATION
The main clinical manifestations of the patient were high fever and intracranial hypertension. Then, we completed the routine cerebrospinal fluid examination, biochemical detection, cytological examination, bacterial culture, and India ink staining. Firstly, the blood culture suggested actinomyces odontolyticus infection, considering the possibility of actinomyces odontolyticus sepsis and intracranial actinomyces odontolyticus infection. Accordingly, the patient was administered penicillin for treatment. Although the fever was slightly relieved, the symptoms of intracranial hypertension did not relieve. After 7 days, the characteristics of brain magnetic resonance imaging and the results of pathogenic metagenomics sequencing and cryptococcal capsular polysaccharide antigen suggested that cryptococcal infection. Based on the above results, the patient was diagnosed with a combined infection of cryptococcal meningoencephalitis and actinomyces odontolyticus sepsis. Anti-infection therapy with 'penicillin, amphotericin, and fluconazole' was provided, improving the clinical manifestations and objective indexes.
CONCLUSION
The combined infection of Actinomyces odontolyticus sepsis and cryptococcal encephalitis is first reported in this case report, and combined antibiotics with 'penicillin, amphotericin, and fluconazole' are effective.
Topics: Humans; Fluconazole; Amphotericin B; Cryptococcus neoformans; Actinomycosis; Penicillins; Sepsis; Meningoencephalitis; Actinomyces; Intracranial Hypertension; Antifungal Agents; Meningitis, Cryptococcal
PubMed: 37365493
DOI: 10.1186/s12879-023-08391-w -
Journal of Clinical Periodontology Feb 1998It has been recognized for some time that bacterial species exist in complexes in subgingival plaque. The purpose of the present investigation was to attempt to define...
It has been recognized for some time that bacterial species exist in complexes in subgingival plaque. The purpose of the present investigation was to attempt to define such communities using data from large numbers of plaque samples and different clustering and ordination techniques. Subgingival plaque samples were taken from the mesial aspect of each tooth in 185 subjects (mean age 51 +/- 16 years) with (n = 160) or without (n = 25) periodontitis. The presence and levels of 40 subgingival taxa were determined in 13,261 plaque samples using whole genomic DNA probes and checkerboard DNA-DNA hybridization. Clinical assessments were made at 6 sites per tooth at each visit. Similarities between pairs of species were computed using phi coefficients and species clustered using an averaged unweighted linkage sort. Community ordination was performed using principal components analysis and correspondence analysis. 5 major complexes were consistently observed using any of the analytical methods. One complex consisted of the tightly related group: Bacteroides forsythus, Porphyromonas gingivalis and Treponema denticola. The 2nd complex consisted of a tightly related core group including members of the Fusobacterium nucleatum/periodonticum subspecies, Prevotella intermedia, Prevotella nigrescens and Peptostreptococcus micros. Species associated with this group included: Eubacterium nodatum, Campylobacter rectus, Campylobacter showae, Streptococcus constellatus and Campylobacter gracilis. The 3rd complex consisted of Streptococcus sanguis, S. oralis, S. mitis, S. gordonii and S. intermedius. The 4th complex was comprised of 3 Capnocytophaga species, Campylobacter concisus, Eikenella corrodens and Actinobacillus actinomycetemcomitans serotype a. The 5th complex consisted of Veillonella parvula and Actinomyces odontolyticus. A. actinomycetemcomitans serotype b, Selenomonas noxia and Actinomyces naeslundii genospecies 2 (A. viscosus) were outliers with little relation to each other and the 5 major complexes. The 1st complex related strikingly to clinical measures of periodontal disease particularly pocket depth and bleeding on probing.
Topics: Adult; Aged; Aged, 80 and over; Bacteria, Anaerobic; Bacterial Typing Techniques; Cluster Analysis; DNA Probes; DNA, Bacterial; Dental Plaque; Ecosystem; Female; Humans; Male; Middle Aged; Periodontal Index; Periodontal Pocket; Periodontitis; Regression Analysis; Statistics, Nonparametric
PubMed: 9495612
DOI: 10.1111/j.1600-051x.1998.tb02419.x -
Nature Medicine Jun 2019In most cases of sporadic colorectal cancers, tumorigenesis is a multistep process, involving genomic alterations in parallel with morphologic changes. In addition,...
In most cases of sporadic colorectal cancers, tumorigenesis is a multistep process, involving genomic alterations in parallel with morphologic changes. In addition, accumulating evidence suggests that the human gut microbiome is linked to the development of colorectal cancer. Here we performed fecal metagenomic and metabolomic studies on samples from a large cohort of 616 participants who underwent colonoscopy to assess taxonomic and functional characteristics of gut microbiota and metabolites. Microbiome and metabolome shifts were apparent in cases of multiple polypoid adenomas and intramucosal carcinomas, in addition to more advanced lesions. We found two distinct patterns of microbiome elevations. First, the relative abundance of Fusobacterium nucleatum spp. was significantly (P < 0.005) elevated continuously from intramucosal carcinoma to more advanced stages. Second, Atopobium parvulum and Actinomyces odontolyticus, which co-occurred in intramucosal carcinomas, were significantly (P < 0.005) increased only in multiple polypoid adenomas and/or intramucosal carcinomas. Metabolome analyses showed that branched-chain amino acids and phenylalanine were significantly (P < 0.005) increased in intramucosal carcinomas and bile acids, including deoxycholate, were significantly (P < 0.005) elevated in multiple polypoid adenomas and/or intramucosal carcinomas. We identified metagenomic and metabolomic markers to discriminate cases of intramucosal carcinoma from the healthy controls. Our large-cohort multi-omics data indicate that shifts in the microbiome and metabolome occur from the very early stages of the development of colorectal cancer, which is of possible etiological and diagnostic importance.
Topics: Adult; Aged; Case-Control Studies; Colorectal Neoplasms; Disease Progression; Female; Gastrointestinal Microbiome; Humans; Male; Metabolomics; Metagenomics; Middle Aged; Neoplasm Staging; Young Adult
PubMed: 31171880
DOI: 10.1038/s41591-019-0458-7 -
Proceedings (Baylor University. Medical... Apr 2021spp. are filamentous gram-positive bacilli found in humans as a common flora of the oropharynx, gastrointestinal tract, and urogenital tract. Actinobacteria are...
spp. are filamentous gram-positive bacilli found in humans as a common flora of the oropharynx, gastrointestinal tract, and urogenital tract. Actinobacteria are normally present in the gums and are a common cause of infection in dental procedures and oral abscesses. To date, no cases of causing meningitis and cervical abscess have been reported in online databases. Therefore, we report the first case of meningitis and recurrent cervical abscess due to translocation from the oral cavity.
PubMed: 34219934
DOI: 10.1080/08998280.2021.1907079 -
Surgical Infections Jun 2013
Topics: Abscess; Actinomyces; Actinomycosis; Adult; Anti-Bacterial Agents; Breast Diseases; Female; Humans; Penicillin V
PubMed: 23586367
DOI: 10.1089/sur.2012.090 -
Monaldi Archives For Chest Disease =... Dec 2021Dear Editor, We read with interest the article by Balis et al. on pulmonary tuberculosis and actinomyces co-infection as a lung mass....
Dear Editor, We read with interest the article by Balis et al. on pulmonary tuberculosis and actinomyces co-infection as a lung mass....
Topics: Actinomyces; Actinomycosis; Coinfection; Humans; Lung; Mycobacterium
PubMed: 34874131
DOI: 10.4081/monaldi.2021.2102 -
Porto Biomedical Journal 2017Abdominal actinomycosis is a rare infection and the non-recognition of this particular microorganism may led to a prolonged septic process and recurrent disease. We...
Abdominal actinomycosis is a rare infection and the non-recognition of this particular microorganism may led to a prolonged septic process and recurrent disease. We hereby present a case report of 53 years-old woman with a secondary peritonitis due to this microorganism and our option to perform a long course of penicillin derived antibiotics, after suture of a perforated gastric ulcer caused by a foreign body.
PubMed: 32258616
DOI: 10.1016/j.pbj.2017.03.002