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Applied Radiation and Isotopes :... Jun 2009k(0) Instrumental Neutron Activation Analysis (k(0) INAA) was evaluated at the University of Missouri Research Reactor (MURR). The MURR, unlike many other research...
k(0) Instrumental Neutron Activation Analysis (k(0) INAA) was evaluated at the University of Missouri Research Reactor (MURR). The MURR, unlike many other research reactors that employ k(0) INAA, is refueled on a weekly basis. To determine if the neutron spectrum is stable enough for routine k(0) INAA analysis, the neutron spectrum parameters alpha and f were measured over a 9 month period. The average values of f and alpha measured using the Cd ratio multi monitor technique were 57.4+/-4.5 and 0.039+/-0.012, respectively. It was determined that k(0) INAA could be used at the MURR by employing the average value of alpha and f. However, significant measurement bias could occur for elements with high Q(0) values if the true spectral parameters deviate by more than 10% from the average value.
Topics: Missouri; Neutron Activation Analysis; Research; Universities
PubMed: 19231216
DOI: 10.1016/j.apradiso.2009.01.070 -
Analytical and Bioanalytical Chemistry Oct 2012Boron determination in blood and tissue samples is a crucial task especially for treatment planning, preclinical research, and clinical application of boron neutron... (Comparative Study)
Comparative Study
Intercomparison of inductively coupled plasma mass spectrometry, quantitative neutron capture radiography, and prompt gamma activation analysis for the determination of boron in biological samples.
Boron determination in blood and tissue samples is a crucial task especially for treatment planning, preclinical research, and clinical application of boron neutron capture therapy (BNCT). Comparison of clinical findings remains difficult due to a variety of analytical methods, protocols, and standard reference materials in use. This paper addresses the comparability of inductively coupled plasma mass spectrometry, quantitative neutron capture radiography, and prompt gamma activation analysis for the determination of boron in biological samples. It was possible to demonstrate that three different methods relying on three different principles of sample preparation and boron detection can be validated against each other and yield consistent results for both blood and tissue samples. The samples were obtained during a clinical study for the application of BNCT for liver malignancies and therefore represent a realistic situation for boron analysis.
Topics: Activation Analysis; Boron; Gamma Rays; Humans; Mass Spectrometry; Radiography
PubMed: 22918535
DOI: 10.1007/s00216-012-6329-4 -
The American Journal of Physiology Feb 1986In vivo neutron activation analysis (NAA) is currently used to measure body composition in metabolic and nutritional studies in many clinical situations, but has not... (Comparative Study)
Comparative Study
In vivo neutron activation analysis (NAA) is currently used to measure body composition in metabolic and nutritional studies in many clinical situations, but has not previously been validated by comparison with chemical analysis of human cadavers. Total body nitrogen (TBN) and chlorine (TBCl) were measured in two human cadavers by NAA before homogenization and chemical analysis (CHEM) after (cadaver 1: TBN, 1.47 NAA, 1.51 CHEM; TBCl, 0.144 NAA, 0.147 CHEM; cadaver 2: TBN, 0.576 NAA, 0.572 CHEM; TBCl, 0.0227 NAA, 0.0250 CHEM). The homogenates were also analyzed by NAA, and no significant differences were found, indicating that the effects of elemental inhomogeneity on the measurement of TBN and TBCl are insignificant. Total body water, fat, protein, minerals, and carbohydrates were measured chemically for each cadaver and compared with estimates for these compartments obtained from a body composition model, which when used in vivo involves NAA and tritium dilution. The agreement found justifies the use of the model for the measurement of changes in total body protein, water, and fat in sequential studies in groups of patients.
Topics: Activation Analysis; Anthropometry; Body Composition; Chemistry Techniques, Analytical; Chlorine; Female; Humans; Male; Middle Aged; Models, Biological; Neutron Activation Analysis; Nitrogen
PubMed: 3953790
DOI: 10.1152/ajpendo.1986.250.2.E179 -
Journal of the American Oil Chemists'... Nov 1968
Topics: Activation Analysis; Food Analysis
PubMed: 5697029
DOI: 10.1007/BF02631952 -
Nucleonics Mar 1951
Topics: Activation Analysis; Chemical Phenomena; Chemistry; Elements; Isotopes; Radioactivity; Radioisotopes
PubMed: 14827348
DOI: No ID Found -
Archives of Environmental Health 1980Neutron activation analysis and instrumental semiconductor gamma-ray spectrometry were used for analysis of 20 trace elements in 10 autopsied human organs and tissues...
Neutron activation analysis and instrumental semiconductor gamma-ray spectrometry were used for analysis of 20 trace elements in 10 autopsied human organs and tissues (liver, kidney, cerebrum, cerebellum, heart, muscle, pancreas, spleen, lung, and aorta) from 63 Japanese persons, whose ages ranged from 15 days to 85 yr. Distributions of aluminum, bromine, magnesium, manganese, rubidium, selenium, and vanadium in human body were almost uniform. High concentrations of cadmium were found in kidney and liver samples. There was a high mercury concentration in the liver, kidney, and brain samples. Concentrations of other elements (arsenic, gold, cobalt, chromium, copper, iron, indium, antimony, selenium, titanium, and zinc) in each organ or tissue are also presented in this paper.
Topics: Activation Analysis; Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Neutron Activation Analysis; Sex Factors; Spectrometry, Gamma; Tissue Distribution; Trace Elements
PubMed: 7362268
DOI: 10.1080/00039896.1980.10667459 -
Applied Radiation and Isotopes :... Oct 2008In this work, a comparative study of neutron activation analysis (NAA) was performed by the nuclear institutes: CDTN/CNEN-Brazil, CCHEN-Chile and the SCK.CEN-Belgium... (Comparative Study)
Comparative Study
In this work, a comparative study of neutron activation analysis (NAA) was performed by the nuclear institutes: CDTN/CNEN-Brazil, CCHEN-Chile and the SCK.CEN-Belgium aiming to investigate some generic, manipulated and reference medicines largely commercialized in Brazil. Some impurities such as: As, Ba, Br, Ce, Co, Cr, Eu, Fe, Hf, Sb, Sc, Sm, Ti and Zn were found, and the heterogeneity of the samples pointed out the lack of an efficient public system of quality control.
Topics: Brazil; Drug Evaluation; Drugs, Generic; Neutron Activation Analysis; Reference Values
PubMed: 18455924
DOI: 10.1016/j.apradiso.2008.03.004 -
International Journal of Radiation... 1990Prompt gamma-ray neutron activation analysis of 10B concentrations in biological samples was carried out using a germanium detector and single crystal silicon filtered...
Prompt gamma-ray neutron activation analysis of 10B concentrations in biological samples was carried out using a germanium detector and single crystal silicon filtered neutron beams from the TRIGA-II reactor. The 10B concentrations of biological samples such as tumors, tissues, blood and cultured cells were estimated from calibration curves obtained by using standard samples containing various 10B concentrations. A method of measuring absolute 10B concentrations was also presented.
Topics: Boron; Gamma Rays; Isotopes; Neutron Activation Analysis
PubMed: 2176195
DOI: 10.1016/0883-2889(90)90070-w -
Nature Feb 1963
Topics: Activation Analysis; Chromatography; Chromatography, Paper; Iodine; Iodine Isotopes
PubMed: 14027918
DOI: 10.1038/197446a0 -
Nature May 1963
Topics: Activation Analysis; Chromatography; Chromatography, Paper; Iodine; Iodine Isotopes
PubMed: 14027917
DOI: 10.1038/198576a0