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The American Journal of Dermatopathology Jul 2016Adenomyoepithelioma (AME) is a biphasic neoplasm of epithelial and myoepithelial cells. It is most commonly found in the breast, although rare cases have been reported... (Review)
Review
Adenomyoepithelioma (AME) is a biphasic neoplasm of epithelial and myoepithelial cells. It is most commonly found in the breast, although rare cases have been reported from the lung, salivary glands, and skin. There are 5 well-documented cases of cutaneous AME in the literature. We report a new case of cutaneous AME. Our case was commingled with apocrine hidrocystoma. This is the first report of cutaneous AME in a male patient and the first to describe SOX10 immunostaining in cutaneous AME. We review the literature on cutaneous AME and note the greater than chance colocalization with other adnexal tumors. We speculate that AME may represent localized overgrowth of myoepithelial cells within a pre-existent sweat gland tumor. Histopathologists should be aware of the potential of SOX10-positive myoepithelial neoplasms to mimic nodular melanocytic proliferations.
Topics: Adenomyoepithelioma; Adult; Aged, 80 and over; Apocrine Glands; Biomarkers, Tumor; Biopsy; Female; Hidrocystoma; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasms, Complex and Mixed; SOXE Transcription Factors; Skin Neoplasms; Sweat Gland Neoplasms; Treatment Outcome
PubMed: 26981739
DOI: 10.1097/DAD.0000000000000519 -
Breast Disease 2022Breast adenomyoepithelioma is a very uncommon tumor, which is generally considered to be benign, however malignant transformation has been reported.
INTRODUCTION
Breast adenomyoepithelioma is a very uncommon tumor, which is generally considered to be benign, however malignant transformation has been reported.
PRESENTATION OF CASE
We report two cases of two women with breast adenomyoepithelioma.
CONCLUSION
Diagnosis of adenomyoepithelioma is challenging because tumor may mimic other breast diseases. It has neither specific clinical signs nor radiological features, and the diagnosis is based on histopathological examination of the lesion. The treatment of choice is surgery. The type of surgery depends on the tumor factors and breast size. In malignant cases treatment such as radiotherapy, chemotherapy, immunotherapy may be used as well. It is very important to give an adequate treatment, otherwise the risk of tumor recurrence, growth or even metastatic spread, when tumor has malignant potential, increases.
Topics: Adenomyoepithelioma; Breast Neoplasms; Cell Transformation, Neoplastic; Female; Humans; Neoplasm Recurrence, Local
PubMed: 35811510
DOI: 10.3233/BD-210077 -
Surgical Case Reports Dec 2023Adenomyoepithelioma (AME) of the breast is an uncommon tumor characterized by the proliferation of ductal epithelial and myoepithelial cells with the heterogeneity....
BACKGROUND
Adenomyoepithelioma (AME) of the breast is an uncommon tumor characterized by the proliferation of ductal epithelial and myoepithelial cells with the heterogeneity. Although benign AME is relatively easy to differentiate from breast cancer by core needle biopsy (CNB) alone, a definitive diagnosis is often difficult. The imaging findings of AME are also variable, and there are particularly few reports about radiological features, including contrast-enhanced magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) values in AME.
CASE PRESENTATION
We present two cases of benign AME. Case 1 is a 30-year-old woman with a history of asthma. The cystic tumor shows smooth borders, and the intracystic solid component is irregular in shape and high vascularity. The pathological findings of the tumor were benign on CNB. The MRI scan showed a decreased ADC value. Case 2 is a 60-year-old woman with only a history of arrhythmia. The tumor shows a lobulated mass with cystic space and coarse calcifications. The pathological findings of the tumor were found to be benign by CNB. Dynamic MRI scan showed a fast washout pattern with a decreased ADC value. Both patients underwent excisional biopsy to confirm the diagnosis, and the pathological diagnosis was benign AME in both cases.
CONCLUSIONS
The AME of the breast has little specific imaging information, so it can be difficult to diagnose based on pathological findings of biopsy specimen. In our case, the ADC values were exceptionally low, contrary to previous reports. It is essential to carefully diagnose AME, considering the discrepancies in imaging findings observed in this case.
PubMed: 38123876
DOI: 10.1186/s40792-023-01793-7 -
The American Journal of Surgical... Jan 2020Pneumocytic adenomyoepithelioma (PAM) was first described in 2007 and was included in the 2015 World Health Organization Classification of lung tumors as a variant of... (Review)
Review
Pneumocytic adenomyoepithelioma (PAM) was first described in 2007 and was included in the 2015 World Health Organization Classification of lung tumors as a variant of epithelial-myoepithelial tumor. This rare pulmonary neoplasm was reported to show both myoepithelial and duct-like components, with the latter exhibiting pneumocytic differentiation with TTF-1 expression. We present an index case and 6 additional retrospectively identified cases of pulmonary tumors with prototypical features of PAM. However, with additional clinicoradiologic, histologic, immunohistochemical and cytogenetic data, we were able to reclassify them as myoepithelial neoplasms-both primary and metastatic-with entrapped exuberantly hyperplastic alveolar structures lined by TTF-1 pneumocytes. We reviewed the available literature related to PAM and myoepithelial tumors. Our cases suggest that the entity referred to as PAM represents interstitial growth of myoepithelial neoplasms enticing marked proliferation of entrapped pneumocytes rather than a distinct biphasic neoplasm with pneumocytic differentiation.
Topics: Adenomyoepithelioma; Aged; Aged, 80 and over; Alveolar Epithelial Cells; Female; Humans; Lung Neoplasms; Male; Middle Aged; Myoepithelioma; Retrospective Studies
PubMed: 31567188
DOI: 10.1097/PAS.0000000000001376 -
The Pan African Medical Journal 2022The diagnosis of adenomyoepitheliomas is difficult and relies on the presence of a double component of epithelial and myoepithelial cells belonging to the breast lobules...
The diagnosis of adenomyoepitheliomas is difficult and relies on the presence of a double component of epithelial and myoepithelial cells belonging to the breast lobules and ducts. The clinical and imaging characteristics are not specific; thus, the diagnosis is histological. In this article, we present a case of a young female who presented with a 2 cm lump in the breast without other clinical symptoms, which revealed a benign adenomyoepithelioma (AME). We performed a large excisional lumpectomy, and the patient recovered well with no complication or recurrence within two years follow-up. When it comes to adenomyoepitheliomas, the published literature is mainly composed of case reports, so much so that there are no evidence-based guidelines. Our case shows that an excisional lumpectomy is often enough when facing a small size tumor with no signs of malignancy, which contributes to the limited data on the subject.
Topics: Adenomyoepithelioma; Breast; Breast Neoplasms; Female; Humans; Mastectomy, Segmental
PubMed: 35145599
DOI: 10.11604/pamj.2022.41.7.28654 -
American Journal of Clinical Pathology Mar 1988Three adenomyoepitheliomas of the breast that occurred in elderly women are reported and the features of the six previously reported cases are reviewed. The tumors were... (Review)
Review
Three adenomyoepitheliomas of the breast that occurred in elderly women are reported and the features of the six previously reported cases are reviewed. The tumors were characterized by a proliferation of glands lined by a dual population of cells. On the basis of their appearance in rountinely stained sections and their immunohistochemical features, the inner cells were interpreted as epithelial, whereas the cells of the outer layer, which typically had abundant, clear cytoplasm, were interpreted as myoepithelial. One tumor was associated with, and may have arisen from, an adenomyoepithelial type of adenosis. Despite relatively bland cytologic features, one lesion recurred three times over the course of seven years. Follow-up for the other two patients is of short duration. Because of the possibility of local recurrence, wide local excision is recommended.
Topics: Aged; Breast Neoplasms; Carcinoma, Adenoid Cystic; Female; Humans; Mastectomy; Microscopy, Electron; Middle Aged; Neoplasm Recurrence, Local
PubMed: 2831705
DOI: 10.1093/ajcp/89.3.308 -
Journal of Cardiothoracic Surgery Aug 2016Adenomyoepithelioma (AME) of the breast is a rare tumour of unpredictable clinical behaviour. Most of the tumours are benign with some giving local recurrences or... (Review)
Review
BACKGROUND
Adenomyoepithelioma (AME) of the breast is a rare tumour of unpredictable clinical behaviour. Most of the tumours are benign with some giving local recurrences or distant metastases.
CASE PRESENTATION
We report a case of late lung metastases in a woman with a history of breast adenomyoepithelioma. Partial lobectomy was performed for lung lesions and initial diagnosis was epithelial-myoepithelial carcinoma.
CONCLUSION
Careful slide's revision of both breast and pulmonary lesions showed identical microscopic appearance with lung tumour performing more malignant features. Tumour cells in both: breast and pulmonary lesions were positive for cytokeratin and EMA (epithelial cells) and also for SMA, S100 and vimentin (myoepithelial cells). Two years and 7 months follow-up showed no recurrent neoplastic disease in our patient.
Topics: Adenomyoepithelioma; Breast Neoplasms; Female; Humans; Lung Neoplasms; Middle Aged; Pneumonectomy
PubMed: 27487934
DOI: 10.1186/s13019-016-0518-8 -
Human Pathology Dec 1987Adenomyoepithelioma, an uncommon benign breast tumor in which the proliferation of myoepithelial cells is a conspicuous component, was examined in 18 women. The initial...
Adenomyoepithelioma, an uncommon benign breast tumor in which the proliferation of myoepithelial cells is a conspicuous component, was examined in 18 women. The initial clinical finding was usually a mass in the periphery of the breast. Grossly, adenomyoepithelioma produced a circumscribed, firm tumor (average, 1.5 cm) with nodularity and cysts noted in some instances. Proliferating myoepithelial cells and gland-forming epithelial cells were conspicuous in all cases. In most, myoepithelial cells were polygonal and had clear vacuolated cytoplasm. Myoid, spindle-cell differentiation was rarely prominent, but cells of this type were present focally in most cases. Intraductal papillary adenomyoepitheliomatous hyperplasia was present within the tumors and sometimes in surrounding ducts. Immunohistochemical studies distinguished epithelial from myoepithelial cells. Hormone receptor studies showed four tumors were estrogen receptor positive, two were estrogen receptor negative, and five were progesterone receptor negative. One patient who underwent immediate mastectomy is well 4 years later. Two of the 17 women treated by local excision had recurrent adenomyoepithelioma in the same breast. All 18 patients remain well from 0.5 to 5.5 years after diagnosis. No patient had prior, coexistent, or subsequent adenocarcinoma of either breast. These findings indicate that adenomyoepithelioma is a benign tumor that can be adequately treated by complete local excision.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Adenoid Cystic; Epithelium; Female; Humans; Middle Aged; Muscles; Neoplasm Recurrence, Local
PubMed: 2824328
DOI: 10.1016/s0046-8177(87)80406-9 -
Asian Journal of Surgery Apr 2024
PubMed: 38641532
DOI: 10.1016/j.asjsur.2024.03.183 -
Journal of Clinical Pathology Jun 2011This review describes the classification, clinical presentation, pathological features and clinical behaviour of adenomyoepithelioma (AME) of the breast. It is based on... (Review)
Review
This review describes the classification, clinical presentation, pathological features and clinical behaviour of adenomyoepithelioma (AME) of the breast. It is based on an extensive review of the literature and study of a collection of cases built up over a 17-year period at the British Columbia Cancer Agency. The diversity of the morphology encountered in both benign and malignant AME is described. The behaviour of malignant AME seems to be related to the grade of the malignant component.
Topics: Adenomyoepithelioma; Breast Neoplasms; Cell Transformation, Neoplastic; Female; Humans
PubMed: 21307156
DOI: 10.1136/jcp.2010.087718