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Annales de Pathologie Oct 2015We report a case of adenomyoepithelioma with predominant myoepithelial quota, a rare tumor of the breast due to proliferation of epithelial and myoepithelial cells in a... (Review)
Review
We report a case of adenomyoepithelioma with predominant myoepithelial quota, a rare tumor of the breast due to proliferation of epithelial and myoepithelial cells in a patient of 71 years. This lesion, with difficult radiological and pathological diagnosis (biopsy) in the initial stage of the treatment, should benefit from surgical resection in healthy margin. In fact, this tumor is evolving in most cases on a benin mode, but cases of local or metastatic recurrences were reported. Histological and immunohistochemical arguments are important to reach the final diagnosis.
Topics: Adenomyoepithelioma; Aged; Biomarkers, Tumor; Biopsy; Breast Neoplasms; Epithelial Cells; Female; Humans; Mammography; Mastectomy, Segmental
PubMed: 26386768
DOI: 10.1016/j.annpat.2015.05.006 -
The American Journal of Surgical... Aug 1995A 66-year-old man with an extremely rare neoplasm of the lung, adenomyoepithelioma, is described. The tumor was a well-circumscribed lesion that showed solid, glandular,...
A 66-year-old man with an extremely rare neoplasm of the lung, adenomyoepithelioma, is described. The tumor was a well-circumscribed lesion that showed solid, glandular, and papillary growth patterns and was composed of two types of cells, inner epithelial cells and outer myoepithelial cells. This bidirectional differentiation was confirmed immunohistochemically. The inner epithelial cells were positive for carcinoembryonic antigen and epithelial membrane antigen, while the outer myoepithelial cells were S-100 protein-positive. Electron microscopically, the tumor was characterized by a large amount of microfilaments in the cytoplasm and layers of basement membrane-like material in the intercellular spaces. Some glycogen granules were detected.
Topics: Adenomyoma; Aged; Humans; Immunohistochemistry; Lung Neoplasms; Male; Myoepithelioma
PubMed: 7611543
DOI: 10.1097/00000478-199508000-00012 -
International Journal of Surgery Case... 2019Adenomyoepithelioma of the breast is a rarely reported and mostly benign disease that seldom undergoes malignant transformation.
INTRODUCTION
Adenomyoepithelioma of the breast is a rarely reported and mostly benign disease that seldom undergoes malignant transformation.
PRESENTATION OF THE CASE
Here, we present a case of malignant adenomyoepithelioma of the breast in a patient who initially presented with pain following an excision procedure at local clinic. The condition was finally diagnosed after a third surgical procedure, pathologic analysis with hematoxylin and eosin staining, and immunohistochemistry analysis to detect smooth muscle actin and S100 expression.
CONCLUSION
The patient developed no complications or recurrences after a total mastectomy with sentinel node dissection.
PubMed: 31128547
DOI: 10.1016/j.ijscr.2019.04.045 -
International Journal of Surgery Case... 2020Malignant breast adenomyoepithelioma (AME) is a rare subtype of breast cancer. AME is mostly a benign disease that uncommonly undergoes malignant transformation.
INTRODUCTION
Malignant breast adenomyoepithelioma (AME) is a rare subtype of breast cancer. AME is mostly a benign disease that uncommonly undergoes malignant transformation.
PRESENTATION OF CASE
Here we present a case of a young, previously healthy female who initially presented with a painless breast lump. The patient underwent wide local excision for atypical cells with squamous metaplasia by core biopsy, but final histopathology showed AME with carcinoma. Thus, a mastectomy and a sentinel lymph node biopsy was undertaken. The patient had an uneventful recovery and no recurrence after the second surgery.
DISCUSSION AND CONCLUSION
Malignant transformation of adenomyoepithelioma is reported in a small number of cases. Benign AME may be treated with wide local excision as recurrence is rare locally. Whereas malignant AME tends to be treated with simple mastectomy with or without lymph node biopsy.
PubMed: 32506031
DOI: 10.1016/j.ijscr.2020.05.061 -
Clinical Case Reports May 2019Adenomyoepithelioma with myoepithelial carcinoma of the breast is rare and diagnosed with histology and immunohistochemistry. We present a case of malignant...
Adenomyoepithelioma with myoepithelial carcinoma of the breast is rare and diagnosed with histology and immunohistochemistry. We present a case of malignant transformation over 10 years, with ultrasonographic findings, highlighting the importance of an early excisional biopsy. Conservative surgery and radiation therapy were performed. There was no recurrence for 2 years.
PubMed: 31110717
DOI: 10.1002/ccr3.2100 -
Pathology Apr 2017
Topics: Adenomyoepithelioma; Aged; Breast Neoplasms; Female; Humans
PubMed: 28249686
DOI: 10.1016/j.pathol.2016.11.015 -
BMJ Case Reports Feb 2022A woman in her 80s was referred as an emergency case with a large oedematous and ulcerating lesion of the right breast. There was a 5-month history of increasing breast...
A woman in her 80s was referred as an emergency case with a large oedematous and ulcerating lesion of the right breast. There was a 5-month history of increasing breast volume with new onset skin breakdown and discharge. Imaging revealed an extensive heterogeneous mass requiring drainage. No diagnosis was received from multiple biopsies and immediate surgical resection of the breast and axillary sampling was prioritised given the deteriorating patient condition. Postoperative histology identified a biphasic Adenomyoepithelioma of low malignant potential, a rare presentation compounding the complexity of management. The diagnostic uncertainty of this case highlighted the importance of MDT collaboration and the flexibility of current management pathways when dealing with cases requiring urgent surgical intervention. Axillary sampling in the context of unsuccessful preoperative biopsy represented a comprehensive means for assessing the need for further surgical or systemic management in the context of unconfirmed malignancy in a deteriorating patient.
Topics: Adenomyoepithelioma; Biopsy; Breast; Breast Neoplasms; Female; Humans; Uncertainty
PubMed: 35135791
DOI: 10.1136/bcr-2021-246390 -
Journal of Cutaneous Pathology Aug 2007An 83-year-old Caucasian woman presented to her dermatologist with a 5-cm subcutaneous tumor on her right thigh. The lesion had been present for many years, but had...
An 83-year-old Caucasian woman presented to her dermatologist with a 5-cm subcutaneous tumor on her right thigh. The lesion had been present for many years, but had recently enlarged. Incisional biopsy showed a multinodular tumor composed of variably sized glands comprised of a luminal layer of epithelial cells surrounded by one or more layers of myoepithelial cells. The histopathologic features resembled those of adenomyoepithelioma, an uncommon neoplasm usually encountered within the breast. Primary cutaneous adenomyoepithelioma is very rare yet shares histopathologic features with common cutaneous lesions such as spiradenomas and benign mixed tumors (chondroid syringomas). Primary cutaneous adenomyoepithelioma is part of the spectrum of epithelial-myoepithelial tumors that includes benign mixed tumor, myoepithelioma and myoepithelial carcinoma. This rare tumor may mimic malignant lesions including metastatic adenocarcinoma. Like its breast counterpart, primary cutaneous adenomyoepithelioma should probably be regarded as a neoplasm of borderline malignant potential.
Topics: Adenomyoma; Aged, 80 and over; Biopsy; Female; Humans; Myoepithelioma; Skin Neoplasms; Thigh
PubMed: 17640238
DOI: 10.1111/j.1600-0560.2006.00671.x -
International Journal of Surgical... Aug 2023
Topics: Humans; Female; Adenomyoepithelioma; Colorectal Neoplasms, Hereditary Nonpolyposis; Breast; Breast Neoplasms
PubMed: 35707990
DOI: 10.1177/10668969221105623 -
BMC Women's Health Aug 2021Adenomyoepithelioma (AME) of the breast is a rare subtype of breast tumor. Most of AMEs reported are solid, however, cystic or prominent cystic changes are extremely...
BACKGROUND
Adenomyoepithelioma (AME) of the breast is a rare subtype of breast tumor. Most of AMEs reported are solid, however, cystic or prominent cystic changes are extremely rare.
CASE PRESENTATION
A 51-year-old woman presented a lump in the upper outer quadrant of right breast, and it was accompanied by continuous breast pain and bilateral axillary itching for more than 2 months. There were no other symptoms found. Preoperative mammography and ultrasound examination were performed. Mammography showed a noncalcified lobulated mass, and it was considered to be a benign cyst with septum on ultrasound, but ductal carcinoma of breast, adenoid cystic carcinoma could not be excluded. At first, AME was not considered preoperatively, because the imaging features of this rare tumor may vary widely, which may result in an incorrect diagnosis. But eventually, AME was diagnosed by postoperative pathology and immunohistochemistry.
CONCLUSION
We herein present a rare case of breast AME with prominent cystic changes. AME has no-specific imaging features, but the benign or malignant nature of the lesion might be suspected on imaging.
Topics: Adenomyoepithelioma; Breast; Breast Neoplasms; Carcinoma, Adenoid Cystic; Female; Humans; Immunohistochemistry; Middle Aged
PubMed: 34348700
DOI: 10.1186/s12905-021-01432-z