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Diagnostic Cytopathology Nov 2019Sclerosing polycystic adenosis (SPA) is a rare salivary gland disease. Histologically it resembles a low-grade ductal carcinoma in situ or sclerosing adenosis of the...
Sclerosing polycystic adenosis (SPA) is a rare salivary gland disease. Histologically it resembles a low-grade ductal carcinoma in situ or sclerosing adenosis of the breast, characterized by lobular proliferation of ducts with apocrine cellular features surrounded by fibrosclerotic stroma. Although SPA is typically benign, recurrence is not uncommon, and cases with a malignant component have been documented. Thus, complete excision is desirable but preoperative diagnosis is challenging. A 12-year-old boy presented with a painless mass in the right neck. We identified a well-demarcated mass in the right parotid region measuring approximately 2 cm using cervical echography and magnetic resonance (MR) imaging. Fine-needle aspiration (FNA) revealed two cell types. There were loosely cohesive clusters of polymorphic epithelioid cells with irregular nuclei and abundant vacuolated cytoplasm containing zymogen granules. Some of these cells were binuclear. The other cell types represented normal ductal cells. The original cytological diagnosis was Warthin tumor. Right parotidectomy was performed. Histologically, we observed proliferation of ducts with granular, vacuolated, zymogen granules, and apocrine-like features in the cytoplasm with hyalinizing sclerotic stroma and some binuclear cells. Four years after parotidectomy, there has been no recurrence or malignant transformation.Cytological diagnosis of SPA is challenging on FNA specimens since SPA is a very rare entity of the salivary gland that can mimic other salivary gland neoplasms. A mixture of apocrine-like cells and sebaceous-like cells, nuclear pleomorphism, and zymogen granules can help to diagnose this rare lesion during the initial cytological diagnosis.
Topics: Adenolymphoma; Biopsy, Fine-Needle; Child; Diagnosis, Differential; Humans; Magnetic Resonance Imaging; Male; Salivary Gland Neoplasms; Scleroderma, Localized; Scleroderma, Systemic; Ultrasonography
PubMed: 31329351
DOI: 10.1002/dc.24283 -
Revista Espanola de Patologia :... 2020The risk of secondary tumors in patients who have received mediastinal radiation therapy is well-known. Microglandular adenosis of the breast is a rare lesion that is...
The risk of secondary tumors in patients who have received mediastinal radiation therapy is well-known. Microglandular adenosis of the breast is a rare lesion that is considered benign, although its possible role as a precursor of invasive breast carcinoma has been considered. We present a case of microglandular adenosis in a patient who received mediastinal radiation therapy in childhood for Hodgkin's lymphoma. To our knowledge, this is the first reported case of microglandular adenosis in a patient with mediastinal radiotherapy which may shed light on its pathogenesis.
Topics: Breast Neoplasms; Female; Fibrocystic Breast Disease; Hodgkin Disease; Humans; Radiation Injuries
PubMed: 33012496
DOI: 10.1016/j.patol.2020.01.003 -
American Journal of Obstetrics and... Sep 1965
Topics: Cysts; Diagnosis; Female; Genital Diseases, Female; Humans; Mucous Membrane; Pathology; Vagina
PubMed: 14336650
DOI: 10.1016/0002-9378(65)90660-5 -
Zhonghua Bing Li Xue Za Zhi = Chinese... Dec 2022
Topics: Humans; Female; Fibrocystic Breast Disease; Carcinoma
PubMed: 36480840
DOI: 10.3760/cma.j.cn112151-20220927-00812 -
Radiology Case Reports Aug 2020We report a case of nodular sclerosing adenosis presenting as false-positive uptake on molecular breast imaging (MBI). A 51-year-old woman with elevated lifetime risk of...
We report a case of nodular sclerosing adenosis presenting as false-positive uptake on molecular breast imaging (MBI). A 51-year-old woman with elevated lifetime risk of breast cancer underwent supplemental MBI which showed focal uptake in the right breast. A corresponding mass was found on ultrasound with subsequent biopsy yielding nodular sclerosing adenosis. After the biopsy results were reviewed, a problem solving breast MR was recommended. Breast MR showed a solitary enhancing right breast mass containing a marker clip, and the sonographic biopsy was then deemed concordant with pathology. While adenosis lesions are known mimickers of malignancy on other breast imaging modalities, their appearance on MBI has not been previously published.
PubMed: 32566066
DOI: 10.1016/j.radcr.2020.04.008 -
The Breast Journal 2009Microglandular adenosis of the breast is an extremely rare, benign lesion. Carcinoma arising in microglandular adenosis has been reported in up to 27% of patients with... (Review)
Review
Microglandular adenosis of the breast is an extremely rare, benign lesion. Carcinoma arising in microglandular adenosis has been reported in up to 27% of patients with microglandular adenosis. We reported a case of invasive carcinoma arising in microglandular adenosis. A lumpectomy was performed on a 42-year-old female because of a mass in the right breast. Grossly, the lesion was ill-defined with thickened areas. Histologically, this case was consistent with carcinoma arising in microglandular adenosis and showed clear transition from microglandular adenosis through atypical microglandular adenosis to in situ and invasive carcinoma. All the epithelial cells were positive for cytokeratin7, S-100 protein, but negative for estrogen receptor, progesterone receptor, and Her2/Neu. No myoepithelial cells were demonstrable with immunohistochemical staining for smooth muscle actin, muscle-specific antigen or P63. Periodic acid-Schiff staining showed the presence of a basement membrane in microglandular adenosis, atypical microglandular adenosis, in situ carcinoma and the absence in invasive carcinoma. To the best of our knowledge, this is the first reported case of carcinoma arising in microglandular adenosis in China.
Topics: Adult; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Fibrocystic Breast Disease; Humans; Immunohistochemistry
PubMed: 19824997
DOI: 10.1111/j.1524-4741.2009.00839.x -
International Journal of Surgical... Oct 2019Microglandular adenosis (MGA) of the breast is exceedingly rare, with only a few case reports and series published to date. Previous studies have elegantly demonstrated...
Microglandular adenosis (MGA) of the breast is exceedingly rare, with only a few case reports and series published to date. Previous studies have elegantly demonstrated the progression of benign MGA to atypical MGA to MGA-in situ carcinoma to invasive carcinoma and therefore suggest MGA as a possible non-obligate precursor lesion to a subset of breast carcinomas. Immunohistochemically, MGA is negative for estrogen receptor (ER), progesterone receptor (PR), and HER2-neu oncoprotein expression, and carcinomas arising in the setting of MGA are often reported to be triple negative. In this article, we present a unique case of an ER+/PR+/HER2- invasive carcinoma associated with MGA and atypical MGA. Our case highlights the diagnostic pitfall of MGA and suggests that MGA is a heterogeneous group of lesions with potential for either luminal-type or basal-type differentiation during progression to breast carcinoma.
Topics: Biomarkers, Tumor; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Disease Progression; Female; Fibrocystic Breast Disease; Humans; Mammography; Mastectomy; Middle Aged; Precancerous Conditions
PubMed: 31046496
DOI: 10.1177/1066896919845493 -
The British Journal of Oral &... Oct 2018Minor salivary glands are ubiquitous in the oral cavity, and related diseases are often indolent and asymptomatic. We describe the unusual features of sclerosing...
Minor salivary glands are ubiquitous in the oral cavity, and related diseases are often indolent and asymptomatic. We describe the unusual features of sclerosing polycystic adenosis, and its similarities to more sinister conditions of the minor salivary glands. Its importance is currently uncertain and research points to a pathogenesis that is neoplastic, which can create ambiguity. Sclerosing polycystic adenosis is a newly-discovered condition that merits further discussion and research to evaluate its full impact.
Topics: Cysts; Diagnosis, Differential; Female; Humans; Middle Aged; Salivary Gland Diseases; Salivary Glands, Minor; Sclerosis
PubMed: 30054028
DOI: 10.1016/j.bjoms.2018.07.007 -
Human Pathology Mar 2019Microglandular adenosis (MGA) is a rare breast lesion reported to be associated with invasive carcinoma in up to 20% to 30% of cases and has been proposed as a...
Microglandular adenosis (MGA) is a rare breast lesion reported to be associated with invasive carcinoma in up to 20% to 30% of cases and has been proposed as a nonobligate precursor to basal-like breast cancers. We identified a case of matrix-producing metaplastic carcinoma with morphologic and immunohistochemical evidence of progression from MGA to atypical MGA, carcinoma in situ, and invasive carcinoma. We performed whole-exome sequencing of each component (MGA, atypical MGA, carcinoma in situ, and cancer) to characterize the mutational landscape of these foci. There was a significant copy number overlap between all foci, including a segmental amplification of the CCND1 locus (partial chromosome 11 trisomy) and MYC (8q24.12-13). Using a bioinformatics approach, we were able to identify 3 putative mutational clusters and recurrent, stop-gain nonsynonymous mutations in both ZNF862 and TP53 that were shared across all foci. Finally, we identified a novel deleterious splice-acceptor site mutation of chr5:5186164 G>T (chromosome 5p15) encoding the gene, ADAMTS16, in the invasive component.
Topics: ADAMTS Proteins; Breast Neoplasms; Carcinoma, Ductal, Breast; Disease Progression; Female; Fibrocystic Breast Disease; Humans; Immunohistochemistry; Precancerous Conditions; Tumor Suppressor Protein p53
PubMed: 30428388
DOI: 10.1016/j.humpath.2018.10.021 -
Diagnostic Cytopathology May 2022A 15-year-old male presented to the hospital with a 2-month history of a right parotid mass. Magnetic resonance imaging revealed an encapsulated 3.7 cm mass....
A 15-year-old male presented to the hospital with a 2-month history of a right parotid mass. Magnetic resonance imaging revealed an encapsulated 3.7 cm mass. Fine-needle aspiration suggested a monomorphic adenoma (prior to utilization of the Milan Classification system). Total parotidectomy was performed with dissection and preservation of the facial nerve. Surgical pathology identified the lesion as sclerosing polycystic adenosis (SPA) after examining the histopathological and immunohistochemistry findings. SPA is a rare lesion which leads to inflammatory changes in the salivary gland. The most common site impacted is the parotid gland but also can affect other major or minor salivary glands. The fibrocystic changes are morphologically like the histological developments of sclerosing adenosis of breast tissue. Those changes consist of fibrosis, apocrine metaplasia, and different degrees of proliferation of ducts, acini, and myoepithelial cells. The pathogenesis of SPA is unknown but recent studies suggest that it could be a neoplasm. Treatment with surgical excision is effective and its' recurrence is rare. This case report details the cytomorphology, histology, and immunohistochemical profile of SPA.
Topics: Adolescent; Biopsy, Fine-Needle; Cysts; Female; Fibrocystic Breast Disease; Humans; Male; Parotid Gland; Parotid Neoplasms; Salivary Glands
PubMed: 34965020
DOI: 10.1002/dc.24926