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Seminars in Diagnostic Pathology Jul 2014Adenosquamous carcinoma is an unusual and aggressive form of non-small cell lung carcinoma. Although extensively studied, there is persistent uncertainty with regard to... (Review)
Review
Adenosquamous carcinoma is an unusual and aggressive form of non-small cell lung carcinoma. Although extensively studied, there is persistent uncertainty with regard to its histogenesis and clinical and histopathologic features, related to the inherent heterogeneity of lung carcinoma. This review will attempt a reappraisal of the definition and diagnostic criteria and address problem areas and practical issues in the pathologic evaluation of this neoplasm.
Topics: Carcinoma, Adenosquamous; Humans; Lung; Lung Neoplasms
PubMed: 25002356
DOI: 10.1053/j.semdp.2014.06.004 -
Pathology Oct 2022
Topics: Adenocarcinoma; Carcinoma, Adenosquamous; Humans
PubMed: 35183354
DOI: 10.1016/j.pathol.2021.11.012 -
Scandinavian Journal of Gastroenterology Nov 2020Adenosquamous carcinoma (ASC), containing both adenocarcinoma and squamous cell carcinoma components, is rare in the digestive system. Limited data is available on ASC... (Review)
Review
Adenosquamous carcinoma (ASC), containing both adenocarcinoma and squamous cell carcinoma components, is rare in the digestive system. Limited data is available on ASC of the digestive system (AS-ASC), and the current evidence is available mainly in the form of case reports and case series. We performed a thorough search of the available literature and compiled a review on the epidemiology, histopathology, pathogenesis, clinical manifestations, diagnosis, treatment, and prognosis of AS-ASC. Non-specific clinical and imaging presentations and low diagnostic accuracy of biopsy lead to difficulties in preoperative diagnosis in a high proportion of patients and high malignancy. The pathogenesis remains obscure. Surgery remains the mainstay of treatment for AS-ASC. The role of chemoradiotherapy as an adjuvant treatment is still inconclusive. Key messages Metastatic linings and the lack of efficacious treatments lead to an unfavorable outcome in AS-ASC patients. Further research could help us understand the pathophysiology of AS-ASCand the unique needs of AS-ASC patients.
Topics: Adenocarcinoma; Carcinoma, Adenosquamous; Carcinoma, Squamous Cell; Digestive System; Humans; Prognosis
PubMed: 33070641
DOI: 10.1080/00365521.2020.1832571 -
Journal of Medical Case Reports Oct 2022Among the total reported cases of pancreatic duct adenocarcinomas, around 1-2.9% are adenosquamous carcinomas of the pancreas. Due to limited data, preoperative... (Review)
Review
BACKGROUND
Among the total reported cases of pancreatic duct adenocarcinomas, around 1-2.9% are adenosquamous carcinomas of the pancreas. Due to limited data, preoperative diagnosis is a great challenge for physicians, and it is usually set post-operational, based on the pathologist report. We operated on two cases of adenosquamous carcinoma of the pancreas, which we present alongside the operation and treatment planning.
CASE REPORT
A 69-year-old Caucasian female and a 63-year-old Caucasian male presented themselves with jaundice in our department. The abdomen computed tomography and magnetic resonance imaging scans revealed lesions of the pancreas. A pancreas-duodenumectomy was performed in both patients, and the post-operational histology analysis revealed adenosquamous carcinoma of the pancreas head. The patients were discharged in good condition and received further chemotherapy treatment after surgery.
CONCLUSIONS
Two case reports of adenosquamous carcinoma of the pancreas are described here, which both underwent surgery resection. The limited available literature on this topic substantially limits the knowledge and guidance on treatment. A summarization of the available literature is attempted, alongside a description of possible fields of future research.
Topics: Humans; Male; Female; Aged; Middle Aged; Carcinoma, Adenosquamous; Pancreatic Neoplasms; Pancreas; Tomography, X-Ray Computed; Abdomen
PubMed: 36309754
DOI: 10.1186/s13256-022-03610-5 -
Indian Journal of Pathology &... Jun 2021Primary hepatic adenosquamous carcinoma (ASC) is an extremely rare primary hepatic malignant tumor, which is easily misdiagnosed as hepatocellular carcinoma before... (Review)
Review
Primary hepatic adenosquamous carcinoma (ASC) is an extremely rare primary hepatic malignant tumor, which is easily misdiagnosed as hepatocellular carcinoma before surgery. It has both the histologic features-adenocarcinoma and squamous cell carcinoma. Primary hepatic ASC incidence rate in intrahepatic cholangiocarcinoma is 2% to 3%. Patients with hepatic ASC may experience recurrence or metastasis after surgery. The epidemiology, clinical diagnosis, etiology, and treatment of the disease remain challenging. It is important to improve the recognition of hepatic ASC because of its bad prognosis. Here, we report a man who had complained of an upper stomachache for 2 months and was diagnosed with primary hepatic ASC by histology and immunohistochemistry (IHC) after laparoscopic hepatectomy. The patient remained asymptomatic and survived well for 2 years post surgery and long-term follow-up was continued till now. In addition, we offer a brief discussion about the histopathological features, clinical behavior, and treatment of hepatic ASC and review the relevant literature.
Topics: Adenocarcinoma; Aged; Carcinoma, Adenosquamous; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Hepatectomy; Histological Techniques; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Male
PubMed: 34135156
DOI: 10.4103/IJPM.IJPM_785_18 -
International Journal of Gynecological... May 2023Although both the 2014 and 2020 World Health Organization (WHO) criteria require unequivocal glandular and squamous differentiation for a diagnosis of cervical... (Review)
Review
Although both the 2014 and 2020 World Health Organization (WHO) criteria require unequivocal glandular and squamous differentiation for a diagnosis of cervical adenosquamous carcinoma (ASC), in practice, ASC diagnoses are often made in tumors that lack unequivocal squamous and/or glandular differentiation. Considering the ambiguous etiologic, morphologic, and clinical features and outcomes associated with ASCs, we sought to redefine these tumors. We reviewed slides from 59 initially diagnosed ASCs (including glassy cell carcinoma and related lesions) to confirm an ASC diagnosis only in the presence of unequivocal malignant glandular and squamous differentiation. Select cases underwent immunohistochemical profiling as well as human papillomavirus (HPV) testing by in situ hybridization. Of the 59 cases originally classified as ASCs, 34 retained their ASC diagnosis, 9 were reclassified as pure invasive stratified mucin-producing carcinomas, 10 as invasive stratified mucin-producing carcinomas with other components (such as HPV-associated mucinous, usual-type, or ASCs), and 4 as HPV-associated usual or mucinous adenocarcinomas with benign-appearing squamous metaplasia. Two glassy adenocarcinomas were reclassified as poorly differentiated HPV-associated carcinomas based on morphology and immunophenotype. There were no significant immunophenotypic differences between ASCs and pure invasive stratified mucin-producing carcinomas with regard to HPV and other markers including p16 expression. Although limited by a small sample size, survival outcomes seemed to be similar between all groups. ASCs should be diagnosed only in the presence of unequivocal malignant glandular and squamous differentiation. The 2 putative glassy cell carcinomas studied did not meet our criteria for ASC and categorizing them as such should be reconsidered.
Topics: Female; Humans; Carcinoma, Adenosquamous; Papillomavirus Infections; Uterine Cervical Neoplasms; Adenocarcinoma; Carcinoma, Squamous Cell; Mucins
PubMed: 36044310
DOI: 10.1097/PGP.0000000000000921 -
Clinics and Research in Hepatology and... Nov 2020
Topics: Carcinoma, Adenosquamous; Female; Humans; Middle Aged; Pancreatectomy; Pancreatic Neoplasms
PubMed: 32107164
DOI: 10.1016/j.clinre.2020.01.008 -
Cellular Oncology (Dordrecht) Feb 2023As a malignant tumor, pancreatic cancer has an extremely low overall 5-year survival rate. Pancreatic adenosquamous carcinoma (PASC), a rare pancreatic malignancy, owns... (Review)
Review
BACKGROUND
As a malignant tumor, pancreatic cancer has an extremely low overall 5-year survival rate. Pancreatic adenosquamous carcinoma (PASC), a rare pancreatic malignancy, owns clinical presentation similar to pancreatic ductal adenocarcinoma (PDAC), which is the most prevalent pancreatic cancer subtype. PASC is generally defined as a pancreatic tumor consisting mainly of adenocarcinoma tissue and squamous carcinoma tissue. Compared with PDAC, PASC has a higher metastatic potential and worse prognosis, and lacks of effective treatment options to date. However, the pathogenesis and treatment of PASC are not yet clear and are accompanied with difficulties.
CONCLUSION
The present paper systematically summarizes the possible pathogenesis, diagnosis methods, and further suggests potential new treatment directions through reviewing research results of PASC, including the clinical manifestations, pathological manifestation, the original hypothesis of squamous carcinoma and the potential regulatory mechanism. In short, the present paper provides a systematic review of the research progress and new ideas for the development mechanism and treatment of PASC.
Topics: Humans; Carcinoma, Adenosquamous; Pancreatic Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Adenocarcinoma
PubMed: 36316580
DOI: 10.1007/s13402-022-00732-2 -
Odontology Jan 2017Adenosquamous carcinoma (ASC) of the tongue is an uncommon malignant oral neoplasm with mixed glandular and squamous differentiation and a propensity for aggressive... (Review)
Review
Adenosquamous carcinoma (ASC) of the tongue is an uncommon malignant oral neoplasm with mixed glandular and squamous differentiation and a propensity for aggressive clinical behavior. Here, we report a rare case of ASC of the lateral border of the tongue in a 65-year-old Japanese man. The patient was treated by radical operation and remained well for 6 months before developing metastasis of the hilar and pretracheal lymph nodes. Subsequently, the patient was treated with combined chemotherapy (nedaplatin plus docetaxel and S-1 for two cycles, intravenously) and radiotherapy. Radiation therapy of metastatic lymph nodes was performed at a total dose of 60 Gy and was delivered in 2 Gy fractions 5 days/week. The patient is currently tumor free and is being followed up carefully. This article describes a rare case of ASC of the tongue and its conventional histologic, immunohistochemical, and electron microscopic findings, together with a review of the literature. The findings provide important information to better understand the possible clinical and therapeutic approaches for this uncommon tumor of the tongue.
Topics: Aged; Carcinoma, Adenosquamous; Diagnostic Imaging; Humans; Immunohistochemistry; Male; Microscopy, Electron; Tongue Neoplasms
PubMed: 27456683
DOI: 10.1007/s10266-016-0261-6 -
Journal of Clinical Pathology Jun 2013Low-grade adenosquamous carcinoma is a rare and unique form of invasive mammary carcinoma. Though it is categorised as a variant of metaplastic carcinoma, it differs... (Review)
Review
Low-grade adenosquamous carcinoma is a rare and unique form of invasive mammary carcinoma. Though it is categorised as a variant of metaplastic carcinoma, it differs from its counterparts in this heterogeneous category by its relative clinical indolence, also reflected histologically in its low-grade cytomorphology. Descriptions of such a tumour were reported as early as 1912. However, low-grade adenosquamous carcinoma was only formally recognised in 1987 with the publication of Rosen and Ernsberger's landmark paper. Since then, several case reports and larger series have reaffirmed the clinicopathological characteristics of this unusual and uncommon tumour. Due to its rarity, however, many aspects of low-grade adenosquamous carcinoma, including its immunohistochemical and genetic profiles, remain unclear. This paper reviews the literature on this entity from 1987 to date, summarising its clinical and pathological features, and highlighting the diagnostic challenges it poses.
Topics: Breast Neoplasms; Carcinoma, Adenosquamous; Female; Humans
PubMed: 23268316
DOI: 10.1136/jclinpath-2012-201084