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Anesthesia and Analgesia 1976Intractable pain in a patient with adiposis dolorosa (Dercum's disease) was treated by IV administration of lidocaine (200 to 400 mg). Relief was maximum 20 minutes...
Intractable pain in a patient with adiposis dolorosa (Dercum's disease) was treated by IV administration of lidocaine (200 to 400 mg). Relief was maximum 20 minutes after the end of drug infusion and persisted for over 10 hours. Toxicity was minimal. Slow EEG waves which appeared during drug administration disappeared within 20 minutes.
Topics: Adiposis Dolorosa; Anesthesia, Intravenous; Female; Humans; Infusions, Parenteral; Lidocaine; Middle Aged; Pain, Intractable
PubMed: 943987
DOI: 10.1213/00000539-197603000-00028 -
Sovetskaia Meditsina 1969
Topics: Adiposis Dolorosa; Adult; Female; Humans
PubMed: 5379364
DOI: No ID Found -
International Journal of Obesity (2005) Feb 2017People with lipedema or Dercum's disease (DD) can have a similar distribution of excess painful nodular subcutaneous adipose tissue (SAT), making them difficult to...
BACKGROUND
People with lipedema or Dercum's disease (DD) can have a similar distribution of excess painful nodular subcutaneous adipose tissue (SAT), making them difficult to differentiate.
METHODS
Case series of 94 patients with DD, 160 with lipedema and 18 with both diagnoses (Lip+DD) from a single clinic in an academic medical center to improve identification and differentiation of these disorders by comparison of clinical findings, prevalence of type 2 diabetes (DM2), hypermobility by the Beighton score and assessment of a marker of inflammation, Total complement activity (CH50).
RESULTS
Differences between groups were by Student's t-test with α of 0.05. The Lipedema Group had significantly greater weight, body mass index (BMI), gynoid distributed nodular SAT and fibrotic and heavy tissue than the DD Group. Hypermobility was significantly higher in the Lipedema (58±0.5%) than DD Group (23±0.4%; P<0.0001). DM2 was significantly greater in the DD (16±0.2%; P=0.0007) than the Lipedema Group (6±0.2%). Average pain by an analog scale was significantly higher in the DD (6±2.5%) than the Lipedema Group (4±2.1%; P<0.0001). Fatigue and swelling were common in both groups. Easy bruising was more common in the Lipedema Group, whereas abdominal pain, shortness of breath, fibromyalgia, migraines and lipomas were more prevalent in the DD Group. The percentage of patients with elevated CH50 was significantly positive in both groups.
CONCLUSIONS
The significantly lower prevalence of DM2 in people with lipedema compared with DD may be due to the greater amount of gynoid fat known to be protective against metabolic disorders. The high percentage of hypermobility in lipedema patients indicates that it may be a comorbid condition. The location of fat, high average daily pain, presence of lipomas and comorbid painful disorders in DD patients may help differentiate from lipedema.
Topics: Adiposis Dolorosa; Diabetes Mellitus, Type 2; Diagnosis, Differential; Female; Humans; Lipedema; Magnetic Resonance Imaging; Male; Middle Aged; Pain; Pain Measurement; Practice Guidelines as Topic; Subcutaneous Fat
PubMed: 27857136
DOI: 10.1038/ijo.2016.205 -
International Journal of Obesity 1982Adiposis dolorosa (Dercum's disease) is a syndrome of painful adipose tissue which occurs most often in post-menopausal women and is associated with obesity, asthenia,... (Clinical Trial)
Clinical Trial
Adiposis dolorosa (Dercum's disease) is a syndrome of painful adipose tissue which occurs most often in post-menopausal women and is associated with obesity, asthenia, and emotional disturbances. The etiology is uncertain, but is probably multifactorial. Numerous treatments to relieve the pain have generally been unsuccessful. A patient with adiposis dolorosa was treated with intravenous infusions of lidocaine over a two-year period. Relief from pain lasted from two to 12 months after each infusion. A single-blind placebo infusion did not relieve the pain. Lidocaine infusions did not relieve the pain of diabetic neuropathy or of angina in this patient. The mechanism of relief of pain of adiposis dolorosa by lidocaine is uncertain, but previously reported central effects of lidocaine suggest that alterations in the central nervous system may be responsible.
Topics: Adiposis Dolorosa; Female; Humans; Injections, Intravenous; Lidocaine; Middle Aged; Pain, Intractable; Placebos; Time Factors
PubMed: 7129748
DOI: No ID Found -
British Medical Journal Jul 1904
PubMed: 20761653
DOI: 10.1136/bmj.2.2272.121-a -
Orvosi Hetilap Sep 2009Overweight and obesity is a public health problem in Hungary and in the Western world. It is important to underline that obesity is an illness and an important risk... (Review)
Review
Overweight and obesity is a public health problem in Hungary and in the Western world. It is important to underline that obesity is an illness and an important risk factor for several skin and other diseases. An overview of skin diseases caused or aggravated by obesity (acanthosis nigricans, acrochordons, keratosis pilaris, hyperandrogenism, stria, adiposis dolorosa, lymphoedema, chronic venous insufficiency, plantar hyperkeratosis, lipoedema, skin infections, acne inversa, psoriasis, tophi) helps us to look and see as well. Look for the possibility of skin infections as it helps the early diagnosis and to avoid complications. Draw patients' attention to the preventive importance of skin care. In case of an obese patient the usual dosage of most local and systemic drugs should be modified. It must be kept in mind that obesity directly or indirectly starts unfavorable processes in almost all organ systems. Therefore, only a multidisciplinary care may secure treatment and rehabilitation of obese patients. Dermatological and lymphological care is often part of the rehabilitation.
Topics: Acanthosis Nigricans; Adiposis Dolorosa; Early Diagnosis; Female; Hidradenitis Suppurativa; Humans; Hungary; Hyperandrogenism; Interdisciplinary Communication; Keratosis; Lymphedema; Male; Obesity; Obesity, Morbid; Overweight; Patient Care Team; Psoriasis; Risk Factors; Skin Diseases; Skin Diseases, Infectious; Venous Insufficiency
PubMed: 19723602
DOI: 10.1556/OH.2009.28693 -
Journal of Vascular Surgery Cases and... Sep 2023Lower limb venous obstruction secondary to a lipoma is a rare occurrence. Patients with these benign soft tissue tumors can be asymptomatic, or may experience symptoms...
Lower limb venous obstruction secondary to a lipoma is a rare occurrence. Patients with these benign soft tissue tumors can be asymptomatic, or may experience symptoms of pain, parasthesia, paralysis and swelling secondary to compression on adjacent neurovascular structures. Duplex ultrasound examination is the first-line investigation, but has its limitations. We report on a case of venous obstruction syndrome misdiagnosed as chronic venous insufficiency on duplex ultrasound examination, from a deep-seated giant lipoma compressing on the common femoral and distal external iliac vein in a patient with Dercum's disease.
PubMed: 37662572
DOI: 10.1016/j.jvscit.2023.101275 -
Zeitschrift Fur Rheumaforschung 1973
Topics: Adiposis Dolorosa; Cellulitis; Diagnosis, Differential; Erythema Nodosum; Female; Humans; Male; Pain; Panniculitis, Nodular Nonsuppurative; Sex Factors; Tuberculosis, Cutaneous
PubMed: 4724521
DOI: No ID Found -
International Journal of Dermatology Jun 1995
Review
Topics: Acne Vulgaris; Adiposis Dolorosa; Adolescent; Adult; Aged; Autoimmune Diseases; Child; Child, Preschool; Dermatitis; Dermatitis, Contact; Erythrocytes; Estrogen Replacement Therapy; Female; Humans; Hyperpigmentation; Infant; Lichen Sclerosus et Atrophicus; Menopause; Middle Aged; Nail Diseases; Paget's Disease, Mammary; Pregnancy; Pregnancy Complications; Progesterone; Skin Diseases; Skin Diseases, Infectious; Trichotillomania
PubMed: 7657432
DOI: 10.1111/j.1365-4362.1995.tb04434.x -
Der Nervenarzt Feb 2002Dercum's disease (lipomatosis dolorosa) is a relatively unknown illness. The disorder usually affects middle-aged females. Subcutaneous fatty tissue deposits may occur...
Dercum's disease (lipomatosis dolorosa) is a relatively unknown illness. The disorder usually affects middle-aged females. Subcutaneous fatty tissue deposits may occur in many parts of the body. The upper arms, elbows, stomach wall, buttocks, thighs, or knees are most commonly affected. Severe hyperalgesia is found on light pressure and touch. Analgesics or pain-modulating drugs usually have little or no effect. The following case report demonstrates successful symptomatic treatment of the otherwise nearly unbearable complaints: intravenous infusions of 5 mg/kg body weight of lidocaine over 30-90 min may give pain relief lasting several weeks or even months. Alternatively, patients are treated with 150-750 mg orally administered mexiletine daily. Surgical excision or liposuction of these fatty tissue deposits have shown significant reduction of pain. However, this effect reduces over time and recurrences often develop.
Topics: Adiposis Dolorosa; Diagnosis, Differential; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Lidocaine; Mexiletine; Middle Aged
PubMed: 11975097
DOI: 10.1007/s00115-001-1240-9