-
The Journal of Investigative... Jan 2018Platelet-rich plasma and microneedling have been investigated recently as potential therapeutic options for the treatment of hair disorders. Evidence from laboratory... (Review)
Review
Platelet-rich plasma and microneedling have been investigated recently as potential therapeutic options for the treatment of hair disorders. Evidence from laboratory studies indicates that these treatments enhance growth factor production that in turn facilitates hair follicle development and cycling. Several small studies and case reports have presented encouraging findings regarding the use of these treatments for alopecia areata. Future investigations will be needed to validate these therapeutic techniques for patients with alopecia areata and further refine which subtypes of the disease these methods are best indicated for.
Topics: Alopecia Areata; Female; Humans; Intercellular Signaling Peptides and Proteins; Male; Needles; Platelet-Rich Plasma
PubMed: 29273100
DOI: 10.1016/j.jisp.2017.10.002 -
Journal of Cosmetic Dermatology Dec 2021
Topics: Alopecia Areata; COVID-19; Humans; SARS-CoV-2
PubMed: 34559937
DOI: 10.1111/jocd.14459 -
Acta Dermato-venereologica Feb 2018Alopecia areata (AA) is an immune-mediated disease causing temporary or permanent hair loss. Up to 46% of patients with AA also have nail involvement. The aim of this... (Review)
Review
Alopecia areata (AA) is an immune-mediated disease causing temporary or permanent hair loss. Up to 46% of patients with AA also have nail involvement. The aim of this study was to determine the presence, types, and clinical implications of nail changes in patients with AA. This questionnaire-based survey evaluated 256 patients with AA. General demographic variables, specific nail changes, nail-related quality of life (QoL), and treatment history and need were evaluated. Prevalence of nail involvement in AA was 64.1%. The specific nail signs reported most frequently were pitting (29.7%, p = 0.008) and trachyonychia (18.0%). Red spots on the lunula were less frequent (5.1%), but very specific for severe AA. Nail-related QoL was only minimally affected by nail changes. In conclusion, nail involvement is common in patients with AA and presents mostly with pitting and trachyonychia. The presence of these nail changes reflects the severity of the disease, with red spots on the lunula as a predictor for severe alopecia.
Topics: Adult; Aged; Alopecia Areata; Case-Control Studies; Cost of Illness; Female; Health Surveys; Humans; Male; Middle Aged; Nail Diseases; Nails; Nails, Malformed; Netherlands; Prevalence; Prognosis; Quality of Life
PubMed: 28967977
DOI: 10.2340/00015555-2810 -
European Journal of Dermatology : EJD Jul 2022
Topics: Humans; Alopecia Areata; Immune Checkpoint Inhibitors
PubMed: 36301769
DOI: 10.1684/ejd.2022.4315 -
Dermatologic Therapy Jul 2021The aim of this study was to evaluate metabolic syndrome prevalence in patients with Alopecia Areata compared to controls. Sixty eligible patients with Alopecia Areata...
The aim of this study was to evaluate metabolic syndrome prevalence in patients with Alopecia Areata compared to controls. Sixty eligible patients with Alopecia Areata and 60 healthy subjects frequency matched for age and sex attending to our referral dermatology clinics from 2015 to 2017 were enrolled. Prevalence of metabolic syndrome and its components were compared between the two groups. Metabolic syndrome was only seen in seven patients (11.67%) and four controls (6.67%) without a significant difference (P = .34). The clinical presentations of AA included patch type (38.33%), ophiasis (6.67%), alopecia totalis (16.67%), and alopecia universalis (38.33%). Presence of metabolic syndrome was significantly associated with abdominal circumference (OR: 1.10, 95% CI for OR: 1.02to 1.19). Although there was no significant association between Alopecia Areata and metabolic syndrome, some components of metabolic syndrome were more prevalent in these patients. It may be concluded Alopecia Areata patients are at a higher risk of developing metabolic syndrome in the future. Further studies with larger sample sizes are needed.
Topics: Alopecia Areata; Case-Control Studies; Humans; Metabolic Syndrome; Prevalence
PubMed: 33991033
DOI: 10.1111/dth.14979 -
International Journal of Dermatology May 1999
Review
Topics: Alopecia Areata; Diagnosis, Differential; Female; Humans; Male; Prognosis
PubMed: 10369536
DOI: 10.1046/j.1365-4362.1999.00004.x -
Pediatric Dermatology 2023Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inherited disorder of immunity which leads to increased risk for mucocutaneous candidiasis...
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is an inherited disorder of immunity which leads to increased risk for mucocutaneous candidiasis and multiorgan autoimmune disease. While alopecia areata (AA) has been described in some patients with APECED, the extent and timing of AA is not well established and extent and timing of concomitant vitiligo and hypothyroidism has not been described. We evaluated an APECED cohort followed at the National Institutes of Health for the timing of development of associated diseases. We found AA occurred earlier in those with APECED than in the general population, was rarely the first sign of APECED, and the timing of AA onset did correlate with the timing of onset of vitiligo or hypothyroidism which also occurred at high rates and early age.
Topics: Humans; Polyendocrinopathies, Autoimmune; Alopecia Areata; Vitiligo; Hypothyroidism
PubMed: 37495514
DOI: 10.1111/pde.15380 -
Journal of the American Academy of... Feb 2019
Topics: Alopecia Areata; Clinical Trials as Topic; Female; Humans; Janus Kinase Inhibitors; Male; Prognosis; Severity of Illness Index; Thinking; Treatment Outcome; World Health Organization
PubMed: 30244065
DOI: 10.1016/j.jaad.2018.08.059 -
The British Journal of Dermatology Aug 1981The prevalence of auto-antibodies against thyroid constituents, gastric parietal cells, smooth muscle cells, mitochondria, reticulin, nuclear constituents and rheumatoid...
The prevalence of auto-antibodies against thyroid constituents, gastric parietal cells, smooth muscle cells, mitochondria, reticulin, nuclear constituents and rheumatoid factor in 108 patients with alopecia areata was compared with that found in a previous survey of the local population. Female patients had a significantly increased prevalence of anti-thyroid antibodies which were present in 30% overall and in 44% of the youngest age group (11-17 years). Smooth muscle antibodies were more frequent in female patients but the increase was not significant. Male patients had a significant increased prevalence of thyroid and gastric parietal cell antibodies (11.4% each). In females, antithyroid antibodies were associated with extensive hair loss: they were found in 42% of female patients with total alopecia and only 20% of males with total hair loss. A family history of alopecia areata was obtained from 24% of patients; 10% had relatives with thyroid disease and 10% had diabetic relatives. These findings confirm the association between alopecia areata and the other auto-immune diseases.
Topics: Adolescent; Adult; Age Factors; Aged; Alopecia Areata; Autoantibodies; Child; Female; Humans; Male; Middle Aged; Sex Factors; Thyroid Gland
PubMed: 7284245
DOI: 10.1111/j.1365-2133.1981.tb01200.x -
The Australasian Journal of Dermatology Aug 2023
Topics: Humans; Alopecia Areata; Antibodies, Monoclonal, Humanized
PubMed: 37186297
DOI: 10.1111/ajd.14062