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Pathologica Aug 2022Alveolar adenoma is a rare tumour of the lung. It is typically found in asymptomatic adults as a peripheral or subplerual nodule on imaging examination. Microscopically,... (Review)
Review
Alveolar adenoma is a rare tumour of the lung. It is typically found in asymptomatic adults as a peripheral or subplerual nodule on imaging examination. Microscopically, the tumour is composed of admixture of epithelial and mesenchymal component in variable sized cystic or alveolar structures. The tumour shows a benign nature. There have been no reported recurrences or metastases. Malignant transformation of alveolar adenoma and coexisting with lung carcinoma have been rarely described. In this article, we report a case of an alveolar adenoma and coexisting atypical adenomatous hyperplasia. This case, contributing to the limited numbers of cases described to date, illustrates the importance of awareness on the possibility of alveolar adenoma being associated with lung carcinoma and its precursor lesions especially when diagnosed by small biopsy specimens.
Topics: Adenoma; Adult; Carcinoma; Humans; Hyperplasia; Lung Neoplasms; Precancerous Conditions
PubMed: 36136901
DOI: 10.32074/1591-951X-755 -
Human Pathology Oct 1986This report describes six cases of an unusual pulmonary neoplasm, the alveolar adenoma, that consists of a benign proliferation of alveolar epithelium and septal...
This report describes six cases of an unusual pulmonary neoplasm, the alveolar adenoma, that consists of a benign proliferation of alveolar epithelium and septal mesenchyme. The neoplasm presents as a solitary peripheral lesion on chest radiographs, particularly in older patients. It has unique histologic features, which should be distinguished from those of sclerosing hemangioma, lymphangioma, and bronchioloalveolar carcinoma.
Topics: Adenoma; Histocytochemistry; Humans; Immunochemistry; Lung Neoplasms; Microscopy, Electron; Middle Aged; Pulmonary Alveoli
PubMed: 3759064
DOI: 10.1016/s0046-8177(86)80092-2 -
Jornal Brasileiro de Pneumologia :... 2006Alveolar adenoma is a rare benign neoplasm of the lungs, and very few cases have been described in the literature. Patients with alveolar adenoma are frequently...
Alveolar adenoma is a rare benign neoplasm of the lungs, and very few cases have been described in the literature. Patients with alveolar adenoma are frequently asymptomatic and are diagnosed through the accidental discovery of a singular, well-delineated nodule on a routine chest X-ray. The definitive diagnosis is made histologically, and the treatment consists of surgical resection of the nodule.
Topics: Adenoma; Adult; Female; Humans; Lung Neoplasms; Thoracotomy; Tomography, X-Ray Computed
PubMed: 17273617
DOI: 10.1590/s1806-37132006000300014 -
Journal of Investigative Medicine High... 2023Alveolar adenoma (AA) is a rare type of pulmonary neoplasm showing proliferation of alveolar epithelium and septal mesenchyme. Clinically, AA is asymptomatic, benign,... (Review)
Review
Alveolar adenoma (AA) is a rare type of pulmonary neoplasm showing proliferation of alveolar epithelium and septal mesenchyme. Clinically, AA is asymptomatic, benign, and usually diagnosed incidentally. Surgical excision is curative. The etiology of AA is controversial and the pathogenesis is unknown, but it is thought to stem from type II pneumocytes and fibroblasts or fibroblast-like cells. The stromal cells in AA may show rare staining for CD34. Diffuse CD34 positivity of the interstitial stromal cells has rarely been described and reviewed. Here, we report a case of AA with strong and diffuse CD34 staining in the stromal cells.
Topics: Humans; Lung Neoplasms; Adenoma; Diagnosis, Differential
PubMed: 37530218
DOI: 10.1177/23247096231181959 -
The Journal of International Medical... Jun 2013Alveolar adenoma is an extremely rare and benign pulmonary neoplasm; it is always asymptomatic and is usually detected incidentally on routine chest X-radiography.... (Review)
Review
Alveolar adenoma is an extremely rare and benign pulmonary neoplasm; it is always asymptomatic and is usually detected incidentally on routine chest X-radiography. Typically on imaging examinations, alveolar adenoma exhibits as a peripheral, solitary, cystic nodule in the lung, which may easily imitate other lung lesions, consequently leading to difficulties in the differential diagnosis of this condition. Surgical resection is the primary treatment option. The diagnosis of alveolar adenoma is mainly based on postoperative histopathology, with features of proliferative type 2 alveolar epithelial cells and septal mesenchyme. The present case was a 60-year-old woman with alveolar adenoma, combined with systemic mutifocal cystic lesions. She underwent surgery following the obvious enlargement of this mass and a cystic nodule 7 cm in maximum diameter was resected. Postoperative histopathology confirmed a diagnosis of alveolar adenoma; her prognosis was favourable. In addition to reporting a rare case of alveolar adenoma coexisting with multifocal cysts, the English-language literature was reviewed for similar cases of alveolar adenoma.
Topics: Adenoma; Adult; Aged; Alveolar Epithelial Cells; Cysts; Diagnosis, Differential; Female; Humans; Lung Neoplasms; Male; Middle Aged; Pulmonary Alveoli; Radiography; Solitary Pulmonary Nodule
PubMed: 23653367
DOI: 10.1177/0300060513477304 -
The Journal of International Medical... Mar 2020Alveolar adenoma is an isolated, well-defined peripheral lung tumor that originates from type II alveolar cells. The tumor consists of a network of simple, low-cubic,...
Alveolar adenoma is an isolated, well-defined peripheral lung tumor that originates from type II alveolar cells. The tumor consists of a network of simple, low-cubic, epithelium-coated lacunae with varying amounts of fine and inconspicuous-to-thick spindle cells that sometimes contain mucus sample matrix. Few cases of alveolar adenoma have been reported. These tumors are usually detected by imaging examinations where the alveolar adenoma typically presents as a peripheral, solitary cystic nodule in the lung. The presentation may mimic that of other types of lung tumors, consequently leading to difficulties in the differential diagnosis of this condition. Thus, accurate diagnosis of alveolar adenoma is based on a combination of pathological sections and immunohistochemistry. This study describes an alveolar adenoma in a 59-year-old female patient. Chest X-ray imaging and chest computed tomography identified malignant lesions in the right upper lobe. The patient subsequently underwent a thoracoscopic right upper lobectomy. The diagnosis of alveolar adenoma was confirmed after pathological examination of the excised postoperative tissue. The disease course was stable, and there was no recurrence of pulmonary lesions during 3 years of postoperative patient follow-up. Herein, we report the case of a patient with benign alveolar adenoma with poor imaging and pathological results.
Topics: Adenoma; Female; Humans; Immunohistochemistry; Lung Neoplasms; Middle Aged; Neoplasm Recurrence, Local; Tomography, X-Ray Computed
PubMed: 31709862
DOI: 10.1177/0300060519885269 -
The Annals of Thoracic Surgery Nov 2004Alveolar adenoma of the lung is a rare benign neoplasm with proliferation of alveolar epithelium and septal mesenchyme. This unusual neoplasm presents as a solitary mass...
Alveolar adenoma of the lung is a rare benign neoplasm with proliferation of alveolar epithelium and septal mesenchyme. This unusual neoplasm presents as a solitary mass on chest roentgenograms, especially in older, asymptomatic patients. We report a case of this unusual neoplasm and describe the histologic and radiographic features of this tumor, which should be included in the differential diagnosis of a solitary pulmonary mass.
Topics: Adenoma; Diagnosis, Differential; Female; Humans; Lung Neoplasms; Middle Aged; Radiography; Solitary Pulmonary Nodule; Thoracotomy
PubMed: 15511494
DOI: 10.1016/j.athoracsur.2003.07.015 -
Radiologia 2022
Topics: Humans; Radiography; Lung Neoplasms; Radiology; Adenoma
PubMed: 36402545
DOI: 10.1016/j.rxeng.2022.10.004 -
Zhonghua Bing Li Xue Za Zhi = Chinese... Apr 2021
Review
Topics: Adenoma; Humans; Lung Neoplasms
PubMed: 33832000
DOI: 10.3760/cma.j.cn112151-20200804-00620 -
Turk Patoloji Dergisi 2022Alveolar adenoma is a rare lung benign tumour originating from type II pneumocytes. It presents as a well-defined nodule. In some cases, it is difficult to differentiate...
Alveolar adenoma is a rare lung benign tumour originating from type II pneumocytes. It presents as a well-defined nodule. In some cases, it is difficult to differentiate from lung cancer. Few cases of this tumour have been reported. We describe here a case of alveolar adenoma in a 63-year-old man discovered incidentally on chest X-ray. The lesion was reported as lepidic adenocarcinoma in bronchoscopic biopsy. The patient underwent a thoracoscopic left lower lobectomy. The histopathological and immunohistochemical examinations resulted in a diagnosis of alveolar adenoma. We report this case to describe its morphological and immunohistochemical characteristics and to emphasize its diagnostic difficulties.
Topics: Adenoma; Biopsy; Diagnosis, Differential; Humans; Incidental Findings; Lung Neoplasms; Male; Middle Aged; Radiography
PubMed: 34514578
DOI: 10.5146/tjpath.2021.01547